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NIH funding notice PAR-22-200

Development of Medications to Prevent and Treat Opioid and/or Stimulant Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional)

Closed on January 3, 2025.

Posted
September 1, 2022
Close date
January 3, 2025
Activity codes
UG3, UH3
Institutes taking part
NIDA

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

  1. Reissues: PAR-20-092 Development of Medications to Prevent and Treat Opioid Use Disorders and Overdose (UG3/UH3) (Clinical Trial Optional)
  2. 2 steps back: RFA-DA-19-002 Development of Medications to Prevent and Treat Opioid Use Disorders and Overdose (UG3/UH3) (Clinical Trials Optional)

Replaced by PAR-25-329.

Who won it before

74 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $231,898,594 in first-year total cost, median $2,920,292.

Most frequent study sections

  1. Special Emphasis Panel[ZDA1 IXN-O (01)]24
  2. Medication Development Research Study Section[NIDA-L]23
  3. Special Emphasis Panel[ZDA1 IXN-O (11)]9
  4. Special Emphasis Panel[ZDA1 IXN-O (17)]6
  5. Special Emphasis Panel[ZDA1 IXN-O (04)]3

Most frequent institutions

  1. VIRGINIA COMMONWEALTH UNIVERSITY4
  2. NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC3
  3. SPARIAN BIOSCIENCES, INC.3
  4. ENSYSCE BIOSCIENCES, INC.2
  5. ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI2
Competing awards under PAR-22-200 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2025MEB-1170: A New Chemical Entity for the Treatment of Opioid Use Disorder1UG3DA063357-01COMER, SANDRA D.FREEMAN, KEVIN B.KUO, LAWRENCE CREINES, SCOTT A.MEBIAS DISCOVERY, INC., CT$4,710,576ZDA1
2025IND-enabling studies and phase I clinical trials to advance CD74-target, DRhQ, as a treatment for stimulant use disorder1UG3DA061709-01LOFTIS, JENNIFER MMURNANE, KEVIN SEANSHIRLEY, RENEE LYNNVIROGENOMICS BIODEVELOPMENT, INC., OR$3,287,052NIDA
2025Clinical Development of SBS-147: First-in-class Oral Arylepoxamide Agonist for Pain1UG3DA064392-01ASHWORTH, JUDYPASTERNAK, ANNASPARIAN BIOSCIENCES, INC., NY$3,138,031NIDA
2025Development of a bioabsorbable, subcutaneous, extended-release buprenorphine implant for opioid use disorder1UG3DA062511-01BENNER, JEFFREYCOHEN, STEVEN MAKYSO THERAPEUTICS, LLC, MD$2,932,500NIDA
2025Optimization and Development of Non-Hallucinogenic 5-HT2A/2C Agonists as Opioid Use Disorder Therapeutics1UG3DA064403-01SHORT III, GLENNATAI THERAPEUTICS, INC., NY$2,923,842NIDA
2025Development of negative allosteric modulators at the mu opioid receptor1UG3DA063363-01KOBILKA, BRIAN KMAJUMDAR, SUSRUTAMCLAUGHLIN, JAY P.SUN, BINGFAWASHINGTON UNIVERSITY, MO$2,664,000NIDA
2025Repurposing FDA-approved oxytocin to treat opioid-induced respiratory depression1UG3DA062506-01A1MENDELOWITZ, DAVIDPOLOTSKY, VSEVOLOD YGEORGE WASHINGTON UNIVERSITY, DC$2,104,389NIDA
2025Advancing a non-addictive, peripherally acting opioid analgesic as a medication strategy to prevent opioid use disorder in patients undergoing treatment for pain1UG3DA061645-01A1SANDERS, VIRGINIA JDIMERX, CA$1,593,126NIDA
2025Novel 5-HT2A/mGluR5 Antagonist for Opioid Use Disorder1UG3DA063353-01MARTIN, CAITLIN EILEENMOELLER, FREDERICK GERARDVIRGINIA COMMONWEALTH UNIVERSITY, VA$1,153,945NIDA
2025Glutide for Ending Methamphetamine1UG3DA063329-01COFFIN, PHILLIP OPUBLIC HEALTH FOUNDATION ENTERPRISES, CA$977,129NIDA
2024Development of SBS-226, a MOR agonist / DOR antagonist, for OUD1UG3DA059278-01A1REICH, JEFFREYSPARIAN BIOSCIENCES, INC., NY$3,957,359NIDA
2024Registration Development Program for LUCEMYRA (Lofexidine) Label Expansion for Opioid Withdrawal Treatment in Adolescents1UG3DA061620-01MASSEY, VERONICA LYNCHSCHMIDT, LEEUSWM, LLC, KY$2,916,742NIDA
2024Development of a Safer and More Effective Ibogaine Analog for the Treatment of Opioid Use Disorder1UG3DA060053-01MAREK, GERARD JOSEPHGILGAMESH PHARMACEUTICALS INC, NY$2,747,151NIDA
2023Development of a Potent and Selective Nav1.8 inhibitor for the Treatment of Acute and Chronic Pain with the Goal of Reducing Opioid Use and Preventing Opioid Use Disorders1UG3DA058552-01 · under PAR-20-092HUNTER, JOHN CURETONMULCAHY, JOHN VINCENTSITEONE THERAPEUTICS, INC., CA$5,341,667NIDA
2023Antibody-based therapy for fentanyl-related opioid use disorder1UG3DA058544-01A1BREMER, PAUL TDESAI, RAJEEV INDRAJITMCLEAN HOSPITAL, MA$4,202,550NIDA
2023Development of cebranopadol, a potent dual MOP/NOP agonist, for the treatment of Opioid Use Disorder (OUD)1UG3DA059285-01CICCOCIOPPO, ROBERTOGREENWALD, MARK KGRIECO, JOSEPHPARK THERAPEUTICS, INC., NJ$3,329,591NIDA
2023A Therapeutic Agent to Lower the Level of Synthetic Opioids in the Body1UG3DA059286-01LI, XINHUACLEAR SCIENTIFIC, LLC, MA$3,035,865NIDA
2023Development of sigma receptor/DAT dual-targeting compounds to treat stimulant use disorder1UG3DA058553-01 · under PAR-20-092REICH, JEFFREYSPARIAN BIOSCIENCES, INC., NY$2,886,286NIDA
2023Long acting biodegradable buprenorphine depots1UG3DA059270-01OTTE, ANDREWPURDUE UNIVERSITY, IN$631,404NIDA
2022Development of a monoclonal antibody to reverse overdose from fentanyl and its analogs: from manufacturing to clinical trials1UG3DA057850-01 · under PAR-20-092COMER, SANDRA DPRAVETONI, MARCOUNIVERSITY OF WASHINGTON, WA$8,267,350ZDA1
2022Phase 1 and 2 studies of sublingual dexmedetomidine, an alpha 2 adrenergic agonist, for treating opioid withdrawal1UG3DA056247-01 · under PAR-20-092COMER, SANDRA DLEVIN, FRANCES RUDNICKNEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC, NY$3,312,204ZDA1
2022Naltrexone Transdermal Patch - An Accessible, Patient-Focused Option to Treat OUD Relapse1UG3DA057853-01 · under PAR-20-092GARDINER, ANDREWLIBERO PHARMA LIMITED$3,187,507NIDA
2022Development of Specific Mu Opioid Receptor Antagonists to Reverse the Acute and Chronic Toxicity of Fentanyls1UG3DA054785-01A1 · under PAR-20-092ZHANG, YANVIRGINIA COMMONWEALTH UNIVERSITY, VA$2,824,374NIDA
2021An Intranasal GDNF Gene Therapy for Opioid Relapse Reduction1UG3DA050942-01A1 · under PAR-20-092BYRNES, ELIZABETH MPOTHOS, EMMANUEL NWASZCZAK, BARBARA LEENORTHEASTERN UNIVERSITY, MA$6,693,512ZDA1
2021CVL-354, a kappa opioid receptor antagonist for treatment of opioid use disorder, withdrawal and relapse1UG3DA052166-01A1 · under PAR-20-092IREDALE, PHILIPLEONI, MATTHEWCEREVEL THERAPEUTICS, LLC, MA$5,400,000NIDA
2021Development of Lofexidine as a First-line Non-Opioid Pharmacologic Treatment for Neonatal Opioid Withdrawal Syndrome1UG3DA054799-01 · under PAR-20-092GULLO, KRISTEN LEANNSEBURG, RANDALUSWM, LLC, KY$5,353,314NIDA
2021A novel and highly selective orexin 1 receptor antagonist for the treatment of patients with opioid use disorder.1UG3DA054825-01 · under PAR-20-092OSTENFELD, THORTHOMSON, FIONA J.ASTRAZENECA PHARMACEUTICALS, LP, DE$3,032,676NIDA
2021Bacteriophage virus-like particle vaccines for fentanyl and heroin overdose1UG3DA053123-01 · under PAR-20-092CHACKERIAN, BRYCE CUNIVERSITY OF NEW MEXICO HEALTH SCIS CTR, NM$1,572,708ZDA1
2020Evaluation of the Safety and Efficacy of a New Oral Small Molecule GABA-B Receptor Positive Allosteric Modulator (PAM) as an Add-on Maintenance Therapy for Opioid Use Disorder (OUD)1UG3DA051392-01 · under RFA-DA-19-002ERDMAN, JAYMAREK, GERARD JOSEPHASTELLAS PHARMA GLOBAL DEVELOPMENT, INC., IL$6,000,000ZDA1
2020Brexpiprazole as an adjunctive treatment to buprenorphine to treat Opioid Use Disorder1UG3DA051383-01A1 · under PAR-20-092FORBES, ANDYOTSUKA PHARMACEUTICAL DEVELOPMENT & COMMERCIALIZATION, INC., NJ$4,023,155ZDA1
2020NOP Receptor Antagonist for OUD Pharmacotherapy1UG3DA052282-01 · under RFA-DA-19-002CUNNINGHAM, KATHRYN A.MOELLER, FREDERICK GERARDUNIVERSITY OF TEXAS MED BR GALVESTON, TX$2,793,808ZDA1
2020AMPA Antagonism: A Novel Pharmacology for Launching Recovery from Opioid Addiction1UG3DA050923-01 · under RFA-DA-19-002CHAMBERS, ROBERT ANDREWTOOMBS, CHRISTOPHER FRANCISINDIANA UNIVERSITY INDIANAPOLIS, IN$1,854,492ZDA1
2019Cannabidiol in the treatment of opioid use disorder1UG3DA050323-01 · under RFA-DA-19-002HURD, YASMIN L.ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$7,484,180ZDA1
2019A once-weekly oral methadone for maintenance therapy for opioid use disorder1UG3DA050310-01 · under RFA-DA-19-002SCRANTON, RICHARDZALE, STEPHENLYNDRA THERAPEUTICS, INC., MA$6,854,394ZDA1
2019Novel Therapeutics for Opioid Use Disorder in the Acute Overdose and Maintenance Settings1UG3DA049598-01 · under RFA-DA-19-002GEHLERT, DONALD RSCHMIDT, WILLIAM KEPIODYNE, INC., CA$6,461,202ZDA1
2019Nalmefene Long-Acting Injectable (AP007) for the Treatment of Opioid Use Disorder1UG3DA048745-01A1 · under RFA-DA-19-002WALKER, ANDREWEMERGENT PRODUCT DEVELOPMENT GAITHERSBUR, MD$6,354,906ZDA1
2019R-methadone-TAAP/MPAR: an abuse deterrent methadone prodrug with overdose protection: Pre-Clinical Development and Phase 1 Clinical Trial1UG3DA050271-01 · under RFA-DA-19-002KIRKPATRICK, LYNNENSYSCE BIOSCIENCES, INC., CA$5,389,398ZDA1
2019Combining Pregabalin with Lofexidine: Can it Increase the Success of Transition to Naltrexone?1UG3DA049694-01 · under RFA-DA-19-002KAMPMAN, KYLE MATTHEWWOODY, GEORGE EDWARDUNIVERSITY OF PENNSYLVANIA, PA$4,061,892ZDA1
2019Development of SBI-553, an allosteric modulator of NTR1, for the treatment of substance use disorders1UG3DA050316-01 · under RFA-DA-19-002BARAK, LAWRENCE S.CARON, MARC G.GUPTILL, JEFFREY TJACKSON, MICHAELSANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, CA$3,588,880ZDA1
2019Arylepoxamides: A new class of potent, safer analgesics1UG3DA048379-01 · under RFA-DA-19-002PAN, YING-XIANSLOAN-KETTERING INST CAN RESEARCH, NY$3,263,463ZDA1
2019Development of ITI-333, a μ-opioid Receptor Partial Agonist and 5HT2A and D1 Receptor Antagonist, for the Treatment of Opioid Use Disorders1UG3DA047699-01 · under RFA-DA-19-002COMER, SANDRA DSNYDER, GRETCHEN LWONG, DEAN FOSTERINTRA-CELLULAR THERAPIES, INC., NY$3,249,130ZDA1
2019Development of a safe and effective novel mechanism analgesic to treat moderate to severe pain with low or absent abuse liability.1UG3DA047708-01 · under RFA-DA-19-002LARK, MICHAEL WILLIAMZADINA, JAMES EARTYS BIOTECH, LLC, PA$3,102,560ZDA1
2019A Long-Acting Bioabsorbable Naltrexone Subcutaneous Implant for Opioid Use Disorder1UG3DA048338-01A1 · under RFA-DA-19-002BENNER, JEFFREYCOHEN, STEVEN MDRUG DELIVERY COMPANY, LLC, THE, MD$3,083,969ZDA1
2019Development of a novel drug for treating opioid use disorder1UG3DA048234-01 · under RFA-DA-19-002SHAH, NIKEJVOCCI, FRANK J.NIRSUM LABORATORIES, INC., NY$3,060,540ZDA1
2019Development of a Soluble Epoxide Hydrolase Inhibitor to Spare or Replace Opioid Analgesics1UG3DA048767-01 · under RFA-DA-19-002BUCKPITT, ALAN RHAMMOCK, BRUCE DEICOSIS, LLC, CA$3,036,135ZDA1
2019Clinical Evaluation of C4X3256, a Non-Opioid, Highly-Selective Orexin-1 Receptor Antagonist for the Treatment of Opioid Use Disorder1UG3DA050308-01 · under RFA-DA-19-002HEIDBREDER, CHRISTIAN ARTHURINDIVIOR, INC., VA$3,016,228ZDA1
2019Development of a Potent and Highly Selective NaV1.7 Inhibitor for the Treatment of Acute Pain with the Goal of Reducing Opioid Use and Preventing Opioid Use Disorders1UG3DA049599-01 · under RFA-DA-19-002HUNTER, JOHN CURETONODINK, DEBRASITEONE THERAPEUTICS, INC., CA$2,937,963ZDA1
2019The long-term reduction of pain and opioid usage following mastectomy and tissue expander/implant surgery with a single administration of brivoligide, a non-opioid, disease-modifying drug candidate1UG3DA048375-01 · under RFA-DA-19-002MAMET, JULIENMANNING, DONALD CADYNXX, INC., CA$2,858,544ZDA1
2019Development of a 3-month implantable depot pellet of Naltrexone for the treatment of Opioid Use Disorder.1UG3DA047925-01 · under RFA-DA-19-002BRAR, BALBIRBIOCORRX, INC., CA$2,842,430ZDA1
2019Advancing KNX100 for the treatment of opioid withdrawal: preclinical efficacy and toxicology, and a phase 1 clinical program.1UG3DA048743-01 · under RFA-DA-19-002ALSOP, HUGH WILLIAMBOWEN, MICHAEL THOMASMCGREGOR, IAIN STEWARTKINOXIS THERAPEUTICS PTY LTD$2,798,940ZDA1
2019Methocinnamox (MCAM): A novel µ-opioid receptor antagonist for opioid use disorders1UG3DA048387-01A1 · under RFA-DA-19-002FRANCE, CHARLES PUNIVERSITY OF TEXAS HLTH SCIENCE CENTER, TX$2,750,111ZDA1
20191-Year Sustained Release Naltrexone Implant for the prevention of relapse to opioid dependence1UG3DA050306-01 · under RFA-DA-19-002MARTIN, FRANCIS JOSEPHDELPOR, INC., CA$2,572,678ZDA1
2019A novel therapeutic to ameliorate chronic pain and reduce opiate use1UG3DA047680-01 · under RFA-DA-19-002TABAKOFF, BORISLOHOCLA RESEARCH CORPORATION, CO$2,382,426ZDA1
2019Use of a GLP-1 Agonist to Treat Opioid Use Disorder in Rats and Man1UG3DA050325-01 · under RFA-DA-19-002BUNCE, SCOTT CGRIGSON, PATRICIA SUEPENNSYLVANIA STATE UNIV HERSHEY MED CTR, PA$2,367,195ZDA1
2019Targeting the Ghrelin System for Novel Opioid Use Disorder Therapeutics1UG3DA050317-01 · under RFA-DA-19-002CUNNINGHAM, KATHRYN A.UNIVERSITY OF TEXAS MED BR GALVESTON, TX$2,230,347ZDA1
2019Preclinical and clinical evaluation of the NMDA modulator NYX-783 for OUD1UG3DA050322-01 · under RFA-DA-19-002DILEONE, RALPH JMALISON, ROBERT TSINHA, RAJITATAYLOR, JANE RYALE UNIVERSITY, CT$2,182,107ZDA1
2019Development of an implantable closed-loop system for delivery of naloxone for the prevention of opioid-related overdose deaths1UG3DA050303-01 · under RFA-DA-19-002GEREAU, ROBERT WROGERS, JOHNWASHINGTON UNIVERSITY, MO$2,096,911ZDA1
2019Opioid use disorders: UF Pharmacy medications discovery and development1UG3DA048353-01 · under RFA-DA-19-002MCCURDY, CHRISTOPHER RMCMAHON, LANCE R.UNIVERSITY OF FLORIDA, FL$2,023,489ZDA1
2019Novel LAAM formulations to treat Opioid Use Disorder (UG3 DA048768-01A1)1UG3DA048768-01A1 · under RFA-DA-19-002HALQUIST, MATTHEW SEANMOELLER, FREDERICK GERARDO'KEEFFE, CHARLESXU, QINGGUOVIRGINIA COMMONWEALTH UNIVERSITY, VA$1,614,668ZDA1
2019Vaccines for fentanyl and its derivatives: A strategy to reduce illicit use and overdose1UG3DA048386-01 · under RFA-DA-19-002PRAVETONI, MARCOUNIVERSITY OF MINNESOTA, MN$1,562,143ZDA1
2019Novel nanovaccines against opioid use disorders1UG3DA048775-01 · under RFA-DA-19-002PRAVETONI, MARCOZHANG, CHENMING MVIRGINIA POLYTECHNIC INST AND ST UNIV, VA$1,537,430ZDA1
2019Development of Next-generation Pharmacotherapy for Opioid Use Disorders1UG3DA048371-01 · under RFA-DA-19-002ZAVERI, NURULAIN TASTRAEA THERAPEUTICS, LLC, CA$1,458,094ZDA1
2019Evaluating Suvorexant for Sleep Disturbance in Opioid Use Disorder1UG3DA048734-01 · under RFA-DA-19-002DUNN, KELLY EHUHN, ANDREW SJOHNS HOPKINS UNIVERSITY, MD$1,139,075ZDA1
2019Mu Opioid Receptor Modulator Development to Treat Opioid Use Disorder1UG3DA050311-01 · under RFA-DA-19-002ZHANG, YANVIRGINIA COMMONWEALTH UNIVERSITY, VA$996,755ZDA1
2019MOR/DOR Heterodimer Antagonists: A Novel Treatment for Opioid Dependence1UG3DA047717-01 · under RFA-DA-19-002MORGAN, MICHAEL MWASHINGTON STATE UNIVERSITY, WA$922,540ZDA1
2019Injectable naltrexone 2-month depot formulations1UG3DA048774-01 · under RFA-DA-19-002PARK, KINAMPURDUE UNIVERSITY, IN$712,935ZDA1
2018Phase 1a/1b Clinical Trials of Multivalent Opioid Vaccine Components1UG3DA047711-01 · under RFA-DA-19-002COMER, SANDRA DPRAVETONI, MARCONEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC, NY$4,121,081ZDA1
2018A Phase I/IIa Clinical Trial Testing the Safety and Immunogenicity of a Heroin Vaccine and its Efficacy Against Morphine Challenge.1UG3DA048351-01 · under RFA-DA-19-002MATYAS, GARY R.HENRY M. JACKSON FDN FOR THE ADV MIL/MED, MD$3,690,224ZDA1
2018Evaluation of safety and pharmacokinetics of naltrexone implant1UG3DA047720-01 · under RFA-DA-19-002BISAGA, ADAMNUNES, EDWARD V.NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC, NY$3,010,138ZDA1
2018Nalmefene Implant for the Long-Term Treatment of Opioid Use Disorder1UG3DA047707-01 · under RFA-DA-19-002BEEBE DEVARNEY, KATHERINETITAN PHARMACEUTICALS, INC., CA$2,666,592ZDA1
2018An ultra-long-acting oral treatment for opioid use disorder1UG3DA047709-01 · under RFA-DA-19-002BELLINGER, ANDREW MARTINLYNDRA THERAPEUTICS, INC., MA$2,543,976ZDA1
2018PF614 MPAR Abuse Deterrent opioid prodrug with overdose protection: Pre-Clinical Development and Phase 1 Clinical Trial1UG3DA047682-01 · under RFA-DA-19-002KIRKPATRICK, LYNNENSYSCE BIOSCIENCES, INC., CA$2,123,989ZDA1
2018Development of novel therapeutics for opioid dependence1UG3DA048385-01 · under RFA-DA-19-002KAMENECKA, THEODORE MKENNY, PAUL J.ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$2,007,235ZDA1
2018Biased Mu-Opioid Receptor Analgesics to Prevent Overdose and Opioid Use Disorders1UG3DA047700-01 · under RFA-DA-19-002BARRETT, JAMES E.KUO, LAWRENCE CMEBIAS DISCOVERY, INC., PA$893,396ZDA1

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