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NIH funding notice PAR-27-127

Silvio O. Conte Centers for Basic Neuroscience or Translational Mental Health Research (P50 Clinical Trial Optional)

Open. Closes May 25, 2028.

Posted
September 1, 2026
Close date
May 25, 2028
Activity codes
P50
Institutes taking part
NIMH

Read the notice on Grants.gov

The notices it replaced

  1. Reissues: PAR-22-155 Silvio O. Conte Centers for Basic Neuroscience or Translational Mental Health Research (P50 Clinical Trial Optional)
  2. 2 steps back: PAR-20-093 Silvio O. Conte Centers for Basic Neuroscience or Translational Mental Health Research (P50 Clinical Trial Optional)
  3. 3 steps back: PAR-18-737 Silvio O. Conte Centers for Basic Neuroscience or Translational Mental Health Research (P50 Clinical Trial Optional)
  4. 4 steps back: PAR-17-168 Silvio O. Conte Centers for Basic Neuroscience or Translational Mental Health Research (P50)
  5. 5 steps back: PAR-14-120 Silvio O. Conte Centers for Basic or Translational Mental Health Research (P50)
  6. 6 steps back: PAR-11-126 Silvio O. Conte Centers for Basic and Translational Mental Health Research (P50)
  7. 7 steps back: PAR-08-194 Silvio O. Conte Centers for Basic and Translational Mental Health Research (P50)

Who won it before

29 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $75,705,344 in first-year total cost, median $2,703,016.

Most frequent study sections

  1. Special Emphasis Panel[ZMH1 ERB-L (01)]11
  2. Special Emphasis Panel[ZMH1 ERB-S (01)]10
  3. Special Emphasis Panel[ZMH1 ERB-E (01)]3
  4. Special Emphasis Panel[ZMH1 ERB-G (01)]2
  5. Special Emphasis Panel[ZMH1 ERB-Q (01)]2

Most frequent institutions

  1. BOSTON CHILDREN'S HOSPITAL2
  2. JOHNS HOPKINS UNIVERSITY2
  3. MCLEAN HOSPITAL2
  4. PRINCETON UNIVERSITY2
  5. UNIVERSITY OF CALIFORNIA AT DAVIS2
Competing awards under PAR-27-127 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2025Dysfunctional State Representations in Psychosis: From Neurophysiology to Neuroplasticity-based Treatment2P50MH119569-06 · under PAR-22-155REDISH, A DAVIDVINOGRADOV, SOPHIAUNIVERSITY OF MINNESOTA, MN$3,095,644ZMH1
2024Impact of the olfactory system on higher brain function and schizophrenia1P50MH136297-01 · under PAR-22-155SAWA, AKIRAJOHNS HOPKINS UNIVERSITY, MD$3,359,892ZMH1
2024Control of synaptic circuits by small GTPase pathways1P50MH132775-01A1 · under PAR-22-155PENZES, PETERNORTHWESTERN UNIVERSITY AT CHICAGO, IL$3,262,895ZMH1
2024Conte Center: Understanding Latent Cause Inference in Health and Illness1P50MH136296-01 · under PAR-22-155NIV, YAELPRINCETON UNIVERSITY, NJ$3,225,980ZMH1
2023Neurobiology and Cognitive Role of Slow Brain Network Fluctuations2P50MH109429-06 · under PAR-20-093MILHAM, MICHAEL PETERSCHROEDER, CHARLES ENATHAN S. KLINE INSTITUTE FOR PSYCH RES, NY$3,427,178ZMH1
2023Cognitive Thalamus1P50MH132642-01 · under PAR-20-093KASTNER, SABINEPRINCETON UNIVERSITY, NJ$3,266,884ZMH1
2022Neural-immune Mechanisms and Synaptic Connectivity in Psychiatric Illness2P50MH112491-06 · under PAR-20-093CARROLL, MICHAEL CRAIGSTEVENS, BETH ANNBOSTON CHILDREN'S HOSPITAL, MA$3,395,087ZMH1
2022Neurocircuitry of OCD: Effects of Modulation2P50MH106435-06A1 · under PAR-20-093HABER, SUZANNE NUNIVERSITY OF ROCHESTER, NY$3,180,058ZMH1
2021UC Davis Conte Center: Neuroimmune Mechanisms of Psychiatric Disorders2P50MH106438-06 · under PAR-20-093CARTER, CAMERON S.MCALLISTER, A KIMBERLEYUNIVERSITY OF CALIFORNIA AT DAVIS, CA$3,129,214ZMH1
2021Neuroactive steroids as novel psychiatric treatments: mechanistic studies1P50MH122379-01A1 · under PAR-20-093MENNERICK, STEVEN JZORUMSKI, CHARLES FWASHINGTON UNIVERSITY, MO$2,535,717ZMH1
2020Novel Treatment Targets For Affective Disorders Through Cross-Species Investigation of Approach/Avoidance Decision Making1P50MH119467-01A1 · under PAR-18-737PIZZAGALLI, DIEGO AMCLEAN HOSPITAL, MA$3,225,604ZMH1
2020Dysfunctional State Representations in Psychosis: From Neurophysiology to Neuroplasticity-based Treatment1P50MH119569-01A1 · under PAR-18-737REDISH, A DAVIDVINOGRADOV, SOPHIAUNIVERSITY OF MINNESOTA, MN$3,009,915ZMH1
2019Fragmented early-life experiences, aberrant circuit maturation, emotional vulnerabilities2P50MH096889-06A1 · under PAR-18-737BARAM, TALLIE Z.UNIVERSITY OF CALIFORNIA-IRVINE, CA$3,020,227ZMH1
2019Kynurenic Acid and Cognitive Abnormalities in Schizophrenia2P50MH103222-06 · under PAR-18-737SCHWARCZ, ROBERTUNIVERSITY OF MARYLAND BALTIMORE, MD$2,875,721ZMH1
2019Silvio O. Conte Center for Stress Peptide Advanced Research, Education, & Dissemination (SPARED) at McLean Hospital1P50MH115874-01A1 · under PAR-18-737CARLEZON, WILLIAM A.MCLEAN HOSPITAL, MA$2,703,016ZMH1
2018Antecedents of Suicidal Behavior Related Neurobiology2P50MH090964-06 · under PAR-17-168MANN, JOSEPH JOHNNEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC, NY$2,783,896ZMH1
2018Silvio O. Conte Center for Oxytocin and Social Cognition2P50MH100023-06 · under PAR-17-168YOUNG, LARRY JEMORY UNIVERSITY, GA$2,564,458ZMH1
2018Developmental origins of mental illness: evolution and reversibility2P50MH094271-06 · under PAR-17-168HENSCH, TAKAO KHARVARD UNIVERSITY, MA$2,000,511ZMH1
2017Epigenetic Mechanisms of Depression2P50MH096890-06 · under PAR-14-120NESTLER, ERIC J.ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$2,000,000ZMH1
2017Neural-immune mechanisms and synaptic connectivity in psychiatric illness1P50MH112491-01 · under PAR-14-120CARROLL, MICHAEL CRAIGMCCARROLL, STEVEN ANDREWSTEVENS, BETH ANNBOSTON CHILDREN'S HOSPITAL, MA$2,000,000ZMH1
2017Neurobiology and dynamics of Active Sensing1P50MH109429-01A1 · under PAR-14-120SCHROEDER, CHARLES ECOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$1,912,097ZMH1
2017The Neurobiology of Social Decision-Making: Social Inference and Context2P50MH094258-06 · under PAR-14-120ADOLPHS, RALPHCALIFORNIA INSTITUTE OF TECHNOLOGY, CA$1,809,622ZMH1
2016Gene-Environment Interactions for Cortical Development and Schizophrenia2P50MH094268-06 · under PAR-14-120SAWA, AKIRAJOHNS HOPKINS UNIVERSITY, MD$1,998,575ZMH1
2015Neuroimmune Mechanisms of Psychiatric Disorders1P50MH106438-01 · under PAR-14-120CARTER, CAMERON S.UNIVERSITY OF CALIFORNIA AT DAVIS, CA$2,000,000ZMH1
2015Neurocircuitry of OCD: Effects of Modulation1P50MH106435-01 · under PAR-14-120HABER, SUZANNE NUNIVERSITY OF ROCHESTER, NY$2,000,000ZMH1
2015Activity-dependent Synaptic and Circuit Plasticity2P50MH086403-06 · under PAR-14-120MALENKA, ROBERT CSTANFORD UNIVERSITY, CA$1,990,139ZMH1
2015Stress Mechanisms Increasing Risk of Mood-Disorders1P50MH106428-01 · under PAR-14-120CHAVKIN, CHARLESUNIVERSITY OF WASHINGTON, WA$1,638,571ZMH1
2014Cortical Cells Circuits Connectivity and Cognition in Schizophrenia1P50MH103204-01 · under PAR-11-126LEWIS, DAVID AUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$2,149,999ZMH1
2014Kynurenic Acid and Cognitive Abnormalities in Schizophrenia1P50MH103222-01 · under PAR-11-126SCHWARCZ, ROBERTUNIVERSITY OF MARYLAND BALTIMORE, MD$2,144,444ZMH1

Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-09-0.1.0. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

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PAR-27-127: Silvio O. Conte Centers for Basic Neuroscience or Translational Mental Health Research (P50 Clinical Trial Optional) | ScienceDex | ConductScience