Skip to main content
NIH funding notice PAS-22-197

Advancing Research on Alzheimer's Disease (AD) and AD-Related Dementias (ADRD) (R41/R42 Clinical Trial Optional)

Closed on September 5, 2025.

Posted
June 21, 2022
Close date
September 5, 2025
Activity codes
Not stated on the notice page
Institutes taking part
Not stated on the notice page

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

Its page was not saved, so the notices it replaced are not known.

Who won it before

36 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $18,961,164 in first-year total cost, median $499,897.

Most frequent study sections

  1. Special Emphasis Panel[ZRG1 AN-P (11)]15
  2. Special Emphasis Panel[ZRG1 NV-G (13)]4
  3. Special Emphasis Panel[ZRG1 NV-H (13)]4
  4. Special Emphasis Panel[ZAG1 ZIJ-2 (M2)]2
  5. Special Emphasis Panel[ZRG1 AN-P (10)]2

Most frequent institutions

  1. 3P BIOTECHNOLOGIES, INC.3
  2. AROMHA, INC.2
  3. CEIBA BIO INC.2
  4. NEUCYTE, INC.2
  5. 3D BIOANALYTIX, INC.1
Competing awards under PAS-22-197 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2025Digital Accessible Remote Olfactory Mediated Health Assessments forPreclinical AD2R42AG062130-05REINEKE, SEANAROMHA, INC., MD$1,249,670ZRG1
2025Development of a therapeutic nanobody targeting brain TNFa for the treatment of Alzheimer Disease2R42AG080864-02D'ADAMIO, LUCIANOTAGLIETTI, MARCONANONEWRON LLC, NJ$979,592ZRG1
2025Development of "Imagnostix": A Liquid Biopsy System for Alzheimer's Disease2R42AG078718-02A1LI, YUANCHENGMAO, HUI5M BIOMED, LLC, GA$888,723ZRG1
2025Mosaic Display of Multivalent Tau and A-Beta peptides on Immunogenic SNAP Liposomes2R42AG082620-03DAI, CHUNLINGHUANG, WEI-CHIAOPOP BIOTECHNOLOGIES, INC, NY$833,334ZAG1
2025Trans Spinal Delivery of Targeted Exosomal Formulation of Curcuminoids to Treat AD1R41AG090217-01A1GUPTA, RAMESH C3P BIOTECHNOLOGIES, INC., KY$506,434ZRG1
2025Development of Platelet-Derived Exercise Mimetics as a Treatment for Alzheimer's Disease and Alzhimer's Disease Related Dementias1R42AG097334-01DING, ZHAOQINGCEIBA BIO INC., CA$506,198ZAG1
2025Scalable cGMP production of SV2A PET tracers using photoredox chemistry for applications in clinical trials and early AD diagnosis1R41AG097311-01CAI, ZHENGXINSYNVEST IMAGING INC., NC$499,844ZAG1
2025Preclinical efficacy of an APOE targeted antibody for Alzheimer's disease1R41AG092063-01O'HARE, MICHAELYOU, JINSAMEPOCH BIOTECH, LLC, MA$498,709ZRG1
2025Digital Accessible Remote Olfactory Mediated Health Assessments for Lewy Body Disease1R41AG091992-01A1ALBERS, MARK WREINEKE, SEANAROMHA, INC., MD$493,964ZRG1
2025An Eyedrop Diagnostic Test for Alzheimer's Disease1R42AG097309-01BENNETT, RACHEL ELISEDUBACH, JOHNTAUVISION, INC., MA$493,384ZAG1
2025Neurotrophic Drug Development for Alzheimer's Disease1R41AG094359-01SATHYANESAN, SAMUEL NEWTONENRECTEC LLC, SD$475,014ZRG1
2025Commercial production of alpha-synuclein fibrils amplified from human postmortem brain tissue to expand the availability of a critical research tool for Parkinson's disease1R41NS145857-01KOTZBAUER, PAUL THELICAL BIOSCIENCES LLC, MO$395,951ZNS1
2025VR-CARES: Feasibility of Virtual Reality for Caregiver Assembly, Relief, Empowerment, and Support to improve social connection, health, and at-home dementia care1R41AG092119-01BANDINI, JULIASTAMPS, JENNIFER JOYRENDEVER, INC., MA$349,333ZRG1
2025Targeting aVb8 integrin to restore astrocyte-microglia crosstalk to treat Alzheimer's disease1R41AG092194-01A1ARNOLD, THOMAS DARMODYBUTOVSKY, OLEGSHEPPARD, DEANGLIAL THERAPEUTICS, LLC, MA$254,896ZRG1
2025Phase I STTR: Targeting substrate of gamma-secretase for selective amyloid reduction in Alzheimer’s Disease1R41AG092199-01WANG, CHUNYUALPHAMEMORY, LLC, NY$252,124ZRG1
2025Novel AI-driven music-based intervention to reduce behavioral and psychological symptoms for people living with dementia1R41AG092161-01A1KOFFLER, RICHARDMCCREEDY, ELLEN MRUBATO, INC., CA$250,812ZRG1
2024Developing blood-based exercise mimetic as a treatment for Alzheimer's disease and related dementias1R41AG090238-01DING, ZHAOQINGCEIBA BIO INC., CA$509,038ZRG1
2024Developing a blood fatty acid-based algorithm as an early predictor of cognitive decline and dementia: Applying machine learning to harmonized data from prospective cohort studies1R41AG085816-01HARRIS, BILLOMEGAQUANT ANALYTICS, LLC, SD$506,500ZRG1
2024Targeted Exosomal Delivery of siRNA Therapeutics for Neuroinflammatory Diseases1R41AG084384-01A1GUPTA, RAMESH CWALLEN, RENA MARGARET3P BIOTECHNOLOGIES, INC., KY$506,451ZRG1
2024Development of orally bioavailable and blood-brain barrier penetrant, small molecule TAK1 inhibitors as a novel treatment for Alzheimer's Disease1R41AG090212-01SCARNEO, SCOTTEYDIS BIO, INC., NC$506,267ZRG1
2024NanoLuciferase-based AD/ADRD Microphysiological Systems Platform for High-throughput Screening1R41AG085831-01POON, WAYNE WNEUCYTE, INC., CA$500,000ZRG1
2024Multi-target Peptide Drug for Alzheimer's Disease1R41AG084429-01A1KASUS-JACOBI, ANNEALZARROK BIO LLC, OK$500,000ZRG1
2024Trans Spinal Delivery of a Targeted Nanoformulation of Curcuminoids to Treat AD1R41AG085737-01GUPTA, RAMESH C3P BIOTECHNOLOGIES, INC., KY$499,964ZRG1
2024Dementia IDEAs: An Evidence-based Intervention for Dysphagia to supportthe Unique Needs of AD/ADRD Care Partners1R41AG085909-01WERNER, NICOLE EZURAW, MATTHEWBETTER BRAINS, INC, CA$499,964ZRG1
2024Acetylated Tau Immunotherapy for Alzheimer's Disease1R41AG085770-01GAN, LISINHA, ANJANAAETON THERAPEUTICS, INC., CA$499,911ZRG1
2024Development of Small-Molecule Degraders of APP as the first-in-class drugs for Alzheimer's therapy1R41AG090241-01HAO, CHUNHAI CHARLIEDEGROME THERAPEUTICS, INC., IN$499,883ZRG1
2024Develop a novel strategy to deliver N-acetylcysteine for AD treatment1R41AG087769-01A1FAN, DAPINGXU, PEISHENGACEPRE, LLC, SC$499,441ZRG1
2024Non-toxic CNS drug delivery across the BBB in Alzheimer's and other dementias1R41AG079748-01A1ROSENZWEIG, STEVEN ALANSOMATOCEUTICS, LLC, SC$474,531ZRG1
2024High-Content Screen to Identify Small Molecule Therapeutics that Reduce Aberrant Lipid Accumulation in APOE4 Alzheimer's Disease1R41AG087802-01A1LAM, KELVIN TMCM6 THERAPEUTICS, INC., MA$473,216ZRG1
2024Development of a blood-based test for neurodegenerative diseases1R41AG087866-01PANKOW, SANDRAYATES III, JOHN R3D BIOANALYTIX, INC., CA$472,695ZRG1
2024Development of a Growth Hormone Receptor antagonist for the delay or prevention of ADRD1R41AG085916-01BRODY, RICHARD SHUFFMAN, DEREK MAJORKOPCHICK, JOHN JOSEPHMILMAN, SOFIYAMOLECULAR TECHNOLOGIES LABORATORIES LLC, OH$275,070ZRG1
2023Phase 1 Trial to Assess Safety and Immune Effects of Xenon Gas in Healthy Human Subjects2R42AG073059-02ILIN, ILYAWEINER, HOWARD LGENERAL BIOPHYSICS, LLC, MA$1,318,445ZRG1
2023Miniaturized AD/ADRD Microphysiological Systems Platform for High-throughput Screening1R41AG084421-01POON, WAYNE WNEUCYTE, INC., CA$500,000ZRG1
2023Creating an sxRNA Organoid Product for Advancing the Study, Prevention and Treatment of Alzheimer's disease (AD) and Alzheimer's-disease-related dementias (ADRD)1R41AG081123-01A1PALUH, JANET LTENENBAUM, SCOTTSXRNA TECHNOLOGIES, INC., NY$500,000ZRG1
2023Developing a novel system combining cognitive assessment with PASCALL FDA-cleared intraoperative anesthesia EEG brain monitor to prevent postoperative neurocognitive disorders in aging patients1R42AG084399-01LE MAU, TUANPURDON, PATRICK L.PASCALL SYSTEMS, INCORPORATED, MA$299,893ZRG1
2023A Novel Technology to Disseminate WOOP (Wish, Outcome, Obstacle, Plan) to Dementia Caregivers1R41AG084405-01FEDUS, DONNA BBORROW MY GLASSES, LLC, CT$191,913ZRG1

Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-09-0.1.0. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

ScienceDex for faculty

Your academic CV and NIH biosketch

Make your CV in your school's format and your NIH biosketch from it, then download both as Word files.

PAS-22-197: Advancing Research on Alzheimer's Disease (AD) and AD-Related Dementias (ADRD) (R41/R42 Clinical Trial Optional) | ScienceDex | ConductScience