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NIH funding notice RFA-OD-27-003

INCLUDE Project: Exploratory/Developmental Research Awards for Down syndrome (R21 Clinical Trial Not Allowed)

Open. Closes June 15, 2028.

Posted
May 12, 2026
Close date
June 15, 2028
Activity codes
R21
Institutes taking part
OD, NEI, NHLBI, NIA, NIAID, NIAMS, NICHD, NIDCD, NIDCR, NLM, ORIP, NCI

Read the notice on Grants.gov

The notices it replaced

  1. Reissues: RFA-OD-21-007 INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Exploratory/Developmental Research Grant Award (R21 Clinical Trial Not Allowed)

Who won it before

10 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $3,224,280 in first-year total cost, median $246,375.

Most frequent study sections

  1. Special Emphasis Panel[ZRG1 IVBH-A (56)]5
  2. Special Emphasis Panel[ZRG1 VH-N (90)]3
  3. Special Emphasis Panel[ZRG1 IVBH-B (56)]2

Most frequent institutions

  1. UNIVERSITY OF COLORADO DENVER2
  2. ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI1
  3. LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER1
  4. MASSACHUSETTS GENERAL HOSPITAL1
  5. RESEARCH INST NATIONWIDE CHILDREN'S HOSP1
Competing awards under RFA-OD-27-003 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2025Characterizing DNA Methylation Dynamics in Trisomy 21-Associated Hematopoiesis and Leukemia1R21CA301237-01 · under RFA-OD-21-007MA, SAIWAGENBLAST, ELVINICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$462,454ZRG1
2025CRISPR interference to identify HSA21 genes reducing neurogenesis1R21HD118402-01 · under RFA-OD-21-007MUNSHI, NIKHIL VILASROTHERMEL, BEVERLY AUT SOUTHWESTERN MEDICAL CENTER, TX$451,000ZRG1
2025Developing and implementing community based participatory health research with young adults with Down syndrome1R21HD118449-01 · under RFA-OD-21-007CHANNELL, MARIE MOOREUNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL$446,096ZRG1
2025Defining the association between trisomy 21 and placentation defects1R21HD118444-01 · under RFA-OD-21-007BRUMBAUGH, JUSTINUNIVERSITY OF COLORADO, CO$430,375ZRG1
2025Single cell analysis of dysregulated inducible DNA amplifications of immune response genes in Down syndrome1R21AI190900-01 · under RFA-OD-21-007SULLIVAN, KELLY D.UNIVERSITY OF COLORADO DENVER, CO$234,000ZRG1
2024Imaging of Mitochondial Complex I function in Down Syndrome1R21AG086927-01 · under RFA-OD-21-007PRICE, JULIE CROSAS, HERMINIA DIANAMASSACHUSETTS GENERAL HOSPITAL, MA$250,500ZRG1
2024Characterizing Language and Motor Development of Racially/Ethnically Diverse Infants and Toddlers with Down Syndrome1R21DC021818-01 · under RFA-OD-21-007FLORES, MEGANVANEGAS, SANDRAUNIVERSITY OF TEXAS AT AUSTIN, TX$240,355ZRG1
2022type I interferon regulates angiogenesis in Down Syndrome1R21HL165411-01 · under RFA-OD-21-007AL-ALAM, DENISEDANOPOULOS, SOULA ATHANASIALUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER, CA$242,250ZRG1
2022Dissecting SARS-CoV-2 infection in Down syndrome with congenital heart defects using patient-specific iPSCs1R21HL165406-01 · under RFA-OD-21-007ZHAO, MINGTAORESEARCH INST NATIONWIDE CHILDREN'S HOSP, OH$234,000ZRG1
2022Abnormal HIF signaling in Down syndrome-related pulmonary hypertension1R21HL165364-01 · under RFA-OD-21-007GALAMBOS, CSABAUNIVERSITY OF COLORADO DENVER, CO$233,250ZRG1

Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-10-0.1.1. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

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