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NIH funding notice PAR-25-179

Confirmatory Efficacy Clinical Trials of Non-Pharmacological and Pharmacological Interventions for Mental Disorders (R01 Clinical Trial Required)

Open. Closes October 15, 2027.

Posted
November 26, 2024
Close date
October 15, 2027
Activity codes
R01
Institutes taking part
NIMH

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

  1. Reissues: PAR-21-132 Confirmatory Efficacy Clinical Trials of Non-Pharmacological Interventions for Mental Disorders (R01 Clinical Trial Required)
  2. 2 steps back: RFA-MH-18-707 Confirmatory Efficacy Clinical Trials of Non-Pharmacological Interventions for Mental Disorders (R01- Clinical Trial Required)
  3. 3 steps back: RFA-MH-17-614 Confirmatory Efficacy Clinical Trials of Non-Pharmacological Interventions for Mental Disorders (R01)
  4. 4 steps back: RFA-MH-16-425 Confirmatory Efficacy Clinical Trials of Non-Pharmacological Interventions for Mental Disorders (R01)
  5. 5 steps back: RFA-MH-15-340 Confirmatory Efficacy Clinical Trials of Non-Pharmacological Interventions for Mental Disorders (R01)

Who won it before

37 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $33,832,314 in first-year total cost, median $784,741.

Most frequent study sections

  1. Special Emphasis Panel[ZMH1 ERB-D (01)]6
  2. Special Emphasis Panel[ZMH1 ERB-D (04)]5
  3. Special Emphasis Panel[ZMH1 ERB-N (04)]5
  4. Special Emphasis Panel[ZMH1 ERB-B (04)]3
  5. Special Emphasis Panel[ZMH1 ERB-D (03)]3

Most frequent institutions

  1. UNIVERSITY OF PITTSBURGH AT PITTSBURGH5
  2. UNIVERSITY OF CALIFORNIA LOS ANGELES4
  3. UNIVERSITY OF CALIFORNIA, SAN FRANCISCO3
  4. FLORIDA STATE UNIVERSITY2
  5. ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI2
Competing awards under PAR-25-179 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2025A Large-scale Efficacy Trial of a Resilience Training Program for First Responders1R01MH137282-01A1 · under PAR-21-132GONZALEZ, ADAMMAHAFFEY, BRITTAIN LYNNSCHWARTZ, REBECCAVUJANOVIC, ANKA ANNASTATE UNIVERSITY NEW YORK STONY BROOK, NY$696,207ZMH1
2024Multi-site, double-blind, randomized-controlled, efficacy trial of the Transdiagnostic Intervention for Sleep and Circadian Dysfunction for depression symptoms in older adults with high suicide risk1R01MH137185-01 · under PAR-21-132SMAGULA, STEPHEN FUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$2,809,928ZMH1
2024A randomized controlled trial of a preventive behavioral intervention for young adults with psychotic experiences1R01MH134936-01A1 · under PAR-21-132HOLT, DAPHNE JMASSACHUSETTS GENERAL HOSPITAL, MA$976,424ZMH1
2024Confirmatory Efficacy of the Building a Strong Identity and Coping Skills Program for Low-Income Young Adolescents1R01MH134938-01A1 · under PAR-21-132WADSWORTH, MARTHA EPENNSYLVANIA STATE UNIVERSITY, THE, PA$914,649ZMH1
2023Improving Cognition Through Telehealth Aerobic Exercise and Cognitive Training After a First Schizophrenia Episode1R01MH130848-01A1 · under PAR-21-132NUECHTERLEIN, KEITH HUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$1,254,368ZMH1
2023A Confirmatory Efficacy Study of Interoceptive Exposure for Adolescents with Low Weight Eating Disorders1R01MH131655-01 · under PAR-21-132HILDEBRANDT, THOMAS BICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$786,153ZMH1
2023A Confirmatory Efficacy Trial of Engaging a Novel Sleep/Circadian Rhythm Target as Treatment for Depression in Adolescents1R01MH129558-01A1 · under PAR-21-132ASARNOW, LAURENUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$766,514ZMH1
2023Confirmatory Efficacy Clinical Trial of Amygdala Neurofeedback for Depression1R01MH130337-01A1 · under PAR-21-132YOUNG, KYMUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$744,194ZMH1
2023Resistance Exercise to Treat Major Depression via Cerebrovascular Mechanisms: Confirming Efficacy and Informing Precision Medicine1R01MH130566-01A1 · under PAR-21-132MEYER, JACOB DIOWA STATE UNIVERSITY, IA$721,296ZMH1
2023Confirmatory Efficacy Trial of a Traditional vs. Gamified Attention Bias Modification for Depression1R01MH131750-01A1 · under PAR-21-132BEEVERS, CHRISTOPHER GUNIVERSITY OF TEXAS AT AUSTIN, TX$714,349ZMH1
2022Evaluating the Efficacy of Sequenced Central Executive and Behavioral Parent Training for Children with ADHD1R01MH125893-01A1 · under PAR-21-132CHACKO, ANILKOFLER, MICHAEL JFLORIDA STATE UNIVERSITY, FL$995,963ZMH1
2022Efficacy of External Trigeminal Nerve Stimulation for Treatment of ADHD1R01MH126041-01A1 · under PAR-21-132LOO, SANDRA KMCGOUGH, JAMES JOHNSTEIN, MARK AUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$812,735ZMH1
2022Efficacy of digital cognitive behavior therapy for insomnia for the prevention of perinatal depression1R01MH126040-01A1 · under PAR-21-132FELDER, JENNIFER NICOLEUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$808,043ZMH1
2022Neurofeedback from the supplementary motor area for Tourette Syndrome1R01MH127147-01A1 · under PAR-21-132HAMPSON, MICHELLEYALE UNIVERSITY, CT$770,539ZMH1
2022Cognitive Rehabilitation and Exposure Therapy for Geriatric Hoarding1R01MH127056-01A1 · under PAR-21-132AYERS, CATHERINEUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$730,759ZMH1
2021Neuroplasticity-Based Computerized Cognitive Remediation (nCCR) for Treatment Resistant Late-Life Depression1R01MH126051-01 · under RFA-MH-18-707MORIMOTO, SARAH SHIZUKOSTEFFENS, DAVID C.UNIVERSITY OF UTAH, UT$1,503,141ZMH1
2021Early Intervention for Youth At-Risk for Bipolar Disorder1R01MH125971-01 · under RFA-MH-18-707GOLDSTEIN, TINA RUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$664,442ZMH1
2021A Wearable Morning Light Treatment for Postpartum Depression: Confirming Efficacy and Mechanisms1R01MH121531-01A1 · under RFA-MH-18-707SWANSON, LESLIE MUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$560,929ZMH1
2021Efficacy of an integrated intervention to treat maternal depression and children’s behavior problems: A transactional perspective1R56MH127032-01 · under RFA-MH-18-707ROUBINOV, DANIELLE S.UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$429,059ZMH1
2020Family-Focused Therapy for Individuals at High Clinical Risk for Psychosis: A Confirmatory Efficacy Trial1R01MH123575-01 · under RFA-MH-18-707BEARDEN, CARRIE EMIKLOWITZ, DAVID JAYUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$1,477,527ZMH1
2020Personalized Integrated Chronotherapy for Perinatal Depression1R01MH118269-01A1 · under RFA-MH-18-707SHARKEY, KATHERINE MRHODE ISLAND HOSPITAL, RI$1,377,132ZMH1
2020Confirming the Efficacy/Mechanism of Family Therapy for Children with Low Weight Avoidant/Restrictive Food Intake Disorder (ARFID)1R01MH121292-01A1 · under RFA-MH-18-707LOCK, JAMES DSTANFORD UNIVERSITY, CA$709,636ZMH1
2020Efficacy of Personalizing Cognitive Remediation for Schizophrenia by Targeting Impairments in Early Auditory Processing1R01MH123561-01 · under RFA-MH-18-707MEDALIA, ALICECOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$496,849ZMH1
2020Suicide Prevention for Patients with Chronic Pain1R56MH121555-01 · under RFA-MH-18-707MCANDREW, LISA MARIEVETERANS BIOMEDICAL RESEARCH INSTITUTE, NJ$336,791ZMH1
2019Efficacy of biomarker-guided rTMS for treatment resistant depression1R01MH118388-01 · under RFA-MH-18-707GUNNING, FAITH MLISTON, CONOR MWILLIAMS, NOLAN R.WEILL MEDICAL COLL OF CORNELL UNIV, NY$1,245,371ZMH1
2019Targeting Attention Orienting to Social Threat to Reduce Social Anxiety in Youth1R01MH119299-01 · under RFA-MH-18-707PETTIT, JEREMY WSILVERMAN, WENDY K.FLORIDA INTERNATIONAL UNIVERSITY, FL$1,130,654ZMH1
2019Cognitive Enhancement for Persistent Negative Symptoms in Schizophrenia1R01MH118267-01A1 · under RFA-MH-18-707EACK, SHAUN MUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$741,755ZMH1
2019Efficacy of a Healthy Lifestyle Intervention to Prevent Depression in Older Spousally-bereaved Adults1R01MH118270-01A1 · under RFA-MH-18-707STAHL, SARAH TUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$445,778ZMH1
2018Investigating Social Competence in Youth with Autism: A Multisite RCT1R01MH114906-01 · under RFA-MH-17-614CORBETT, BLYTHE ANNEVANDERBILT UNIVERSITY MEDICAL CENTER, TN$784,741ZMH1
2018Optimizing Long-Term Outcomes for Winter Depression with CBT-SAD and Light Therapy: Confirming the Targets, Mechanisms, and Treatment Sequence1R01MH112819-01A1 · under RFA-MH-17-614ROHAN, KELLY J.UNIVERSITY OF VERMONT & ST AGRIC COLLEGE, VT$679,218ZMH1
2018Evaluating the Efficacy of Central Executive Training (CET) for ADHD1R01MH115048-01 · under RFA-MH-17-614KOFLER, MICHAEL JFLORIDA STATE UNIVERSITY, FL$382,500ZMH1
2017Improving Cognition via Exercise in Schizophrenia1R01MH110623-01A1 · under RFA-MH-16-425KIMHY, DAVIDSTROUP, THOMAS SCOTTICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$1,555,921ZMH1
2017Confirmatory Safety and Efficacy Trial of Magnetic Seizure Therapy for Depression1R01MH112815-01 · under RFA-MH-16-425DASKALAKIS, ZAFIRIS J.CENTRE FOR ADDICTION AND MENTAL HEALTH, ON$1,542,062ZMH1
2017Confirmatory Double-Blind Placebo-Controlled Efficacy Trial of a Gluten-Free Diet in a Subgroup of Persons with Schizophrenia Who Have High Levels of IgG Anti-Gliadin Antibodies1R01MH113617-01 · under RFA-MH-16-425EATON, WILLIAM WKELLY, DEANNA LUNIVERSITY OF MARYLAND BALTIMORE, MD$801,031ZMH1
2017Confirming the Efficacy/Mechanism of an Adaptive Treatment for Adolescent Anorexia Nervosa1R01MH110538-01A1 · under RFA-MH-16-425LOCK, JAMES DSTANFORD UNIVERSITY, CA$794,125ZMH1
2016Enhancing Cognitive Training Through Exercise Following a First Schizophrenia Episode1R01MH110544-01 · under RFA-MH-16-425NUECHTERLEIN, KEITH HUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$903,718ZMH1
2016Improving Depression Outcome by Enhancing Memory for Cognitive Therapy1R01MH108657-01A1 · under RFA-MH-16-425HARVEY, ALLISON GUNIVERSITY OF CALIFORNIA BERKELEY, CA$767,813ZMH1

Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-09-0.1.0. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

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PAR-25-179: Confirmatory Efficacy Clinical Trials of Non-Pharmacological and Pharmacological Interventions for Mental Disorders (R01 Clinical Trial Required) | ScienceDex | ConductScience