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NIH funding notice PAR-22-216

NCI Clinical and Translational Exploratory/Developmental Studies (R21 Clinical Trial Optional)

Closed on November 3, 2024.

Posted
July 14, 2022
Close date
November 3, 2024
Activity codes
Not stated on the notice page
Institutes taking part
Not stated on the notice page

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

Its page was not saved, so the notices it replaced are not known.

Who won it before

276 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $78,544,505 in first-year total cost, median $230,617.

Most frequent study sections

  1. Special Emphasis Panel[ZCA1 SRB-A (M1)]13
  2. Special Emphasis Panel[ZCA1 SRB-P (M2)]13
  3. Special Emphasis Panel[ZCA1 SRB-A (O1)]12
  4. Special Emphasis Panel[ZCA1 SRB-X (M2)]12
  5. Special Emphasis Panel[ZCA1 SRB-K (J1)]10

Most frequent institutions

  1. UNIVERSITY OF TX MD ANDERSON CAN CTR13
  2. UNIVERSITY OF ALABAMA AT BIRMINGHAM8
  3. RESEARCH INST OF FOX CHASE CAN CTR7
  4. UNIVERSITY OF CALIFORNIA LOS ANGELES7
  5. H. LEE MOFFITT CANCER CTR & RES INST6
Competing awards under PAR-22-216 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2025Targeting p300/CBP in renal cell carcinoma1R21CA296705-01A1KOLENKO, VLADIMIR MRESEARCH INST OF FOX CHASE CAN CTR, PA$483,395ZCA1
2025pA-regulator controlled, JMJD6 reprogrammed GPC3-CAR T cells for patients with hepatocellular carcinoma1R21CA299361-01HECZEY, ANDRAS A.YEN, LAISING LEWISSEATTLE CHILDREN'S HOSPITAL, WA$470,759ZCA1
2025Determinants of PARP-inhibitor response in Breast Cancer Patients without germline mutations in BRCA1/21R21CA303219-01WULF, GERBURG MBETH ISRAEL DEACONESS MEDICAL CENTER, MA$470,567ZCA1
2025Electronic Nose Technology to Predict and Assess Pathologic Response After Neoadjuvant Therapy and Recurrence for Non-Small Cell Lung Cancer1R21CA299070-01ROCCO, GAETANOSLOAN-KETTERING INST CAN RESEARCH, NY$452,540ZCA1
2025Exploiting synthetic lethality to enhance KRAS inhibitor therapy of cancer1R21CA302807-01NEEL, BENJAMIN G.NEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$435,827ZCA1
2025A Drosophila model for Aromatase Inhibitor-induced Musculoskeletal Pain1R21CA303409-01PFLEGER, CATHIE MICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$434,542ZCA1
2025Developing Multispecific T cell Engaging Therapy for Mixed Phenotype Acute Leukemia1R21CA296748-01A1LOH, MIGNON LEE-CHEUNPRICE, JANET E.SEATTLE CHILDREN'S HOSPITAL, WA$434,361ZCA1
2025Exploring anti-sense RNAs in melanocyte transformation and melanoma formation1R21CA303007-01KARRETH, FLORIANH. LEE MOFFITT CANCER CTR & RES INST, FL$433,256ZCA1
2025Extracellular vesicle enclosed circular RNA and interferon responses in tumor host interactions.1R21CA299812-01GUARNERIO, JLENIASILVA, TAYLON FELIPECEDARS-SINAI MEDICAL CENTER, CA$429,399ZCA1
2025Exploring the Neuroprotective Potential of CBD in Preventing Oxaliplatin-Induced Neuropathy: A Prospective Study1R21CA292276-01A1VIJAYVERGIA, NAMRATAWARD, SARA JRESEARCH INST OF FOX CHASE CAN CTR, PA$429,162ZCA1
2025Cross-talk between social determinants of health and MTOR pathway, the missing link in fatigue1R21CA288925-01A1GONZALEZ-MERCADO, VELDA JANETNEW YORK UNIVERSITY, NY$427,085ZCA1
2025DNA Methylation Markers for early detection and monitoring the trajectory of tumor burden in Bladder Cancer1R21CA296470-01A1DANESHMAND, SIAMAKLIANG, GANGNINGUNIVERSITY OF SOUTHERN CALIFORNIA, CA$426,828ZCA1
2025Multi-omics & AI-based imaging to identify biomarkers of molecular targets for breast cancer prevention1R21CA291905-01A1MODUGNO, FRANCESMARYMAGEE-WOMEN'S RES INST AND FOUNDATION, PA$425,573ZCA1
2025Therapeutic targeting and biophysical characterization of CAR-mediated trogocytosis1R21CA297125-01A1LUETKENS, TIMUPADHYAYA, ARPITAUNIVERSITY OF MARYLAND BALTIMORE, MD$422,799ZCA1
2025Targeting a Novel Secreted Immune Checkpoint to Enhance Liver Cancer Immunotherapy1R21CA302797-01DENG, YALANUNIVERSITY OF TX MD ANDERSON CAN CTR, TX$421,685ZCA1
2025Exploratory studies of cellular resistance to MTA-cooperative PRMT5 inhibitors in MTAP-loss tumors.1R21CA296234-01A1AHNERT, JORDI RODONBEDFORD, MARK T.XU, HANUNIVERSITY OF TX MD ANDERSON CAN CTR, TX$420,400ZCA1
2025Leveraging combination histotripsy tumor ablation and N-dihydrogalactochitosan immunostimulation to advance osteosarcoma therapy1R21CA296742-01A1TUOHY, JOANNEVIRGINIA POLYTECHNIC INST AND ST UNIV, VA$419,080RTB
2025Improving CAR-T cell therapy in metastatic breast cancers by reprogramming obesity-aggravated tumor microenvironment via physical activity1R21CA302986-01FUKUMURA, DAIMASSACHUSETTS GENERAL HOSPITAL, MA$416,818ZCA1
2025Boosting Oncolytic HSV Immunotherapy by Enabling Necroptosis1R21CA303392-01GUO, HONGYANLOUISIANA STATE UNIV HSC SHREVEPORT, LA$416,040ZCA1
2025Harnessing B Cells after Stem Cell Transplant to Produce Novel CAR-Ts1R21CA302979-01SARANTOPOULOS, STEFANIEDUKE UNIVERSITY, NC$415,257ZCA1
2025Directed evolution of TCRs with improved antigen sensitivity1R21CA305319-01BIRNBAUM, MICHAELMASSACHUSETTS INSTITUTE OF TECHNOLOGY, MA$414,803ZCA1
2025CCNE1 is synthetically lethal with drug induced nuclear Cathepsin L (nCTSL)1R21CA302968-01SHRIDHAR, VIJIMAYO CLINIC ROCHESTER, MN$412,429ZCA1
2025Using Vagal Nerve Stimulation in Conjunction with NRT for Smoking Cessation1R21CA302802-01CROGHAN, IVANA TALLERICOHURT, RYAN THOMASMAYO CLINIC ROCHESTER, MN$411,939ZCA1
2025GENES WITH SIGNIFICANT DEFICIT OF LOSS-OF-FUNCTION MUTATIONS IN LUNG TUMOR1R21CA291676-01A1GORLOV, IVAN PBAYLOR COLLEGE OF MEDICINE, TX$411,404ZCA1
2025Noncovalent interaction of mutant KRAS inhibitors1R21CA297690-01A1CHI, JEN-TSAN ASHLEYDUKE UNIVERSITY, NC$411,152ZCA1
2025Enhancing anti-PD-1 blockade antitumor efficacy by oncolytic virotherapy-mediated tumor microenvironment immunomodulation1R21CA302730-01GOMEZ-GUTIERREZ, JORGE GUNIVERSITY OF MISSOURI-COLUMBIA, MO$409,158ZCA1
2025Develop positive allosteric modulators to enhance XCR1 signaling in cancer1R21CA299543-01ZHANG, CHENGUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$408,829ZCA1
2025Harnessing Phosphorus Fluoride Exchange (PFEx) Click Chemistry for Developing Covalent Anti-Cancer Drugs1R21CA303396-01YU, BINGCHENGEORGIA STATE UNIVERSITY, GA$406,258ZCA1
2025Targeting tumor microenvironment-mediated radiopharmaceutical therapy resistance in prostate cancer1R21CA303173-01ABT, EVAN ROBERTMONA, CHRISTINE EUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$404,972ZCA1
2025Development of new Pt-based ROS storm inducing polymers with tumor specific toxicity1R21CA292295-01A1MAI, JUNHUAMETHODIST HOSPITAL RESEARCH INSTITUTE, TX$403,485ZCA1
2025Cognitive behavioral theory-assisted virtual reality for chronic cancer pain (VR-CAN): device prototype development and feasibility testing1R21CA299799-01GRONINGER, J. HUNTERKELLEHER, SARAHMEDSTAR HEALTH RESEARCH INSTITUTE, MD$403,383ZCA1
2025Targeting CXCR2+ PMN-MDSCs for immunotherapy of hepatoblastoma1R21CA292251-01A1CHEN, XINUNIVERSITY OF HAWAII AT MANOA, HI$402,400ZCA1
2025Contrast-enhanced ultrasound evaluation of radioembolization treatment response1R21CA303648-01EISENBREY, JOHNTHOMAS JEFFERSON UNIVERSITY, PA$401,115ZCA1
2025New models for interrogating the impact of sex chromosomes and sex hormones on glioblastoma1R21CA296713-01A1IPPOLITO, JOSEPH EDWARDWASHINGTON UNIVERSITY, MO$399,829ZCA1
2025Targeting DDX3 for triple-negative breast cancer treatment1R21CA295917-01A1RAMAN, VENUJOHNS HOPKINS UNIVERSITY, MD$399,129ZCA1
2025Development of deazaflavin analogs as potent and selective MRP1 inhibitors for cancer chemosensitization1R21CA303454-01WANG, ZHENGQIANGXIE, JIASHUUNIVERSITY OF MINNESOTA, MN$395,973ZCA1
2025Mechanism and pathways of Glucocorticoid Receptor (GR) signaling in TNBC progression1R21CA296504-01A1RIEGEL, ANNA TATEGEORGETOWN UNIVERSITY, DC$395,356ZCA1
2025Enhancing antitumor efficacy by intratumoral delivering LAIR1 inhibitory signaling1R21CA288943-01A1HUANG, JIANPINGUNIVERSITY OF FLORIDA, FL$394,687ZCA1
2025LAT1 as a Novel Therapeutic Target in Colorectal Cancer1R21CA292205-01A1SUBRAMANIAN, SUBBAYAUNIVERSITY OF MINNESOTA, MN$394,532ZCA1
2025Therapeutic co-targeting of LGR5 and MET to overcome heterogeneity and therapy resistance in colorectal tumors1R21CA302991-01CARMON, KENDRA S.UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, TX$393,872ZCA1
2025Co-targeting IGF-1R and Glutaminase in Ewing Sarcoma1R21CA297629-01A1BAND, HAMIDUNIVERSITY OF NEBRASKA MEDICAL CENTER, NE$391,186ZCA1
2025Biologic rationale of fallopian tube removal to prevent uterine serous carcinoma1R21CA292343-01A1DELANEY, JOE RMEDICAL UNIVERSITY OF SOUTH CAROLINA, SC$388,256ZCA1
2025Preclinical development and validation of targeted mass spectrometry assays for serous ovarian cancer diagnosis1R21CA288922-01A1THOMAS, STEFANIUNIVERSITY OF MINNESOTA, MN$386,700ZCA1
2025Advanced Dual-Nuclei MRI for Differentiation of Recurrent Brain Metastases and Radiation Necrosis1R21CA303383-01KIM, WONYAO, JINGWENUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$382,449ZCA1
2025Combining c-Myc inhibitor and SHetA2 for cervical cancer: A promising low-to-no toxicity therapeutic strategy1R21CA296216-01A1RAI, RAJANIUNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR, OK$376,490ZCA1
2025A Pilot Study to Correlate 4-[18F]fluoro-1-naphthol PET/CT Imaging with Chronic Graft Versus Host Disease Manifestations1R21CA303350-01CHEN, GEORGE LIWEIPIWNICA-WORMS, DAVIDUNIVERSITY OF TX MD ANDERSON CAN CTR, TX$358,605ZCA1
2025Proximity-triggered, mutant-specific modification of K-Ras(G12C) with local polypharmaceutical release1R21CA296712-01MOSES, JOHN EDWARDCOLD SPRING HARBOR LABORATORY, NY$269,280ZCA1
2025Targeting cellular senescense in pancreatic cancer1R21CA299593-01HAN, HAIYONGTRANSLATIONAL GENOMICS RESEARCH INST, AZ$269,280ZCA1
2025Immune Checkpoint Blockade Targeting the Novel PSGL-1/VISTA Axis for Pancreatic Cancer1R21CA293150-01A1BRADLEY, LINDA MAC PHERSONSANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, CA$268,345ZCA1
2025Targeting SMARCA2 to overcome resistance of SMARCA4-mutant lung cancer to KRAS G12C inhibitors1R21CA295906-01LISSANU, YONATHANUNIVERSITY OF TX MD ANDERSON CAN CTR, TX$267,527ZCA1
2025Targeting the CDK4/6 pathway in MiT/TFE-translocation renal cell carcinoma1R21CA296230-01VISWANATHAN, SRINIVAS RAGHAVANDANA-FARBER CANCER INST, MA$267,298ZCA1
2025Multiparametric endoscopic ultrasound for improved pancreatic cancer screening and characterization1R21CA296688-01BURGESS, MARK THOMASSLOAN-KETTERING INST CAN RESEARCH, NY$263,086ZCA1
2025Advanced Genetic Engineering to Unravel Tumor-Specific B Cell Responses1R21CA296527-01GENOVESE, PIETROBOSTON CHILDREN'S HOSPITAL, MA$249,645ZCA1
2025Characterizing the autologous fat graft microenvironment resulting from differential intraoperative processing techniques: A comparative analysis and its clinical implications1R21CA287340-01A1BROWN, KRISTY A.OTTERBURN, DAVIDWEILL MEDICAL COLL OF CORNELL UNIV, NY$247,660ZCA1
2025Integrating Radiologist Insights for Safe and Accurate AI-Assisted Prostate MRI Interpretation1R21CA301093-01AKIN, OGUZPENG, XIUNIVERSITY OF DELAWARE, DE$245,087ZCA1
2025Focused Ultrasound and CAR T Cells for Pediatric Brain Malignancies1R21CA292273-01A1HAYDAR, DALIASHEYBANI, NATASHA DIBAUNIVERSITY OF VIRGINIA, VA$244,839ZCA1
2025Proteomics-driven precision molecular mapping of patient tumors to preclinical models in lung cancer1R21CA288901-01A1GIRARD, LUCLI, JUNLIANG, HANUNIVERSITY OF TX MD ANDERSON CAN CTR, TX$244,228ZCA1
2025Novel biologic therapeutics targeting vacuolar ATPase localized on plasma membrane1R21CA292032-01A1BAR-SAGI, DAFNAKOIDE, SHOHEINEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$237,724ZCA1
2025Precision use of radiation for in situ cancer immunization1R21CA292282-01A1DEMARIA, SANDRAWEILL MEDICAL COLL OF CORNELL UNIV, NY$237,724ZCA1
2025Somatostatin Receptor 2 Expression in Pituitary Neuroendocrine Tumors as a Basis for PET/MRI guided Subtype Stratification and Radiotherapy Planning1R21CA289111-01A1IVANIDZE, JANAKNISELY, JONATHAN P.S.WEILL MEDICAL COLL OF CORNELL UNIV, NY$235,707ZCA1
2025Prevention and Therapy of Inflammation Associated Colorectal Cancer1R21CA295643-01AUGENLICHT, LEONARD HALBERT EINSTEIN COLLEGE OF MEDICINE, NY$235,620ZCA1
2025Guadecitabine-directed immune regulation in targeting prostate cancer1R21CA292333-01A1KARAN, DEVUNIVERSITY OF LOUISVILLE, KY$234,889ZCA1
2025Targeting Tumor-Associated Macrophages via Hedgehog Inhibition to Enhance Immunotherapy in Non-Small Cell Lung Cancer1R21CA299786-01HUANG, XIAOPEIOWEN, DWIGHT H.OHIO STATE UNIVERSITY, OH$234,749ZCA1
2025Targeting Tumor-Driven Immune Tolerance to Overcome Resistance to Hedgehog Inhibition1R21CA301201-01KIM, ARIANNA LCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$230,711ZCA1
2025Unraveling Metastasis Drivers in Small Cell Lung Cancer via Human Pluripotent Stem Cell-Based Approach1R21CA299377-01CHEN, JOYCE HUANHUANUNIVERSITY OF CHICAGO, IL$230,010ZCA1
2025Examining the Role of Nono Pathway on the Innate Immunity Against Oncolytic Adenoviruses1R21CA283514-01A1FUEYO, JUANGOMEZ-MANZANO, CANDELARIAUNIVERSITY OF TX MD ANDERSON CAN CTR, TX$229,309ZCA1
2025Photofrin dark effects and heme oxygenase inducers as therapeutic in mesothelioma1R21CA286282-01A1BUSCH, THERESA MUNIVERSITY OF PENNSYLVANIA, PA$227,906ZCA1
2025Inhibition of diacylglycerol lipase α as a novel strategy to mitigate the nephrotoxicity of cisplatin1R21CA289216-01A1LI, NINGJUNVIRGINIA COMMONWEALTH UNIVERSITY, VA$227,221ZCA1
2025Tobacco use trajectories and related mechanisms among US adults and youth representing minority and intersecting minority identities1R21CA292195-01A1BERG, CARLA JWANG, YANGEORGE WASHINGTON UNIVERSITY, DC$226,504ZCA1
2025Evaluating Maintenance In Light chain Amyloidosis (EMILIA)1R21CA288898-01A1KOURELIS, TAXIARCHISMAYO CLINIC ROCHESTER, MN$226,435ZCA1
2025Mechanisms underlying increased risk of hematological malignancy in sickle cell disease.1R21CA299166-01MALIK, PUNAMCINCINNATI CHILDRENS HOSP MED CTR, OH$225,101ZCA1
2025MYCN drives a suppressive tumor immune microenvironment in neuroblastoma.1R21CA300631-01BARBIERI, EVELINEBAYLOR COLLEGE OF MEDICINE, TX$225,101ZCA1
2025Neutralizing oxidative damage at telomeres prevents T cell dysfunction and improves adoptive cell therapies against cancer1R21CA296693-01RIVADENEIRA, DAYANAUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$222,998ZCA1
2025Cancer therapy by targeting innate immune cells in vivo using novel virus-like particles1R21CA289083-01A1KAUFMAN, DAN S.UNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$222,998ZCA1
2025Identifying novel targets for cancer using high throughput deformability screening1R21CA289090-01A1ROWAT, AMY CUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$220,894ZCA1
2025Elucidate the role and mechanism of IFNε in Kras-driven lung tumorigenesis1R21CA288674-01A1CHANG, THERESA LGUO, YANXIANGRUTGERS BIOMEDICAL AND HEALTH SCIENCES, NJ$220,193ZCA1
2025Mitochondrial regulation of chemotherapy-induced reactive myelopoiesis and pro-metastatic effects1R21CA288604-01A1DING, CHUANLINUNIVERSITY OF LOUISVILLE, KY$220,018ZCA1
2025Epigenetic Regulation of T Cell Metabolism and Immune Functions by Sirt61R21CA288808-01A1HAMAIDI, IMENEMAYO CLINIC JACKSONVILLE, FL$219,491ZCA1
2025ECT2 Isoform Switch in Pancreatic Cancer.1R21CA296671-01JUSTILIEN, VERLINEMAYO CLINIC JACKSONVILLE, FL$219,491ZCA1
2025Mapping the origin of HER2 plasticity in breast cancer1R21CA286273-01A1SPANGLE, JENNIFER MARIEEMORY UNIVERSITY, GA$219,491ZCA1
2025Assessment of Efficacy and Toxicity of T3 for Medulloblastoma Treatment1R21CA296696-01YANG, ZENG-JIERESEARCH INST OF FOX CHASE CAN CTR, PA$219,351ZCA1
2025CSP7 inhibits toxicity of ionizing radiation to the lung1R21CA282561-01A1SHETTY, SREERAMAUNIVERSITY OF TEXAS HLTH CTR AT TYLER, TX$219,024ZCA1
2025Mechanism and treatment of Wilms Tumors caused by CTR9 mutations1R21CA295443-01XU, WEIUNIVERSITY OF WISCONSIN-MADISON, WI$218,089ZCA1
2025Novel Immunotherapy Targeting Local and Systemic Immunity for Treatment of Ocular Surface Squamous Neoplasia1R21CA289152-01A1DOW, STEVEN W.COLORADO STATE UNIVERSITY, CO$215,985ZCA1
2025Alleviating stress, loneliness, and social isolation among South Asian families managing breast cancer1R21CA292256-01A1TRIVEDI, RANAKSTANFORD UNIVERSITY, CA$215,985ZCA1
2025Exosome Signatures of Kidney Cancer Response to Immune Checkpoint Inhibitor1R21CA299766-01FAN, ALICE CHENSTANFORD UNIVERSITY, CA$215,985ZCA1
2025Preclinical efficacy of GPR56 antibody-drug conjugates and combination therapies for triple-negative breast cancer1R21CA291788-01A1CARMON, KENDRA S.UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, TX$215,311ZCA1
2025Evaluation of a triple negative matrix signature in tumor progression and resistance1R21CA286211-01A1MARTIN, ELIZABETHTULANE UNIVERSITY OF LOUISIANA, LA$214,583ZCA1
2025Contribution of cutaneous neuro-immune interactions to chemotherapy-induced peripheral neuropathy1R21CA297068-01SHIOZAWA, YUSUKEWAKE FOREST UNIVERSITY HEALTH SCIENCES, NC$213,480ZCA1
2025Characterize the metabolic landscape of ARID1A-mutated ovarian cancer1R21CA287351-01A1BAZZARO, MARTINATHOMAS, STEFANIUNIVERSITY OF MINNESOTA, MN$212,013ZCA1
2025A Dkk-1 targeting antisense therapy for human osteosarcoma, developed with help from man’s best friend1R21CA286523-01A1GREGORY, CARL A.TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR, TX$210,789ZCA1
2025A Novel Approach to Enhance Therapeutic Efficacy of Tarlatamab for Small Cell Lung Cancer Treatment1R21CA298890-01WAJAPEYEE, NARENDRAUNIVERSITY OF ALABAMA AT BIRMINGHAM, AL$208,271ZCA1
2025Targeting Chromosomal Instability in the Evolution of Resistance to Matched Therapies Against Colorectal Cancer to Extend Treatment Response1R21CA292178-01A1YAEGER, RONASLOAN-KETTERING INST CAN RESEARCH, NY$205,700ZCA1
2025Modifying the Single Domain Antibody Framework as Platform for Enhanced Radiotherapy1R21CA297395-01LARIMER, BENJAMIN MUNIVERSITY OF ALABAMA AT BIRMINGHAM, AL$205,621ZCA1
2025Advanced PET/MRI to quantify heterogeneity of HER2 and vasculature in HER2+ breast-to-brain metastasis prior to combination targeted and radiotherapy1R21CA289166-01A1SORACE, ANNA CUNIVERSITY OF ALABAMA AT BIRMINGHAM, AL$204,295ZCA1
2025RANK Signaling Inhibitors for Osteolytic Lesions in Multiple Myeloma1R21CA296500-01FENG, XUUNIVERSITY OF ALABAMA AT BIRMINGHAM, AL$201,609ZCA1
2025DISSECTING THE ROLE OF THE IMMUNE MICROENVIRONMENT IN MELANOMA BONE METASTASIS1R21CA297650-01HERNANDO, EVANEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$198,103ZCA1
2025Development of a Clinically Relevant Genetically Engineered Mouse Model for Human High-Risk Rhabdomyosarcoma1R21CA286286-01A1TAO, JIANNINGSANFORD RESEARCH/USD, SD$194,013ZCA1
2025Development of a new tool to treat small cell lung cancer1R21CA301276-01OFFRINGA, ITE AUNIVERSITY OF SOUTHERN CALIFORNIA, CA$194,013ZCA1
2025Jumonji KDM4A drives targetable oncogenic programs in small cell lung cancer1R21CA280319-01A1MARTINEZ, ELISABETH DUT SOUTHWESTERN MEDICAL CENTER, TX$191,675ZCA1
2025Characterization of KSHV-Associated Disease Specific Gene Therapy1R21CA299587-01IZUMIYA, YOSHIHIROUNIVERSITY OF CALIFORNIA AT DAVIS, CA$188,169ZCA1
2025Lipid-initiated epigenetic reprogramming of the breast to a neural phenotype1R21CA288676-01A1CLARE, SUSAN E.NORTHWESTERN UNIVERSITY, IL$187,000ZCA1
2025Discovery and Development of Allosteric Inhibitors of Src-family Kinases for AML1R21CA291724-01A1SMITHGALL, THOMAS E.UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$185,831ZCA1
2025Glyco-MAP: a high-throughput multiplexed platform for Glycosylated Mucin Antibody Profiling with glycoengineered cell lines expressing well-defined homogeneous glycostructures1R21CA296660-01A1QIU, JIARIZONA STATE UNIVERSITY-TEMPE CAMPUS, AZ$183,494ZCA1
2025Inhibition of NLRP3 inflammasome for the treatment of Chemotherapy-induced peripheral neuropathy1R21CA296516-01DAMAJ, M. IMADVIRGINIA COMMONWEALTH UNIVERSITY, VA$181,448ZCA1
2025Flupirtine Analogue Synthesis and Screening for the Treatment of Chemotherapy-Induced Neuropathic Pain1R21CA298918-01DUAN, BINTRIPPIER, PAULUNIVERSITY OF NEBRASKA MEDICAL CENTER, NE$179,403ZCA1
2025Co-stimulation of T cell responses to nascent, emerging tumors1R21CA286410-01A1BINDER, ROBERT JUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$176,712ZCA1
2025Electrical impedance dermography as a biomarker for basal and squamous cell carcinoma1R21CA289101-01A1GROSSMAN, DOUGLASSANCHEZ TERRONES, BENJAMINUTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH, UT$174,939ZCA1
2025Monitoring CAR T Cell Therapeutic Response and Toxicity with Real-time, Label-free Cell Quantification1R21CA301006-01DIONNE, JENNIFER A.STANFORD UNIVERSITY, CA$170,376ZCA1
2025A BCR transgenic mouse model to study glycan-specific B cells1R21CA297692-01HAAS, KAREN MWAKE FOREST UNIVERSITY HEALTH SCIENCES, NC$169,329ZCA1
2025Identifying the effects of NRF2 signaling on lung squamous cell carcinoma development1R21CA292297-01A1MAJOR, MICHAEL BENJAMINWEISSMAN, BERNARD E.UNIV OF NORTH CAROLINA CHAPEL HILL, NC$158,365ZCA1
2025Sequential infection of laboratory mice for enhanced cancer and immunotherapy translation1R21CA296062-01A1BROOKS, DAVID GUNIVERSITY HEALTH NETWORK, ON$138,846ZCA1
2024Assessing the efficacy of a ROR1:PD-L1:CD2 multispecific T cell engager in ROR1-positive and -negative neuroblastoma models1R21CA292221-01OLSON, JAMES MSEATTLE CHILDREN'S HOSPITAL, WA$503,194ZCA1
2024A novel engineered IL-21-based immunocytokine as a therapeutic approach for tumor targeting in renal cancer1R21CA286231-01A1MAKHOV, PETR B.RESEARCH INST OF FOX CHASE CAN CTR, PA$483,395ZCA1
2024Estrogen Suppression as a Strategy to Enhance Immunotherapy Efficacy in EGFR-Mutated Non-Small Cell Lung Cancer1R21CA282851-01A1BODOR, JOSEPH NICHOLASRESEARCH INST OF FOX CHASE CAN CTR, PA$483,395ZCA1
2024Identifying Chemo-Neoepitopes for Immunotherapy Interventions Against Triple-Negative Breast Cancer1R21CA286342-01A1ABRAMS, SCOTT I.IONOV, YURIJROSWELL PARK CANCER INSTITUTE CORP, NY$460,977ZCA1
2024Targeting Tregs in the solid tumor microenvironment by modulating metabolite signaling1R21CA280643-01A1KINSELLA, SINÉADFRED HUTCHINSON CANCER CENTER, WA$452,544ZCA1
2024MUC1-C is a target for advancing immunotherapy of non-small cell lung cancer1R21CA289134-01KUFE, DONALD W.DANA-FARBER CANCER INST, MA$450,429ZCA1
2024Using patient-derived co-culture models of breast cancer to develop new treatment strategies targeting succinate signaling.1R21CA292302-01MURANEN, TARU ELIISABETH ISRAEL DEACONESS MEDICAL CENTER, MA$444,569ZCA1
2024Adapting and testing a smoking cessation intervention for transgender and gender-diverse individuals1R21CA292185-01O'CLEIRIGH, CONALL MICHAELSTANTON, AMELIA M.MASSACHUSETTS GENERAL HOSPITAL, MA$439,966ZCA1
2024Targeting a PHGDH metabolic vulnerability in melanoma1R21CA289213-01KARRETH, FLORIANH. LEE MOFFITT CANCER CTR & RES INST, FL$433,256ZCA1
2024Lipid-Rich Macrophages at the Tumor-Adipose Interface: A New Target for Locally-Invasive Prostate Cancer Therapy1R21CA291898-01HAYWARD, SIMON WENDEAVOR HEALTH CLINICAL OPERATIONS, IL$433,157ZCA1
2024Monitoring Listeria in vivo using 18FDG and PET scan1R21CA292190-01GRAVEKAMP, CLAUDIAALBERT EINSTEIN COLLEGE OF MEDICINE, NY$431,970ZCA1
2024Hijacking Post-translational Arginylation for Targeted Protein Degradation1R21CA292191-01LIN, ZONGTAOLYU, DONGWENWASHINGTON UNIVERSITY, MO$425,587ZCA1
2024Unraveling Vascular Mediated Immune Exclusion in Melanoma1R21CA293766-01KIM, MINAHCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$422,971ZCA1
2024Frontiers in Bone Metastatic Models for Prostate Cancer1R21CA282396-01A1BERKMAN, CLIFFORDCAROMILE, LESLIE ANNUNIVERSITY OF CONNECTICUT SCH OF MED/DNT, CT$422,874ZCA1
2024Enabling a rapid transition from synthase to structure1R21CA280558-01A1BURKART, MICHAEL D.EUSTAQUIO, ALESSANDRA SUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$422,036ZCA1
2024Inhibition of pleiotrophin to combat pancreatic cancer metastasis1R21CA286348-01A1BREKKEN, ROLF AUT SOUTHWESTERN MEDICAL CENTER, TX$421,685ZCA1
2024A study of IDH1-mutant prostate cancer to identify novel therapeutic targets1R21CA292179-01SENA, LAURA A.JOHNS HOPKINS UNIVERSITY, MD$421,042ZCA1
2024Enhancing CAR-T cell therapy through theranostic targeted radionuclide therapy1R21CA292224-01JIN, MOONSOO M.YANG, YANPINGMETHODIST HOSPITAL RESEARCH INSTITUTE, TX$415,260ZCA1
2024Targeting metabolic stress response to improve CAR-T cell efficacy.1R21CA280566-01A1MIN, IRENE M.METHODIST HOSPITAL RESEARCH INSTITUTE, TX$415,257ZCA1
2024Development of a pre-clinical syngeneic pig glioma model for research and translational studies1R21CA287157-01A1HORNER, PHILIP JROSTOMILY, ROBERT CVISHNOI, MONIKAMETHODIST HOSPITAL RESEARCH INSTITUTE, TX$415,257ZCA1
2024The urinary microbiome and bladder toxicity after pelvic radiotherapy1R21CA280170-01A1GILL, STEVEN R.KERNS, SARAH L.MARPLES, BRIANUNIVERSITY OF ROCHESTER, NY$414,781ZCA1
2024Investigating a Novel Inhibitory Receptor in Regulating CAR-T Cell Persistence and Function1R21CA286304-01A1WANG, LI LILYCLEVELAND CLINIC LERNER COM-CWRU, OH$413,971ZCA1
2024Discovery of MAP2K7 Inhibitors Through DNA-Encoded Chemical Screens to Treat T-Cell Acute Lymphoblastic Leukemia1R21CA286412-01A1LACORAZZA, DANIELBAYLOR COLLEGE OF MEDICINE, TX$412,685ZCA1
2024Explore piRNAs as a novel group of biomarkers for ovarian cancer early detection1R21CA277412-01A1ZHU, YONGUNIV OF ARKANSAS FOR MED SCIS, AR$411,876ZCA1
2024Nanoparticle-coated macrophages for targeted disruption of YAP/TEAD interactions in breast cancer brain metastasis1R21CA291723-01ER, EKREM EMRAHZHAO, ZONGMINUNIVERSITY OF ILLINOIS AT CHICAGO, IL$411,143ZCA1
2024Targeted nanotherapies for the treatment of prostate cancer1R21CA286235-01A1SHARMA, ANJALIWASHINGTON STATE UNIVERSITY, WA$406,520ZCA1
2024Circadian regulation of astrocytic adenosine kinase in the irradiated and cancer brain1R21CA292148-01ACHARYA, MUNJAL MMAHAN, KRISTIN ECKELUNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, TX$406,217ZCA1
2024Investigating KIF20A as a therapeutic target in glioblastoma1R21CA271217-01A1SUMMERS, MATTHEW KVENERE, MONICAOHIO STATE UNIVERSITY, OH$404,974ZCA1
2024Develop universal CAR macrophage cell therapy for pancreatic cancer1R21CA286398-01A1HOU, PINGPINGRUTGERS BIOMEDICAL AND HEALTH SCIENCES, NJ$403,687ZCA1
2024High-throughput assessment of chemotherapy-induced cardiotoxicity in 3D human cardiomyocytes1R21CA285254-01A1XU, CHUNHUIEMORY UNIVERSITY, GA$402,403ZCA1
2024Development of a PET CCR2 Imaging Agent to Profile PDAC Microenvironment1R21CA286283-01A1GOODMAN, MARK MYRONLESINSKI, GREGORY B.EMORY UNIVERSITY, GA$402,401ZCA1
2024Pilot testing of metacognitive strategy training to address cancer-related cognitive impairment in breast cancer1R21CA286404-01A1BOONE, ANNAFROELIGER, BRETTWOLF, TIMOTHY J.UNIVERSITY OF MISSOURI-COLUMBIA, MO$402,401ZCA1
2024Understanding and overcoming resistance of breast cancer brain metastases to RET inhibition1R21CA286225-01A1LO, HUI-WENUNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, TX$401,115ZCA1
2024S1PR1-targeted PET imaging to predict and monitor response to HER2-targeting antibody-drug conjugates1R21CA291680-01RIBEIRO PEREIRA, PATRICIA MANUELATU, ZHUDEWASHINGTON UNIVERSITY, MO$399,829ZCA1
2024A generalizable model of normal tissue recovery to enable personalized re-irradiation1R21CA292207-01GRASSBERGER, CLEMENSUNIVERSITY OF WASHINGTON, WA$399,829ZCA1
2024Augmenting focused ultrasound-mediated drug delivery to brain tumors with vascular normalization1R21CA286367-01A1PRICE, RICHARD J.UNIVERSITY OF VIRGINIA, VA$399,294ZCA1
2024Modeling Marginal Zone Lymphomagenesis1R21CA270930-01A1YAZBECK, VICTORVIRGINIA COMMONWEALTH UNIVERSITY, VA$399,187ZCA1
2024Stress, inflammation, and health-related quality of life of long-term breast cancer survivors1R21CA290430-01JOHN, ESTHER M.STANFORD UNIVERSITY, CA$396,543ZCA1
2024Assessment of a recently developed boron-based HIF inhibitor as a prospective therapy for renal cell carcinoma (RCC)1R21CA292298-01MUKHERJI, MRIDULUNIVERSITY OF MISSOURI KANSAS CITY, MO$396,061ZCA1
2024Targeting Senescence and the senescent secretome to impact breast cancer formation1R21CA286419-01A1KORKOLA, JAMESOREGON HEALTH & SCIENCE UNIVERSITY, OR$395,973ZCA1
2024Tumor-Activated Dual Payload-Drug Conjugates1R21CA292338-01BERKMAN, CLIFFORDWASHINGTON STATE UNIVERSITY, WA$393,401ZCA1
2024Leveraging cancer-evolved resistance mechanisms to enhance EZH2 activity in adoptive T cells1R21CA292278-01KOSS, BRIANTACKETT, ALANUNIV OF ARKANSAS FOR MED SCIS, AR$393,401ZCA1
2024ILT3 (LILRB4) in anti-tumor immunity and immunotherapy1R21CA273885-01A1COLONNA, MARCOWASHINGTON UNIVERSITY, MO$391,277ZCA1
2024MAIT cells as a therapeutic approach for gastrointestinal cancers1R21CA280224-01A1BESWICK, ELLEN J.LEUNG, DANIEL TEDUNIVERSITY OF UTAH, UT$384,092ZCA1
2024Spatial stromal proteomic biosignatures of DCIS risk and progression1R21CA286287-01A1ANGEL, PEGGI MMEDICAL UNIVERSITY OF SOUTH CAROLINA, SC$380,057ZCA1
2024Combination optical imaging to guide transoral laser microsurgery in larynx cancer1R21CA292196-01PANUGANTI, BHARATWARRAM, JASON MORGANUNIVERSITY OF ALABAMA AT BIRMINGHAM, AL$374,880ZCA1
2024Preclinical Efficacy of Allogeneic and Human Silicified Cancer Vaccines1R21CA282618-01A1SERDA, RITA ELENAUNIVERSITY OF NEW MEXICO HEALTH SCIS CTR, NM$356,469ZCA1
2024Pilot in vivo trial with T-cell-based delivery of immunostimulatory proteins1R21CA288900-01RADHAKRISHNAN, HARIKRISHNANSRI INTERNATIONAL, CA$293,028ZCA1
2024Identifying non-cardiotoxic drug combinations for patients with relapsed sarcoma1R21CA280139-01A1LAWLOR, ELIZABETH RSEATTLE CHILDREN'S HOSPITAL, WA$276,152ZCA1
2024In vivo testing of an agonistic anti-GITR mAb that induces cell surface clustering to augment signal transduction and a 2nd Gen bispecific anti-GITR/PD1 Ab derivative for improved anti-tumor activity1R21CA286345-01MARASCO, WAYNE A.DANA-FARBER CANCER INST, MA$268,059ZCA1
2024A multimodal single-cell approach to developing personalized combinatorial treatments for glioblastoma1R21CA286215-01PETTI, ALLEGRA ADELEMASSACHUSETTS GENERAL HOSPITAL, MA$249,832ZCA1
2024Targeting alloantigen presentation in bone marrow to enhance graft-versus-leukemia effects1R21CA286216-01KOYAMA, MOTOKOFRED HUTCHINSON CANCER CENTER, WA$246,840ZCA1
2024Harnessing Cytomegalovirus (CMV)-specific T-cells for pancreatic cancer immunotherapy1R21CA286198-01BENEDICT, CHRISTOPHER AHURTADO DE MENDOZA, TATIANAUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$242,178ZCA1
2024CAR mast cell for solid tumor1R21CA286364-01SU, XIAOLEIYALE UNIVERSITY, CT$241,713ZCA1
2024Cardiopulmonary function and cerebral blood flow in Hodgkin Lymphoma survivors1R21CA280230-01A1PHILLIPS, NICHOLAS SST. JUDE CHILDREN'S RESEARCH HOSPITAL, TN$239,921ZCA1
2024Targeting the Androgen Receptor to Sensitize Bladder Cancer to Immune Check Point Blockade.1R21CA286309-01MULHOLLAND, DAVIDICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$237,023ZCA1
2024L-fucose-mediated enrichment of memory CD4+T cells and enhanced anti-melanoma immunity1R21CA286226-01LAU, ERIC KIRKH. LEE MOFFITT CANCER CTR & RES INST, FL$236,321ZCA1
2024Development of bifunctional CDK2 inhibitors for treatment of CCNE1-driven cancers1R21CA288927-01LOPCHUK, JUSTIN MATTHEWSCHONBRUNN, ERNSTH. LEE MOFFITT CANCER CTR & RES INST, FL$236,321ZCA1
2024Adipose Tissue Reprograms Acute Lymphoblastic Leukemia Cells to Facilitate CNS and Bone Invasion1R21CA289085-01MITTELMAN, STEVEN DAVIDORGEL, ETANUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$236,073ZCA1
2024Defining signatures of epigenetic sensitization to lung cancer in a mouse model1R21CA288677-01LESCH, BLUMA JYALE UNIVERSITY, CT$234,730ZCA1
2024Response assessment of glioblastoma using magnetic resonance elastography1R21CA282393-01A1DENG, BINGERSTNER, ELIZABETHMASSACHUSETTS GENERAL HOSPITAL, MA$234,218ZCA1
2024Using DNA Methylation Markers for Diagnosis and Prognosis of Upper Tract Urothelial Carcinoma1R21CA288920-01DJALADAT, HOOMANLIANG, GANGNINGUNIVERSITY OF SOUTHERN CALIFORNIA, CA$232,640ZCA1
2024Enhancing Tumor Cell Immunogenicity using Improved Molecules Targeting Chromatin Remodeling1R21CA277437-01A1LANDRY, JOSEPH WILLIAMPOMERANTZ, WILLIAM CHARLES KRAUSEVIRGINIA COMMONWEALTH UNIVERSITY, VA$230,523ZCA1
2024Dual inhibition of PARP and STAT3 as a novel therapeutic approach for triple-negative breast cancer1R21CA270591-01A1LIN, JIAYUHUNIVERSITY OF MARYLAND BALTIMORE, MD$230,361ZCA1
2024Exosome-mediated therapy for liver cancer1R21CA280232-01A1KRAITCHMAN, DARA LJOHNS HOPKINS UNIVERSITY, MD$229,659ZCA1
2024Monitoring response of neoadjuvant therapy in primary bladder cancer using hyperpolarized 13C MRI1R21CA288687-01SRIRAM, RENUKAUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$229,134ZCA1
2024Cheminformatics-based identification of leukemia-targeting molecules1R21CA280500-01A1KIRIENKO, NATASHARICE UNIVERSITY, TX$227,612ZCA1
2024Preclinical studies of non-nucleoside DNMT3A/3B inhibitors1R21CA277152-01A1CHEN, TAIPINGCHENG, XIAODONGUNIVERSITY OF TX MD ANDERSON CAN CTR, TX$227,205ZCA1
2024A novel uterine leiomyosarcoma mouse model for therapeutic development1R21CA273661-01A1WONG, KWONG KWOKUNIVERSITY OF TX MD ANDERSON CAN CTR, TX$227,205ZCA1
2024Exploring new strategy for breast cancer immunoprevention by targeting histamine receptor H11R21CA286318-01XIAO, YIYU, DIHUAUNIVERSITY OF TX MD ANDERSON CAN CTR, TX$227,205ZCA1
2024Characterization and treatment of a novel model of radiation optic neuropathy using the tree shrew1R21CA286349-01DALVIN, LAUREN ARODDY, GAVIN WMAYO CLINIC ROCHESTER, MN$226,364ZCA1
2024Development of a novel, CNS-penetrant synthetic triterpenoid for pediatric high-grade glioma.1R21CA280426-01A1LETTERIO, JOHN JAMESCASE WESTERN RESERVE UNIVERSITY, OH$225,803ZCA1
2024Forging a new path with cyclin-dependent kinase inhibitors to treat epithelioid hemangioendothelioma1R21CA288673-01POBBATI, AJAYBABURUBIN, BRIAN PCLEVELAND CLINIC LERNER COM-CWRU, OH$225,803ZCA1
2024Expanding the targetable landscape in cancer with serine-targeting covalent ligands1R21CA280163-01A1ZHANG, ZIYANGUNIVERSITY OF CALIFORNIA BERKELEY, CA$225,101ZCA1
2024Discovery of chemoresistant tumor subclones in pediatric liver cancers1R21CA286257-01SUMAZIN, PAVELBAYLOR COLLEGE OF MEDICINE, TX$225,084ZCA1
2024Developing inhibitor combinations through identification of drug tolerant cell populations1R21CA282428-01A1BENEVOLENSKAYA, ELIZAVETA VUNIVERSITY OF ILLINOIS AT CHICAGO, IL$224,260ZCA1
2024Delineating the myeloid-centric immunosuppressive crosstalk as targets for prognosis and therapy in neuroendocrine tumors1R21CA286402-01DRIES, RUBENHEAPHY, CHRISTOPHER MBOSTON MEDICAL CENTER, MA$223,377ZCA1
2024Detecting Reversal of Apoptosis in Cancer Cells in Mice1R21CA286284-01TANG, HO LAMJOHNS HOPKINS UNIVERSITY, MD$221,911ZCA1
2024Exploring the interaction of lipid metabolism with the hexosamine pathway and tumor growth1R21CA280452-01A1PAPANDREOU, IOANNAOHIO STATE UNIVERSITY, OH$220,894ZCA1
2024Developing TCR-T cell therapy in renal cell carcinoma1R21CA286389-01CHIOU, SHIN-HENGHINRICHS, CHRISTIANRUTGERS BIOMEDICAL AND HEALTH SCIENCES, NJ$220,193ZCA1
2024Ligand-directed therapeutic CRISPR/Cas gene editing in tumor cells1R21CA286340-01ARAP, WADIHPASQUALINI, RENATARUTGERS BIOMEDICAL AND HEALTH SCIENCES, NJ$220,193ZCA1
2024NPC1 as a novel therapeutic target in ccRCC1R21CA289161-01KOLENKO, VLADIMIR MRESEARCH INST OF FOX CHASE CAN CTR, PA$219,725ZCA1
2024Develop IL13Ra1 for diagnosis of early-stage mycosis fungoides1R21CA280445-01A1FUSCHIOTTI, PATRIZIAGESKIN, LARISA JUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$218,886ZCA1
2024The Role of the Tumor Microenvironment in Resistance to Oncogenic KRAS Inhibition in Lung Cancer1R21CA286372-01GALBAN, STEFANIEPASCA DI MAGLIANO, MARINAUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$218,790ZCA1
2024Ligand-Induced Recruitment of CAR-T Cells to Colorectal Cancers1R21CA286339-01KIM, SANGWON VINCENTSNOOK, ADAMTHOMAS JEFFERSON UNIVERSITY, PA$218,790ZCA1
2024Genetic architecture of thyroid cancer and its clinical utility1R21CA282380-01A1GIGNOUX, CHRISTOPHER RPOZDEYEV, NIKITAUNIVERSITY OF COLORADO DENVER, CO$218,790ZCA1
2024Cultural and Linguistic Adaptation of a Breast Reconstruction Decision Tool1R21CA287321-01LEE, CLARA NAN-HIUNIV OF NORTH CAROLINA CHAPEL HILL, NC$218,162ZCA1
2024Proteomic signatures to predict drug response in cancer1R21CA288806-01ONG, SHAO-ENYEUNG, RAYMONDUNIVERSITY OF WASHINGTON, WA$218,089ZCA1

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