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NIH funding notice PAR-25-266

Innovative Screening Approaches and Therapies for Screenable Disorders in Newborns (R21 - Clinical Trial Optional)

Open. Closes November 16, 2027.

Posted
December 2, 2024
Close date
November 16, 2027
Activity codes
R21
Institutes taking part
NICHD

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

  1. Reissues: PAR-21-355 Innovative Screening Approaches and Therapies for Screenable Disorders in Newborns (R21 - Clinical Trial Optional)
  2. 2 steps back: PAR-18-691 Innovative Therapies and Tools for Screenable Disorders (R21 Clinical Trial Optional)
  3. 3 steps back: PAR-14-269 Innovative Therapies and Tools for Screenable Disorders in Newborns (R21)
  4. 4 steps back: PAR-10-232 Innovative Therapies and Tools for Screenable Disorders in Newborns (R21)
  5. 5 steps back: PAR-06-059

Who won it before

13 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $3,507,326 in first-year total cost, median $240,804.

Most frequent study sections

  1. Therapeutic Approaches to Genetic Diseases Study Section[TAG]9
  2. Special Emphasis Panel[ZRG1 GGG-A (50)]2
  3. Special Emphasis Panel[ZRG1 GGG-B (50)]2

Most frequent institutions

  1. ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI3
  2. CINCINNATI CHILDRENS HOSP MED CTR2
  3. CHILDREN'S RESEARCH INSTITUTE1
  4. RESEARCH INST NATIONWIDE CHILDREN'S HOSP1
  5. STATE UNIVERSITY OF NEW YORK AT BUFFALO1
Competing awards under PAR-25-266 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2025Microglia-Integrated Brain Organoids for Gaucher Disease Modeling and Therapeutic Discovery1R21HD119083-01 · under PAR-21-355SUN, YINGCINCINNATI CHILDRENS HOSP MED CTR, OH$441,375TAG
2023Evaluating the feasibility of an innovative point-of-care screening tool for detection of infant motor delay within the newborn period1R21HD110784-01A1 · under PAR-21-355ALFANO, LINDSAY NRESEARCH INST NATIONWIDE CHILDREN'S HOSP, OH$429,000TAG
2022Developing Synthetic Enzymes to Treat Inborn Errors of Metabolism1R21HD105934-01 · under PAR-18-691NAIR, NIKHIL UNNITUFTS UNIVERSITY MEDFORD, MA$190,711TAG
2021Substrate reduction as a novel therapeutic strategy for Glutaric Aciduria Type 11R21HD102745-01A1 · under PAR-18-691DEVITA, ROBERT JHOUTEN, SANDER MICHELICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$296,407TAG
2021Identification of biomarkers for biochemical, pathophysiological and neurological effects of high ammonia concentration on the central nervous system in a preclinical model of neonatal hyperammonemia1R21HD099329-01A1 · under PAR-18-691AH MEW, NICHOLASCALDOVIC, LJUBICA MORIZONOCHILDREN'S RESEARCH INSTITUTE, DC$267,750TAG
2021Advancing a novel experimental mRNA-based therapy for Classic Galactosemia1R21HD104056-01A1 · under PAR-18-691LAI, KENTUNIVERSITY OF UTAH, UT$228,750TAG
2021Biochemical and Molecular Newborn Screening for Familial Hypercholesterolemia1R21HD102793-01A1 · under PAR-18-691PETERSON, AMY LHUNIVERSITY OF WISCONSIN-MADISON, WI$155,417TAG
2020Brain organoid modeling of Gaucher disease for identification of pathogenic pathways and therapy development1R21HD102788-01 · under PAR-18-691SUN, YINGCINCINNATI CHILDRENS HOSP MED CTR, OH$238,500TAG
2019Improving Critical Congenital Heart Disease Screening and Detection of "Secondary" Targets1R21HD099239-01 · under PAR-18-691SIEFKES, HEATHER MUNIVERSITY OF CALIFORNIA AT DAVIS, CA$240,804TAG
2018T cell-mediated Gene Replacement Therapy1R21HD091461-01A1 · under PAR-14-269BROWN, BRIAN DICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$251,737ZRG1
2018Surfactant Protein-A as a biomarker to predict development of NEC in infants1R21HD094069-01 · under PAR-14-269ALCORN, JOSEPH LUNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, TX$231,000ZRG1
2017Novel Treatment Options for Glutaric Aciduria1R21HD088775-01A1 · under PAR-14-269DEVITA, ROBERT JHOUTEN, SANDER MICHELICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$296,625ZRG1
2016Enhancement Newborn Screening to Improve the Efficacy of Cord Blood Transplant for Krabbe Disease1R21HD087818-01 · under PAR-14-269CARTER, RANDOLPH LEELANGAN, THOMAS JSTATE UNIVERSITY OF NEW YORK AT BUFFALO, NY$239,250ZRG1

Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-09-0.1.0. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

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