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NIH funding notice PAR-27-058

NIDCR Prospective Observational or Biomarker Validation Study Cooperative Agreement (U01 Clinical Trial Not Allowed)

Open. Closes July 5, 2029.

Posted
June 16, 2026
Close date
July 5, 2029
Activity codes
U01
Institutes taking part
NIDCR

Read the notice on Grants.gov

The notices it replaced

  1. Reissues: PAR-25-239 NIDCR Prospective Observational or Biomarker Validation Study Cooperative Agreement (U01 Clinical Trial Not Allowed)
  2. 2 steps back: PAR-23-162 NIDCR Prospective Observational or Biomarker Validation Study Cooperative Agreement (U01 Clinical Trial Not Allowed)
  3. 3 steps back: PAR-20-060 NIDCR Prospective Observational or Biomarker Validation Study Cooperative Agreement (U01 Clinical Trial Not Allowed)
  4. 4 steps back: PAR-17-154 NIDCR Prospective Observational or Biomarker Clinical Validation Study Cooperative Agreement (U01)

Who won it before

20 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $18,414,160 in first-year total cost, median $789,382.

Most frequent study sections

  1. Special Emphasis Panel[ZDE1 YM (12)]4
  2. Special Emphasis Panel[ZDE1 YM (07)]3
  3. Special Emphasis Panel[ZDE1 YM (06)]2
  4. Special Emphasis Panel[ZDE1 YM (11)]2
  5. Special Emphasis Panel[ZDE1 YM (16)]2

Most frequent institutions

  1. UNIVERSITY OF CALIFORNIA, SAN FRANCISCO3
  2. CAROLINAS MEDICAL CENTER2
  3. UNIVERSITY OF CALIFORNIA LOS ANGELES2
  4. UNIVERSITY OF MICHIGAN AT ANN ARBOR2
  5. WASHINGTON UNIVERSITY2
Competing awards under PAR-27-058 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2025Validating the hybrid epithelial/mesenchymal state as a biomarker of treatment response and outcomes in head and neck cancer1U01DE034109-01A1 · under PAR-23-162PURAM, SIDHARTH VENKATASTOTT, SHANNON LWASHINGTON UNIVERSITY, MO$702,871ZDE1
2025Validation of a clinically accessible prognostic biomarker for oropharynx cancer using molecular and spatial data1U01DE034565-01 · under PAR-23-162PURAM, SIDHARTH VENKATAVIRANI, SHAMAWASHINGTON UNIVERSITY, MO$534,915ZDE1
2024Economic Stressors and Opportunities as Influences of Emerging Adult Oral Health1U01DE033953-01 · under PAR-23-162CHAFFEE, BENJAMIN WUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$721,722ZDE1
2024HPV-related Oropharyngeal Cancer Screening and Monitoring through Remote Self-Sampling1U01DE032997-01A1 · under PAR-23-162STURGIS, ERICH MADISONBAYLOR COLLEGE OF MEDICINE, TX$707,991ZDE1
2023Predicting Caries Lesion Patterns and Trajectories in Underserved Children, from Infancy to Early Adolescence, in Primary Healthcare Settings2U01DE021412-12A1 · under PAR-20-060FONTANA, MARGHERITA RUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$1,846,431ZDE1
2023Quantitative Imaging Biomarker Prospective Validation of Dynamic Contrast-Enhanced MRI as a Metric of Orodental Injury After Radiotherapy (QI-ProVE-MRI)1U01DE032168-01A1 · under PAR-20-060FULLER, CLIFTON DAVIDLAI, STEPHEN YUNIVERSITY OF TX MD ANDERSON CAN CTR, TX$717,338ZDE1
2023Examining impacts of structural racism and discrimination on Hispanic treatment differences and oral health disparities; known internally as "Smiles of Hope - Proyecto Hispanico de Esperanza" (SoPHE)1R56DE032675-01A1 · under PAR-20-060GANSKY, STUART ARAMOS-GOMEZ, FRANCISCO J.TIWARI, TAMANNAUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$572,261ZDE1
2022Susceptibility Patterns for Grade C Periodontitis in Young Individuals1U01DE031223-01A1 · under PAR-20-060SHADDOX, LUCIANA MACCHIONUNIVERSITY OF KENTUCKY, KY$898,405ZDE1
2021Long-term Oral Complications of an Established Head and Neck Cancer Cohort- Clinical Registry of Dental Outcomes in Head and Neck Cancer Patients: OraRad2U01DE022939-09 · under PAR-20-060BRENNAN, MICHAEL TLALLA, RAJESH V.CAROLINAS MEDICAL CENTER, NC$1,242,008ZDE1
2021Coordinated Oral Health Promotion (CO-OP) Chicago Cohort Study1U01DE030067-01A1 · under PAR-20-060MARTIN, MOLLY AUNIVERSITY OF ILLINOIS AT CHICAGO, IL$1,215,509ZDE1
2021Understanding Oral Diseases in Cystic Fibrosis to Develop Tailored Preventive Dental Interventions1U01DE030418-01 · under PAR-20-060CHI, DONALD LESLIEROSENFELD, MARGARETUNIVERSITY OF WASHINGTON, WA$795,360ZDE1
2021Health and Psychosocial Outcomes in Young Children with Cleft Palate1U01DE030065-01A1 · under PAR-20-060CRERAND, CANICE ELLENRESEARCH INST NATIONWIDE CHILDREN'S HOSP, OH$775,361ZDE1
2020Velopharyngeal insufficiency following cleft palate repair: a comparative effectiveness study of existing surgical procedures and identification of criteria to guide a personalized treatment approach1U01DE029750-01 · under PAR-17-154SITZMAN, THOMAS JAMESPHOENIX CHILDREN'S HOSPITAL, AZ$842,190ZDE1
2020Observational study to validate circulating HPVDNA and prognostic genomic biomarkers for diagnosis and treatment of HPV-associated OPSCC1U01DE029754-01 · under PAR-17-154CHERA, BHISHAMGUPTA, GAORAV P.ISSAEVA, NATALIAYARBROUGH, WENDELL GUNIV OF NORTH CAROLINA CHAPEL HILL, NC$809,450ZDE1
2020Sjögren's International Collaborative Clinical Alliance Next Generation Studies (SICCA-NextGen)1U01DE028891-01A1 · under PAR-17-154SHIBOSKI, CAROLINE HELENEUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$807,082ZDE1
2020PROMIS oral health toolkit-supported school-based oral health program1U01DE029491-01 · under PAR-17-154LIU, HONGHUUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$783,404ZDE1
2019Fluoride, Dietary, and Other Factors Related to Young Adult Bone Measures and Dental Caries1U01DE028522-01 · under PAR-17-154LEVY, STEVEN M.UNIVERSITY OF IOWA, IA$341,942ZDE1
2019Sjögren’s International Collaborative Clinical Alliance Next Generation Studies (SICCA-NextGen)1R56DE028891-01 · under PAR-17-154CRISWELL, LINDSEY ANNSHIBOSKI, CAROLINE HELENEUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$63,700ZDE1
2018Clinical Registry of Dental Outcomes in Head and Neck Cancer Patients (ORARAD)2U01DE022939-06A1 · under PAR-17-154BRENNAN, MICHAEL TLALLA, RAJESH V.CAROLINAS MEDICAL CENTER, NC$2,079,075ZDE1
2017Predicting Caries Risk in Underserved Children, from Toddlers to the School-Age Years, in Primary Healthcare Settings2U01DE021412-07 · under PAR-17-154FONTANA, MARGHERITA RUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$1,957,145ZDE1

Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-09-0.1.0. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

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