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NIH funding notice RFA-DA-28-013

Neural Ensembles & Used Substances (NExUS) Collaboratory: Building a Multimodal Inventory of Cell Ensembles Encoding the Effects of Addictive Substances (U01 Clinical Trial Not Allowed)

Open. Closes February 8, 2027.

Posted
October 9, 2026
Close date
February 8, 2027
Activity codes
U01
Institutes taking part
NIDA

Read the notice on Grants.gov

The notices it replaced

  1. Reissues: RFA-DA-25-023 Integrated Functional Mapping and Molecular Profiling of Cell Ensembles Encoding the Effects of Addictive Substances in Rodents (R01 Clinical Trial Not Allowed)
  2. 2 steps back: RFA-DA-23-035 Large Scale Integrated Mapping and Molecular Profiling of Cell Ensembles and/or Cell-Types Mediating Opioid Action in the Rodent Brain (R01 - Clinical Trial Not Allowed)
  3. 3 steps back: RFA-DA-22-011 Large Scale Mapping and/or Molecular Profiling of Ensembles and/or Cell-Types Mediating Opioid Action in the Rodent Brain (R01 - Clinical Trial Not Allowed)
  4. 4 steps back: PAR-20-241 Large scale mapping and/or molecular profiling of ensembles and/or cell-types mediating opioid action in the rodent brain (R01 - Clinical Trial Not Allowed)
  5. 5 steps back: PAR-20-182 Large scale mapping and/or molecular profiling of ensembles and/or cell-types mediating opioid action in the rodent brain (R01 - Clinical Trial Not Allowed)

Who won it before

13 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $10,547,244 in first-year total cost, median $765,953.

Most frequent study sections

  1. Special Emphasis Panel[ZDA1 BSW-N (A1)]4
  2. Special Emphasis Panel[ZRG1 ETTN-B (55)]4
  3. Special Emphasis Panel[ZDA1 SXC-G (03)]3
  4. Special Emphasis Panel[ZDA1 CEM-N (O1)]2

Most frequent institutions

  1. UNIVERSITY OF PENNSYLVANIA2
  2. UNIVERSITY OF WASHINGTON2
  3. MASSACHUSETTS INSTITUTE OF TECHNOLOGY1
  4. MEDICAL UNIVERSITY OF SOUTH CAROLINA1
  5. SCRIPPS RESEARCH INSTITUTE, THE1
Competing awards under RFA-DA-28-013 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2025Molecular determinants of ensemble recruitment by drugs of abuse1R01DA062024-01 · under RFA-DA-25-023CALIPARI, ERINVANDERBILT UNIVERSITY, TN$1,159,396ZDA1
2025Multiplexed dissection of neuronal ensembles in circuits that underlie the facilitation and disinhibition of opioid and alcohol seeking1R01DA062041-01 · under RFA-DA-25-023BERTO, STEFANOCOWAN, CHRISTOPHER WOTIS, JAMES MRINKER, JENNIFER ANNEMEDICAL UNIVERSITY OF SOUTH CAROLINA, SC$1,039,420ZDA1
2023Mapping brain-wide opioid actions by profiling neuronal activities and in vivo cellular target engagement1R01DA059393-01 · under RFA-DA-23-035BOHN, LAURA M.SHENVI, RYAN ASHOKYE, LISCRIPPS RESEARCH INSTITUTE, THE, CA$839,850ZDA1
2023Ventral pallidal transcriptional adaptations underlying punishment-resistant opioid intake1R01DA056829-01A1 · under RFA-DA-23-035CREED, MEAGHAN CSAMINENI, VIJAY KWASHINGTON UNIVERSITY, MO$808,852ZDA1
2023Integrative single-cell spatial transcriptomic, anatomical, and functional profiling of brain-wide ensembles engaged by opioid relapse1R01DA059374-01 · under RFA-DA-23-035GOLDEN, SAMGU, LIANGCAINEUMAIER, JOHN FSTEINMETZ, NICHOLASUNIVERSITY OF WASHINGTON, WA$801,537ZDA1
2023Multi-modal profiling of spatially resolved cell types mediating opioid withdrawal1R01DA059602-01 · under RFA-DA-23-035BINTU, BOGDANCHEN, XIAOKEZHU, QUANSTANFORD UNIVERSITY, CA$765,953ZDA1
2022Circuitry dynamics underlying opioid-dependence: Integrating structural, functional, and transcriptomic mechanisms1R01DA056599-01 · under RFA-DA-22-011BASSETT, DANIELLE SMITHBEIER, KEVIN TBLENDY, JULIE ACORDER, GREGORYUNIVERSITY OF PENNSYLVANIA, PA$753,253ZDA1
2022Genomic profiling mediating the protective effect of social reward on opioid craving1R01DA056440-01 · under RFA-DA-22-011AMENT, SETH ABRAMSLOBO, MARY KAYVENNIRO, MARCOUNIVERSITY OF MARYLAND BALTIMORE, MD$684,285ZDA1
2022Single-Cell Dissection of Ensembles and Cell Types Mediating Opioid Action in the Rodent Brain1R01DA054584-01 · under PAR-20-241ALVAREZ, VERONICA AHEIMAN, MYRIAMKELLIS, MANOLISMASSACHUSETTS INSTITUTE OF TECHNOLOGY, MA$616,630ZRG1
2022Multiomic profiling of cell types mediating opioid use disorder in rats1R01DA056602-01 · under RFA-DA-22-011TELESE, FRANCESCAUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$554,504ZDA1
2021A comprehensive dissection of cell types, circuits and molecular adaptations during opioid use1R01DA054583-01 · under PAR-20-241SCHERRER, GREGORYSCHNITZER, MARK JZENG, HONGKUIUNIV OF NORTH CAROLINA CHAPEL HILL, NC$1,437,329ZRG1
2021Transcriptional, functional, and circuit profiling at single cell resolution of neuronal ensembles engaged by heroin relapse1R01DA054317-01 · under PAR-20-241FERGUSON, SUSAN MARIESTUBER, GARRET DUNIVERSITY OF WASHINGTON, WA$569,937ZRG1
2021Mapping opioid-dependence state transitions across structural, functional, and transcriptomic topologies1R01DA054374-01 · under PAR-20-241BLENDY, JULIE ACORDER, GREGORYUNIVERSITY OF PENNSYLVANIA, PA$516,298ZRG1

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