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NIH funding notice RFA-CA-22-045

NCI Outstanding Investigator Award (R35 Clinical Trial Optional)

Closed on November 7, 2024.

Posted
July 26, 2022
Close date
November 7, 2024
Activity codes
Not stated on the notice page
Institutes taking part
Not stated on the notice page

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

Its page was not saved, so the notices it replaced are not known.

Who won it before

42 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $39,027,620 in first-year total cost, median $961,452.

Most frequent study sections

  1. Special Emphasis Panel[ZCA1 SRB-E (M1)]42

Most frequent institutions

  1. DANA-FARBER CANCER INST6
  2. SLOAN-KETTERING INST CAN RESEARCH5
  3. COLUMBIA UNIVERSITY HEALTH SCIENCES2
  4. ST. JUDE CHILDREN'S RESEARCH HOSPITAL2
  5. UT SOUTHWESTERN MEDICAL CENTER2
Competing awards under RFA-CA-22-045 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2025Discovering mechanisms of neuroblastoma tumorigenesis to improve patient outcomes2R35CA220500-08A1MARIS, JOHN MCHILDREN'S HOSP OF PHILADELPHIA, PA$1,068,000ZCA1
2025Overcoming Resistance to Targeted Therapy in Breast Cancer1R35CA305347-01CHANDARLAPATY, SARATSLOAN-KETTERING INST CAN RESEARCH, NY$1,056,000ZCA1
2025Understanding and Targeting Aberrant RNA Splicing in Leukemia1R35CA304457-01ABDEL-WAHAB, OMARSLOAN-KETTERING INST CAN RESEARCH, NY$1,034,176ZCA1
2025Targeting DNA Repair for Cancer Therapy.2R35CA197574-08A1GLAZER, PETER MYALE UNIVERSITY, CT$1,005,000ZCA1
2025Understanding and Exploiting Loss of Y in Cancer1R35CA294022-01A1THEODORESCU, DANUNIVERSITY OF ARIZONA, AZ$930,500ZCA1
2025Chemical Proteomic Platforms for Radically Expanding Cancer Druggability2R35CA231991-08CRAVATT, BENJAMIN FSCRIPPS RESEARCH INSTITUTE, THE, CA$916,320ZCA1
2025Effect of tumor editing on antitumor immunity1R35CA305089-01LIEBERMAN, JUDYBOSTON CHILDREN'S HOSPITAL, MA$901,205ZCA1
2025Human natural killer cells: Advancing biology and clinical applications2R35CA210087-08A1CALIGIURI, MICHAEL ABECKMAN RESEARCH INSTITUTE/CITY OF HOPE, CA$886,438ZCA1
2025New approaches to targeting cell cycle proteins for cancer treatment1R35CA305086-01SICINSKI, PETERDANA-FARBER CANCER INST, MA$855,249ZCA1
2025Navigating Pathways of Innate Immunity and Epigenetic Memory in Checkpoint Immunotherapy1R35CA294015-01A1BOUSSIOTIS, VASSILIKI ABETH ISRAEL DEACONESS MEDICAL CENTER, MA$846,982ZCA1
2025Systems genetics analysis of tumor evolution in the mouse2R35CA210018-08A1BALMAIN, ALLANUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$816,707ZCA1
2025Mesoscale and Nanoscale Technologies Integrated by Structures for DNA Repair Complexes (MANTIS-DRC)2R35CA220430-08TAINER, JOHN A.UNIVERSITY OF TX MD ANDERSON CAN CTR, TX$814,230ZCA1
2025Optimizing Hematopoietic Stem Cell Transplantation For The Treatment Of Hematological Malignancies2R35CA210084-08A1DIPERSIO, JOHN F.WASHINGTON UNIVERSITY, MO$713,138ZCA1
2024Decoding And Targeting The LKB1-AMPK Signaling Pathway In Cancer2R35CA220538-08SHAW, REUBENSALK INSTITUTE FOR BIOLOGICAL STUDIES, CA$1,140,000ZCA1
2024The TET-DNMT-ASXL1-OGT axis: relevance to clonal hematopoiesis, heterochromatin integrity and cancer2R35CA210043-08A1RAO, ANJANALA JOLLA INSTITUTE FOR IMMUNOLOGY, CA$1,098,000ZCA1
2024Early to Late Events in Colorectal Neoplasia: Basic Biology to Clinical Implementation2R35CA197570-08COFFEY, ROBERT J.VANDERBILT UNIVERSITY MEDICAL CENTER, TN$1,062,441ZCA1
2024Role of Phosphoinositides and Protein Kinases in the control of Cancer Metabolism2R35CA197588-08CANTLEY, LEWIS C.DANA-FARBER CANCER INST, MA$1,052,496ZCA1
2024Precision Engineering of STING-DC Immunity to Overcome Tumor Immune Evasion1R35CA294010-01GAO, JINMINGUT SOUTHWESTERN MEDICAL CENTER, TX$984,000ZCA1
2024MECHANISMS OF REGULATED CELL DEATH2R35CA231620-08GREEN, DOUGLAS R.ST. JUDE CHILDREN'S RESEARCH HOSPITAL, TN$955,876ZCA1
2024Targeting Glioblastoma Stem Cells1R35CA283998-01A1RICH, JEREMY NUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$954,000ZCA1
2024Mechanisms Driving the Rapid Evolution of Cancer Genomes1R35CA293978-01PELLMAN, DAVID SDANA-FARBER CANCER INST, MA$942,442ZCA1
2024Defining Drivers of HPV-associated Carcinogenesis2R35CA210807-08LAMBERT, PAUL F.UNIVERSITY OF WISCONSIN-MADISON, WI$933,000ZCA1
2024Next Generation Immunotherapies for Pediatric Cancers1R35CA283888-01A1MACKALL, CRYSTALSTANFORD UNIVERSITY, CA$931,841ZCA1
2024Emerging Strategies for Therapy of Metastatic Brain Cancer1R35CA283939-01A1LESNIAK, MACIEJ SNORTHWESTERN UNIVERSITY AT CHICAGO, IL$895,779ZCA1
2024Rewired Signaling at the Nexus of Melanoma Metastasis and Resistance1R35CA283706-01A1RONAI, ZEEV A.SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, CA$343,564ZCA1
2023Establishing and Interpreting Abnormal DNA Methylation in Cancer2R35CA209859-08JONES, PETER AVAN ANDEL RESEARCH INSTITUTE, MI$1,146,514ZCA1
2023Translating genomic discoveries to improved outcomes for high risk acute leukemia2R35CA197695-08MULLIGHAN, CHARLES G.ST. JUDE CHILDREN'S RESEARCH HOSPITAL, TN$1,092,000ZCA1
2023Targeting Pediatric Cancer Vulnerabilities1R35CA283977-01STEGMAIER, KIMBERLYDANA-FARBER CANCER INST, MA$1,066,178ZCA1
2023Synergistic role of signaling and epigenetics in leukemic transformation2R35CA197594-08LEVINE, ROSS LSLOAN-KETTERING INST CAN RESEARCH, NY$1,062,000ZCA1
2023Integrating targeted therapy and immunotherapy to break through cancer2R35CA210057-08ZHAO, JEANDANA-FARBER CANCER INST, MA$1,027,633ZCA1
2023Genome instability in cancer: telomeres and DNA repair2R35CA210036-08DE LANGE, TITIAROCKEFELLER UNIVERSITY, NY$1,007,774ZCA1
2023The von Hippel-Lindau Tumor Suppressor Gene and Kidney Cancer: Insights into Oxygen Sensing and Treating Cancers Caused by Undruggable Mutations2R35CA210068-08KAELIN, WILLIAM G.DANA-FARBER CANCER INST, MA$997,800ZCA1
2023From pathogenesis to new therapeutic targets in diffuse large B cell lymphoma2R35CA210105-08DALLA-FAVERA, RICCARDOCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$987,000ZCA1
2023The role of stem cells and the microenvironment in gastrointestinal cancers2R35CA210088-08WANG, TIMOTHY CRAGINCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$987,000ZCA1
2023Social Determinants of Health as Transducers of Cellular Aging: A New Multi-level Paradigm to Reduce Survivorship Disparities at the Intersection of Cancer and Aging1R35CA283926-01MANDELBLATT, JEANNEGEORGETOWN UNIVERSITY, DC$980,446ZCA1
2023Overcoming resistance to anti-PD1 immunotherapy2R35CA210098-08GAJEWSKI, THOMAS FUNIVERSITY OF CHICAGO, IL$970,168ZCA1
2023Human metabolic variation as a window into cancer initiation and progression2R35CA220449-07DEBERARDINIS, RALPH JUT SOUTHWESTERN MEDICAL CENTER, TX$967,027ZCA1
2023Targeting off-the-shelf iPSC-derived natural killer cells against solid tumors1R35CA283892-01MILLER, JEFFREY S.UNIVERSITY OF MINNESOTA, MN$928,524ZCA1
2023Exploring the Role of Nitrogen Metabolism in Cancer1R35CA283988-01THOMPSON, CRAIG BSLOAN-KETTERING INST CAN RESEARCH, NY$926,340ZCA1
2023Metabolic Influences on Complex Tumor Neighborhoods2R35CA220483-08SIMON, M. CELESTEUNIVERSITY OF PENNSYLVANIA, PA$925,000ZCA1
2023Developing a Suite of Targeted Anticancer Drugs1R35CA283859-01HERGENROTHER, PAULUNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL$515,200ZCA1
2023The role of the intestinal microbiome in cancer immunotherapy1R35CA284024-01VAN DEN BRINK, MARCEL R MSLOAN-KETTERING INST CAN RESEARCH, NY$303,632ZCA1

Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-10-0.1.1. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

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RFA-CA-22-045: NCI Outstanding Investigator Award (R35 Clinical Trial Optional) | ScienceDex | ConductScience