The notices it replaced
- Reissues: RFA-OD-19-016 Transformative Research Award for the INCLUDE (Investigation of Co-occurring Conditions across the Lifespan to Understand Down syndrome) Project (R01 Clinical Trial Not Allowed)
Replaced by RFA-OD-22-009.
Who won it before
26 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $63,846,554 in first-year total cost, median $2,215,322.
Most frequent study sections
- Special Emphasis Panel[ZRG1 VH-A (90)]7
- Special Emphasis Panel[ZRG1 BST-J (50)]6
- Special Emphasis Panel[ZRG1 BST-L (51)]6
- Special Emphasis Panel[ZRG1 BST-W (55)]6
- Special Emphasis Panel[ZRG1-BST-W(55)]1
Most frequent institutions
- UNIVERSITY OF COLORADO DENVER7
- UNIVERSITY OF CALIFORNIA, SAN DIEGO2
- BETH ISRAEL DEACONESS MEDICAL CENTER1
- CHILDREN'S HOSP OF PHILADELPHIA1
- CHILDREN'S RESEARCH INSTITUTE1
| FY | Project | PIs | Institution | First-year cost | Study section |
|---|---|---|---|---|---|
| 2022 | Neurovascular unit dysfunction in Down syndrome revealed by TBI1RF1NS128739-01 | HUANG, MINGXIAPOTTER, HUNTINGTONSULLIVAN, KELLY D. | UNIVERSITY OF COLORADO DENVER, CO | $2,601,812 | ZRG1 |
| 2022 | Why do Down Syndrome patients have high risk of Hirschsprung disease?1R01DK135089-01 | CHAKRAVARTI, ARAVINDACHATTERJEE, SUMANTRADAVOLI, TERESA | NEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY | $2,486,641 | ZRG1 |
| 2022 | Novel computational strategies to deconvolute co-occurring conditions in Down syndrome1R01HD109765-01 | COSTELLO, JAMES CHRISTOPHERGREENE, CASEY S | UNIVERSITY OF COLORADO DENVER, CO | $2,353,137 | ZRG1 |
| 2022 | The role of APP in neurogenesis and AD in Down syndrome1RF1AG079002-01 | LAZAROV, ORLY | UNIVERSITY OF ILLINOIS AT CHICAGO, IL | $2,005,131 | ZRG1 |
| 2022 | Restoration of proteostasis to address co-occurring conditions in Down Syndrome1RF1AG078969-01 | NAIDOO, NIRMALA NIRINJINI | UNIVERSITY OF PENNSYLVANIA, PA | $1,856,328 | ZRG1 |
| 2022 | Down Syndrome: a potential treatment XISTs1R01HD109794-01 | SHEEN, VOLNEY L | BETH ISRAEL DEACONESS MEDICAL CENTER, MA | $1,693,316 | ZRG1 |
| 2022 | Generation and analysis of new mouse models to determine novel therapeutic targets for Down syndrome-associated cognitive deficits1R01HD109750-01 | YU, EUGENE | ROSWELL PARK CANCER INSTITUTE CORP, NY | $475,839 | ZRG1 |
| 2021 | Human cortical development and neural plasticity altered by trisomy 211R01HD106197-01 | BHATTACHARYYA, ANITAZHANG, SU-CHUN | UNIVERSITY OF WISCONSIN-MADISON, WI | $7,005,920 | ZRG1 |
| 2021 | Precision Medicine for Inflammatory Treatment for Alzheimer's Disease in Down Syndrome1RF1AG073979-01 | RAFII, MICHAEL SRISSMAN, ROBERT | UNIVERSITY OF CALIFORNIA, SAN DIEGO, CA | $2,328,791 | ZRG1 |
| 2021 | Emulating Immune Dysregulation by Trisomy 21 in a Multi-Organ-on-a-Chip System1R01HL159494-01 | HAJIPOURAN BENAM, KAMBEZ | UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA | $2,101,852 | ZRG1 |
| 2021 | A Human iPSC-Based Chimeric Mouse Model of Alzheimers Disease in Down Syndrome1R01AG073779-01 | JIANG, PENG | RUTGERS, THE STATE UNIV OF N.J., NJ | $2,008,397 | ZRG1 |
| 2021 | Defining the Role of DNA Rereplication of Chromosome 21 in the Development and Pathophysiology of Down Syndrome1R01AI155918-01 | BLACK, JOSHUA CRANSTONSULLIVAN, KELLY D. | UNIVERSITY OF COLORADO DENVER, CO | $1,918,500 | ZRG1 |
| 2021 | Molecular mechanism of dysregulated airway antiviral responses in children with Trisomy 211R01HL159595-01 | JAISWAL, JYOTI KNINO, GUSTAVO | CHILDREN'S RESEARCH INSTITUTE, DC | $1,643,687 | ZRG1 |
| 2021 | New Down syndrome brain organization revealed by single-cell genomics1R56AG073965-01 | CHUN, JEROLD | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, CA | $1,395,349 | ZRG1 |
| 2021 | Targeting protein synthesis dysregulation in Down syndrome-associated cognitive impairment with aging1R01AG073823-01 | MA, TAO | WAKE FOREST UNIVERSITY HEALTH SCIENCES, NC | $1,142,664 | ZRG1 |
| 2020 | Multiplexed Single Nucleus RNA and ATAC-seq Sequencing and Cortical Organoids: Transformative Insights into Down Syndrome1R01AG070154-01 | MOBLEY, WILLIAM CROSENFELD, MICHAEL G | UNIVERSITY OF CALIFORNIA, SAN DIEGO, CA | $5,047,008 | ZRG1 |
| 2020 | Characterizing Innate Immune Dysregulation in Tonsils of Individuals with Down Syndrome1R01HL155691-01 | VERNERIS, MICHAEL R. | UNIVERSITY OF COLORADO DENVER, CO | $3,038,439 | ZRG1 |
| 2020 | Down Syndrome as a systemic autophagy deficiency disorder1R01HD103828-01 | DEGREGORI, JAMES VTHORBURN, ANDREW M | UNIVERSITY OF COLORADO DENVER, CO | $2,594,673 | ZRG1 |
| 2020 | Strategies for treatment of Down syndrome: Identifying age- and sex-specific developmental windows using inducible genetic reduction of Dyrk1a1R01AR078663-01 | GOODLETT, CHARLES R.ROPER, RANDALL J | INDIANA UNIVERSITY INDIANAPOLIS, IN | $1,919,804 | ZRG1 |
| 2020 | Noradrenergic dysfunction in Down Syndrome1RF1AG070153-01 | LEDREUX, AURÉLIE | UNIVERSITY OF DENVER (COLORADO SEMINARY), CO | $264,005 | ZRG1 |
| 2019 | Molecular Causes of Down Syndrome Associated Congenital Heart Disease and Other Phenotypes1R01HL151257-01 · under RFA-OD-19-016 | SEIDMAN, JONATHAN G | HARVARD MEDICAL SCHOOL, MA | $3,724,305 | ZRG1 |
| 2019 | Understanding the complexity of gene dosage imbalance in Down syndrome1R01HL151260-01 · under RFA-OD-19-016 | CHOU, STELLA T | CHILDREN'S HOSP OF PHILADELPHIA, PA | $3,352,210 | ZRG1 |
| 2019 | Type I Interferon Dysregulation in Down Syndrome1R01AI150300-01 · under RFA-OD-19-016 | BOGUNOVIC, DUSAN | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY | $3,207,900 | ZRG1 |
| 2019 | Understanding Down Syndrome as an Interferonopathy1R01AI150305-01 · under RFA-OD-19-016 | ESPINOSA, JOAQUIN M. | UNIVERSITY OF COLORADO DENVER, CO | $2,830,725 | ZRG1 |
| 2019 | Trisomy 21 and RNA polymerase II function1R01HD100935-01 · under RFA-OD-19-016 | BENTLEY, DAVID L | UNIVERSITY OF COLORADO DENVER, CO | $2,828,221 | ZRG1 |
| 2019 | Elevated mitochondrial fusion and function in Down syndrome1R01HD101006-01 · under RFA-OD-19-016 | ROTHERMEL, BEVERLY A | UT SOUTHWESTERN MEDICAL CENTER, TX | $2,021,900 | ZRG1 |
Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-09-0.1.0. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.