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NIH funding notice RFA-DA-19-019

HEAL Initiative: Americas Startups and Small Businesses Build Technologies to Stop the Opioid Epidemic (R43/R44 - Clinical Trial Optional)

Closed on September 8, 2021.

Posted
December 10, 2018
Close date
September 8, 2021
Activity codes
Not stated on the notice page
Institutes taking part
Not stated on the notice page

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

Its page was not saved, so the notices it replaced are not known.

Who won it before

90 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $39,227,339 in first-year total cost, median $260,664.

Most frequent study sections

  1. Special Emphasis Panel[ZDA1 GXM-A (03)]25
  2. Special Emphasis Panel[ZDA1 GXM-A (02)]18
  3. Special Emphasis Panel[ZDA1 GXM-A (01)]13
  4. Special Emphasis Panel[ZDA1 GXM-A (15)]13
  5. Special Emphasis Panel[ZDA1 GXM-A (24)]12

Most frequent institutions

  1. CLEAR SCIENTIFIC, LLC3
  2. SPARK BIOMEDICAL INC3
  3. AYUDA MEDICAL2
  4. BDH PHARMA, LLC2
  5. CREATIVE BIO-PEPTIDES, INC.2
Competing awards under RFA-DA-19-019 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2022A Project to Test the Efficacy and Safety of An Innovative Treatment for Opiate Use Disorders.2R44DA050358-02A1SCHIFFER, FREDRICTEICHER, MARTIN HMINDLIGHT, LLC, MA$1,519,167ZDA1
2022Abuse-deterrence and prevention of respiratory depression by an oral opioid analgesic and doxapram combination1R44DA055336-01RIX, PETER JEFFREYSESSLER, DANIEL IQUIVIVE PHARMA, INC, CA$1,393,153ZDA1
2022Wireless withdrawal detection and monitoring system for neonatal abstinence syndrome.2R44DA049615-02A1AL FARUQUE, MOHAMMAD ABDULLAHSHARAREH, SHIVATSENG, PETERREKOVAR INC., CA$1,215,174ZDA1
2022A Naloxone Parachute: Novel Wearable Dual-Sensor Regional Oximeter to Detect Opioid-Induced Hypoxia and Enable Emergent Naloxone Rescue2R44DA051257-02HITE, DESISLAVA ZLATANOVAAYUDA MEDICAL, WA$911,396ZDA1
2022Rapid Assessment of Illicit Drugs in Wastewater2R44DA051105-02ARGUN, AVNI AGINER, INC., MA$849,128ZDA1
2022Wearable sensor for opioids detection based on electrochemical sensor arrayintegrated with Bluetooth device2R44DA051289-02LEVITSKY, IGOR AEMITECH, INC., MA$775,215ZDA1
2022Evaluation of a Mobile Application for Patients and Clinical Decision-making Support Tools for Prescribers to Decrease Opioid Misuse and Habit-forming Behaviors Following Post-operative Prescription1R44DA055408-01WALTHER, STEVENCONTINUOUS PRECISION MEDICINE, INC., NC$762,017ZDA1
2022Reducing Opioid Use and Adverse Effects through Proactive Precision Pain Management Following Spine Surgery1R44DA056280-01PLUMP, STEVEN R.SADHASIVAM, SENTHILKUMAROPALGENIX, INC., IN$326,500ZDA1
2022Fentanyl induces naloxone-resistant vocal cord closure: target validation and development of opioid overdose treatments using a peer-reviewed animal model.1R44DA056267-01TORRALVA, PHILLIP RANDOLPHTORRALVA MEDICAL THERAPEUTICS, LLC, OR$324,196ZDA1
2022User-centric development of closed-loop therapy for opioid overdose1R44DA056277-01LE, VYLEE, HYOWONRESCUE BIOMEDICAL, LLC, IN$319,995ZDA1
2022A novel therapeutic approach for treatment of acute intoxication by co-use of opioids and stimulants1R43DA056272-01LI, XINHUACLEAR SCIENTIFIC, LLC, MA$319,695ZDA1
2022Development and Commercialization of a pupillometer to predict postoperative opioid-induced respiratory depression in children1R44DA055407-01OLIVER, JEFFREY WADEPRIVITERA, CLAUDIOSADHASIVAM, SENTHILKUMARNEUROPTICS, INC., CA$319,082ZDA1
2022Remotely Observed Methadone Evaluation (ROME)1R43DA056259-01BAILEY, STEFFANI RGILES, MICHAELSONARA HEALTH INC, TX$267,861ZDA1
2022Fast-track: Scalable digital delivery of evidence-based training for addiction professionals to maximize treatment admission and retention rates of opioid use disorder in affected families.1R44DA053845-01A1MACKY, JANEWE THE VILLAGE, INC., NY$259,585ZDA1
2022New therapeutic approaches to identifying molecules for opioid abuse treatment1R43DA055419-01EKINS, SEANCOLLABORATIONS PHARMACEUTICALS, INC., NC$256,220ZDA1
2022Identification of Cyclic Peptide Antagonists of an Anti-Opioid G Protein-Coupled Receptor1R43DA053844-01LABED, SID AHMEDEVODENOVO, INC., MA$255,061ZDA1
2022Modeling Physiology and Behavior of Veterans to Avert Opioid Related Mortality Through Timely Intervention1R44DA053874-01A1FORMAN, STEVEN D.FORSTER, SARAH EGORDON, ELLIEBEHAIVIOR, LLC, PA$253,479ZDA1
2022Digital Peer Support for Opioid Use Disorders: Scaling Chat Support Groups to meet Community Needs1R43DA056275-01BOMMARAJU, SATYA PRATEEKBEACON TECH, INC., MA$252,131ZDA1
2022Booth™ by Opio™: Developing technology to expand the reach of opioid treatment programs into rural and underserved areas.1R44DA056251-01NORBECK, AMBEROPIO CONNECT, INC., MT$156,220ZDA1
2021Prapela™ SVS: A cost-effective stochastic vibrotactile stimulation device toimprove the clinical course of infants with neonatal abstinence syndrome.2R44DA049300-02KONSIN, JOHN PHILLIPSINGH, RACHANAPRAPELA, INC., ME$1,330,596ZDA1
2021Novel Therapeutic Agents to Reverse Opioid Overdose2R44DA052957-02LI, XINHUACLEAR SCIENTIFIC, LLC, MA$1,283,728ZDA1
2021Delivering Transcutaneous Auricular Neurostimulation as an Adjunct Treatment for Neonatal Opioid Withdrawal Syndrome2R44DA050360-02JENKINS, DOROTHEA DENISEKHODAPARAST, NAVIDSPARK BIOMEDICAL INC, TX$1,249,662ZDA1
2021Delivering Transcutaneous Auricular Neurostimulation to Improve Treatment Retention in Opioid Use Disorder1R44DA053876-01KHODAPARAST, NAVIDSPARK BIOMEDICAL INC, TX$1,246,700ZDA1
2021Development of a Novel Chemokine Receptor Antagonist as a Treatment for Opioid Use Disorder2R44DA050349-02RUFF, MICHAEL RCREATIVE BIO-PEPTIDES, INC., MD$1,151,331ZDA1
2021Development of cannabinoid-opioid combination with opioid sparing and synergistic analgesic effects to prevent opioid use disorder and overdose.2R44DA050397-02BRIONES, MARISABDH PHARMA, LLC, CA$973,920ZDA1
2021Transcranial ultrasound device for enhancing sleep in OUD1R43DA055399-01MAHADEVAN, RAJIVATTUNE NEUROSCIENCES, INC., CA$319,441ZDA1
2021Development of CP-analogs as novel treatments for opioid use disorder.1R44DA053846-01REICH, JEFFREYSPARIAN BIOSCIENCES, INC., NY$319,223ZDA1
2021Digital Therapeutic Development of Virtual Cognitive-Affective Training for Opioid Use Disorder1R44DA053848-01WEISBERG, RISA BBEHAVR, LLC, KY$319,021ZDA1
2021DEVELOPMENT OF A FULLY-INTEGRATED CHATBOT TO IMPROVE MEMBER ENGAGEMENT IN ONLINE ADDICTION TREATMENT PROGRAMS1R44DA054010-01MCINTOSH, ROBINWORKIT HEALTH, INC., MI$314,004ZDA1
2021Network Synchrony Neurofeedback for Opioid Dependence1R43DA052945-01A1FEIN, GEORGENEUROBEHAVIORAL RESEARCH, INC., HI$269,320ZDA1
2021Incentivized Collaborative Care to Desseminate Contingency Management1R44DA055396-01DEFULIO, ANTHONYGASTFRIEND, DAVID RDYNAMICARE HEALTH, INC., MA$255,071ZDA1
2021Using Augmented Reality illusion therapy to develop a non-opioid chronic pain digital treatment1R43DA053048-01LAFFERTY, PAULVRX MEDICAL INC., CA$250,616ZDA1
2021BoostOne1R43DA051270-01A1PATEL, SALILNXTECH INC, TX$245,648ZDA1
2021Opioid Support and Risk Reduction Online Platform1R43DA049606-01A1GARETT, RENEEELEVATEU, CA$238,994ZDA1
2021On Demand Electrostimulation1R43DA055401-01LEVIN, HOWARDCORIDEA, LLC, NY$223,921ZDA1
2021Technologies for OUD Prevention, Control and Supportive Care - Development of Patient/Caregiver mobile application and Provider Dashboard1R43DA053870-01ELUMALAI, SATHYAAIDAR HEALTH, INC, MD$221,150ZDA1
2020BioMote for Opioid Use Disorder (OUD) Recovery2R44DA044905-02SCHMIDLE, PATRIKCARI HEALTH, INC., CA$1,781,902ZDA1
2020Development and Evaluation of Computerized Chemosensory-Based Orbitofrontal Cortex Training (CBOT) for Opioid Use Disorder2R44DA049616-02NWULIA, EVARISTUS ASETH, SUMEETEVON MEDICS, LLC, MD$820,883ZDA1
2020A patient self-assessment software combining compliance protocols to improve prescriber confidence, reduce liability, and improve patient outcomes.1R44DA051272-01HARTZEMA, ABRAHAM GCLARITY, LLC, AL$722,339ZDA1
2020Investigation of Microglial CRAC Channels as a Novel Drug Target for Opioid Use Disorder1R43DA053010-01GREENBERG, MILTON LVIVREON BIOSCIENCES, LLC, CA$349,967ZDA1
2020Wearable Device for Prevention of Opioid-Induced Respiratory Depression, Hypoxemia and Death1R43DA050336-01A1OLSON, LLOYDLLOYD OLSON, MD, LLC, CO$349,336ZDA1
2020Wearable Device for Automatic Delivery of Naloxone during Respiratory Arrest due to Opioid Overdose1R43DA049622-01VAZIRI, ASHKANBIOSENSICS, LLC, MA$348,832ZDA1
2020A Naloxone Parachute: Novel Wearable Dual-Sensor Regional Oximeter to Detect Opioid-Induced Hypoxia and Enable Emergent Naloxone Rescue1R43DA051257-01A1HITE, DESISLAVA ZLATANOVAAYUDA MEDICAL, WA$338,084ZDA1
2020Deep Brain Stimulation Probe Insertion System Utilizing Ultrasonic Vibration for Less Invasive Implantation with Improved Targeting Accuracy for Addiction Therapy1R43DA051265-01CLEMENT, RYAN SACTUATED MEDICAL, INC., PA$333,133ZDA1
2020"Wearable sensor for opioids detection based on electrochemical sensor array integrated with Bluetooth device "1R43DA051289-01A1LEVITSKY, IGOR AEMITECH, INC., MA$328,961ZDA1
2020Development of a novel translational pain-drug screening platform for the generation of human-relevant data in preclinical pain drug discovery1R43DA052947-01GHETTI, ANDREAANABIOS CORPORATION, CA$320,054ZDA1
2020PROCare: Cloud Process Support for Opioid Recovery Participation and Learning1R43DA051298-01A1PROCTOR, STEVENTIEN, ALLEN Y.MEDICAL DECISION LOGIC, INC., MD$290,832ZDA1
2020A Fentanyl Vaccine to Prevent Overdose1R43DA052960-01VERDI, JOSEPH PHEPIONE THERAPEUTICS INC., NY$261,742ZDA1
2020Fathering in Recovery1R43DA052949-01JONES, JEREMY AUSTINOREGON RES BEHAVIORAL INTERVENTION STRAT, OR$256,521ZDA1
2020Longer-acting intravaginal formulation of buprenorphine1R44DA053073-01SMITH, THOMAS J.AURITEC PHARMACEUTICALS, INC., CA$253,692ZDA1
2020ProGel Technology for Better Management of Osteoarthritis Pain1R44DA051278-01GOLDRING, STEVENENSIGN PHARMACEUTICAL, INC, NE$252,131ZDA1
2020Leveraging Roundtrip, the single touchpoint for medical transportation, to eliminate transportation as a barrier to care for specialized patient populations such as those with opioid use disorder.1R43DA051263-01MCNIFF, BRENDANRIDE ROUNDTRIP, INC., PA$252,131ZDA1
2020Rapid and non-invasive device for drug detection through sweat1R43DA052941-01KULKARNI, GIRISHARBORSENSE, INC., MI$252,062ZDA1
2020A Chatbot Utilizing Machine Learning and Natural Language Processing to Implement the Brief Negotiation Interview to Improve Engagement in Buprenorphine Treatment among Justice-Involved Individuals1R43DA051267-01A1PANTALON, MARIANNE SHARSKYPANTALON, MICHAEL VCENTER FOR PROGRESSIVE RECOVERY, LLC, CT$251,500ZDA1
2020Project Motivate: A digital motivation and prediction platform to improve treatment retention and reduce relapse in opioid use disorder1R43DA051279-01GUTTMAN, JEREMYBIOMOTIVATE, LLC, PA$251,492ZDA1
2020Survive-OUD: AI Platform to Integrate Complex Data Sources, Predict Relapse, and Recommend Interventions for Opioid Use Disorder1R43DA052916-01LUECHTEFELD, THOMASINSILICA, LLC, MD$251,348ZDA1
2020Neurxtem Neural Organoid Human Platform Development for Substance and Opioid Use Disorders1R44DA051281-01ANAND, RENENEURXSTEM, INC., OH$241,742ZDA1
2020Mobile brain sensing platform for detection of opioid craving and treatment response1R43DA053072-01BURWELL, SCOTTNEUROTYPE INC., MN$235,084ZDA1
2020Development of safe and effective immunotherapeutics for treatment of opioid abuse and overdose1R43DA051296-01ZHOU, XICHUNVITAN-BIOTECH, LLC, CO$224,940ZDA1
2020Novel Therapeutic Agents to Reverse Opioid Overdose1R43DA052957-01LI, XINHUACLEAR SCIENTIFIC, LLC, MA$224,889ZDA1
2020Reducing high school athletes' prescription opioids misuse and diversion through the Student Athlete Wellness Portal1R44DA051243-01CHOI, HYE JEONGHECHT, MICHAELREAL PREVENTION, LLC, NJ$224,551ZDA1
2020Development of a scalable, portable device platform to help objectively monitor the treatment of substance abuse.1R43DA053012-01OAKLEY, DAVIDSTUBBLEFIELD, JAMESWAVI COMPANY, CO$221,675ZDA1
2020Discovering Therapeutic Agents for the Treatment of Opioid Use Disorder by Targeting Negative Allosteric Modulators of the mu-Opioid Receptor1R43DA050383-01A1ANDERSON, RICHARDSTIEGLITZ, KIMBERLY ANNSYMMETRIC COMPUTING, INC., MA$217,405ZDA1
2020Developing a Novel Mixed Opioid Agonist for the Treatment of OUD1R43DA053055-01VERSI, EBRAHIMDMK PHARMACEUTICALS, INC., NJ$191,062ZDA1
2019Advancing a novel potent double anti-HCV nucleoside analog combination treatment for the OUD population to the clinic1R44DA050368-01KLUMPP, KLAUSRIBOSCIENCE, LLC, CA$995,102ZDA1
2019BD2K product for enhancing phenotypic screens2R44DA050376-02FULLER, JENNIFERGENECENTRIX, INC., NY$742,912ZDA1
2019Virtual Reality as a Opioid Sparing Intervention for Acute Postoperative Pain Management2R44DA049640-02AYAD, SABRYMADDOX, WILLIAM TODDSUK, MICHAELAPPLIEDVR, INC., CA$734,714ZDA1
2019Evaluation of the therapeutic potential of exclusive antagonists of extrasynaptic NMDA receptors for treatment of opioid use disorders1R43DA050393-01MOLOKANOVA, ELENANEURANO BIOSCIENCE, CA$349,999ZDA1
2019High-throughput profiling of compound abuse liabilities and identification of addiction-related drug targets using an iPSC-enabled platform1R44DA048686-01A1MAEDER, CELINECAIRN BIOSCIENCES, INC., CA$323,750ZDA1
2019A Novel Chemokine Receptor Antagonist to Block Opioid Reinforcement, Relapse and Physical Dependence1R43DA050349-01RUFF, MICHAEL RCREATIVE BIO-PEPTIDES, INC., MD$321,800ZDA1
2019Screen molecules modulating MOR trafficking with a newly developed MOR/14-3-3 bioassay.1R43DA050264-01EISHINGDRELO, HAIFENGBIOINVENU CORPORATION, NJ$321,000ZDA1
2019Remote vital sign and opioid overdose detection via a non-invasive wearable sensing patch1R43DA050344-01LI, JIANGVIVALNK, INC., CA$299,814ZDA1
2019Development of cannabinoid-opioid combination with opioid sparing and synergistic analgesic effects to prevent opioid use disorder and overdose.1R43DA050397-01BRIONES, MARISABDH PHARMA, LLC, CA$283,935ZDA1
2019NarcoBond: Opioid Targeted Biomimetic Nanosponges for Treatment of Opioid Overdose1R43DA050384-01ESMAELI-AZAD, BABAKCIBOTS, INC., CA$254,039ZDA1
2019NeoGUARD: An easy-to-use, low-cost brain monitor for objective screening and treatment of opioid-exposed infants1R43DA049620-01ZIKOV, TATJANANEUROWAVE SYSTEMS, INC., OH$244,569ZDA1
2019Connected Pharmacy Platform to Improve Adherence to Buprenorphine-Naloxone Prescription Treatment of Opioid Use Disorder1R44DA049629-01LEBRUN, JEFFREYMCPHERSON, STERLING MOPTIMIZE SYSTEMS INC, WA$234,570ZDA1
2019Opioid-Sparing pain management for Chronic Low Back Pain patients using TMC-CP01 - A VANISH (Virtual Autonomic Neuromodulation Induced Systemic Healing) based program1R44DA049630-01LUCAS, GALEMAHAJAN, AMANTIEN, CELINETAMADE, LLC, CA$225,000ZDA1
2019At-Home Virtual Reality Guided Imagery Intervention for Chronic Pain1R43DA049617-01LEWIS, BENJAMINRICHEIMER, STEVEN HLIMBIX HEALTH, INC., CA$225,000ZDA1
2019Development and Evaluation of Computerized Chemosensory-Based Orbitofrontal Cortex Training (CBOT) for relapse preventionin patients with Opioid Use (OUD)1R43DA049616-01LAWSON, WILLIAM BRADFORDNWULIA, EVARISTUS AEVON MEDICS, LLC, MD$225,000ZDA1
2019A Novel Workflow to Screen for Illicit Drug Exposure in Newborns1R44DA050375-01KENNEDY, ADAM DAVIDBAEBIES, INC., NC$224,999ZDA1
2019Neurofeedback-EEG-VR (NEVR) System for Non-opioid Pain Therapy1R43DA050380-01SOUSSOU, WALIDQUASAR, INC., CA$224,942ZDA1
2019A Project to Test The Efficacy And Safety Of An Innovative Treatment Of Opiate Use Disorders1R43DA050358-01SCHIFFER, FREDRICTEICHER, MARTIN HMINDLIGHT, LLC, MA$224,907ZDA1
2019A universal approach for improving the limit of detection for fentanyl and fentanyl derivatives in urine1R43DA050338-01LEPENE, BENJAMIN SCOTTCERES NANOSCIENCES, LLLP, VA$224,750ZDA1
2019Transforming smartphones into active sonar systems to detect opioid overdose1R44DA050339-01MARK, NICHOLAS MAXWELLSOUND LIFE SCIENCES, INC., WA$223,507ZDA1
2019Non-invasive Neuromodulation Device for Decreasing Withdrawal Symptoms and Craving during Treatment of Opioid Use Disorder1R43DA049623-01BURNETT, DANIEL ROGERSTHERANOVA, LLC, CA$223,176ZDA1
2019Fixed dose analgesic combination with non-opioid mechanism to prevent opioid misuse1R43DA050395-01GOMTSIAN, ARTOURSYNVENTA, LLC, AZ$222,276ZDA1
2019Addressing Opioid Use Disorder with an External Multimodal Neuromodulation Device: Development and Clinical Evaluation of DuoTherm for Opioid-Sparing in Acute and Chronic Low Back Pain.1R44DA049631-01BAXTER, AMY LYNNMMJ LABS, LLC, GA$221,959ZDA1
2019An optimized screening platform for identifying and quantifying biased agonists as drugs for the treatment of Opioid Use Disorder1R44DA050357-01HUGHES, THOMAS EQUINN, ANNE MARIEMONTANA MOLECULAR, LLC, MT$221,097ZDA1
2019Evaluating the Usability, Efficacy and Commercial Utility of a Digital Platform to Deliver Comprehensive Treatment for Opioid Use Disorder1R44DA050354-01PAPES, STEPHANIEBOULDER CARE, INC., OR$220,921ZDA1
2019Transcutaneous auricular neurostimulation for neonatal abstinence syndrome1R43DA050360-01JENKINS, DOROTHEA DENISEKHODAPARAST, NAVIDSPARK BIOMEDICAL INC, TX$217,690ZDA1

Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-09-0.1.0. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

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