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NIH funding notice RFA-DA-23-021

Developing Regulated Therapeutic and Diagnostic Solutions for Patients Affected by Opioid and/or Stimulants use Disorders (OUD/StUD) (R43/R44 - Clinical Trial Optional)

Closed on February 14, 2025.

Posted
March 28, 2022
Close date
February 14, 2025
Activity codes
Not stated on the notice page
Institutes taking part
Not stated on the notice page

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

Its page was not saved, so the notices it replaced are not known.

Who won it before

38 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $19,589,340 in first-year total cost, median $326,455.

Most frequent study sections

  1. Special Emphasis Panel[ZDA1 SAI-S (A1)]13
  2. Special Emphasis Panel[ZDA1 SUY-S (J1)]12
  3. Special Emphasis Panel[ZDA1 GXM-A (J1)]8
  4. Special Emphasis Panel[ZDA1 SUY-S (A1)]5

Most frequent institutions

  1. AUTONOMOUS HEALTHCARE, INC.2
  2. INSTANOSIS, INC.2
  3. ACTIOX LLC1
  4. AFASCI, INC.1
  5. AKINA, INC.1
Competing awards under RFA-DA-23-021 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2025A Rapid, Sensitive and Instrument-free Oral Fluid Fentanyl Test1R44DA061963-01WANG, PINGXIA, XIAOFENGINSTANOSIS, INC., DE$1,576,513ZDA1
2025Phase 0/1b Clinical Trial of Novel Therapeutic Agent MT-110 for the Reduction of Methamphetamine Use - Part 21R44DA063266-01YOUNG, ERICA JMYOSIN THERAPEUTICS INC., FL$1,496,586ZDA1
2025Noncontact Monitoring for the Detection of Opioid-Induced Respiratory Depression2R44DA058470-02GHOLAMI, BEHNOODAUTONOMOUS HEALTHCARE, INC., CA$1,157,858ZDA1
2025Wireless Wearable with AI Analytics for Monitoring Neonatal Abstinence Syndrome (NAS)1R44DA060640-01A1SHARAREH, SHIVAREKOVAR INC., CA$411,800ZDA1
2025Building a Contextually Triggered Just-in-Time Intervention for Opioid UseDisorder: Stakeholder Evaluation and User Centered Design1R43DA060641-01A1ALLEN, NICHOLAS BKSANA HEALTH, INC., OR$406,451ZDA1
2025Advancing FGF13-Nav1.6 modulators to normalize Nucleus Accumbens activity for Cocaine Use Disorder1R43DA063261-01LIJFFIJT, MARIJNIONTX INC., TX$400,000ZDA1
2025User-Centric Development of a Detection Module for a Closed-Loop Solution to Opioid Overdose1R43DA063255-01LE, VYLEE, HYOWONRESCUE BIOMEDICAL, LLC, IN$399,715ZDA1
2025Developing high-precision epigenetic therapeutics for opioid use disorder1R43DA063250-01CHOI, SOONGANGBOSTON INTERACTOME LLC, MA$398,137ZDA1
2025Identification of therapeutic molecules to treat amphetamine use disorders using our DNA-encoded library (DEL) technology1R43DA061909-01FLAJOLET, MARCJILLION THERAPEUTICS INC., NY$398,093ZDA1
2025Rapid Fingerstick Diagnostics for Opioid and Stimulant Use Disorders1R43DA063260-01ERVIN, ERICELECTRONIC BIOSCIENCES, INC., CA$386,452ZDA1
2025COPA: A clinical program to evaluate benefits of a hand-held, automated, personalized oral liquid dispensing system for take-home methadone medication management for patients with opioid use disorder.1R44DA061908-01A1TIMBERLAKE, JOHNBERKSHIRE BIOMEDICAL CORPORATION, TX$326,410ZDA1
2025Etimizol for reversal of Xylazine-fentanyl respiratory depression1R43DA061953-01GOMTSIAN, ARTOURSYNVENTA, LLC, AZ$277,389ZDA1
2024A Novel Reversal Agent for Treatment of Overdose from the Combination of Fentanyl and Xylazine2R44DA056272-02LI, XINHUACLEAR SCIENTIFIC, LLC, MA$1,462,687ZDA1
2024Decentralized clinical trial of contingency management digital therapeutic to treat stimulant use disorder1R44DA059519-01GASTFRIEND, DAVID RRASH, CARLA JDYNAMICARE HEALTH, INC., MA$1,076,018ZDA1
2024Development of small molecule therapeutics for mitigating opioid withdrawal syndrome2R44DA053844-02LABED, SID AHMEDEVODENOVO, INC., MA$880,957ZDA1
2024Rapid, Instrument-free and High Sensitivity Over-the-counter Urine Fentanyl Testing1R44DA060647-01WANG, PINGXIA, XIAOFENGINSTANOSIS, INC., DE$403,636ZDA1
2024Software as a Medical Device for detecting opioid use through voice.1R43DA060696-01SEIILOVA-OLSON, RIMATENVOS INC., CA$400,000ZDA1
2024Developing a wearable medical device to detect opioid overdose1R44DA060643-01HOLDEN, BRADFORD ARESILIENT LIFESCIENCE, INC., PA$399,589ZDA1
2024Investigation of a Novel PDE4B Inhibitor for Stimulant Use Disorder1R43DA060646-01LACKOVIC, JACOB EDWARDVARADHACHARY, ATULFANNIN PARTNERS, LLC, TX$320,000ZDA1
2024Stimulant Use Recovery Via Immersive Virtual Environments (SURVIVE)1R43DA059490-01BRACKEN, BETHANY KCHARLES RIVER ANALYTICS, INC., MA$319,988ZDA1
2024Development of a Machine Learning Algorithm to Detect Opioid Withdrawal and Cravings to Increase Treatment Retention1R43DA059448-01KHODAPARAST, NAVIDSPARK BIOMEDICAL INC, TX$318,875ZDA1
2024Mechanism and Efficacy of a Novel Opioid Adjuvant1R43DA059522-01MEYN, MALCOLM AAMALGENT THERAPEUTICS, INC., NC$220,668ZDA1
2023IND-enabling development of a long-duration antagonist to treat opioid overdose2R44DA050386-02ZANA, LAWRENCE JCONSEGNA PHARMA, INC., PA$1,330,781ZDA1
2023Cue-induced drug craving monitoring for opioid use disorder with visual evoked potentials1R44DA059517-01BURWELL, SCOTTNEUROTYPE INC., MN$328,963ZDA1
2023Modular Virtual Reality Therapeutic for Opioid and Stimulant Use Disorders1R44DA059475-01WASHBURN, MICHELLE (MICKI) EZIEMBA, PAULINNATEVR, LLC, MI$326,500ZDA1
2023Wearable Wireless Respiratory Monitoring System that Detects and Predicts Opioid Induced Respiratory Depression1R44DA059491-01BOSAK, MAGDALENA KIRLAKOVSKYRTM VITAL SIGNS, LLC, PA$325,601ZDA1
2023Predicting and Preventing Adverse Maternal and Child Outcomes of Opioid Use Disorder in Pregnancy1R43DA058430-01PLUMP, STEVEN R.SADHASIVAM, SENTHILKUMAROPALGENIX, INC., IN$325,239ZDA1
2023Noncontact Remote Monitoring for the Detection of Opioid-Induced Respiratory Depression1R43DA058470-01GHOLAMI, BEHNOODAUTONOMOUS HEALTHCARE, INC., CA$325,001ZDA1
2023Injectable 3-month buprenorphine PLGA microparticle formulation1R43DA058410-01PARK, HAESUNAKINA, INC., IN$320,000ZDA1
2023Novel formulation technology for the sustained release naloxone to improve outcomes in the management of opioid overdose1R43DA058477-01A1TORRES LUNA, CESARLYNTHERA CORPORATION, PA$320,000ZDA1
2023Development of a Novel Calcium Channel Therapeutic for Opioid Use Disorder1R44DA058467-01GREENBERG, MILTON LVIVREON BIOSCIENCES, LLC, CA$319,991ZDA1
2023BoostPrime, A Novel Digital Therapeutic for Craving Mitigation in OUD1R44DA058531-01PATEL, SALILNXTECH INC, TX$319,915ZDA1
2023A wearable device for continuous monitoring of methadone1R43DA059516-01TEHRANI, FARSHADACTIOX LLC, CA$319,754ZDA1
2023Development of the OpiAID strength band platform1R44DA058474-01MACQUEEN, DAVID ALDERSONREESER, DAVIDWASHINGTON, WENDY DONLINOPIAID, INC., NC$319,589ZDA1
2023Developing a novel treatment of cocaine use disorder using an IND dual inhibitor of Cav3 channel and soluble epoxide hydrolase1R43DA059524-01XIE, XINMIN SIMONAFASCI, INC., CA$319,547ZDA1
2023Development of an AI-empowered device that utilizes multimodal data-visualization to aid in the diagnosis, and treatment, of OUD1R44DA058431-01OAKLEY, DAVIDWAVI COMPANY, CO$319,080ZDA1
2023Therapeutic Monitoring System (TMS)1R44DA059523-01SCHMIDLE, PATRIKCARI HEALTH, INC., CA$318,257ZDA1
2023Development of compound RUEC2-118, a novel partial GABAAR positive modulator, a fast-acting treatment for general anxiety and panic disorder, to prevent opioid and benzodiazepine overdose fatalities.1R41DA058472-01CARRY, EILEENZENA THERAPEUTICS INC., NJ$313,300ZDA1

Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-09-0.1.0. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

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RFA-DA-23-021: Developing Regulated Therapeutic and Diagnostic Solutions for Patients Affected by Opioid and/or Stimulants use Disorders (OUD/StUD) (R43/R44 - Clinical Trial Optional) | ScienceDex | ConductScience