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NIH funding notice RFA-CA-18-003

Advanced Development and Validation of Emerging Molecular and Cellular Analysis Technologies for Basic and Clinical Cancer Research (R33 - Clinical Trial Not Allowed)

Closed on September 28, 2018.

Posted
November 20, 2017
Close date
September 28, 2018
Activity codes
R33
Institutes taking part
NCI

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

  1. Reissues: RFA-CA-17-011 Advanced Development and Validation of Emerging Molecular and Cellular Analysis Technologies for Basic and Clinical Cancer Research (R33)
  2. 2 steps back: RFA-CA-16-002 Advanced Development and Validation of Emerging Molecular and Cellular Analysis Technologies for Basic and Clinical Cancer Research (R33)
  3. 3 steps back: RFA-CA-15-003 Advanced Development and Validation of Emerging Molecular Analysis Technologies for Cancer Research (R33)
  4. 4 steps back: RFA-CA-14-004 Validation and Advanced Development of Emerging Molecular Analysis Technologies for Cancer Research (R33)
  5. 5 steps back: RFA-CA-13-002 Validation and Advanced Development of Emerging Molecular Analysis Technologies for Cancer Research (R33)
  6. 6 steps back: RFA-CA-12-003 Validation and Advanced Development of Emerging Technologies for Cancer Research (R33)
  7. 7 steps back: RFA-CA-10-004 Validation and Advanced Development of Emerging Technologies for Cancer Research (R33)
  8. 8 steps back: RFA-CA-09-007 Application and Use of Transformative Emerging Technologies in Cancer Research (R33)
  9. 9 steps back: RFA-CA-08-008
  10. 10 steps back: RFA-CA-07-036
  11. 11 steps back: RFA-CA-07-018
  12. 12 steps back: RFA-CA-07-002
  13. 13 steps back: RFA-CA-06-003
  14. 14 steps back: RFA-CA-05-003

Replaced by RFA-CA-19-020.

Who won it before

66 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $25,317,385 in first-year total cost, median $387,787.

Most frequent study sections

  1. Special Emphasis Panel[ZCA1 TCRB-Q (O2)]10
  2. Special Emphasis Panel[ZCA1 TCRB-9 (M1)]7
  3. Special Emphasis Panel[ZCA1 TCRB-D (O1)]5
  4. Special Emphasis Panel[ZCA1 TCRB-J (M1)]5
  5. Special Emphasis Panel[ZCA1 TCRB-Q (J1)]5

Most frequent institutions

  1. CORNELL UNIVERSITY3
  2. UNIVERSITY OF WASHINGTON3
  3. YALE UNIVERSITY3
  4. ARIZONA STATE UNIVERSITY-TEMPE CAMPUS2
  5. CEDARS-SINAI MEDICAL CENTER2
Competing awards under RFA-CA-18-003 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2019A High Throughput Human Tumor Modeling Technology for Cancer Drug Discovery1R33CA225549-01A1LUKER, GARY DTAVANA, HOSSEINUNIVERSITY OF AKRON, OH$476,844ZCA1
2019A high-throughput nanoparticle assay to characterize cancer neoepitope-specific T cells1R33CA229042-01A1SCHNECK, JONATHAN PJOHNS HOPKINS UNIVERSITY, MD$416,450ZCA1
2019GESTALT Barcoding and Single-cell Transcriptomics of Tumor Cell Evolution in Personalized Tumor Models1R33CA236687-01BREUNIG, JOSHUA JOHNCEDARS-SINAI MEDICAL CENTER, CA$413,100ZCA1
2019Advanced Development of the MasSpec Pen for Cancer Diagnosis and Surgical Margin Evaluation1R33CA229068-01A1SCHIAVINATO EBERLIN, LIVIAUNIVERSITY OF TEXAS AT AUSTIN, TX$411,941ZCA1
2019Multi-color Mapping of Cancer Molecular Signatures and Tumor microenvironment1R33CA235319-01A1YANG, JENNY J.GEORGIA STATE UNIVERSITY, GA$407,268ZCA1
2019Rapidly scalable platforms for direct in vivo screening of functional drivers in lethal cancers1R33CA225498-01A1CHEN, SIDIYALE UNIVERSITY, CT$407,025ZCA1
2019Activity based profiling of Phosphoprotein phosphatases in cancer using mass spectrometry-based proteomics1R33CA225458-01A1GERBER, SCOTT A.KETTENBACH, ARMINJA NADINEDARTMOUTH COLLEGE, NH$400,114ZCA1
2019Optimization and validation of integrated microscale technologies for low-cost, automated production of PET molecular imaging tracers for cancer research1R33CA240201-01VAN DAM, ROBERT MICHAELUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$379,082ZCA1
2019Spatially Resolved Metagenomics to Explore Tumor-Microbiome Interactions in Human Colorectal Cancer1R33CA235302-01A1BRITO, ILANA LAURENDE VLAMINCK, IWIJNZIPFEL, WARREN RCORNELL UNIVERSITY, NY$349,262ZCA1
2019Multiscale microscope for 3D cancer imaging in model organisms and organoids1R33CA235254-01FIOLKA, RETO PAULUT SOUTHWESTERN MEDICAL CENTER, TX$328,541ZCA1
2019Increased Sensitivity of Minimal Residual Disease Monitoring using Peripheral Blood in Pediatric Patients with Acute Lymphoblastic Leukemia1R33CA235597-01A1AUGUST, KEITHSOPER, STEVEN ALLANUNIVERSITY OF KANSAS LAWRENCE, KS$241,587ZCA1
2018Pro-Codes: A novel vector and cell barcoding technology1R33CA223947-01A1 · under RFA-CA-17-011BROWN, BRIAN DICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$421,587ZCA1
2018Determining treatment sensitivity in B cell lymphoma by novel microfluidics-based NK cell immunogenicity platform1R33CA223908-01 · under RFA-CA-17-011EVENS, ANDREW MHUANG, TONY JUNKONRY, TANIA TALINORTHEASTERN UNIVERSITY, MA$421,501ZCA1
2018Advanced development and validation of microdevices for high-throughput in situ drug sensitivity testing in tumors1R33CA223904-01 · under RFA-CA-17-011CIMA, MICHAEL JMASSACHUSETTS INSTITUTE OF TECHNOLOGY, MA$416,667ZCA1
2018An integrated therapeutic T cell receptor screening platform for adoptive cell therapy in cancer1R33CA225539-01 · under RFA-CA-17-011JIANG, NING JENNYUNIVERSITY OF TEXAS AT AUSTIN, TX$396,959ZCA1
2018CRISPR-based Enhanced Molecular Chipper Technology for Identifying Functional Noncoding Elements in Cancer1R33CA225863-01 · under RFA-CA-17-011LU, JUNYALE UNIVERSITY, CT$395,674ZCA1
2018Quantitative SRS Imaging of Cancer Metabolism at Single Cell Level1R33CA223581-01A1 · under RFA-CA-17-011CHENG, JI-XINBOSTON UNIVERSITY (CHARLES RIVER CAMPUS), MA$390,880ZCA1
2018Optimization and Validation of Single-Molecule Kinetic Fingerprinting Technology for Rapid, Ultra-Specific Detection of Cancer Mutations1R33CA229023-01 · under RFA-CA-17-011TEWARI, MUNEESHWALTER, NILS GUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$388,440ZCA1
2018Multiplex matrix ELISA for T cell protein-interaction networks in cancer1R33CA228979-01 · under RFA-CA-17-011SCHRUM, ADAM G.UNIVERSITY OF MISSOURI-COLUMBIA, MO$387,880ZCA1
2018Advanced development and validation of genome-scale molecular diagnostics for microsatelliteinstability using targeted molecular counting methods1R33CA222344-01 · under RFA-CA-17-011SALIPANTE, STEPHEN JUNIVERSITY OF WASHINGTON, WA$386,677ZCA1
2018High-throughput super-resolution imaging of chromatin structures at different epigenetic states1R33CA225494-01 · under RFA-CA-17-011LIU, YANGUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$351,864ZCA1
2017Maximum efficiency sequencing using nuclease-based mutation enrichment and digital barcodes1R33CA217652-01 · under RFA-CA-16-002MAKRIGIORGOS, G. MIKEDANA-FARBER CANCER INST, MA$456,746ZCA1
2017Measurement of Aberrant Protein Folds in Malignant Cells with Proteomics and Mass Spectrometry1R33CA212973-01 · under RFA-CA-16-002YATES III, JOHN RSCRIPPS RESEARCH INSTITUTE, THE, CA$435,649ZCA1
2017Droplet microfluidic technology for single cell cancer genomics1R33CA212697-01 · under RFA-CA-16-002KLEIN, ALLON MOSHEHARVARD MEDICAL SCHOOL, MA$411,954ZCA1
2017High Resolution High Throughput Proteomics Platform for Cancer Research1R33CA217699-01 · under RFA-CA-16-002IBRAHIM, YEHIABATTELLE PACIFIC NORTHWEST LABORATORIES, WA$410,858ZCA1
2017Integrated exosomes profiling for minimally invasive diagnosis and monitoring of cancer1R33CA214333-01 · under RFA-CA-16-002GODWIN, ANDREW K.SAMUEL, GLENSONZENG, YONGUNIVERSITY OF KANSAS LAWRENCE, KS$400,098ZCA1
2017Next-generation MOWChIP-seq for high-throughput epigenomic profiling using clinically relevant samples1R33CA214176-01 · under RFA-CA-16-002LU, CHANGVIRGINIA POLYTECHNIC INST AND ST UNIV, VA$391,723ZCA1
2017TARGETED SINGLE-MOLECULE SEQUENCING ASSAY INCORPORATING MOLECULAR BARCODES1R33CA217700-01 · under RFA-CA-16-002DUNCAVAGE, ERIC JWALTER, MATTHEW JWASHINGTON UNIVERSITY, MO$379,725ZCA1
2017Multiplex FRET Imaging of Kinase-Epigenome Interregulations in Live Cancer Cells1R33CA204704-01A1 · under RFA-CA-16-002WANG, YINGXIAOUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$376,821ZCA1
2017Cancer histology and QC via MUSE: Sample-sparing UV surface-excitation microscopy1R33CA202881-01A1 · under RFA-CA-16-002LEVENSON, RICHARD M.UNIVERSITY OF CALIFORNIA AT DAVIS, CA$373,637ZCA1
2017LETSSGo: Lymphoma-on-chip Engineered Technology for Single-Organoid Sequencing and Genomics1R33CA212968-01 · under RFA-CA-16-002SINGH, ANKURCORNELL UNIVERSITY, NY$371,216ZCA1
2017Fluorescence lifetime-based single fluorophore biosensors of post-translational modification enzyme activity1R33CA217780-01 · under RFA-CA-16-002PARKER, LAURIE L.UNIVERSITY OF MINNESOTA, MN$345,244ZCA1
2017Development and validation of nanoparticle-mediated microfluidic profiling approach for rare cell analysis1R33CA204574-01A1 · under RFA-CA-16-002KELLEY, SHANA OUNIVERSITY OF TORONTO, ON$258,952ZCA1
2016Advanced Development and Validation of 3 Dimensional Spheroid Culture of Primary Cancer Cells using Nano3D Technology1R33CA206949-01 · under RFA-CA-15-003SPICER, TIMOTHY PATRICKSCRIPPS FLORIDA, FL$501,426ZCA1
2016Clinical implementation of single cell tumor transcriptome analysis1R33CA202820-01 · under RFA-CA-15-003REGEV, AVIVBROAD INSTITUTE, INC., MA$457,465ZCA1
2016Analysis of scant cancer cells in fine needle aspirates1R33CA202064-01 · under RFA-CA-15-003WEISSLEDER, MD, PHD, RALPHMASSACHUSETTS GENERAL HOSPITAL, MA$433,261ZCA1
2016A Genetic Toolbox for the Identification and Interrogation of Tumor Cells of Origin, Propagation, and Recurrence From Patient-derived Oncogenic Drivers1R33CA202900-01 · under RFA-CA-15-003BREUNIG, JOSHUA JOHNCEDARS-SINAI MEDICAL CENTER, CA$418,128ZCA1
2016Validating Rapid Microfluidic Isolation of Personalized Aptamers for Monitoring Minimal Residual Disease in Multiple Myeloma1R33CA196470-01A1 · under RFA-CA-15-003LIN, QIAOCOLUMBIA UNIV NEW YORK MORNINGSIDE, NY$394,518ZCA1
2016Translational Molecular and Cellular Imaging Technologies for Prostate Tumor Pathology1R33CA196458-01A1 · under RFA-CA-15-003BHARGAVA, ROHITCHEVILLE, JOHN CUNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL$387,693ZCA1
2016Charge sensitive optical detection for high-throughput study of small molecules1R33CA202834-01A1 · under RFA-CA-15-003TAO, NONGJIANARIZONA STATE UNIVERSITY-TEMPE CAMPUS, AZ$381,382ZCA1
2016Online Raman Diagnostics of Oncometabolites1R33CA206922-01 · under RFA-CA-15-003SCHULTZ, ZACHARYUNIVERSITY OF NOTRE DAME, IN$363,875ZCA1
2016GESI: a novel technology for functional imaging in living cells1R33CA196445-01A1 · under RFA-CA-15-003LAM, KIT SUNIVERSITY OF CALIFORNIA AT DAVIS, CA$362,749ZCA1
2016Protein painting identifies therapeutic targets at protein-protein interfaces1R33CA206937-01 · under RFA-CA-15-003LIOTTA, LANCE ALLENGEORGE MASON UNIVERSITY, VA$348,203ZCA1
2016High Throughput GO Chip isolation of Lung CTCs for Molecular Diagnosis and Drug Testing1R33CA202867-01 · under RFA-CA-15-003NAGRATH, SUNITHARAMNATH, NITHYAUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$343,664ZCA1
2016A novel molecular assay for early detection and assessment of cancer risk1R33CA202898-01 · under RFA-CA-15-003QUEIMADO, LURDESUNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR, OK$340,594ZCA1
2016Monitoring Recurrent Bladder Cancer with Electro-Phage Biosensors1R33CA206955-01 · under RFA-CA-15-003WEISS, GREGORY A.UNIVERSITY OF CALIFORNIA-IRVINE, CA$322,131ZCA1
2016Large-Scale Integration of Single Cell RNA-Seq and High-Content Imaging for Analyzing Drug Response in Cancer1R33CA202827-01 · under RFA-CA-15-003SIMS, PETER ALANCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$316,149ZCA1
2016Brillouin confocal microscopy for biomechanical studies of metastatic cascade in 3D microenvironments1R33CA204582-01 · under RFA-CA-15-003SCARCELLI, GIULIANOUNIV OF MARYLAND, COLLEGE PARK, MD$295,733ZCA1
2015Single cell cytokine analysis of circulating malignant hematopoietic cells1R33CA196411-01 · under RFA-CA-14-004FAN, RONGLEVINE, ROSS LYALE UNIVERSITY, CT$421,227ZCA1
2015High-throughput on-chip platform for interrogation of mitochondrial membrane potential and apoptosis1R33CA182384-01A1 · under RFA-CA-14-004BURKE, PETER J.UNIVERSITY OF CALIFORNIA-IRVINE, CA$412,541ZCA1
2015Noninvasive detection of circulating RNAs for lung cancer early detection and prognosis1R33CA191245-01A1 · under RFA-CA-14-004WU, YUNSTATE UNIVERSITY OF NEW YORK AT BUFFALO, NY$411,504ZCA1
2015Development of a virion display (VirD) array to profile human GPCR interactions1R33CA186790-01A1 · under RFA-CA-14-004DESAI, PRASHANT JZHU, HENGJOHNS HOPKINS UNIVERSITY, MD$403,372ZCA1
2015A Cancer Rainbow Mouse for Simultaneous Assessment of Multiple Oncogenes1R33CA191198-01 · under RFA-CA-14-004CARON, MARC G.DUKE UNIVERSITY, NC$389,963ZCA1
2015Using Adductomics to Characterize Exposures to Carcinogens1R33CA191159-01A1 · under RFA-CA-14-004RAPPAPORT, STEPHEN MORRISUNIVERSITY OF CALIFORNIA BERKELEY, CA$380,395ZCA1
2015Advanced development and validation of targeted molecular counting methods for precise and ultrasensitive quantitation of low prevalence somatic mutations1R33CA192980-01 · under RFA-CA-14-004SALIPANTE, STEPHEN JUNIVERSITY OF WASHINGTON, WA$375,858ZCA1
2015Scalable Cancer Genomics via Nanocoding and Sequencing1R33CA182360-01A1 · under RFA-CA-14-004MA, JIANSCHWARTZ, DAVID C.UNIVERSITY OF WISCONSIN-MADISON, WI$372,503ZCA1
2015Fast interference-based super-resolution microscope for cancer mechanobiology1R33CA193043-01 · under RFA-CA-14-004ZIPFEL, WARREN RCORNELL UNIVERSITY, NY$364,273ZCA1
2015Single cell growth assay for residual cells in acute lymphoblastic leukemia1R33CA191143-01 · under RFA-CA-14-004MANALIS, SCOTT RMASSACHUSETTS INSTITUTE OF TECHNOLOGY, MA$363,946ZCA1
2015RASL-Seq Expression Profiling of FFPE Tissues1R33CA183688-01A1 · under RFA-CA-14-004YEAKLEY, JOANNE MULLIGANBIOSPYDER TECHNOLOGIES, INC., CA$363,706ZCA1
2015Validation and Advanced Development of Glycan Node Analysis in Lung Cancer Research1R33CA191110-01 · under RFA-CA-14-004BORGES, CHAD RARIZONA STATE UNIVERSITY-TEMPE CAMPUS, AZ$317,654ZCA1
2014Integrating mass cytometric and transcriptomic profiles of solid tumors1R33CA183692-01 · under RFA-CA-13-002WEISS, WILLIAM AUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$408,712ZCA1
2014Large-Scale Characterization of Anti-Cancer Antibody Responses in Lung Adenocarci1R33CA183659-01 · under RFA-CA-13-002ROBINSON, WILLIAM HSTANFORD UNIVERSITY, CA$399,643ZCA1
2014Validation and Advanced Development of Duplex Sequencing1R33CA181771-01A1 · under RFA-CA-13-002LOEB, LAWRENCE AUNIVERSITY OF WASHINGTON, WA$384,923ZCA1
2014Validating Technology To Optimize Antibody Affinity For Targeting Therapeutics1R33CA177333-01A1 · under RFA-CA-13-002FEDERSPIEL, MARK JMAYO CLINIC ROCHESTER, MN$375,008ZCA1
2014Non-Circulating Microparticles for Improved Localization and Resection Cancer1R33CA177449-01A1 · under RFA-CA-13-002BLAIR, SARAH LUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$361,766ZCA1
2014Multiplexed Kinase Biosensor Technology to Detect Leukemia Signaling with Mass Sp1R33CA183671-01 · under RFA-CA-13-002PARKER, LAURIE L.UNIVERSITY OF MINNESOTA, MN$341,454ZCA1

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