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NIH funding notice RFA-CA-15-008

Research Answers to NCI's Provocative Questions (R01)

Closed on October 28, 2016.

Posted
March 27, 2015
Close date
October 28, 2016
Activity codes
Not stated on the notice page
Institutes taking part
Not stated on the notice page

The notices it replaced

Its page was not saved, so the notices it replaced are not known.

Who won it before

Competing awards, new and renewals, since FY2014, under this notice and the notices it replaced.

Past awards
66
66 new
Median first-year cost
$410,067
$29,893,386 in all
Institutions
46
65 contact PIs
Patents
14
from 8 funded projects

Awards by fiscal year

Fiscal years 2014 to 2026.

Most frequent institutions

  1. UNIVERSITY OF TX MD ANDERSON CAN CTR5
  2. DANA-FARBER CANCER INST4
  3. STANFORD UNIVERSITY3
  4. CEDARS-SINAI MEDICAL CENTER2
  5. ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI2

and 41 other institutions

Most frequent study sections

  1. Special Emphasis Panel (ZCA1 RPRB-M (M5))5
  2. Special Emphasis Panel (ZCA1 RTRB-E (M2))5
  3. Special Emphasis Panel (ZCA1 RPRB-F (M1))4
  4. Special Emphasis Panel (ZCA1 RTRB-R (J1))4
  5. Special Emphasis Panel (ZCA1 RPRB-0 (J1))3

and 24 other study sections

66 awards under RFA-CA-15-008 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
FY2017(PQ6) Radiogenomics of colorectal polyps to assess benign proliferative vs. premalignant states.1R01CA220004-01Grady, William MalloryHalberg, Richard BrottPickhardt, PerryFRED HUTCHINSON CANCER RESEARCH CENTER, WAFirst-year cost $739,041Study section ZCA1
FY2017(PQ7)Multi-scale Analysis of Tumor Microenvironment Heterogeneity1R01CA208735-01A1Felsher, Dean WSTANFORD UNIVERSITY, CAFirst-year cost $729,393Study section ZCA1
FY2017(PQ8) Genetically faithful murine models for studying disease progression in chronic lymphocytic leukemia1R01CA216273-01Wang, LiliWu, Catherine Ju-YingDANA-FARBER CANCER INST, MAFirst-year cost $701,924Study section ZCA1
FY2017(PQ3) Cellular and Molecular Mechanisms Driving Myeloid Compartment Variation in Human Triple Negative Breast Cancer1R01CA219880-01Palucka, Anna KarolinaJACKSON LABORATORY, MEFirst-year cost $697,539Study section ZCA1
FY2017(PQ#3) Novel tumor intrinsic PD-L1 signals direct tumor immune cell infiltration1R01CA205965-01A1Curiel, Tyler J.UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, TXFirst-year cost $650,815Study section ZCA1
FY2017(PQ3) Immune epigenetic biomarkers of bladder cancer outcomes1R01CA216265-01Christensen, Brock ClarkeDARTMOUTH COLLEGE, NHFirst-year cost $632,860Study section ZCA1
FY2017(7) Novel imaging devices for measurement and control of tumor microenvironments1R01CA216248-01Castracane, JamesCondeelis, John SEntenberg, DavidALBERT EINSTEIN COLLEGE OF MEDICINE, INC, NYFirst-year cost $565,675Study section ZCA1
FY2017(PQ9) Directed and unbiased studies of synaptic injuries as sequelae of radiotherapy: mapping, sex-dependence, and reversal1R01CA219667-01Duman, Joseph GBAYLOR COLLEGE OF MEDICINE, TXFirst-year cost $554,770Study section ZCA1
FY2017Immune biological differences between Triple Negative Breast Cancer in African American and non-African American women and potential immunotherapy opportunities to improve treatment outcome1R01CA219647-01Pusztai, LajosYALE UNIVERSITY, CTFirst-year cost $552,594Study section ZCA1
FY2017(PQ9)Mechanistic Role of APE1 and BER in chemotherapy-induced peripheral neuropathy1R01CA205166-01A1Kelley, Mark R.INDIANA UNIVERSITY INDIANAPOLIS, INFirst-year cost $536,312Study section ZCA1
FY2017Obesity Increases Breast Cancer Penetrance in BRCA Mutation Carriers: A Role for Local and Systemic Factors1R01CA215797-01Brown, Kristy A.Dannenberg, Andrew JessWEILL MEDICAL COLL OF CORNELL UNIV, NYFirst-year cost $515,275Study section ZCA1
FY2017(9) Therapeutic strategies to mitigate toxicities of platinum-based therapeutics1R01CA215802-01Pabla, NavjotSparreboom, AlexanderOHIO STATE UNIVERSITY, OHFirst-year cost $503,309Study section ZCA1
FY2017(PQ9)A redox-mediated mechanism of chemotherapy-induced cognitive impairment1R01CA217934-01Bondada, SubbaraoButterfield, D. AllanSt Clair, Daret KUNIVERSITY OF KENTUCKY, KYFirst-year cost $455,149Study section ZCA1
FY2017(PQ#9) Promoting Axon Stability to Prevent Therapy-induced Peripheral Neuropathy1R01CA219866-01Diantonio, AaronMilbrandt, Jeffrey DWASHINGTON UNIVERSITY, MOFirst-year cost $445,407Study section ZCA1
FY2017(PQ 9) Dysregulation of epidermal MMP-13 as cause of paclitaxel-induced peripheral neuropathy1R01CA215973-01Rieger, SandraMOUNT DESERT ISLAND BIOLOGICAL LAB, MEFirst-year cost $443,022Study section ZCA1
FY2017(PQ1) Progenitor cell malfunction, mutations and changes in microenvironment: A dynamic risk spectrum for cancer evolution1R01CA219893-01Ghosh, MoumitaMiller, York ENATIONAL JEWISH HEALTH, COFirst-year cost $442,614Study section ZCA1
FY2017Role of microbiota in therapy to ovarian cancer1R01CA216234-01Randall, Troy DUNIVERSITY OF ALABAMA AT BIRMINGHAM, ALFirst-year cost $426,139Study section ZCA1
FY2017RNF128 Regulation of TP53 in Barrett's Progression1R01CA215596-01Beer, David GeorgeRay, DipankarUNIVERSITY OF MICHIGAN AT ANN ARBOR, MIFirst-year cost $414,063Study section ZCA1
FY2017Exploiting mitochondrial heteroplasmy for cancer chemotherapy1R01CA219859-01Sabatini, David M.WHITEHEAD INSTITUTE FOR BIOMEDICAL RES, MAFirst-year cost $390,000Study section ZCA1
FY2017AN IMAGING-BASED APPROACH TO UNDERSTAND AND PREDICT CHEMOTHERAPY INDUCED PERIPHERAL NEUROPATHY1R01CA208623-01A1Berezin, Mikhail Y.WASHINGTON UNIVERSITY, MOFirst-year cost $389,684Study section ZCA1
FY2017Deciphering How Esco2 Loss Acts as a Penetrance Modifier1R01CA216108-01Parant, John MUNIVERSITY OF ALABAMA AT BIRMINGHAM, ALFirst-year cost $359,477Study section ZCA1
FY2017Role of Senescent Cells in Radiation-induced Pulmonary Fibrosis1R01CA219836-01Zhou, DaohongUNIV OF ARKANSAS FOR MED SCIS, ARFirst-year cost $354,709Study section ZCA1
FY2017Impact of the Microbiome on the Efficacy of Radiation Therapy1R01CA220000-01Shiao, Stephen L.CEDARS-SINAI MEDICAL CENTER, CAFirst-year cost $350,000Study section ZCA1
FY2017(PQ #10) Gut-brain interactions underlying chemotherapy-induced behavioral comorbidities1R01CA216290-01Pyter, Leah MOHIO STATE UNIVERSITY, OHFirst-year cost $338,903Study section ZCA1
FY2017Targeted Payment Cuts to Reduce Unproven Care1R01CA208758-01A1Howard, David HEMORY UNIVERSITY, GAFirst-year cost $336,912Study section ZCA1
FY2017Uncovering the Role of Colorectal Stem Cells on Disease Penetrance in Lynch Syndrome1R01CA219463-01Vilar Sanchez, EduardoUNIVERSITY OF TX MD ANDERSON CAN CTR, TXFirst-year cost $330,675Study section ZCA1
FY2017(PQ1) Identifying and targeting human glioblastoma migrating in the peritumoral niche1R01CA216054-01Hayden Gephart, MelanieSTANFORD UNIVERSITY, CAFirst-year cost $324,411Study section ZCA1
FY2017Mitochondrial Dynamics in Brain TumorInitiating Cells1R01CA208516-01A1Mears, JasonCASE WESTERN RESERVE UNIVERSITY, OHFirst-year cost $320,000Study section ZCA1
FY2017(PQ5) Consequences of imbalanced mitophagy and mitochondrial biogenesis in cancer1R01CA216242-01Macleod, Kay FUNIVERSITY OF CHICAGO, ILFirst-year cost $318,277Study section ZCA1
FY2017Effect of radiotherapy on dendritic cell subsets: implications for immunotherapy1R01CA219994-01Idoyaga, JulianaSTANFORD UNIVERSITY, CAFirst-year cost $314,908Study section ZCA1
FY2017Mechanisms that control the progression from premalignant lesions to adenocarcinomas in the lung1R01CA205165-01A1Galbiati, FerruccioUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PAFirst-year cost $310,250Study section ZCA1
FY2017Targeting the Opioidergic and Adrenergic Systems to Control Breast Cancers1R01CA208632-01A1Sarkar, Dipak KumarRUTGERS, THE STATE UNIV OF N.J., NJFirst-year cost $310,000Study section ZCA1
FY2017(PQ3) Disruption of immune surveillance by aneuploidy and aberrant MHCII expression1R01CA220009-01Carter, Hannah KathrynZanetti, MaurizioUNIVERSITY OF CALIFORNIA, SAN DIEGO, CAFirst-year cost $310,000Study section ZCA1
FY2017Molecular Mechanisms Underlying Environmental Effects that Influence Penetrance in Lynch Syndrome-Associated Endometrial Cancer1R01CA216103-01Yates, Melinda S.UNIVERSITY OF TX MD ANDERSON CAN CTR, TXFirst-year cost $256,000Study section ZCA1
FY2016Host factors, tumor microenvironment and survival in a multiethnic study of Hodgkin lymphoma patients1R01CA206019-01Cozen, WendyUNIVERSITY OF SOUTHERN CALIFORNIA, CAFirst-year cost $735,600Study section ZCA1
FY2016PQ1: Identification and characterization of genetic alterations for the progression of pre-neoplastic lung lesions by using novel PDx models and deep sequencing1R01CA206027-01Hoque, Mohammad ObaidulSidransky, DavidJOHNS HOPKINS UNIVERSITY, MDFirst-year cost $688,142Study section ZCA1
FY2016(PQ#9)Targeting leaky ryanodine receptor (RyR2) to treat and prevent chemotherapy-associated cognitive dysfunction in patients with breast cancer.1R01CA206025-01Guise, Theresa AMarks, Andrew RobertTerrito, Paul RichardINDIANA UNIVERSITY INDIANAPOLIS, INFirst-year cost $655,037Study section ZCA1
FY2016Determinants of genetic penetrance in identical twins with breast cancer1R01CA208772-01Mack, Thomas McCullochUNIVERSITY OF SOUTHERN CALIFORNIA, CAFirst-year cost $588,101Study section ZCA1
FY2016Determinants of pancreatic cancer and malignant melanoma phenotypes in CDKN2A hereditary kindreds1R01CA208517-01Fernandez-Zapico, Martin ErnestoLi, HuPetersen, Gloria M.MAYO CLINIC ROCHESTER, MNFirst-year cost $578,620Study section ZCA1
FY2016(PQ9) The role of Bclw (bcl2l2) in preventing chemotherapy induced neuropathy1R01CA205255-01Segal, Rosalind A.DANA-FARBER CANCER INST, MAFirst-year cost $577,463Study section ZCA1
FY2016(PQ9) Characterization and prophylactic treatment of chemotherapy-induced long-term adverse sequelae1R01CA208634-01Jurecic, RolandUNIVERSITY OF MIAMI SCHOOL OF MEDICINE, FLFirst-year cost $560,277Study section ZCA1
FY2016(PQ 9) Synaptic basis of deficits in attention and executive function following cranial radiation1R01CA208535-01Grosshans, David RUNIVERSITY OF TX MD ANDERSON CAN CTR, TXFirst-year cost $536,390Study section ZCA1
FY2016(PQ7) In Vivo Cellular Optical Imaging of Esophageal Tumors and Microenvironment1R01CA205431-01Perelman, Lev TBETH ISRAEL DEACONESS MEDICAL CENTER, MAFirst-year cost $533,945Study section ZCA1
FY2016(PQ3) The role of damaged DNA in inter-individual variation of tumor immunity1R01CA208756-01Hacohen, NirBROAD INSTITUTE, INC., MAFirst-year cost $518,165Study section ZCA1
FY2016(9) Biophysical Description of Age and Dose Dependent Changes to Dendritic Morphology that Impact Cognition following Radiation Cancer Therapy1R01CA208526-01Cucinotta, Francis AUNIVERSITY OF NEVADA LAS VEGAS, NVFirst-year cost $484,047Study section ZCA1
FY2016(PQ6) Molecular Mechanisms Driving Benign to Malignant Transitions in Breast Cancer1R01CA205632-01Riegel, Anna TateGEORGETOWN UNIVERSITY, DCFirst-year cost $469,489Study section ZCA1
FY2016(PQ1) Characterization of Premalignant Fields in a Murine Model of Head and Neck and Esophageal Cancers1R01CA205258-01Gudas, Lorraine JWEILL MEDICAL COLL OF CORNELL UNIV, NYFirst-year cost $464,261Study section ZCA1
FY2016(PQ1) Genomic characterization of mesenchymal stromal cells in Monoclonal Gammopathy of Undermined Significance (MGUS)1R01CA205954-01Ghobrial, Irene M.DANA-FARBER CANCER INST, MAFirst-year cost $438,499Study section ZCA1
FY2016(PQ5) Mitochondria are endocellular symbionts that serve as targets for immune recognition1R01CA206012-01Facciabene, AndreaUNIVERSITY OF PENNSYLVANIA, PAFirst-year cost $417,457Study section ZCA1
FY2016(PQ7) Quantitative in vivo optical imaging of tumor heterogeneity1R01CA205101-01Skala, Melissa CarolineMORGRIDGE INSTITUTE FOR RESEARCH, INC., WIFirst-year cost $406,070Study section ZCA1
FY2016Mesenchymal Stem Cells to Repair Chemobrain1R01CA208371-01Heijnen, Cobi JKavelaars, AnnemiekeUNIVERSITY OF TX MD ANDERSON CAN CTR, TXFirst-year cost $402,051Study section ZCA1
FY2016Cancer-Associated Fibroblasts Alter the Composition of B cells in Solid Malignancies1R01CA208753-01Orsulic, SandraCEDARS-SINAI MEDICAL CENTER, CAFirst-year cost $400,313Study section ZCA1
FY2016(PQ5) Investigation of intertumoral and intratumoral heterogeneity of mitochondrial apoptotic sensitivity1R01CA205967-01Letai, Anthony GDANA-FARBER CANCER INST, MAFirst-year cost $390,540Study section ZCA1
FY2016(PQ5) Mitochondria in Leukemic Stem Cell Disease Progression1R01CA205975-01A1Ghaffari, SaghiICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NYFirst-year cost $386,619Study section ZCA1
FY2016PQ 5 Exploring whole mitochondrial genome of screen detected pre-neoplastic lung lesions by novel approaches1R01CA208709-01Hoque, Mohammad ObaidulSidransky, DavidJOHNS HOPKINS UNIVERSITY, MDFirst-year cost $383,423Study section ZCA1
FY2016(PQ11) Targeting STING in the context of chemoradiation therapy to overcome poor preexisting immunity in mouse models of pancreatic cancer.1R01CA208644-01Crittenden, MarkaPROVIDENCE PORTLAND MEDICAL CENTER, ORFirst-year cost $377,438Study section ZCA1
FY2016(PQ3) Immune Modulation of DNA Mismatch Repair in Colorectal Cancer1R01CA206010-01Carethers, John MUNIVERSITY OF MICHIGAN AT ANN ARBOR, MIFirst-year cost $369,639Study section ZCA1
FY2016Genomics and Mechanisms of Esophageal Carcinogenesis1R01CA208711-01Sepulveda, Antonia RogadoCOLUMBIA UNIVERSITY HEALTH SCIENCES, NYFirst-year cost $366,000Study section ZCA1
FY2016(PQ9) Mitigation of chemotherapy induced peripheral neuropathy1R01CA206028-01Damaj, M. ImadGewirtz, David A.VIRGINIA COMMONWEALTH UNIVERSITY, VAFirst-year cost $363,112Study section ZCA1
FY2016(PQ1) Progression of the airway field of injury to Kras mutant lung cancer1R01CA205608-01A1Kadara, HumamScheet, Paul AUNIVERSITY OF TX MD ANDERSON CAN CTR, TXFirst-year cost $360,634Study section ZCA1
FY2016(PQ1) Epigenetic effects of the premalignant field1R01CA208620-01Terada, Lance SUT SOUTHWESTERN MEDICAL CENTER, TXFirst-year cost $357,464Study section ZCA1
FY2016(PQ1) GUCY2C hormone loss translates APC-Beta-catenin mutations into epithelial transformation1R01CA206026-01Waldman, Scott ATHOMAS JEFFERSON UNIVERSITY, PAFirst-year cost $356,850Study section ZCA1
FY2016Developing a targeted chemoprevention strategy for Non-Small Cell Lung Cancer1R01CA208303-01Gomperts, Brigitte NUNIVERSITY OF CALIFORNIA LOS ANGELES, CAFirst-year cost $352,275Study section ZCA1
FY2016(PQ5) Imaging mitochondrial heterogeneity in LKB1 mutant lung cancer1R01CA208642-01Shackelford, David BUNIVERSITY OF CALIFORNIA LOS ANGELES, CAFirst-year cost $352,275Study section ZCA1
FY2016(PQ9) A novel mechanism of paclitaxel-induced peripheral neuropathy and potential treatment1R01CA208765-01Yang, QingUNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, TXFirst-year cost $351,874Study section ZCA1
FY2016(PQ5) Role of Mitochondrial Division in Cancer Biology1R01CA206005-01Chipuk, Jerry EdwardICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NYFirst-year cost $351,209Study section ZCA1
Newest fiscal year first, then first-year cost.

Patents from its funded projects

14 patents name 8 of the 66 funded projects. The newest 5, by patent number.

  1. US 12,529,692 (opens the patent at USPTO, a PDF, in a new tab)LIVE CELL IMAGING DYNAMIC BH3 PROFILINGGranted January 20, 2026 to DANA-FARBER CANCER INSTITUTE, INC.R01CA205967 · DANA-FARBER CANCER INST, MA
  2. US 12,508,243 (opens the patent at USPTO, a PDF, in a new tab)COMPOSITIONS AND METHODS FOR TREATING CANCER AND IMPROVING EPITHELIAL HOMEOSTASISGranted December 30, 2025 to THE REGENTS OF THE UNIVERSITY OF CALIFORNIAR01CA208303 · UNIVERSITY OF CALIFORNIA LOS ANGELES, CA
  3. US 12,502,671 (opens the patent at USPTO, a PDF, in a new tab)SYSTEMS AND METHODS FOR CLASSIFYING T CELL ACTIVATION STATEGranted December 23, 2025 to Wisconsin Alumni Research FoundationR01CA205101 · MORGRIDGE INSTITUTE FOR RESEARCH, INC., WI
  4. US 12,441,775 (opens the patent at USPTO, a PDF, in a new tab)BCL-W Polypeptides and Mimetics for Treating or Preventing Chemotherapy-Induced Peripheral Neuropathy and Hearing LossGranted October 14, 2025 to Dana-Farber Cancer Institute, Inc. and President and Fellows of Harvard CollegeR01CA205255 · DANA-FARBER CANCER INST, MA
  5. US 12,441,722 (opens the patent at USPTO, a PDF, in a new tab)THERAPEUTIC AGENTS AND METHODS OF TREATMENTGranted October 14, 2025 to University of Florida Research Foundation, Inc.R01CA219836 · UNIV OF ARKANSAS FOR MED SCIS, AR

Each number opens the patent at USPTO, beside the project NIH ties it to and that project's institution. NIH ties a patent to a project, not to a year of its funding, and says its list is incomplete. The grant date and the owners are USPTO's: the organizations the patent names as assignees on the day it was granted. Source: United States Patent and Trademark Office, www.uspto.gov, which does not endorse ScienceDex.

Data: Grants.gov's daily extract and NIH's notice pages, award files and patents file, in ScienceGraph release conductgrants-2026-11-12-0.3.1. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

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