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NIH funding notice RFA-HL-26-017

Catalyze: Product Definition for Small Molecules, Biologics and Combination Products - Target Identification and Validation, and Preliminary Product/Lead Series Identification (R61/R33 Clinical Trials Not Allowed)

Open. Closes December 23, 2027.

Posted
November 22, 2024
Close date
December 23, 2027
Activity codes
R61, R33
Institutes taking part
NHLBI, NIAID

The notices it replaced

2 notices since 2019, oldest first, each with its awards since FY2014.

  1. Posted 2019RFA-HL-20-0239 awards
  2. Posted 2022RFA-HL-23-01117 awards
  3. Posted 2024RFA-HL-26-017This notice, open · 4 awards

Who won it before

Competing awards, new and renewals, since FY2014, under this notice and the notices it replaced.

Past awards
30
30 new
Median first-year cost
$553,600
$16,596,155 in all
Institutions
25
30 contact PIs

Awards by fiscal year

Fiscal years 2014 to 2026.

Most frequent institutions

  1. UNIVERSITY OF CALIFORNIA, SAN FRANCISCO3
  2. CLEVELAND CLINIC LERNER COM-CWRU2
  3. EMORY UNIVERSITY2
  4. VIRGINIA COMMONWEALTH UNIVERSITY2
  5. BAYLOR COLLEGE OF MEDICINE1

and 20 other institutions

Most frequent study sections

  1. Special Emphasis Panel (ZHL1 CSR-F (J1))4
  2. Special Emphasis Panel (ZHL1 CSR-F (O1))4
  3. Special Emphasis Panel (ZHL1 CSR-E (J1))3
  4. Special Emphasis Panel (ZHL1 CSR-E (O1))3
  5. Special Emphasis Panel (ZHL1 CSR-F (F1))3

and 9 other study sections

30 awards under RFA-HL-26-017 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
FY2026Targeted control of mitochondrial biogenesis as a therapy for heart failure1R61HL183015-01A1Ghanta, Ravi KHilton, IsaacRICE UNIVERSITY, TXFirst-year cost $638,014Study section ZRG1
FY2026Small Molecule Drug Discovery for Cardiac Fibrosis using AI/ML and iPSC-Derived Organoids1R61HL179715-01A1Pang, PaulGREENSTONE BIOSCIENCES, INC., CAFirst-year cost $625,968Study section ZRG1
FY2026Small molecule therapeutics for heart failure through a reduction in the activity of tristetraprolin and improving cardiac metabolism.1R61HL179722-01A1Ardehali, HosseinSchiltz, Gary EUNIVERSITY OF ARIZONA, AZFirst-year cost $562,733Study section ZRG1
FY2026Recombinant hemopexin for the treatment of acute and chronic lung injury1R61HL179700-01A1Matalon, SadisUNIVERSITY OF ALABAMA AT BIRMINGHAM, ALFirst-year cost $519,785Study section ZRG1
FY2025AAV therapies for TNNT2-associated cardiac disorders1R61HL181756-01 · under RFA-HL-23-011Hinson, John TravisUNIVERSITY OF CONNECTICUT SCH OF MED/DNT, CTFirst-year cost $611,014Study section ZHL1
FY2025Triple Gene Therapy for Ischemic Heart Failure1R61HL177472-01 · under RFA-HL-23-011Mohamed, Tamer M ARosengart, Todd KBAYLOR COLLEGE OF MEDICINE, TXFirst-year cost $560,000Study section ZHL1
FY2025Screening of novel compounds through the reversal of gene expression in idiopathic pulmonary fibrosis1R61HL177451-01 · under RFA-HL-23-011Chen, BinLi, XiaopengHENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES, MIFirst-year cost $542,402Study section ZHL1
FY2025Liposomal azithromycin to treat cardiac inflammation1R61HL177474-01 · under RFA-HL-23-011Abdel Latif, AhmedFeola, DavidVenditto, Vincent JosephUNIVERSITY OF KENTUCKY, KYFirst-year cost $542,094Study section ZHL1
FY2025Development of Novel RhoA Nitration Inhibitory Peptides for the Treatment of Acute Lung Injury1R61HL171783-01A1 · under RFA-HL-23-011Black, Stephen MFLORIDA INTERNATIONAL UNIVERSITY, FLFirst-year cost $516,250Study section ZHL1
FY2025Concurrent targeting of inflammation and the inhibition of the fibrinolytic system to increase the efficacy of empyema treatment1R61HL175690-01A1 · under RFA-HL-23-011Komissarov, AndreySigalov, Alexander BUNIVERSITY OF TEXAS HLTH CTR AT TYLER, TXFirst-year cost $499,585Study section ZHL1
FY2025Cobinamide as a disease-modifying treatment for Marfan Syndrome: optimizaation of absorption1R61HL175687-01A1 · under RFA-HL-23-011Boss, Gerry RDretchen, KennethUNIVERSITY OF CALIFORNIA, SAN DIEGO, CAFirst-year cost $405,781Study section ZHL1
FY2024Adeno-associated virus-mediated SGPL1 gene therapy as a first-in-class treatment for idiopathic pulmonary fibrosis that acts by reducing sphingosine-1-phosphate and downstream profibrotic signaling1R61HL171786-01 · under RFA-HL-23-011Saba, Julie DUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CAFirst-year cost $565,250Study section ZHL1
FY2024Small Molecule Therapeutic for Heart Failure1R61HL171717-01 · under RFA-HL-23-011Josyula, Vara Prasad VnPrasad, Sathyamangla VCLEVELAND CLINIC LERNER COM-CWRU, OHFirst-year cost $563,500Study section ZHL1
FY2024Development of a first-in-class complement inhibitor for treating complement-mediated hematologic diseases1R61HL171747-01A1 · under RFA-HL-23-011Lin, Feng CCLEVELAND CLINIC LERNER COM-CWRU, OHFirst-year cost $563,500Study section ZHL1
FY2024Optimizing ELD607 for Delivery by Inhalation1R61HL173911-01 · under RFA-HL-23-011Tarran, RobertUNIVERSITY OF KANSAS MEDICAL CENTER, KSFirst-year cost $542,500Study section ZHL1
FY2024P7C3 based small molecule for Heart failure treatment1R61HL170457-01A1 · under RFA-HL-23-011Tipparaju, Srinivas M.UNIVERSITY OF SOUTH FLORIDA, FLFirst-year cost $517,475Study section ZHL1
FY2023Development of tolerogenic Factor VIII as immunotherapy to prevent inhibitor development in Hemophilia A1R61HL161818-01A1 · under RFA-HL-23-011Balu-Iyer, Sathy VenkatSTATE UNIVERSITY OF NEW YORK AT BUFFALO, NYFirst-year cost $575,469Study section ZHL1
FY2023Targeting Integrin Signaling in Atherosclerosis1R61HL168737-01 · under RFA-HL-23-011Biediger, Ronald JWoodside, Darren GTEXAS HEART INSTITUTE, TXFirst-year cost $572,082Study section ZHL1
FY2023Small Molecule Therapeutics for Sickle Cell Anemia1R61HL163743-01A1 · under RFA-HL-23-011Archer, David REMORY UNIVERSITY, GAFirst-year cost $547,199Study section ZHL1
FY2023Small molecule allosteric inhibitors of PCSK9 processing to phenocopy cardioprotective genetic variants.1R61HL170383-01 · under RFA-HL-23-011Chorba, John SUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CAFirst-year cost $537,538Study section ZHL1
FY2023Optimizing function-selective ERK1/2 inhibitors for reducing AP-1-mediated airway pathology in asthma.1R61HL168723-01 · under RFA-HL-23-011Deshpande, Deepak AShapiro, Paul SUNIVERSITY OF MARYLAND BALTIMORE, MDFirst-year cost $524,977Study section ZHL1
FY2022Optimization of fibroblast-selective inhibitors of YAP/TAZ as novel therapeutics for Pulmonary Fibrosis1R61HL161804-01 · under RFA-HL-20-023Haak, Andrew JonHeynen-Genel, SusanneSANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, CAFirst-year cost $643,499Study section ZHL1
FY2022Mitigation of Exaggerated Smooth Muscle Force with Inhibitors of Integrin Alpha2Beta11R61HL163725-01 · under RFA-HL-20-023Jo, HyunilSundaram, Aparna BalaUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CAFirst-year cost $565,250Study section ZHL1
FY2022Lead identification and pre-clinical studies on allosteric inhibitors of coagulation factor XIa1R61HL161813-01 · under RFA-HL-20-023Desai, Umesh RamanlalVIRGINIA COMMONWEALTH UNIVERSITY, VAFirst-year cost $543,375Study section ZHL1
FY2022Novel Gene Therapy for Critical Limb Ischemia and Limb Salvage in Vascular Occlusive Disease1R61HL156152-01A1 · under RFA-HL-20-023Liu, Zhao-JunVelazquez, Omaida CUNIVERSITY OF MIAMI SCHOOL OF MEDICINE, FLFirst-year cost $533,251Study section ZHL1
FY2022Preclinical development of a nuclear-targeting biologic that safely increases stem cell expansion in vivo to accelerate recovery from neutropenia after chemotherapy and bone marrow transplant1R61HL163739-01 · under RFA-HL-20-023Elser, Jeremy ASHIP OF THESEUS, LLC, PAFirst-year cost $457,450Study section ZHL1
FY2021Functional assay development for tafazzin enzyme replacement candidate selection1R61HL154137-01A1 · under RFA-HL-20-023Chin, Michael TTUFTS MEDICAL CENTER, MAFirst-year cost $623,000Study section ZHL1
FY2021Targeted Identification of Dual Acting Antisickling Agents for Sickle Cell Disease Therapy1R61HL156158-01 · under RFA-HL-20-023Abdulmalik, Osheiza YSafo, Martin KVIRGINIA COMMONWEALTH UNIVERSITY, VAFirst-year cost $575,593Study section ZHL1
FY2020Sudaxine as an analgesia sparing respiratory stimulant for use in critical care1R61HL154136-01 · under RFA-HL-20-023Gaston, BenjaminLewis, Stephen JohnINDIANA UNIVERSITY INDIANAPOLIS, INFirst-year cost $575,621Study section ZHL1
FY2020Human iPSC-derived endothelial cells as Vascular Therapeutics1R61HL154116-01 · under RFA-HL-20-023Yoon, Young-SupEMORY UNIVERSITY, GAFirst-year cost $546,000Study section ZHL1
Newest fiscal year first, then first-year cost.

Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-13-0.3.2. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

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