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NIH funding notice PAS-19-317

Advancing Research on Alzheimer's Disease (AD) and Alzheimer's-Disease-Related Dementias (ADRD) (R41/R42 Clinical Trial Optional)

Closed on September 6, 2022.

Posted
July 18, 2019
Close date
September 6, 2022
Activity codes
Not stated on the notice page
Institutes taking part
Not stated on the notice page

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

Its page was not saved, so the notices it replaced are not known.

Who won it before

35 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $14,557,545 in first-year total cost, median $395,248.

Most frequent study sections

  1. Special Emphasis Panel[ZRG1 ETTN-S (14)]6
  2. Special Emphasis Panel[ZRG1 ETTN-C (10)]4
  3. Special Emphasis Panel[ZRG1 ETTN-H (11)]4
  4. Special Emphasis Panel[ZRG1 RPHB-Y (12)]4
  5. Special Emphasis Panel[ZRG1 AN-P (11)]3

Most frequent institutions

  1. REGENNOVA, INC.2
  2. ACEPRE, LLC1
  3. ACTIVITY RHYTHM SOLUTIONS CORPORATION1
  4. ADAPT DESIGN WORKS, LLC1
  5. AROMHA, INC.1
Competing awards under PAS-19-317 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2023VoiceLove: An App-Based COMmunication Tool Designed to Address DeliriUm and Improve Family ENgagement and PatIent/Family SatisfaCtion in CriticAlly Ill PaTiEnts (COMMUNICATE)1R42AG080891-01ELY, E WESLEYVOICELOVE LLC, NY$506,500ZRG1
2023A Therapeutic Role for Apolipoprotein-E in the Germ Theory of Alzheimer's Dementia1R41AG078111-01A1VITEK, MICHAEL P.REGENNOVA, INC., NC$500,000ZRG1
2023Novel Combinations of Natural Product Compounds for Treatment of Alzheimer Disease and Related Dementias1R41AG080957-01CHANG, RUIRONALDSON, PATRICK THOMASWANG, WEIPATH BIOTECH, LLC, AZ$499,996ZRG1
2023Discovery of therapeutic nanobodies targeting brain TNF-α for the treatment of Alzheimer Disease1R41AG080864-01A1D'ADAMIO, LUCIANOFIORITI, LUANANANONEWRON LLC, NJ$499,828ZRG1
2023SMALL MOLECULE THERAPEUTIC FOR ALZHEIMER'S DISEASE1R41AG080914-01A1WITT, KENSOMATOLYNK, INC., IL$499,592ZRG1
2023Developing of a computer-based multimodal mind and body approach for mild cognitive decline1R41AG082591-01KONG, JIANBRAIN THRIVE TECHNOLOGY LLC, MA$498,094ZRG1
2023Novel multi-sensing seat cover system for prevention of sitting-related pressure injuries in individuals with Alzheimer's disease or related dementias1R41AG080965-01MCGEE, COREY WWUDLICK, ROBADAPT DESIGN WORKS, LLC, MN$496,520ZRG1
2023A Novel Pharmacological Inhibitor of Adenylyl Cyclase Type 5 to Treat Alzheimer's Disease1R41AG080990-01VATNER, STEPHEN FVASADE BIOSCIENCES, INC., NJ$252,130ZRG1
2023Mosaic Display of Multivalent Tau and A-Beta peptides on Immunogenic SNAP Liposomes1R41AG082620-01DAI, CHUNLINGHUANG, WEI-CHIAOPOP BIOTECHNOLOGIES, INC, NY$248,855ZRG1
2023Noninvasive sleep enhancement and behavior monitoring technologies for Alzheimer's model mice1R41AG082600-01O'HARA, BRUCE FREDERICKSIGNAL SOLUTIONS, LLC, KY$180,612ZRG1
2023Optimizing brain penetrance of caspase-6 inhibitors to treat neurodegenerative diseases1R41AG078036-01A1ARKIN, MICHELLECANAN, STACIERENSLO, ADAM RELGIA THERAPEUTICS, INC., CA$180,375ZRG1
2022Therapeutic Reduction of Cerebral Amyloid Angiopathy Pathologies in ADRD1R41NS127666-01A1VITEK, MICHAEL P.REGENNOVA, INC., NC$499,900ZRG1
2022Jigsawdio: an AudioVisual Jigsaw Puzzle for People with Alzheimer's Disease and Alzheimer's-Disease-Related Dementias1R41AG079736-01YOUNG, AMYCALLAHAN-YOUNG LLC, NC$499,670ZRG1
2022APOE-targeted therapy for precision medicine in late onset Alzheimer's disease: A novel epigenome editing approach for downregulation of APOEe4 expression1R41AG077992-01HAMM, ELAINECLAIRIGENE, LLC, NC$492,903ZRG1
2022Using siRNAs against tau circular RNAs as a rational therapy for Alzheimer's disease1R41AG078096-01STAMM, STEFANCIRCCURE CORPORATION, KY$395,248ZRG1
2022Development of a lead candidate for the treatment of Alzheimer's disease1R41AG079775-01LASMEZAS, CORINNE IDAVOVA IDA THERAPEUTICS INC, FL$390,685ZRG1
2022Improving an EEG-based neurodiagnostic software platform to detect Alzheimer's Disease in MCI patients1R41AG078039-01A1CASELLI, RICHARD J.LUCERO, CHESPARK NEURO INC., NY$299,786ZRG1
2022Making Connections Thru Music: A Group Music Therapy-Based Intervention for Persons with Dementia1R42AG076037-01A1GORZELLE, GREGGORSULIC-JERAS, SILVIAHOPEFUL AGING LLC, MA$299,693ZRG1
2022The development of a multifunctional nanoenzyme for AD treatment1R41AG081124-01XU, PEISHENGACEPRE, LLC, SC$299,628ZRG1
2022PET Probes for Senescence Detection in Brain1R41AG081007-01CUI, LINASENOTRAC BIOTECHNOLOGY LLC, FL$293,317ZRG1
2022Early detection and monitoring of Alzheimers Disease and Related Dementias using non-semantic linguistic and acoustic features of speech derived from hearing aids1R41AG080977-01BISCHOFF, BRIAN JOHNHEADWATERS INNOVATION, INC., MN$265,844ZRG1
2022AAV-AIBP Therapy for Alzheimer's Disease1R41AG081004-01JU, WONKYUKOGAN, YAKOVRAFT PHARMACEUTICALS, LLC, CA$247,056ZRG1
2021Using Rendever to improve the quality of life of older adults with cognitive impairments in senior living communities and their family members who live at a distance.2R42AG063640-02AFIFI, TAMARA DAWNCOLLINS, NANCY LEERAND, KYLE PATRICKRENDEVER, INC., MA$1,117,124ZRG1
2021Digital Accessible Remote Olfactory Mediated Health Assessments for Preclinical AD2R42AG062130-03REINEKE, SEANAROMHA, INC., MD$999,982ZRG1
2021Promoting adult hippocampal neurogenesis in Alzheimer's Disease using an antibody-based therapy1R41AG073144-01A1VALAT, ANNEBOLDEN THERAPEUTICS, INC., RI$500,000ZRG1
2021Xenon gas treatment to modulate microglia in neurodegenerative diseases1R41AG073059-01A1BUTOVSKY, OLEGILIN, ILYAGENERAL BIOPHYSICS, LLC, MA$499,546ZRG1
2021An AI-assisted screening platform within a multivariate framework for biomarkers of mild cognitive impairment due to Alzheimer's disease1R41AG073066-01CABRERA-DEBUC, DELIAMENDOZA-SANTIESTEBAN, CARLOS E.RAMOS, ALBERTO RAFAELISCREEN 2 PREVENT LLC, FL$461,215ZRG1
2021Development of perivascular space mapping toolset as a diagnostic aid for Alzheimer's disease1R41AG073024-01CHOUPAN, JEIRANNEUROSCOPE INC., NY$461,031ZRG1
2021Targeting Necroptosis for Neurodegenerative Disease Therapy1R41AG069606-01A1KHANNA, MAYPATEK, MARCELREGENERIX LLC, AZ$449,594ZRG1
2021'Novel Shc Blockers as potential Alzheimer's Disease Therapeutics1R41AG076327-01CORTOPASSI, GINO ABUTO CORPORATION, CA$304,652ZRG1
2021Development of a Digital Cognitive Screening Test to detect Mild Cognitive Impairment and Dementia in Clinical Settings.1R41AG074835-01MANKODIYA, KUNALECHOWEAR LLC, RI$300,234ZRG1
2021Remote Patient Monitoring of Family Caregivers of Patients with Alzheimer's Disease1R41AG072943-01NICOLLA, JONATHANPREPPED HEALTH, LLC, NC$299,782ZRG1
2021Developing a widely-useable wearable Circadian Profiling System to assess 24-hour behavioral rhythm disruption in people with dementia and their family caregivers1R41AG069596-01A1SMAGULA, STEPHEN FACTIVITY RHYTHM SOLUTIONS CORPORATION, PA$299,526ZRG1
2020Nanoparticles for detecting noradrenergic neurons in Alzheimer's Disease1R41AG069539-01MOHANKUMAR, PULIYURS G ENDOCRINE RESEARCH LLC, GA$266,683ZRG1
2020Development of a tool to examine proteomic pathways in the AD brain1R41AG067855-01GUNTHER, ERIK CPROTEOWISE, INC., CT$251,944ZRG1

Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-09-0.1.0. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

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