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NIH funding notice RFA-DA-20-025

Step Up for Substance Use Disorders (SUD): A Drug Target Initiative for Scientists Engaged in Fundamental Research (U18 - Clinical Trial Not Allowed)

Closed on February 13, 2020.

Posted
November 14, 2019
Close date
February 13, 2020
Activity codes
Not stated on the notice page
Institutes taking part
Not stated on the notice page

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

Its page was not saved, so the notices it replaced are not known.

Who won it before

32 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $7,697,710 in first-year total cost, median $239,225.

Most frequent study sections

  1. Special Emphasis Panel[ZDA1 SKM-D (06)]12
  2. Special Emphasis Panel[ZDA1 TXT-V (01)]10
  3. Special Emphasis Panel[ZDA1 TXT-V (05)]10

Most frequent institutions

  1. UNIVERSITY OF TEXAS MED BR GALVESTON4
  2. RESEARCH TRIANGLE INSTITUTE3
  3. JOHNS HOPKINS UNIVERSITY2
  4. MCLEAN HOSPITAL2
  5. OREGON HEALTH & SCIENCE UNIVERSITY2
Competing awards under RFA-DA-20-025 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2021Targeting Leptin Pathway to Treat Opioid-Induced Respiratory Depression1U18DA052301-01POLOTSKY, VSEVOLOD YJOHNS HOPKINS UNIVERSITY, MD$259,438ZDA1
2021Characterization GPR83 and identification of small molecule ligands targeting this receptor for the treatment of substance use disorders.1U18DA052345-01DEVI, LAKSHMI AICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$247,028ZDA1
2021Glycosylated Endomorphin Analogs for Treatment of Opioid Use Disorder (OUD)1U18DA052539-01ZADINA, JAMES ETULANE UNIVERSITY OF LOUISIANA, LA$241,450ZDA1
2021Regulator of G protein Signaling-12 (RGS12) as a target for SUD therapeutics development1U18DA052497-01SETOLA, VINCENTWEST VIRGINIA UNIVERSITY, WV$222,568ZDA1
2021Novel modulators of α7 nAChRs as treatments for nicotine reward1U18DA052553-01BEATON, GRAHAMFORSTER, MICHAEL J.UTESHEV, VICTOR VEPIGEN BIOSCIENCES, INC., CA$192,907ZDA1
2020Strategy for synthetic cannabinoid abuse and toxicity1U18DA052495-01MAITRA, RANGANRESEARCH TRIANGLE INSTITUTE, NC$352,851ZDA1
2020Development of GPR3 probes as a novel target for nicotine cessation1U18DA052416-01GAY, ELAINE ARRINGTONRESEARCH TRIANGLE INSTITUTE, NC$316,773ZDA1
2020Targeting organic cation transporter 3 in treatment of substance use disorders1U18DA052527-01DAWS, LYNETTE CUNIVERSITY OF TEXAS HLTH SCIENCE CENTER, TX$296,485ZDA1
2020Validation of Neuropeptide FF Receptors as Targets for Methamphetamine Use Disorder1U18DA052414-01NGUYEN, THUYRESEARCH TRIANGLE INSTITUTE, NC$266,775ZDA1
2020Targeting Cav1.2 to treat Ketamine-Induced Pathology1U18DA052346-01YU, WEIQUNBETH ISRAEL DEACONESS MEDICAL CENTER, MA$262,500ZDA1
2020Dimethyl fumarate attenuation of opioid withdrawal symptom severity1U18DA052344-01KAUFMAN, MARC JMCLEAN HOSPITAL, MA$245,993ZDA1
2020Erythropoietin and Melatonin Combination Therapy for Perinatal Opioid-Induced Brain Injury1U18DA052402-01JANTZIE, LAUREN LEIGH COONEYJOHNS HOPKINS UNIVERSITY, MD$245,625ZDA1
2020Pharmacological Characterization of KCC2 as a Target for Cocaine Use Disorder1U18DA052399-01DANI, JOHN A.UNIVERSITY OF PENNSYLVANIA, PA$243,188ZDA1
2020Synaptic vesicle glycoprotein 2C (SV2C) and psychostimulant actions1U18DA052498-01MILLER, GARY WCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$242,269ZDA1
2020Stimulation of an ectopic olfactory receptor to reverse ventilatory depression induced by opioids1U18DA052505-01CHANG, ANDY J.UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$242,250ZDA1
2020Validation and pharmacological profiling of a non-psychoactive THC analog, a novel and selective CB2 receptor agonist, in proof of concept studies using rodent models of heroin addiction1U18DA052415-01BARRON, ANNELISE EMILYSHAMLOO, MEHRDADSTANFORD UNIVERSITY, CA$241,871ZDA1
2020Nanodelivery therapeutic systems for substance use disorder1U18DA052394-01BAHAL, RAMANUNIVERSITY OF CONNECTICUT STORRS, CT$241,500ZDA1
2020A novel functionally selective drug for the treatment of cocaine abuse by antagonism of the beta-arrestin signaling arm of the Ghrelin Receptor1U18DA052417-01BARAK, LAWRENCE S.DUKE UNIVERSITY, NC$241,500ZDA1
2020FGF13: a novel druggable target for treating substance abuse disorders1U18DA052504-01LAEZZA, FERNANDAUNIVERSITY OF TEXAS MED BR GALVESTON, TX$237,000ZDA1
2020Validation of GPR52 agonists as a therapeutic approach for stimulant use disorders1U18DA052543-01ALLEN, JOHN AUNIVERSITY OF TEXAS MED BR GALVESTON, TX$237,000ZDA1
2020AMPAkines for Novel Opioid Use Disorder Pharmacotherapy1U18DA052545-01ANASTASIO, NOELLE CCUNNINGHAM, KATHRYN A.ZHOU, JIAUNIVERSITY OF TEXAS MED BR GALVESTON, TX$237,000ZDA1
2020BRD4 Inhibition for Opioid Pharmacotherapy1U18DA052546-01ANASTASIO, NOELLE CCUNNINGHAM, KATHRYN A.ZHOU, JIAUNIVERSITY OF TEXAS MED BR GALVESTON, TX$237,000ZDA1
2020Negative allosteric modulators for the management of Opioid Use Disorder1U18DA052371-01ALT, ANDREWTRAYNOR, JOHN R.UNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$234,000ZDA1
2020Pharmacological activators of Nr4a1 for the treatment of cocaine use disorders1U18DA052513-01HELLER, ELIZABETH AUNIVERSITY OF PENNSYLVANIA, PA$233,112ZDA1
2020Targeting astrocyte iNOS to inhibit cocaine-induced neurovascular deficits in PFC1U18DA052366-01DU, CONGWUYIN, WEISTATE UNIVERSITY NEW YORK STONY BROOK, NY$232,524ZDA1
2020Reduction of psychostimulant craving through positive allosteric modulation of mGlu11U18DA052488-01WOLF, MARINA ELIZABETHOREGON HEALTH & SCIENCE UNIVERSITY, OR$230,471ZDA1
2020VALIDATING THE NOCICEPTIN RECEPTOR FOR TREATING CRAVING AND WITHDRAWAL-ASSOCIATED AFFECT IN COCAINE ADDICTION PHARMACOTHERAPY1U18DA052559-01ZAVERI, NURULAIN TASTRAEA THERAPEUTICS, LLC, CA$229,620ZDA1
2020Validation of ghrelin hydrolysis as an effective approach to treatment of substance use disorders1U18DA052319-01ZHENG, FANGUNIVERSITY OF KENTUCKY, KY$229,500ZDA1
2020BRD4 Inhibitor1U18DA052533-01WAHLESTEDT, CLAES ROBERTUNIVERSITY OF MIAMI SCHOOL OF MEDICINE, FL$219,528ZDA1
2020Dual Fatty Acid Amide Hydrolase (FAAH) and Monoacyglycerol Lipase (MAGL) Inhibitors as Novel Agents for Treatment of Cannabis Use Disorder (CUD)1U18DA052537-01ALAPAFUJA, SHAKIRU OLAJIREMAKSCIENTIFIC, LLC, MA$218,855ZDA1
2020Validation of CD74 as a treatment target for methamphetamine use disorder1U18DA052351-01HUCKANS, MARILYNLOFTIS, JENNIFER MOREGON HEALTH & SCIENCE UNIVERSITY, OR$199,362ZDA1
2020New Therapeutics for Treating Cocaine Addiction Targeting D1-D2 Heteromers1U18DA052509-01SROMEK, ANNA WACLAWAMCLEAN HOSPITAL, MA$119,767ZDA1

Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-09-0.1.0. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

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