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NIH funding notice RFA-NS-27-015

BRAIN Initiative Connectivity across Scales (BRAIN CONNECTS): Specialized Projects for Scalable Technologies (U01 Clinical Trial Not Allowed)

Open. Closes October 4, 2027.

Posted
May 28, 2026
Close date
October 4, 2027
Activity codes
U01
Institutes taking part
NINDS, NEI, NIA, NIAAA, NIBIB, NICHD, NIDCD, NIDA, NIMH, NCCIH

Read the notice on Grants.gov

The notices it replaced

  1. Reissues: RFA-NS-22-049 BRAIN Initiative Connectivity across Scales (BRAIN CONNECTS): Specialized Projects for Scalable Technologies (U01 Clinical Trial Not Allowed)

Who won it before

13 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $25,678,005 in first-year total cost, median $1,749,879.

Most frequent study sections

  1. Special Emphasis Panel[ZNS1 SRB-S (12)]6
  2. Special Emphasis Panel[ZNS1 SRB-S (17)]4
  3. Special Emphasis Panel[ZNS1 SRB-S (27)]3

Most frequent institutions

  1. ALLEN INSTITUTE3
  2. BAYLOR COLLEGE OF MEDICINE1
  3. BOSTON CHILDREN'S HOSPITAL1
  4. BROAD INSTITUTE, INC.1
  5. FRANCIS CRICK INSTITUTE, LTD1
Competing awards under RFA-NS-27-015 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2025FAST-ET: Fast Automated Serial Tape-Enabled Electron Tomography1U01NS142013-01 · under RFA-NS-22-049ELLISMAN, MARK HLEE, WEI-CHUNG ALLENBOSTON CHILDREN'S HOSPITAL, MA$4,095,511ZNS1
2025BRAIN CONNECTS: Light microscopy for cell-type specific mesoscale to nanoscale dense connectomics1U01NS142100-01 · under RFA-NS-22-049MACARICO DA COSTA, NUNOREID, R CLAYALLEN INSTITUTE, WA$2,039,359ZNS1
2025X-ray nanotomography for scalable connectomics1U01NS142093-01 · under RFA-NS-22-049CLOETENS, PETERJACOBSEN, CHRIS JOHNSONJOITA PACUREANU, ALEXANDRA TEODORASCHAEFER, ANDREASFRANCIS CRICK INSTITUTE, LTD$1,009,658ZNS1
2024BRAIN CONNECTS: Scalable Approaches for Bidirectional Brain-wide Trans-Neuronal Connectivity Mapping of Defined Cell Types1U01NS136405-01 · under RFA-NS-22-049DUAN, XINFEINBERG, EVAN HARRIMANYAO, SHENQINUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$2,347,750ZNS1
2024BRAIN CONNECTS: A Scalable Automated Proofreading Framework for Connectomics1U01NS137250-01 · under RFA-NS-22-049REIMER, JACOBRIVLIN, PATRICIA KWESTER, BROCK A.JOHNS HOPKINS UNIVERSITY, MD$1,705,580ZNS1
2024BRAIN CONNECTS: Photoemission Electron Microscopy for Connectomics1U01NS136401-01 · under RFA-NS-22-049BOERGENS, KEVIN MICHAELKASTHURI, NARAYANANMASELLI, ANDREWWILDENBERG, GREGGUNIVERSITY OF CHICAGO, IL$1,609,558ZNS1
2024BRAIN CONNECTS: High-Throughput Single Cell Projection Mapping and Spine Quantification in the Primate Brain by Synaptic Barcoding1U01NS136398-01 · under RFA-NS-22-049DEVERMAN, BENJAMIN EFENG, GUOPINGMACOSKO, EVAN ZBROAD INSTITUTE, INC., MA$1,481,203ZNS1
2023BRAIN CONNECTS: Mapping brain-wide connectivity of neuronal types using barcoded connectomics1U01NS132161-01 · under RFA-NS-22-049CHEN, XIAOYINKEBSCHULL, JUSTUS MWICKERSHAM, IAN RALLEN INSTITUTE, WA$2,204,007ZNS1
2023BRAIN CONNECTS: Synaptic resolution whole-brain circuit mapping of molecularly defined cell types using a barcoded rabies virus1U01NS132353-01 · under RFA-NS-22-049TOLIAS, ANDREASZADOR, ANTHONY MBAYLOR COLLEGE OF MEDICINE, TX$2,189,013ZNS1
2023BRAIN CONNECTS: Rapid and Cost‐effective Connectomics with Intelligent Image Acquisition, Reconstruction, and Querying1U01NS132158-01 · under RFA-NS-22-049LICHTMAN, JEFF WPFISTER, HANSPETERSAMUEL, ARAVINTHAN D.SHAVIT, NIRWESTER, BROCK A.HARVARD UNIVERSITY, MA$2,095,885ZNS1
2023BRAIN CONNECTS: PatchLink, scalable tools for integrating connectomes, projectomes, and transcriptomes1U01NS132267-01 · under RFA-NS-22-049JARSKY, TIM MSORENSEN, STACI ASUMBUL, UYGARALLEN INSTITUTE, WA$1,749,879ZNS1
2023BRAIN CONNECTS: Multi-beam transmission electron microscopy of iteratively milled semi-thick tissue sections1U01NS132317-01 · under RFA-NS-22-049SCHAEFER, ANDREASWANNER, ADRIAN ANDREASPAUL SCHERRER INSTITUT PSI$1,678,795ZNS1
2023BRAIN CONNECTS: Mapping Connectivity of the Human Brainstem in a Nuclear Coordinate System1U01NS132181-01 · under RFA-NS-22-049FISCHL, BRUCEHOF, PATRICK RWANG, HUIMASSACHUSETTS GENERAL HOSPITAL, MA$1,471,807ZNS1

Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-11-0.1.2. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

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RFA-NS-27-015: BRAIN Initiative Connectivity across Scales (BRAIN CONNECTS): Specialized Projects for Scalable Technologies (U01 Clinical Trial Not Allowed) | ScienceDex | ConductScience