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NIH funding notice PAR-24-022

Trailblazer Award for New and Early Stage Investigators (R21 Clinical Trial Optional)

Closed on January 7, 2025.

Posted
November 18, 2022
Close date
January 7, 2025
Activity codes
Not stated on the notice page
Institutes taking part
Not stated on the notice page

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

Its page was not saved, so the notices it replaced are not known.

Who won it before

73 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $24,530,909 in first-year total cost, median $231,000.

Most frequent study sections

  1. Imaging Technology Development Study Section[ITD]6
  2. Bioengineering, Technology and Surgical Sciences Study Section[BTSS]5
  3. Imaging Probes and Contrast Agents Study Section[IPCA]5
  4. Special Emphasis Panel[ZRG1 BBBT-M (82)]5
  5. Musculoskeletal Rehabilitation Sciences Study Section[MRS]4

Most frequent institutions

  1. MASSACHUSETTS GENERAL HOSPITAL4
  2. UNIVERSITY OF CALIFORNIA, SAN DIEGO4
  3. BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)3
  4. JOHNS HOPKINS UNIVERSITY3
  5. NORTHEASTERN UNIVERSITY2
Competing awards under PAR-24-022 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2025Direct Methylation with [11C]CO2 for Production of Radiopharmaceuticals1R21EB037241-01ROSENBERG, ADAM JVANDERBILT UNIVERSITY MEDICAL CENTER, TN$700,000IPCA
2025Programmable RNA-Based Sensors for In Situ Cell Type Detection and Response1R21EB037897-01WANG, LEINORTHEASTERN UNIVERSITY, MA$673,600ZRG1
2025Simplifying Bedside Lung Perfusion Imaging Using Electrical Impedance Tomography1R21EB036735-01A1XIN, YIMASSACHUSETTS GENERAL HOSPITAL, MA$656,750CTIS
2025Developing Imaging and Analysis Tools for Lymphoscintigraphy in Lymphedema1R21EB036619-01A1YANG, JAEWONUT SOUTHWESTERN MEDICAL CENTER, TX$642,639EITA
2025A Deep Learning-based Assessment Pipeline for Peripherally Inserted Central Catheters (PICCs) on Pediatric Radiographs1R21EB036699-01A1LI, HAILONGCINCINNATI CHILDRENS HOSP MED CTR, OH$642,000ITD
2025Bruch's Membrane-On-A-Chip to Study Drusen Formation in AMD1R21EY037260-01TOOMEY, CHRISTOPHER BUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$638,625ZRG1
2025Light-Activated SIte-Specific Conjugation (LASIC) to accelerate clinical translation of catheter-directed antibody-drug-conjugate labeled theranostic microbubbles in an Oncopig liver tumor model1R21EB036670-01CHIANG, CHIH-SHENG JHUI, JAMES ZHEUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$630,000IGIS
2025Human-Centered Development of Guide-dog Robots1R21EY037411-01KIM, DONGHYUNUNIVERSITY OF MASSACHUSETTS AMHERST, MA$624,064ZRG1
2025Sliding microgel-based synthetic platelets for managing traumatic bleeding1R21EB036709-01A1GAO, YONGSHENGUNIVERSITY OF TEXAS DALLAS, TX$621,980ZRG1
2025Design principles for engineering therapeutic macrophages1R21EB037846-01YANG, JASON HUNG-YINGRUTGERS BIOMEDICAL AND HEALTH SCIENCES, NJ$621,158ZRG1
2025Catalyzing visual-haptic acuity for tissue handling mastery in robotic minimally invasive surgery1R21EB037224-01BROWN, JEREMY DELAINEJOHNS HOPKINS UNIVERSITY, MD$620,104BTSS
2025Development of a Novel Biomarker and PET Radiotracer for Specific Imaging of Microglial Responses1R21EB037898-01CHANEY, AISLINGWASHINGTON UNIVERSITY, MO$618,670IPCA
2025In Vivo Optical Imaging of Ultrasound Retinal Stimulation1R21EY037948-01LIU, WENDY W.STANFORD UNIVERSITY, CA$617,743ZRG1
2025Cell Morphology-guided, Scalable and Controllable Molecule Design via Generative AI1R21EB037868-01LI, YANJUNYUAN, XIAOYONGUNIVERSITY OF FLORIDA, FL$616,523ZRG1
2025Quantitative Phase Imaging Meta-Sensors for Noninvasive Real-Time Capillaroscopy1R21EB036774-01A1PAIELLA, ROBERTOBOSTON UNIVERSITY (CHARLES RIVER CAMPUS), MA$613,124ZRG1
2025Engineer A Chemogenetic Toolbox for Unraveling Complex Signaling Networks1R21EB036678-01ZHOU, JIEUNIVERSITY OF CHICAGO, IL$321,146TIO
2025Magnetic Microgels for Composite Musculoskeletal Tissue Regeneration1R21EB037178-01QU, FEINIUNIVERSITY OF WASHINGTON, WA$271,664MTE
2025Magnetic Microrobots Assist AAV4 for CFTR Gene Delivery Through Mucus Barrier1R21EB037346-01LI, JINXINGMICHIGAN STATE UNIVERSITY, MI$235,500ZRG1
2025Developing a sensor to monitor brain-to-gut communication1R21EB036732-01LEE, HOJOONNORTHWESTERN UNIVERSITY, IL$232,342BTSS
2025Lymph node inspired hydrogels for immune cell reprogramming1R21EB034818-01A1CORREA, SANTIAGOCOLUMBIA UNIV NEW YORK MORNINGSIDE, NY$231,934INN
2025Combinatorial engineering of a three-cell synthetic immunotherapy system1R21EB037367-01DANIELS, KYLE GABRIELSTANFORD UNIVERSITY, CA$231,000TIR
2025Calcium Pyrophosphate Deposition Disease Development and Biochemical Pathways for Molecular Modulation.1R21AG090917-01A1FRANCIS, MICHAEL PAULUNIVERSITY OF SOUTH FLORIDA, FL$225,000SBSR
2025Ex vivo and In vivo Model Advancements for Airway Stent Design Optimization1R21EB036775-01MONDAL, ABHIJITBOSTON CHILDREN'S HOSPITAL, MA$222,500BTSS
2025Subwavelength ultrasound focusing using negative index refraction metamaterials1R21EB036218-01A1VAZQUEZ MENA, OSCARUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$221,434ITD
2025Machine-guided design of chaperone-mimetic polymeric carriers for ribonucleoprotein delivery1R21EB036183-01A1KUMAR, RAMYACOLORADO SCHOOL OF MINES, CO$220,717ZRG1
2025Low-voltage liquid lens enabled endoscopic optical coherence tomography1R21EB037238-01GOPINATH, JULIETUNIVERSITY OF COLORADO, CO$213,521ITD
2025Wireless, Closed?loop System to Restore Urological Dysfunction after Spinal Cord Injury1R21EB037317-01LI, ZHENGWEIUNIVERSITY OF HOUSTON, TX$206,132ZRG1
2025Prostate cancer-diagnosing imaging agents1R21EB035705-01A1THOMAS, ALINEJOHNS HOPKINS UNIVERSITY, MD$205,745IPCA
2025Longitudinal MRI imaging of clock gene expression in mice brains1R21AG088596-01A1LI, NANUT SOUTHWESTERN MEDICAL CENTER, TX$205,000ITN
2025AI-driven hip exoskeleton control framework that rapidly generalizes to a broad range of users and real-world locomotor tasks1R21EB037268-01BECK, OWENKANG, INSEUNGCARNEGIE-MELLON UNIVERSITY, PA$187,329MRS
2025Metal Fluorination For biomolecules: Expanding The Radiofluorination Toolbox1R21EB035675-01A1CARROLL, LAURENCEJOHNS HOPKINS UNIVERSITY, MD$174,375IPCA
2025In situ formed microneedle-like depots for spatiotemporally controlled drug delivery1R21EB037174-01A1SAMANDARI, MOHAMADMAHDIUNIVERSITY OF CONNECTICUT SCH OF MED/DNT, CT$1SAT
2024Improving prognosis prediction and therapy selection for cutaneous squamous cell carcinomas using artificial intelligence1R21EB035247-01A1LOTTER, WILLIAM EDWARDDANA-FARBER CANCER INST, MA$693,156CDMA
2024Rapid, Motion-Robust, and Low-Gadolinium MRI for Pediatric Brain Tumors1R21EB036105-01JAIMES COBOS, CAMILOJUN, YOHANMASSACHUSETTS GENERAL HOSPITAL, MA$668,000CTIS
2024Non-rotating nano-optic endoscope for 360 degree in vivo imaging1R21EB034798-01A1ADAMS, DAVID CMASSACHUSETTS GENERAL HOSPITAL, MA$647,900ITD
2024Utilizing spatially-informed cell-specific multicellular genome-scale metabolic models to unveil the mechanisms that regulate the decline of the ovarian reserve1R21AG088610-01PENALVER BERNABE, BEATRIZUNIVERSITY OF ILLINOIS AT CHICAGO, IL$625,898ICER
2024Endothelial cell-assisted extracellular vesicle bioengineering for cytoplasmic delivery of therapeutic molecules1R21EB035738-01CREWE, CLAIRWASHINGTON UNIVERSITY, MO$622,000ZRG1
2024Injectable Optoacoustic Retina Prostheses1R21EY036579-01YANG, CHENBOSTON UNIVERSITY (CHARLES RIVER CAMPUS), MA$588,568ZRG1
2024A Novel Personalized Flow Modeling Paradigm for Fetal Aorta and Its Validation with Fetal Cardiac MRI1R21EB034833-01A1WEI, ZHENGLUN ALANWORCESTER POLYTECHNIC INSTITUTE, MA$516,556CTIS
2024Development of potent and safe CRISPR tools for in vivo gene editing using directed evolution1R21EB036298-01MILLER, SHANNON MARIESCRIPPS RESEARCH INSTITUTE, THE, CA$276,000CBP
2024Three-dimensional imaging of radiopharmaceutical distribution in multicellular organism at cellular resolution1R21EB035205-01SUNG, YONGJINUNIVERSITY OF WISCONSIN MILWAUKEE, WI$263,693ZRG1
2024Optimized and accessible immuno-PET using lipid nanoparticle-mediated in vivo bioreactor1R21EB036323-01NG, SHEUNG CHEE THOMASMASSACHUSETTS GENERAL HOSPITAL, MA$249,861IPCA
2024Angiography-derived Imaging Biomarkers of the Coronary Microcirculation1R21EB035382-01GUERRATY, MARIE AUNIVERSITY OF PENNSYLVANIA, PA$243,750EITA
2024A new clinical device to enable informed prosthesis prescription decision-making.1R21EB035665-01SHEPHERD, MAXNORTHEASTERN UNIVERSITY, MA$239,813MRS
2024Computationally designed, small molecule-responsive cell receptors for treating solid tumors1R21EB035208-01A1GLASGOW, ANUM AZAMCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$236,776CMT
2024A lab-on-a-chip device for measuring multiple biochemical and biophysical biomarkers of Alzheimer’s disease1R21AG085089-01COUGHLAN, MARKBETH ISRAEL DEACONESS MEDICAL CENTER, MA$236,022ZRG1
2024Deep Learning for Individualized Treatment Effect Inference with Multimodal Depiction1R21EB034911-01A1LIU, XIAOFENGYALE UNIVERSITY, CT$234,375CDMA
2024Effective Ultrasound Neuromodulation in the Awake Primate Brain1R21EY036652-01WEBB, TAYLOR DUNIVERSITY OF UTAH, UT$231,000ZRG1
2024Wirelessly Actuated Ciliary Stent for Minimally Invasive Treatment of Cilia Dysfunction1R21EB035200-01A1DONG, XIAOGUANGVANDERBILT UNIVERSITY, TN$228,839BTSS
2024Development of a contact-free assay to evaluate stored blood quality using ultrasound viscoelasticity techniques1R21EB035312-01KARAFIN, MATTHEW SUNIV OF NORTH CAROLINA CHAPEL HILL, NC$226,495ITD
2024Hyperspectral chemical imaging via sum-frequency generation microscopic holography1R21EB034418-01A1GE, NIEN-HUIUNIVERSITY OF CALIFORNIA-IRVINE, CA$224,104ZRG1
2024Autonomous Gaze Coaching for Virtual Reality Telesurgical Simulators1R21EB036161-01CHUA, ZONGHECASE WESTERN RESERVE UNIVERSITY, OH$222,813SAT
2024Dissecting inter-region communication in human organoid models with dual-color optogenetic probes1R21AG087754-01XU, GUANGYUUNIVERSITY OF MASSACHUSETTS AMHERST, MA$222,718CMT
2024A gaze-controlled neck exoskeleton for dropped head syndrome1R21EB035378-01BROWN, DANIEL SUNDQUISTZHANG, HAOHANUNIVERSITY OF UTAH, UT$222,036MRS
2024Development of peptoid-based barcodes for in vivo high-throughput screening of targeted nucleic acid delivery1R21EB036261-01KIM, JAYOUNGUNIVERSITY OF NORTH TEXAS HLTH SCI CTR, TX$222,000INN
2024A high-throughput assay to measure amyloid-β oligomer formation1R21AG088715-01WANG, TINAUNIVERSITY OF WISCONSIN-MADISON, WI$219,930MSFB
2024Quantitative assessment of autologous fat grafting in breast cancer treatment using 3D imaging1R21EB035242-01HANSON, SUMMER EUNIVERSITY OF CHICAGO, IL$217,493IGIS
2024A pulse-driven micropump for continuous drug delivery1R21EB035655-01STAPLES, ANNEVIRGINIA POLYTECHNIC INST AND ST UNIV, VA$205,291ZRG1
2024Metasurface-Integrated Open-Top Lattice Light Sheet Microscope for High-Throughput Bioimaging1R21EB035681-01FU, TIAN-MINGPRINCETON UNIVERSITY, NJ$204,375ZRG1
2024Brain-computer interface (BCI)-based identification of color vision deficiencies (CVDs) related to Parkinson’s Disease (PD)1R21EB036221-01NORTON, JAMES JOHN STANLEYALBANY RESEARCH INSTITUTE, INC., NY$204,000BNVT
2024Towards Physical-Interface Pressure Monitoring Outside the Laboratory with Lower-Limb Electronic Clothing and Robust Optimization1R21EB034879-01A1BOLÍVAR-NIETO, EDGAR ALBERTOUNIVERSITY OF NOTRE DAME, IN$203,097MRS
2024INJECTABLE, TUNABLE CO-DELIVERY THERAPEUTIC IMPLANT TO REDUCE AIRWAY STENOSIS1R21EB034840-01A1DION, GREGORY ROBERTPARK, YOONJEEUNIVERSITY OF CINCINNATI, OH$199,872ZRG1
2024Investigating the effect of mechanical compliance of metamaterial interbody cages on spinal fusion progress in vivo1R21EB034457-01A1ALAVI, AMIRUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$188,950BTSS
2024Optoeletronic Micro-Gadget (OMG): a Photoelectrochemistry-Enabled Multi-Utility Lab-on-a-Chip System for Precise and Localized Sensing and Actuation1R21EB035153-01A1LI, JINGHUAOHIO STATE UNIVERSITY, OH$186,938ZRG1
2024Programmable 'all-in-one' RNA as a molecular scaffold for targeted combinatorial innate immune activation1R21EB035261-01WU, CONNIEUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$186,865ZRG1
2024Ribozyme-mediated killing of cells harboring cancer driver mutations1R21EB036277-01LEIER, ANDRÉMULLER, ULRICH FUNIVERSITY OF ALABAMA AT BIRMINGHAM, AL$185,133DMPC
2024DNA Recorder: Living biosensor for arbitrary DNA1R21EB035772-01COOPER, ROBERT MUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$182,983EBIT
2024Next-gen 3D Modeling of Endoscopy Videos1R21EB035832-01SENGUPTA, RONIUNIV OF NORTH CAROLINA CHAPEL HILL, NC$180,603ITD
2024Preoperative Risk Prediction of Postoperative Complications for Elective Cardiac Surgery using At-home Smartphone Dynamometry1R21AG084975-01A1WANG, EDWARD JAYUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$159,000CIDH
2024The cell-specific neurodegenerative potential of mitochondria post-traumatic brain injury1R21AG085052-01A1LIAUDANSKAYA, VOLHAUNIVERSITY OF CINCINNATI, OH$158,247NOMD
2024SEMI-SIMOA: A Chip-scale Flow-based Single-Molecule Assay at the Point-of-Care using Semiconductor Technology1R21EB036154-01CHIEN, JUN-CHAUUNIVERSITY OF CALIFORNIA BERKELEY, CA$149,101ZRG1
2024New detection paradigms for laser-scanning microscopy leveraging fiber optical amplifiers1R21EB036153-01DEMAS, JEFFREY DAKINBOSTON UNIVERSITY (CHARLES RIVER CAMPUS), MA$19,338ZRG1
2023Imaging spatial transcriptome at single cell resolution to study eye regeneration in old age1R21AG084959-01GUO, LONGHUAUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$195,000CMAD

Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-09-0.1.0. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

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