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NIH funding notice PAR-25-054

NINDS Exploratory Clinical Trials (UG3/UH3 Clinical Trial Required)

Closed on March 10, 2025.

Posted
November 12, 2024
Close date
March 10, 2025
Activity codes
UG3, UH3
Institutes taking part
NINDS

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

  1. Reissues: PAR-22-142 NINDS Exploratory Clinical Trials (UG3/UH3 Clinical Trial Required)
  2. 2 steps back: PAR-21-236 NINDS Exploratory Clinical Trials (U01 - Clinical Trial Required)
  3. 3 steps back: PAR-18-420 NINDS Exploratory Clinical Trials (U01 - Clinical Trials Required)
  4. 4 steps back: PAR-17-122 NINDS Exploratory Clinical Trials (R01)
  5. 5 steps back: PAR-13-281 NINDS Exploratory Clinical Trials (R01)
  6. 6 steps back: PAR-10-199 NINDS Exploratory Clinical Trials (R01)

Replaced by PAR-27-065.

Who won it before

20 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $22,625,028 in first-year total cost, median $806,934.

Most frequent study sections

  1. Special Emphasis Panel[ZRG1 BDCN-W (55)]5
  2. Neurological Sciences and Disorders K Study Section[NSD-K]4
  3. Special Emphasis Panel[ZNS1 SRB-G (65)]3
  4. Special Emphasis Panel[ZNS1 SRB-A (10)]2
  5. Special Emphasis Panel[ZNS1 SRB-G (03)]1

Most frequent institutions

  1. UNIVERSITY OF MICHIGAN AT ANN ARBOR3
  2. UNIVERSITY OF ROCHESTER2
  3. DUKE UNIVERSITY1
  4. HENNEPIN HEALTHCARE RESEARCH INSTITUTE1
  5. MASSACHUSETTS GENERAL HOSPITAL1
Competing awards under PAR-25-054 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2025Induced Suppression of Platelet Activity in Aneurysmal SAH Management-2 (iSPASM-2)1UG3NS138219-01A1 · under PAR-22-142BLACKBURN, SPIROSHASAN, DAVID MMAC GRORY, BRIANDUKE UNIVERSITY, NC$817,591ZNS1
2025Regenerative Peripheral Nerve Interfaces for Improving Activities of Daily Living in People with Upper Limb Amputations1UG3NS138154-01A1 · under PAR-22-142CHESTEK, CYNTHIA ANNEGATES, DEANNA H.UNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$605,832ZNS1
2024Reducing falls with Varenicline in Hypocholinergic Parkinson disease1UG3NS133515-01A1 · under PAR-22-142ALBIN, ROGER LKOTAGAL, VIKASUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$1,180,332ZNS1
2024Transcranial Electrical Stimulation in Stroke EaRly After onset Clinical Trial-2 (TESSERACT 2)1UG3NS134619-01A1 · under PAR-22-142BAHR HOSSEINI, MERSEDEHFENG, WUWEIHILLIS, ARGYE E.UNIVERSITY OF CALIFORNIA LOS ANGELES, CA$800,331ZNS1
2024Theta burst subthalamic nucleus deep brain stimulation for cognitive and motor improvements in Parkinson's Disease1UG3NS132960-01A1 · under PAR-22-142LEE, DARRIN JASONUNIVERSITY OF SOUTHERN CALIFORNIA, CA$682,922ZNS1
2023Pterygopalatine Fossa (PPF) Block as an Opioid Sparing Treatment for AcuteHeadache in Aneurysmal Subarachnold Hemorrhage1U01NS124613-01A1 · under PAR-21-236BUSL, KATHARINA MARIAHOH, BRIAN LIMMACIEL, CAROLINA BSMITH, CAMERON REIDUNIVERSITY OF FLORIDA, FL$3,514,491ZNS1
2022Patient Specific Parameter Optimization of Thalamic Stimulation for Treatment of Epilepsy1U01NS124616-01A1 · under PAR-21-236MCGOVERN, ROBERT ANETOFF, THEODEN IUNIVERSITY OF MINNESOTA, MN$530,004ZNS1
2021A Safety and Efficacy study of AAV2-hAADC for AADC deficiency2R01NS094292-06A1 · under PAR-18-420BANKIEWICZ, KRYSTOF SOHIO STATE UNIVERSITY, OH$3,683,088ZNS1
2018Neurotrophin-3 gene therapy for Charcot-Marie-Tooth 1A1R01NS105986-01 · under PAR-17-122SAHENK, ZARIFERESEARCH INST NATIONWIDE CHILDREN'S HOSP, OH$1,375,170ZRG1
2018A futility trial of sirolimus in multiple system atrophy1R01NS107596-01 · under PAR-17-122KAUFMANN, HORACIOPALMA CARAZO, JOSE ALBERTONEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$807,858ZRG1
2018Atorvastatin Treatment of Cavernous Angiomas with Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial1R01NS107887-01 · under PAR-17-122AWAD, ISSAM AUNIVERSITY OF CHICAGO, IL$806,009ZRG1
2018Investigation of Sleep in the Intensive Care Unit (ICU-SLEEP)1R01NS102190-01A1 · under PAR-17-122WESTOVER, MICHAEL BRANDONMASSACHUSETTS GENERAL HOSPITAL, MA$640,029ZRG1
2018Regenerative Peripheral Nerve Interface for Restoring Individual Finger Movement in People with Upper Limb Amputations1R01NS105132-01A1 · under PAR-17-122CHESTEK, CYNTHIA ANNEUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$406,598ZRG1
2017Hyperbaric Oxygen Brain Injury Treatment (HOBIT) Trial - CCC1U01NS095926-01A1 · under PAR-13-281BARSAN, WILLIAM GGAJEWSKI, BYRON J.ROCKSWOLD, GAYLAN LHENNEPIN HEALTHCARE RESEARCH INSTITUTE, MN$1,919,650NSD
2017Aggressive Antipyretics in CNS Malaria: A Randomized-Controlled Trial Assessing Antipyretic Efficacy and Parasite Clearance1R01NS102176-01 · under PAR-13-281BIRBECK, GRETCHEN L.UNIVERSITY OF ROCHESTER, NY$690,395NSD
2017STARFiSH: Study of Testosterone and rHGH in FSHD: A Proof-of-Concept Study1R01NS095813-01A1 · under PAR-13-281HEATWOLE, CHAD RYDELUNIVERSITY OF ROCHESTER, NY$498,229NSD
2017Hyperbaric Oxygen BrainInjury Treatment (HOBIT) Trial-SDMC1U01NS095814-01A1 · under PAR-13-281MARTIN, RENEE HEBERTMEDICAL UNIVERSITY OF SOUTH CAROLINA, SC$386,126NSD
2016Preventing Epilepsy using Vigabatrin in Infants with Tuberous Sclerosis Complex1U01NS092595-01A1 · under PAR-13-281BEBIN, MARTINAUNIVERSITY OF ALABAMA AT BIRMINGHAM, AL$1,488,631ZNS1
2016A Safety and Efficacy study of AAV2-hAADC for AADC deficiency1R01NS094292-01 · under PAR-13-281BANKIEWICZ, KRYSTOF SUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$967,730ZNS1
2016Dietary treatment of Glucose Transporter Type 1 Deficiency (G1D)1R01NS094257-01A1 · under PAR-13-281PASCUAL, JUAN M.UT SOUTHWESTERN MEDICAL CENTER, TX$824,012ZNS1

Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-09-0.1.0. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

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