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NIH funding notice PAS-18-187

Advancing Research on Alzheimer's Disease (AD) and Alzheimer's-Disease-Related Dementias (ADRD) (R43/R44 Clinical Trial Optional)

Closed on July 18, 2019.

Posted
November 28, 2017
Close date
July 18, 2019
Activity codes
Not stated on the notice page
Institutes taking part
Not stated on the notice page

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

Its page was not saved, so the notices it replaced are not known.

Who won it before

45 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $23,703,728 in first-year total cost, median $342,592.

Most frequent study sections

  1. Special Emphasis Panel[ZRG1 ETTN-H (11)]20
  2. Special Emphasis Panel[ZRG1 ETTN-P (13)]9
  3. Special Emphasis Panel[ZRG1 RPHB-Y (12)]8
  4. Special Emphasis Panel[ZRG1 ETTN-C (10)]3
  5. Special Emphasis Panel[ZRG1 RPHB-Y (13)]3

Most frequent institutions

  1. OLEOLIVE, INC.2
  2. OLIGOMERIX, INC2
  3. PRONEUROGEN, INC.2
  4. VIVREON BIOSCIENCES, LLC2
  5. 712 NORTH, INC.1
Competing awards under PAS-18-187 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2020Open-label extension of a 3-month blinded clinical trial of PTI-1251R44AG065152-01BURNS, LINDSAY HCASSAVA SCIENCES, INC, TX$2,499,896ZRG1
2019Lead Optimization of CRAC Channel Inhibitors for the Treatment of Alzheimer's Disease2R44AG055205-04GREENBERG, MILTON LVIVREON BIOSCIENCES, LLC, CA$1,250,000ZRG1
2019Device to control circadian-effective light in Alzheimer's disease environments2R44AG060857-02PAGE, ERIKERIK PAGE AND ASSOCIATES, INC., CA$1,240,470ZRG1
2019GMP Production of a Tau Oligomer Inhibitor to Enable Clinical Development for ADRD1R44AG066384-01MOE, JAMES G.OLIGOMERIX, INC, NY$1,228,934ZRG1
2019Lead optimization and development of novel targeted small molecule therapeutics for Alzheimers disease2R44AG043243-03NASH, KEVIN RONRAVULA, SATHEESH BEPIGEN BIOSCIENCES, INC., CA$1,169,102ZRG1
2019Rapid Profiling of the Plasma Proteome and Machine Learning Analytics for Non-Invasive Diagnosis of Alzheimer's Disease1R44AG065051-01MANNING, WILLIAM CLARENCESEER, INC., CA$1,130,758ZRG1
2019Structurally Diverse GABA-A α5 Positive Allosteric Modulators for Treatment of MCI due to AD1R44AG063607-01ROSENZWEIG-LIPSON, SHARONAGENEBIO, INC., MD$1,118,843ZRG1
2019Ubiquitin Proteasome System and Molecular Signatures of Alzheimer’s Disease2R44AG057231-02BUTT, TAUSEEF R.LIFESENSORS, INC., PA$1,012,084ZRG1
2019Long-term therapeutic effects of synthetic bryostatin-1 in advanced AD without memantine1R44AG066366-01SUN, MIAO-KUNSYNAPTOGENIX, INC., NY$986,918ZRG1
2019CS6253 development for the treatment of apoE4 driven dementia includingAlzheimer's disease1R44AG060826-01A1JOHANSSON, JANARTERY THERAPEUTICS, INC., CA$479,682ZRG1
2019Development of Serious Games and Physical Activities Instructed by a Social Robot for Improving the Well-being of Elderly Individuals with Alzheimer's Disease and Dementia1R44AG066439-01MAHOOR, MOHAMMADDREAM FACE TECHNOLOGIES, LLC, CO$463,523ZRG1
2019Novel formulations of Allopregnanolone to treat Alzheimer's Disease1R43AG063674-01A1BRINTON, ROBERTA EILEENCROCKETT, TAMARAOSSANNA, NINAPRONEUROGEN, INC., AZ$449,886ZRG1
2019Whole Blood Filter Paper Assay for Alzheimers Disease1R43AG065039-01SELIGMANN, BRUCE E.BIOSPYDER TECHNOLOGIES, INC., CA$436,986ZRG1
2019Evaluation of a selective PPAR-gamma agonist for treatment of Alzheimer’s Disease1R43AG065069-01CARDELLI, JAMESOLEOLIVE, INC., LA$346,991ZRG1
2019Develop GABAergic Neuron Protectors for Treating ApoE4-Related Alzheimer's Disease1R44AG063691-01MAHLEY, ROBERT W.TONG, LESLIEGABAERON, INC., CA$342,592ZRG1
2019A Novel Biological marker and ELISA Assay for Determination of Cognitive Resilience in Alzheimer's Disease1R43AG064998-01XU, DESHENGCOGNEXT DIAGNOSTICS, LLC, MD$337,540ZRG1
2019Advance Care Planning in the Dementias: Culturally-Tailored Caregiver Education for African Americans1R44AG065095-01BONNER, GLORIA JCOLLINGE, WILLIAM B.COLLINGE AND ASSOCIATES, OR$331,097ZRG1
2019Improving Mobile Access for Recruiting Study Volunteers from Underrepresented Populations for Alzheimer's Disease Research and Other Studies1R43AG055218-01A1AGGARWAL, RAJNEESHLANGBAUM, JESSICA BROOKEPROVOC, INC., DC$327,980ZRG1
2019Development of Neurocognitive Eye Tracking for Rapid Screening of Mild Cognitive Impairment1R43AG066427-01ETTENHOFER, MARKLISTON, DORION BRYCENEUROFIT, INC., CA$305,604ZRG1
2019Digital multidomain lifestyle intervention to address cognitive health and modifiable risk factors for Alzheimer's disease1R44AG063672-01BOTT, NICHOLASNEUROTRACK TECHNOLOGIES, INC., CA$298,097ZRG1
2019Preclinical Characterization of CRAC Channel Inhibitors for the Treatment of Alzheimer's Disease1R43AG061995-01A1GREENBERG, MILTON LVIVREON BIOSCIENCES, LLC, CA$270,902ZRG1
2019CareBand: Wearable Technology for People with Dementia1R43AG063685-01RUSSEK-SOBOL, ADAMCAREBAND, INC., OH$228,778ZRG1
2019Generation of potent, safe and deliverable human Tau targeting siRNA for treatment of Tauopathies1R43AG065066-01SUCKOW, ARTHUR THOMASDTX PHARMA, LLC, CA$225,073ZRG1
2019Cycli: A Guided Exercise System for Reducing Comorbidities in Individuals with Alzheimer's Disease1R43AG063651-01ZONDERVAN, DANIELFLINT REHABILITATION DEVICES, CA$225,000ZRG1
2019An acoustofluidic device for diagnosing preclinical Alzheimer's disease1R43AG063643-01WANG, LINASCENT BIO-NANO TECHNOLOGIES, INC., NC$225,000ZRG1
2019Discovery and validation of OMA1 inhibitors1R43AG063642-01ALAVI, MARCEL V712 NORTH, INC., CA$224,960ZRG1
2019Non-invasive efficient brain delivery of Prussian Blue for treatment of Alzheimer disease1R44AG066386-01WEINBERG, IRVINGWEINBERG MEDICAL PHYSICS, LLC, MD$224,888ZRG1
2019ALZ-Stage: Artificial intelligence driven technology with adaptive suite of personalized tests to detect and determine progressive stage of Alzheimers disease1R43AG063581-01A1SCHAFF, JENNIFERELDER RESEARCH, INC., VA$224,850ZRG1
2019Microneedle Formulation for Treating Cognitive Impairment in Patients at-risk for Alzheimer's Disease Related Dementia (ADRD) and Vascular Contributions to Cognitive Impairment and Dementia (VCID)1R43AG063652-01CROCKETT, TAMARAHAY, MEREDITHOSSANNA, NINAPRONEUROGEN, INC., AZ$222,855ZRG1
2019Development of non-invasive research and diagnostics platform for Alzheimer's disease based on plasma exosomes1R43AG063589-01ILIUK, ANTONTYMORA ANALYTICAL OPERATIONS, LLC, IN$215,369ZRG1
2019Presymptomatic Diagnostic Tools for Alzheimers Disease by Blood Neuron Derived Exosome Analysis1R43AG065072-01EITAN, EREZNEURODEX INC, MA$212,300ZRG1
2019Telerehabilitation Combining Virtual Reality Adaptable Games and Drug Therapy for Early Alzheimer's Disease1R43AG065035-01BURDEA, GRIGORE CBRIGHT CLOUD INTERNATIONAL CORPORATION, FL$181,409ZRG1
2019EEG-Based Assessment of the Cognitive Impairment of Alzheimer's Disease1R43AG065058-01KOFFLER, RICHARDGREENWINGS BIOMEDICAL, INC., CA$175,210ZRG1
2019Predicting Impending Cognitive Decline in Cognitively Normal Individuals1R44AG065126-01SHANKLE, WILLIAM RODMANMEDICAL CARE CORPORATION, CA$129,734ZRG1
2019Development and validation of novel tests in the DCT drawing analysis platform for the detection of Alzheimer’s Disease-related early cognitive impairment1R43AG066291-01SOUILLARD-MANDAR, WILLIAMDIGITAL COGNITION TECHNOLOGIES, INC., MA$129,173ZRG1
2018Small molecule therapeutics for Alzheimer's Disease2R44AG055182-02DEWJI, NAZNEEN NCENNA BIOSCIENCES, INC., CA$999,998ZRG1
2018Virtual Patient Behavioral Response Training for Family Caregivers2R44AG057272-02KAJIYAMA, BRUNOPHOTOZIG, INC., CA$732,556ZRG1
2018Scale-up and Synthesis of a Tau Oligomer Inhibitor to initiate IND enabling studies for AD and ADRD1R44AG062021-01MOE, JAMES G.OLIGOMERIX, INC, NY$499,433ZRG1
2018EXTENDING INDEPENDENCE AND QUALITY OF LIFE FOR PEOPLE WITH ALZHEIMER'S DISEASE OR DEMENTIA THROUGH TELEHEALTH PROGRAM DELIVERY1R43AG059520-01A1BENJAMIN, CYNTHIA LOUISETOGETHER SENIOR HEALTH, INC., CA$494,106ZRG1
2018Computerized tests of cognitive decline in presymptomatic Alzheimer’s disease1R44AG062076-01PEBLER, PETERWOODS, DAVID LNEUROBEHAVIORAL SYSTEMS, INC., CA$430,140ZRG1
2018Smartphone phenotype collection for diagnostic screening of mild cognitive impairment1R43AG062072-01ARMENTROUT, STEVEN LPARABON NANOLABS, INC., VA$394,297ZRG1
2018Mechanism of action of oligomer-displacing Alzheimer investigation drug, CT1812:Receptor interactions and signaling pathways1R44AG062129-01IZZO, NICHOLAS JOHNCOGNITION THERAPEUTICS, INC., PA$360,119ZRG1
2018The Development of a High Throughput Whole Brain Alzheimer's Disease Drug Screening Pipeline1R44AG062017-01BLECKERT, ADAM ATISSUEVISION, INC., MA$349,883ZRG1
2018The Alzheimer's Therapeutics Screening Assay: a high-throughput drug-discovery platform utilizing neurons and microglia derived from human induced pluripotent stem cells and Kinetic Image Cytometry1R43AG062012-01MCDONOUGH, PATRICK MVALA SCIENCES, INC., CA$301,078ZRG1
2018Evaluation of oral oleocanthal to prevent and/or treat Alzheimer’s disease and related dementias1R43AG061952-01CARDELLI, JAMESOLEOLIVE, INC., LA$269,634ZRG1

Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-09-0.1.0. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

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PAS-18-187: Advancing Research on Alzheimer's Disease (AD) and Alzheimer's-Disease-Related Dementias (ADRD) (R43/R44 Clinical Trial Optional) | ScienceDex | ConductScience