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NIH funding notice PAS-19-316

Advancing Research on Alzheimer's Disease (AD) and Alzheimer's-Disease-Related Dementias (ADRD) (R43/R44 Clinical Trial Optional)

Closed on September 6, 2022.

Posted
July 18, 2019
Close date
September 6, 2022
Activity codes
Not stated on the notice page
Institutes taking part
Not stated on the notice page

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

Its page was not saved, so the notices it replaced are not known.

Who won it before

145 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $107,246,975 in first-year total cost, median $499,860.

Most frequent study sections

  1. Special Emphasis Panel[ZRG1 RPHB-Y (12)]37
  2. Special Emphasis Panel[ZRG1 ETTN-H (11)]16
  3. Special Emphasis Panel[ZRG1 ETTN-A (13)]12
  4. Special Emphasis Panel[ZRG1 ETTN-G (13)]12
  5. Special Emphasis Panel[ZRG1 ETTN-S (14)]11

Most frequent institutions

  1. BIOSENSICS, LLC4
  2. PRONEUROGEN, INC.3
  3. TOGETHER SENIOR HEALTH, INC.3
  4. ALLIED INNOVATIVE SYSTEMS, LLC2
  5. AMBERGEN, INC2
Competing awards under PAS-19-316 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2023A Novel Algorithm to Identify People with Undiagnosed Alzheimer's Disease and Related Dementias1R44AG082605-01BARNES, DEBORAH E.BENJAMIN, CYNTHIA LOUISETOGETHER SENIOR HEALTH, INC., NY$1,535,530ZRG1
2023Development of a novel, regenerative therapy to reverse synapse loss in Alzheimer's Disease1R44AG082648-01VANDERKLISH, PETER WSPINOGENIX, INC., CA$1,419,610ZRG1
2023Developing a novel EEG-based index for evaluating amyloid and tau burden in Alzheimer's Disease1R44AG080940-01LUCERO, CHESPARK NEURO INC., NY$1,314,973ZRG1
2023Stretching their Reach: Robotic Support for Older Individuals with Mild Cognitive Impairment, Early Alzheimer's Dementia, and Mobility Impairments2R44AG072982-02EDSINGER, AARONROGERS, WENDY AHELLO ROBOT INC, CA$1,279,576ZRG1
2023Novel Approaches for Tau PROTAC Drug Discovery2R44AG066271-02A1KADIMISETTY, KARTEEKLIFESENSORS, INC., PA$1,254,536ZRG1
2023Clinical Development Enablement – Long Term Rodent Testing of the Carcinogenic Potential of the Alzheimer’s Disease Drug Candidate T3D-9591R44AG082580-01DIDSBURY, JOHNT3D THERAPEUTICS, INC., NC$1,249,334ZRG1
2023Clinical Decision Support System for Early Detection of Cognitive Decline Using Electronic Health Records and Deep Learning1R44AG081006-01DU, JINGCHENGMANION, FRANK J.ZHOU, LIMELAX TECHNOLOGIES, INC., TX$1,121,445ZRG1
2023Highly sensitive immunoassay for determination of biomarkers for neurodegenerative diseases2R44AG073141-02BYSTRYAK, SIMONALLIED INNOVATIVE SYSTEMS, LLC, NJ$977,713ZRG1
2023Novel whole-genome analysis methods for Alzheimer's risk prediction2R44AG050366-04GREYTAK, ELLEN MCRAEPARABON NANOLABS, INC., VA$917,300ZRG1
2023Concurrent Aerobic Exercise and Cognitive Training to Prevent Alzheimer's in at-risk Older Adults1R44AG082637-01OLOFINBOBA, OLUSALISBURY, DERECK LMOAI TECHNOLOGIES, LLC, MN$811,421ZRG1
2023Optimization of small molecule SERCA2b activators to inhibit neuron loss in Alzheimer's disease2R44AG062001-04DAHL, RUSSELLNEURODON LLC, IN$529,129ZRG1
2023Novel Intranasal Formulations of Allopregnanolone, a Regenerative Therapeutic for Alzheimer's Disease1R43AG081024-01A1BRINTON, ROBERTA EILEENRINEHART, JOHNNEUTHERAPEUTICS, LLC, AZ$505,836ZRG1
2023A Gesture-Powered Software Platform of Neurologic Music Therapy Games and Puzzles: To Stimulate Neuroplasticity and Prolong Functional Independence in Individuals Diagnosed with Alzheimer's Disease1R43AG081111-01GRAY, PETEROUTLIER TECHNOLOGY, LLC, FL$504,505ZRG1
2023Developing a Personalized and Culturally Responsive Virtual Coach to Engage Persons with Alzheimer's Disease and Related Dementias in Cognitive and Physical Activities1R43AG082546-01WANG, EMILY S.BEAVER HEALTH, INC., CA$499,952ZRG1
2023Inhibition of Complement Pathways with VCP As A Treatment For Alzheimer's Disease1R43AG080890-01ZHOU, JIANHUAINFLAMED, INC., KY$497,200ZRG1
2023VRSingTogether: Digital therapeutic virtual reality tool to mitigate the effects of Alzheimer's Disease (AD) and Alzheimer's-Disease-Related Dementias (ADRD)1R43AG079739-01A1HOAGLAND, RICHARDRALPHVR INC., KY$452,016ZRG1
2023Autonomous Navigating Robot for Detecting Falls and Risk of Falls in Nursing Home Residents with Alzheimer's Disease /ADRD1R43AG082599-01MALINSKY, YUVALVIGOROUS MIND, INC., MA$450,000ZRG1
2023Development and Evaluation of Portable Compendium of Psychophysical and Physiological Tests for Alzheimer's Disease and Related Dementias (ADRD)1R44AG082621-01NWAOKOBIA, CHARLES CHIEDUNWULIA, EVARISTUS AREDDY, VAMSIEVON MEDICS, LLC, MD$448,887ZRG1
2023Diagnostic aptamer reagents to develop multi-analyte blood test for pre-clinical, mild and moderate Alzheimer's disease1R43AG080844-01GAWANDE, BHARATAPTUS BIOSCIENCES LLC, FL$445,554ZRG1
2023Wicked Smart Pad: Washable Sensorized Bedding for the Prevention and Detection of Moisture Events1R43AG078020-01A1TRUTTMANN, ALLISONWICKED SHEETS, LLC, KY$342,745ZRG1
2022Evaluation of a dual PPAR agonist for treatment of Alzheimer's disease2R42AG065069-03A1CARDELLI, JAMESOLEOLIVE, INC., LA$1,692,440ZRG1
2022Screening ADNI patient cohorts to identify a sub-population that are AD early progressors in validating the prognostic ability of the Alzosure Predict blood test, 6 years in advance of current methods1R44AG078051-01KINNON, PAULDIADEM US, INC., CA$1,606,227ZRG1
2022The Proactive Screening and diagnosis of mild cognitive impairment and depression in patients aged 65 and over: An Implementation Study1R44AG079760-01GLENN, SHENLYMIRO HEALTH INC, CA$1,491,441ZRG1
2022Photocleavable Mass-Tags for Spatial Multiomics of Alzheimer’s Brain Tissue1R44AG078097-01LIM, MARKAMBERGEN, INC, MA$1,354,952ZRG1
2022PhytoSERM for Menopausal Hot Flashes and Sustained Brain Health1R44AG078102-01A1BRINTON, ROBERTA EILEENRINEHART, JOHNNEUTHERAPEUTICS, LLC, AZ$1,337,363ZRG1
2022Rapid saliva test for noninvasive diagnostic screening of MCI and dementia1R44AG078044-01ETTENHOFER, MARKNATION, DANIEL ASOUTHERN, SARKA OLIVERAGAIA MEDICAL INSTITUTE, INC., CA$1,282,078ZRG1
2022Automated, Assistive, Non-Contact Sleep Quality Monitor for Individuals with Alzheimer Disease2R44AG058339-02A1KABLAN, JOHNINNOVATIVE DESIGN LABS, INC., MN$1,281,557ZRG1
2022Caring4Caregivers: A theory-driven mobile solution to promote self-care and well-being among caregivers of individuals with Alzheimer’s andrelated dementias1R44AG076345-01EVERS, KERRYPRO-CHANGE BEHAVIOR SYSTEMS, INC., RI$1,278,235ZRG1
2022Preclinical Characterization of CRAC Channel Inhibitors for the Treatment of Alzheimer's Disease2R44AG061995-02A1GREENBERG, MILTON LVIVREON BIOSCIENCES, LLC, CA$1,276,596ZRG1
2022Amadorins for Ameliorating Alzheimer's Disease and Related Dementias (ADRD)1R44AG079696-01KHALIFAH, RAJA GPRAETEGO, INC., NC$1,259,042ZRG1
2022Development of a Remotely Deliverable Cognitive Assessment Sensitive to Early Stage Mild Cognitive Impairment.1R44AG074818-01A1KALLESTRUP, PETERI-FUNCTION, INC., FL$1,251,954ZRG1
2022A Multi-Modal Remote Monitoring Platform for Frontotemporal Lobar Degeneration Syndromes1R44AG080861-01PANTELYAT, ALEXANDER Y.VAZIRI, ASHKANWILLS, ANNE-MARIEBIOSENSICS, LLC, MA$1,250,000ZRG1
2022A light exposure tracker designed to improve the circadian entrainment for Alzheimer Disease patients2R44AG060857-05PAGE, ERIKBLUE IRIS LABS, INC., CA$1,248,510ZRG1
2022A Diagnostic Test for Dementia with Lewy Bodies1R44AG076072-01LEVINE, TODDCND LIFE SCIENCES, INC., AZ$1,239,804ZRG1
2022A 26-week rat toxicity study and efficacy and biomarker studies in Tau-APP Alzheimer's mouse model to support a Phase 1b clinical study1R44AG077991-01A1MOE, JAMES G.OLIGOMERIX, INC, NY$1,124,972ZRG1
2022Multi-modal machine learning detection and tracking of traumatic brain injury neurodegeneration and its differentiation from Alzheimer's disease2R44AG060861-02LUKIC, ANA SADM DIAGNOSTICS, INC., IL$1,044,935ZRG1
2022Multiplexed immunoassay for building patient-specific molecular profiles of CSF amyloid beta and TAU1R44AG080889-01ANTHONYMUTHU, TAMIL SELVANADEPTRIX CORPORATION, MA$1,040,019ZRG1
2022New BDNF Nanoparticles for Early Treatment of Alzheimer's Disease2R44AG058343-04VITALIANO, FRANCOVITALIANO, GORDANA D.EXQOR TECHNOLOGIES, INC., MA$1,006,687ZRG1
2022Augmem: A Novel Digital Cognitive Assessment for the Early Detection of Alzheimer's Disease1R44AG079718-01GILPIN, ADELEAUGNITION LABS LLC, NY$1,004,853ZRG1
2022Multi-site longitudinal Integrated Neurocognitive and Sleep-Behavior Profiler for the Endophenotypic Classification of Dementia Subtypes (INSPECDS)2R44AG050326-03A1BERKA, CHRISADVANCED BRAIN MONITORING, INC., CA$999,922ZRG1
2022Amyloid-Beta and Tau/Glycosaminoglycan Dual Inhibitor for Alzheimer's Disease2R44AG056231-03A1GREGOR, PAULGISMO THERAPEUTICS, INC., NY$983,932ZRG1
2022Validation of a Novel Magnetic Resonance Imaging (MRI) Technology for both Diagnostic Screening and Quantification of Brain Vascular Physiology in Alzheimer's-Disease-Related Dementias1R43AG079732-01GHARAGOUZLOO, CODI AMIRIMAGINOSTICS, INC., FL$915,931ZRG1
2022Fluorescent IRE Sensor for Synucleinopathy Drug Discovery1R44NS130946-01SHEN, WENLUCERNA, INC., NY$853,817ZRG1
2022A novel platform to facilitate provider adoption of cognitive care planning1R44AG078006-01HUANG, BINBRAINCHECK, INC., TX$765,628ZRG1
2022Care Assistant for Family Caregivers of Persons with Dementia During Out of the Home Activities2R42AG058336-02A1ANDERSON, SHANE M.KORONIS BIOMEDICAL TECHNOLOGIES CORPORAT, MN$731,897ZRG1
2022BMS-984923 Non-Clinical Development to Support Phase 2 Trials1R44AG077984-01A1SIEGERT, TIMOTHY RALLYX THERAPEUTICS INC., CT$680,220ZRG1
2022Home Sleep Therapy System for Mild Cognitive Impairment1R44AG077965-01A1TUCKER, DON MBRAIN ELECTROPHYSIOLOGY LABORATORY COMPANY, LLC, OR$555,043ZRG1
2022Development of Blood-based Circular RNA Biomarkers for Alzheimer's Disease1R43AG076106-01A1COLLENS, JULIEVIVID GENOMICS, INC., CA$508,467ZRG1
2022RestEaze: A Novel Wearable Device and Mobile Application to Improve the Diagnosis and Management of Restless Legs Syndrome in Patients with Alzheimer's Disease1R43AG076092-01BROOKS, JUSTINTANZEN MEDICAL, INC., MD$500,709ZRG1
2022Treatment of Alzheimer's disease by clearing both tau and amyloid beta pathologies1R43AG079671-01IQBAL, KHALIDPHANES BIOTECH, INC., PA$500,000ZRG1
2022Digital Transformation to Reduce Social Isolation and Improve the Engagement, Care, and Support of Individuals Living with Alzheimer's Disease and Related Dementias1R43AG076063-01KAISER, SCOTTDETERMINED HEALTH INC., CA$499,952ZRG1
2022Extended-Release Formulation of Mas Receptor Agonists as Novel Therapeutics for Treating Cognitive Impairment in Patients at-risk forAlzheimer's Disease-Related Dementias and Vascular Dementia1R43AG077967-01A1HAY, MEREDITHRILEY, JEREMYPRONEUROGEN, INC., AZ$499,763ZRG1
2022Scale-up Manufacturing and IND Enabling Studies of Extended-Release Formulation of Mas Receptor Agonist for Treating Vascular Cognitive Impairment and Alzheimer's Disease-Related Dementias1R43AG079647-01HAY, MEREDITHRILEY, JEREMYPRONEUROGEN, INC., AZ$499,598ZRG1
2022Single-cell Epigenome Analysis of the Alzheimer's Disease Brain1R43AG079691-01HARTL, CHRISTOPHEREPIGENOME TECHNOLOGIES, INC., CA$499,475ZRG1
2022Novel regulation of autophagic flux for the treatment of Alzheimer's disease1R43AG076052-01GREENLEE, WILLIAM JCERACUITY, INC., MA$499,272ZRG1
2022Development and Validation of Cognitive Status Assessments in Older Adults Utilizing Conversational Agent Technology (CAT) Delivered on Smart Displays - the CAUCAT Study1R43AG076078-01WILLIAMS, RANDALLWELLSAID.AI, LLC, IL$498,925ZRG1
2022PET Imaging of Damaging Neuroinflammation in Alzheimer's Disease1R44AG079734-01LARSON, ANDREW CHRISTIANEINSENCA INC., DE$497,602ZRG1
2022Promoting adult hippocampal neurogenesis using antisense oligonucleotides as an Alzheimer's disease therapy1R43AG078093-01VALAT, ANNEBOLDEN THERAPEUTICS, INC., RI$497,550ZRG1
2022Accessible Eye Tracking Solution for Assessment of Cognitive Deficits in Alzheimer's Disease1R43AG076140-01YOO, HERBERTSENAPTEC INC., OR$497,154ZRG1
2022Ensuring medication ingestion without altering existing medication regimen1R43AG073011-01A1CARNES, TONY CHRISETECTRX, INC., FL$496,388ZRG1
2022Brain-penetrant chemical disaggregators of tau fibrils as therapeutics for Alzheimer's Disease1R43AG073018-01A1APOSTOL, MARCINADRX, INC., CA$476,551ZRG1
2022Community-based Brain Health Program to Address Dementia Risk (C-BBHP)1R43AG074756-01A1VANVLEET, THOMASPOSIT SCIENCE CORPORATION, CA$465,294ZRG1
2022CUSTOMIZABLE TRAINING SOFTWARE FOR PROFESSIONAL ALZHEIMER DIRECT CARE PROVIDERS1R44AG076093-01FOSTER, NORMAN LOUISPROACTIVE MEMORY SERVICES, INC., UT$456,315ZRG1
2022eREACH - Expanding Research and Recruitment by Adults through Community Health workers that automating screenings and referrals plus improving communication and health information delivery1R43AG076186-01MA, TONY XUYENBENTEN TECHNOLOGIES, INC., VA$456,161ZRG1
2022Optimization of an at-home continuous multi-domain monitoring and assessment system to improve Alzheimer's and related disorders clinical trials1R44AG076067-01FRYE, LAWRENCE JLIFE ANALYTICS, INC., CA$453,828ZRG1
2022Development of a Blood-based Test for Identifying Synucleinopathy in Patients with Dementia1R44NS130864-01EITAN, EREZNEURODEX INC, MA$449,999ZRG1
2022A physiologically relevant pre-clinical drug screening platform for Alzheimer's Disease and Traumatic Brain Injury with integrated stretchable microelectrodes1R44AG079777-01GRAUDEJUS, OLIVERBMSEED, LLC, AZ$449,997ZRG1
2022Smart driving technology for non-invasive detection of age-related cognitive decline1R43AG078063-01FORZANI, ERICA SILVIATSOW, FRANCISTF HEALTH CORPORATION, AZ$449,954ZRG1
2022An assistive-technology based Caregiver Training Program (CTP) to enhance caregiver effectiveness, well-being, and quality of life, which will improve overall care for individuals living with AD/ADRD.1R44AG076256-01A1GOLDEN, MATTHEWMAPHABIT, INC., GA$449,826ZRG1
2022Enhancing Social Engagement through Online Gameplay for Older Adults with and without Mild Cognitive Impairment1R44AG078009-01GANDY COLEMAN, MARIBETHMYERS, DILLONVICKERS, KAYCIPOTLUCK, LLC, VA$449,777ZRG1
2022SynchronyGamma: A Music-Based Intervention for Alzheimer's and Mild Cognitive Impairment1R43AG078012-01LARGE, EDWARD WLOUI, PSYCHEOSCILLOSCAPE, LLC, CT$449,695ZRG1
2022Preventing Medication Mismanagement in People Living with Dementia through Automated Medication Dispensing with Facial Recognition and Video Observation1R43AG077737-01GELLMAN, CHARLESHIDO TECHNOLOGIES, INC., CA$449,609ZRG1
2022Developing Novel REV-ERB Agonists for the Treatment of Neuroinflammation in Alzheimer's Disease1R41AG079778-01A1CRESAP, MICHELEPELAGOS PHARMACEUTICALS, INC., TX$449,482ZRG1
2022Virtual Reality Cognitive Therapy forAlzheimer's Disease1R43AG076169-01MASOOD, RAZICLARITYTEK, INC., MN$445,324ZRG1
2022Automated System for Accurate Determination of Activities of Daily Living for Independently-Living Persons with Alzheimers Disease and Related Dementias1R43AG076113-01A1SHEIKH, SUNEEL ISMAILASTER LABS, INC., MN$439,460ZRG1
2022Development of a brain penetrating single-chain antibody selectively targeting three repeat tau protein as a new treatment for frontotemporal dementia1R43NS125810-01SAITO, ERIN3RT INNOVATIONS, CA$433,405ZRG1
2022Identifying Regulators of Cellular Aging that can Prevent Alzheimer's Disease1R43AG076101-01DORANZ, BENJAMIN JINTEGRAL MOLECULAR, PA$358,588ZRG1
2022Decision support tool that uses novel feature extraction and machine learning approaches for early identification of Alzheimer's patients who are candidates for palliative and/or hospice care.1R43AG076191-01VASUDEVAN, ANANTRADIAL ANALYTICS, INC., MA$350,832ZRG1
2022Improved carnosic acid congener compounds for Alzheimer’s disease1R43AG080911-01LARRICK, JAMES WMENDELSOHN, ANDREW RLARIX BIOSCIENCE, LLC, CA$326,205ZRG1
2022Tau mislocalization assay to screen AD therapeutics using compartmentalized chips1R43AG072985-01A1TAYLOR, ANNE MARIONXONA MICROFLUIDICS, LLC, NC$268,419ZRG1
2022All About Me: An Intervention to Ease the Transition to Long-term Care, Build Community, and Improve Quality of Care for Persons with Dementia1R43AG077993-01GORZELLE, GREGGSKRAJNER, MICHAEL JOHNHOPEFUL AGING LLC, MA$259,010ZRG1
2022SAFE at Home: A Service to Provide Social Engagement to Community-Dwelling Persons with Dementia1R43AG075974-01SKRAJNER, MICHAEL JOHNHOPEFUL AGING LLC, MA$252,014ZRG1
2022Quantifying microstructural changes in Alzheimer's disease using Restriction Spectrum Imaging1R44AG076194-01ULUG, AZIZ MCORTECHS LABS, INC., CA$247,965ZRG1
2021BRAIN HEALTH TOGETHER: A LIVE-STREAMING GROUP-BASED DIGITAL PROGRAM2R44AG074727-02BARNES, DEBORAH E.BENJAMIN, CYNTHIA LOUISETOGETHER SENIOR HEALTH, INC., NY$1,504,982ZRG1
2021An Informatics Platform for Objectively Quantifying Electric Power Wheelchair Usage for those with Alzheimer's Disease, Alzheimer's Disease Related Dementias, and Cognitive Impairments1R44AG074779-01BECKER, ADAMINNOVATIVE DESIGN LABS, INC., MN$1,337,053ZRG1
2021Enabling nationwide AD PET imaging to support most efficient clinical trials by adoption of radically simplified and standardized quality control in commercial production of AD PET tracers.1R44AG071409-01ELIZAROV, ARKADIJTRACE-ABILITY, INC., CA$1,256,349ZRG1
2021Tele-CF: A practical platform for remote monitoring of cognitive frailty2R44AG061951-02NAJAFI, BIJANVAZIRI, ASHKANBIOSENSICS, LLC, MA$1,250,000ZRG1
2021Development and Evaluation of Computerized Olfactory Training Program (COT) for Cognitive Decline in Early Alzheimer's Disease (AD)2R44AG061981-03A1NWAOKOBIA, CHARLES CHIEDUNWULIA, EVARISTUS ASETH, SUMEETEVON MEDICS, LLC, MD$1,247,784ZRG1
2021An acoustofluidic device for diagnosing preclinical Alzheimer's disease2R44AG063643-02WANG, LINASCENT BIO-NANO TECHNOLOGIES, INC., NC$1,240,614ZRG1
2021Using gamification, predictive analytics, artificial intelligence, and Alexa Voice to optimize user experience for individuals living with AD/ADRD and their caregivers2R44AG065081-03A1GOLDEN, MATTHEWMAPHABIT, INC., GA$1,189,927ZRG1
2021Smartphone phenotype collection for diagnostic screening of mild cognitive impairment2R44AG062072-02A1ARMENTROUT, STEVEN LPARABON NANOLABS, INC., VA$1,186,625ZRG1
2021Development of a PIKFYVE antisense oligonucleotide treatment for FTD1R44NS124454-01ALWORTH, SAMUEL VCHANG, WEN-HSUANACURASTEM, INC., CA$1,014,266ZRG1
2021Mindfulness-based Cognitive Coping Mobile App Intervention for caregivers of individuals with Alzheimer's Disease2R44AG058277-02A1KAJIYAMA, BRUNOPHOTOZIG, INC., CA$980,975ZRG1
2021FitMi AD: a safe and motivating computer-guided exercise system for individuals with MCI or mild dementia due to Alzheimer's disease2R44AG063651-02ZONDERVAN, DANIELFLINT REHABILITATION DEVICES, CA$717,425ZRG1
2021Alzheimer's disease and novel nanotherapeutics exclusively targeting extrasynaptic NMDA receptors1R43AG076088-01MOLOKANOVA, ELENANEURANO BIOSCIENCE, CA$500,000ZRG1
2021Plasma Assays for NPTX2 in Alzheimer's Disease1R43AG074773-01WORLEY, PAUL FXIAO, MEIFANGCOGNEXT DIAGNOSTICS, LLC, MD$499,999ZRG1
2021Feasibility and acceptability of introducing person-centered narratives in an acute care setting for people with Alzheimer's and Dementia1R43AG074775-01NEWTON-SMALL, JAYROGERS, STEPHANIEMEMORYWELL LLC, NM$499,994ZRG1
2021Autonomous Navigating Telepresence Robot for Alleviating Loneliness and Engaging Nursing Home Residents with and without Dementia1R43AG073004-01MALINSKY, YUVALVIGOROUS MIND, INC., MA$499,981ZRG1
2021Development of Memesto, a wearable repetitive message and music therapy device that senses and reduces agitation in persons with AD/ADRD.1R43AG074725-01BANKER, JEFFERYEDGEWATER SAFETY SYSTEMS LLC, MI$499,969ZRG1
2021Optimization of a Chemokine Receptor Antagonist Peptide as a Synapse Protecting Treatment for Neurodegeneration in Alzheimer's Disease1R43AG074715-01RUFF, MICHAEL RCREATIVE BIO-PEPTIDES, INC., MD$499,860ZRG1
2021Discovery of PDE2A inhibitors to treat memory deficits in mild cognitive impairment and Alzheimer's disease1R43AG071045-01A1DU, FUO'DONNELL, JAMES MWANG, WEIFD NEUROTECHNOLOGIES CONSULTING & SERVICES, INC., MD$499,784ZRG1
2021Drug Discovery Pipeline Targeting Pathologically Leaky Calcium Release Channels in Age-Related Indications1R43AG069582-01A1CORNEA, RAZVAN LIVIUTHOMAS, JENNIFER JEWELLPHOTONIC PHARMA, LLC, MN$499,443ZRG1
2021Interactive Software for Assessing Meaningful Cognitive Function1R43AG074740-01FERGUSON, JOHN ERICHUGHES, ADRIANAABILITY INTERACTIVE LLC, MN$499,360ZRG1
2021A randomized double-blind placebo controlled Phase 1 SAD study in male and female healthy volunteers to assess safety, pharmacokinetics, and transient biomarker changes by the ABCA1 agonist CS62531R44AG076299-01JOHANSSON, JANARTERY THERAPEUTICS, INC., CA$499,197ZRG1
2021A MULTIFACETED DIGITAL HEALTH PLATFORM TO ADVANCE ALZHEIMER'S DISEASE PATIENT MONITORING, SAFETY, CARE, AND RESEARCH.1R43AG072981-01A1CORKEY, JON ANDREWAMISSA, INC., NC$495,787ZRG1
2021Assessing a Novel Virtual Environment that Primes Individuals Living with AD/ADRD to Accomplish Activities of Daily Living.1R43AG071102-01A1SALOMON, MANDYMENTIA DTX, INC., CA$491,272ZRG1
2021An Automated platform for 3D reconstruction and profiling of post-mortem Alzheimer's Disease brains1R43AG076342-01RAGAN, TIMOTHY M.TISSUEVISION, INC., MA$478,759ZRG1
2021A first-in-class orally bioavailable small molecule dual inhibitor targeting NLRP3 and the dopamine transporter to treat AD1R44AG069622-01A1BROWN, RUSSELL WAYNEGABBITA, SOMASUNDAR PRASADP2D, INC., OH$470,041ZRG1
2021Validating Digital Cognitive Biomarkers to Advance Alzheimer's Drug Development1R43AG074769-01SHANKLE, WILLIAM RODMANMEDICAL CARE CORPORATION, CA$455,341ZRG1
2021A Humanized Organ Plate Paradigm for High Throughput Alzheimer's disease Therapeutics1R43AG073040-01COLLINS, JOHNBIOPICO, CA$454,753ZRG1
2021Development of a novel anti-neuroinflammatory experimental therapeutic for epilepsy and Alzheimer's risk1R44AG071062-01A1KEARNEY, JENNIFER ASHIFRIN, VICTORIMMUNOCHEM THERAPEUTICS, LLC, MA$450,367ZRG1
2021Discovery of 12/15-lipoxygenase inhibitors to suppress neuroinflammation and slow disease progression in Alzheimer's disease1R43AG071337-01A1SHRADER, WILLIAM DVORAKACUREX THERAPEUTICS CORPORATION, CA$450,060ZRG1
2021Development of Aberrant Cdk5 imaging agent for early detection ofAlzheimer's disease pathology and treatment outcome measurement1R43AG069655-01A1UPADHYA, SUDARSHAN CAESTAS PHARMA INC., NC$450,000ZRG1
2021Optimizing Small Molecule Lipoxin-Mimicking FPR2 Agonists for the Treatment of Alzheimers Disease1R43AG072963-01GAFFNEY, KEVIN JOHNRISERX LLC, AZ$449,931ZRG1
2021Development of Nav1.1 Enhancers to Treat Alzheimer's Disease1R44AG071137-01A1PLEISS, MICHAELCURE NETWORK DOLBY ACCELERATION PARTNERS LLC, CA$449,821ZRG1
2021Automated Contact Tracing System for Rapid High-Accuracy Assessment to Management Dementia Patients and Staff Exposed to Infectious Diseases in Long Term Care Facilities1R44AG072957-01SHEIKH, SUNEEL ISMAILASTER LABS, INC., MN$449,145ZRG1
2021LifeBio-ALZ: AI driven digital biomarker engine leveraging natural conversation to widely scale accessibility for early detection and assessment of Alzheimers disease progression1R43AG076341-01SANDERS, LISBETHLIFEBIO INC, OH$448,462ZRG1
2021Auracle: An AI-Enabled Telecare System to Support the Independence and Safety of Individuals with AD/ADRD and Other Dementias1R44AG071211-01A1FAUCI, MARK AGEN-9, INC., CA$445,911ZRG1
2021Development of a technology-enabled care coaching service for families caring for AD/ADRD & a 300-family study to assess the service's impact on CG financial knowledge, efficacy, strain & action.1R44AG074778-01CHUNG, JOSEPHKINTO, MA$437,367ZRG1
2021Circular mimics of Iron-response elements to inhibit ferroptosis1R43NS122654-01PICKERING, BRIAN FREDERICKCHIMERNA THERAPEUTICS INC., NY$433,356ZRG1
2021Discovery of Novel Blood-Brain Barrier Targeting Antibodies for the Treatment of Alzheimer's Disease1R43AG073065-01MILENI, MAUROABILITA BIO, INC., CA$432,856ZRG1
2021RETAIN: A digital therapeutic for Alzheimer's risk reduction1R44AG071416-01A1MCINNIS, MARKRETAIN HEALTH INC, MA$430,707ZRG1
2021Highly sensitive immunoassay for determination of biomarkers for neurodegenerative diseases1R43AG073141-01BYSTRYAK, SIMONALLIED INNOVATIVE SYSTEMS, LLC, NJ$422,885ZRG1
2021Prototype Multimedia ADRD Falls Prevention System for Family Caregivers1R43AG071360-01A1PANZER, VICTORIA PBROOKSIDE RESEARCH & DEVELOPMENT COMPANY, WA$246,663ZRG1
2020Safety and Pharmacokinetics of JOTROL for Alzheimer's Disease1R44AG067907-01A1HAYWARD, MARSHALLJUPITER NEUROSCIENCES, INC., FL$1,764,270ZRG1
2020GaitIQ: Establishing a Digital Biomarker of Preclinical Alzheimer's Disease2R44AG060855-02JACOB, MINI ELIZABETHMORRIS, RICHARDNICOLELLA, DANIEL PGAITIQ, LLC, TX$1,549,244ZRG1
2020EXTENDING INDEPENDENCE AND QUALITY OF LIFE FOR PEOPLE WITH ALZHEIMER'S DISEASE OR DEMENTIA THROUGH TELEHEALTH PROGRAM DELIVERY2R44AG059520-02A1BARNES, DEBORAH E.BENJAMIN, CYNTHIA LOUISETOGETHER SENIOR HEALTH, INC., CA$1,428,688ZRG1
2020Development of a reminiscence therapy online platform with machine learning to increase engagement with people living with dementia and their care partners1R44AG069566-01SANDERS, LISBETHLIFEBIO INC, OH$1,384,248ZRG1
2020Neuro-exergaming for the prevention and remediation of decline due to Alzheimer's disease and related dementias: A clinical trial of the interactive Physical and Cognitive Exercise System (iPACES v3)1R44AG071063-01ANDERSON-HANLEY, CAYARCIERO, JOHN P.ARCIERO, PAUL JDUNNAM, MINAMERRILL, DAVID ARTHURPANOS, STELLA ESAULNIER, EMILIEIPACES, LLC, NY$1,352,991ZRG1
2020Photocleavage Technology for Blood-based Multi-Biomarker Alzheimer's Disease Assay1R44AG067866-01LIM, MARKAMBERGEN, INC, MA$1,249,958ZRG1
2020A non-pharmacological multi-modal therapy to improve sleep and cognition and reduce mild cognitive impairment risk2R44AG056250-03A1GARTENBERG, DANIELPROACTIVE LIFE, INC., VA$1,243,520ZRG1
2020Optimization of small molecule SERCA2b activators to inhibit neuron loss in Alzheimer's disease2R42AG062001-02A1DAHL, RUSSELLNEURODON LLC, IN$988,940ZRG1
2020Enhancing Quality of Life for Older Adults With and Without MCI through Social Engagement Over Video Technology2R44AG059450-02A1MYERS, DILLONROGERS, WENDY APOTLUCK, LLC, VA$902,580ZRG1
2020Hyperphosphorylated tau aggregation kit to identify tauopathy risk factor2R44AG057274-02MORANO, MARIA INESCAYMAN CHEMICAL COMPANY, INC., MI$778,104ZRG1
2020Mechanistic Validation of Selective Brain-Penetrant HDAC6 Inhibitors as a Disease- Modifying Treatment for Tauopathies including Alzheimer's Disease1R43AG067939-01A1SCHROEDER, FREDERICK ALBERTEIKONIZO THERAPEUTICS, INC., MA$509,672ZRG1
2020LEAD IT! An App to Enable Persons with Early Stage Dementia to Lead Group Activities for Their Peers2R44AG059443-02SKRAJNER, MICHAEL JOHNHEARTHSTONE ALZHEIMER CARE, LTD, MA$497,150ZRG1
2020Innovation in Person-centered Dementia Care and Dementia Assessments: Development of the Care Team Connect App deployed for Home Care Agencies1R43AG071060-01POTTEIGER, MICHAEL THOMASPOTTEIGER CONSULTING SERVICES LLC DBA GENERATION CONNECT, PA$454,916ZRG1
2020TeleExergame: An Interactive Tele-Rehabilitation Platform for Improving Motor Function in Older Adults with Cognitive Deficit1R44AG067909-01NAJAFI, BIJANNGUYEN, HUNG P.BIOSENSICS, LLC, MA$450,002ZRG1
2020Care4AD: A Comprehensive Care Coordination and Management Platform for Alzheimer Disease and Related Dementias1R44AG066360-01A1NAJAFI, BIJANVAZIRI, ASHKANBIOSENSICS, LLC, MA$450,000ZRG1
2020Development of a Novel Chemokine Receptor Antagonist Peptide as a Synapse Protecting Treatment for Neurodegeneration in Alzheimer's Disease1R43AG071064-01RUFF, MICHAEL RCREATIVE BIO-PEPTIDES, INC., MD$449,230ZRG1
2020Novel Dopaminergic Stimulant Prodrug for the Treatment of Apathy in AD1R44AG066378-01A1PATIL, SANDEEPPOTTER, WILLIAM ZEIGLERPRAXIS BIORESEARCH, LLC, CA$448,752ZRG1
2020Direct activators of protein phosphatase 2A (PP2A) as novel Alzheimer's Disease (AD) therapeutics1R43AG071040-01OHLMEYER, MICHAELATUX ISKAY GROUP LLC, NJ$447,795ZRG1
2020Formulation of a Novel Therapeutic for Treating Cognitive Impairment in Patients at-risk for Alzheimer's Disease-Related Dementias and Vascular Contributions to Cognitive Impairment1R43AG069524-01CROCKETT, TAMARAHAY, MEREDITHOSSANNA, NINAPRONEUROGEN, INC., AZ$439,355ZRG1
2020Novel Approaches for PROTAC Drug Discovery1R43AG066271-01A1KADIMISETTY, KARTEEKLIFESENSORS, INC., PA$397,101ZRG1
2020Targeted ultrasound contrast agents for the disruption of Alzheimer's plaques.1R43AG067894-01UNGER, WYATT DANIELMICROVASCULAR THERAPEUTICS, LLC, AZ$395,506ZRG1

Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-09-0.1.0. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

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