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NIH funding notice RFA-RM-21-016

NIH Directors New Innovator Award Program (DP2 Clinical Trial Optional)

Closed on August 20, 2021.

Posted
May 20, 2021
Close date
August 20, 2021
Activity codes
Not stated on the notice page
Institutes taking part
Not stated on the notice page

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

Its page was not saved, so the notices it replaced are not known.

Who won it before

73 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $99,629,199 in first-year total cost, median $1,416,600.

Most frequent study sections

  1. Special Emphasis Panel[ZRG1 CVRS-B (70)]73

Most frequent institutions

  1. COLUMBIA UNIVERSITY HEALTH SCIENCES4
  2. MASSACHUSETTS GENERAL HOSPITAL3
  3. UNIVERSITY OF CALIFORNIA-IRVINE3
  4. YALE UNIVERSITY3
  5. ARIZONA STATE UNIVERSITY-TEMPE CAMPUS2
Competing awards under RFA-RM-21-016 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2023THWART-TB : Testing Health Workers At Risk to advance our understanding of TB infection1DP2AI176896-01NATHAVITHARANA, RUVANDHIBETH ISRAEL DEACONESS MEDICAL CENTER, MA$1,189,520ZRG1
2022Biology and applications of mammalian hibernation-like states1DP2DK136123-01HRVATIN, SINISAWHITEHEAD INSTITUTE FOR BIOMEDICAL RES, MA$1,755,000ZRG1
2022A Novel Approach to Crack Neuronal Mechanisms that Shape Computations in the Brain1DP2NS132108-01INAGAKI, HIDEHIKOMAX PLANCK FLORIDA CORPORATION, FL$1,737,000ZRG1
2022Neuroimmunological insights into brain development and dysfunction: an integrative approach focused on microglial dynamics1DP2MH132943-01CHEADLE, LUCAS MCOLD SPRING HARBOR LABORATORY, NY$1,728,000ZRG1
2022Understanding Metabolism in Space and Time – Mechanistic Analysis of the Dynamic Spatial Organization of Metabolism1DP2GM150192-01CHANG, CHI-LUNST. JUDE CHILDREN'S RESEARCH HOSPITAL, TN$1,638,000ZRG1
2022Manipulating Epitope Immunodominance and Tracking B-cell-Antigen Interactions for Vaccine Design.1DP2AI175470-01ESCOLANO, AMELIAWISTAR INSTITUTE, PA$1,616,010ZRG1
2022Translating the tumor regulome from cell-free DNA for precision oncology1DP2CA280624-01HA, GAVINFRED HUTCHINSON CANCER CENTER, WA$1,542,081ZRG1
2022Defining mechanisms for natural vision in the primate brain with machine learning1DP2EY035176-01PONCE, CARLOS RAMONHARVARD MEDICAL SCHOOL, MA$1,525,500ZRG1
2022Constructing the nest - understanding the mechanisms of nidoviridae RNA genomes transcription and recombination1DP2AI175475-01ROUSKIN, SILVIAHARVARD MEDICAL SCHOOL, MA$1,525,500ZRG1
2022The Optics of Health: Race Skin Tone Minority Health and Health Disparities in the U.S.1DP2MH132941-01MONK, ELLISHARVARD UNIVERSITY, MA$1,521,000ZRG1
2022Life history of the menstruating uterus1DP2HD111708-01MCKINLEY, KARA LAVIDGEHARVARD UNIVERSITY, MA$1,513,271ZRG1
2022The inactive X: discovering sex genes that influence female vulnerability to Alzheimer's disease1DP2AG082342-01BUCKLEY, RACHEL FRANCESMASSACHUSETTS GENERAL HOSPITAL, MA$1,512,000ZRG1
2022Dissecting the enhancer logic governing immune cell fate decisions1DP2AI176139-01SEN, DEBATTAMA RAIMASSACHUSETTS GENERAL HOSPITAL, MA$1,512,000ZRG1
2022Scalable Development of Custom Genome Editing Technologies1DP2CA281401-01KLEINSTIVER, BENJAMIN PETERMASSACHUSETTS GENERAL HOSPITAL, MA$1,512,000ZRG1
2022Deciphering Principles of Human Embryonic Patterning in Development and Disease1DP2HD112040-01SOZEN, BERNAYALE UNIVERSITY, CT$1,507,500ZRG1
2022Enhancing dengue virus genomic surveillance to uncover circulating genetic diversity1DP2AI176740-01GRUBAUGH, NATHAN DALEYALE UNIVERSITY, CT$1,507,500ZRG1
2022Unleashing T-cell anti-tumor response through repair of altered RNA splicing and antigen mimicry recognition1DP2CA280625-01ESCOBAR HOYOS, LUISAYALE UNIVERSITY, CT$1,507,500ZRG1
2022Cross-regulation between loop extrusion, chromatin fiber structure and chromatin-associated RNAs1DP2GM150021-01RISCA, VIVIANA IROCKEFELLER UNIVERSITY, NY$1,485,041ZRG1
2022Probing functioning lung at the cellular resolution in health and disease1DP2HL168562-01NIA, HADI TAVAKOLIBOSTON UNIVERSITY (CHARLES RIVER CAMPUS), MA$1,485,000ZRG1
2022Unraveling the developmental logic of cortical long-range projections using in situ sequencing-based neuroanatomy1DP2MH132940-01CHEN, XIAOYINALLEN INSTITUTE, WA$1,484,888ZRG1
2022Deciphering multi-scale differentiation and patterning cues driving whole craniofacial joint regeneration1DP2DE032725-01SMEETON, JOANNA MARJORIECOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$1,480,500ZRG1
2022The Female Songbird as a Novel Mechanistic Model for the Neural Basis of Social Evaluation1DP2AT012347-01GADAGKAR, VIKRAMCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$1,480,500ZRG1
2022SPATIALLY MAPPING OF POOLED IN VIVO CRISPR SCREENS IN THE TUMOR MICROENVIRONMENT1DP2CA281605-01GAUBLOMME, JELLERTCOLUMBIA UNIV NEW YORK MORNINGSIDE, NY$1,480,500ZRG1
2022Annotated lineage trees of murine development1DP2GM149750-01MCKENNA, AARON HDARTMOUTH COLLEGE, NH$1,476,000ZRG1
2022A blueprint for neutrophil heterogeneity and reprogramming in cancer1DP2CA280834-01JIN, CHENGCHENGUNIVERSITY OF PENNSYLVANIA, PA$1,462,500ZRG1
2022Genomic tools for massively parallel recording of signaling activity at cellular resolution in a brain-wide manner1DP2NS131787-01RAJ, BUSHRAUNIVERSITY OF PENNSYLVANIA, PA$1,462,500ZRG1
2022Discovering mechanisms of tissue-resident immune aging1DP2AI175641-01GOLDBERG, EMILY LAURENUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$1,453,500ZRG1
2022The Synthetic Kidney: A Revolutionary Solution for the Shortage of Kidneys for Transplantation1DP2DK135739-01LI, ZHONGWEIUNIVERSITY OF SOUTHERN CALIFORNIA, CA$1,446,372ZRG1
2022Building a Systematic, Comprehensive Mammalian Cell Fate Map1DP2HD111537-01CHAN, MICHELLEPRINCETON UNIVERSITY, NJ$1,438,780ZRG1
2022Unlocking the postnatal human brain using activity augmented organoids1DP2MH132944-01MAKINSON, CHRISTOPHER DONALDCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$1,437,896ZRG1
2022New insights into the molecular regulation of mechanotransduction1DP2GM149549-01CASE, LINDSAYMASSACHUSETTS INSTITUTE OF TECHNOLOGY, MA$1,431,000ZRG1
2022Circulatronics: A New Paradigm for Biomedical Implants1DP2HL168072-01SARKAR, DEBLINAMASSACHUSETTS INSTITUTE OF TECHNOLOGY, MA$1,431,000ZRG1
2022Uncovering brain-wide molecular determinants of individual memory performance across lifespan1DP2NS132372-01AREY, RACHEL NICOLEBAYLOR COLLEGE OF MEDICINE, TX$1,427,700ZRG1
2022A new framework for self-adaptive artificial intelligence to personalize assistance for patients using robotic exoskeletons and prostheses1DP2HD111709-01YOUNG, AARON JOHNGEORGIA INSTITUTE OF TECHNOLOGY, GA$1,423,800ZRG1
2022Chemical Control of Misfolded Protein Fate1DP2NS132610-01FERGUSON, FLEUR MARCIAUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$1,422,000ZRG1
2022Decode Mitochondrial Morphology Dynamics to Predict Cell Fate Decisions1DP2GM150022-01SCHOENEBERG, JOHANNESUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$1,422,000ZRG1
2022Harnessing the chromatin conformational code for epigenetic regulation1DP2GM149752-01SANULLI, SERENASTANFORD UNIVERSITY, CA$1,416,600ZRG1
2022Trillion cell culture to fuel organ biofabrication1DP2HL168563-01SKYLAR-SCOTT, MARK A.STANFORD UNIVERSITY, CA$1,416,600ZRG1
2022Deciphering the mechanism of long-range gene regulation in vivo1DP2GM149555-01KVON, EVGENYUNIVERSITY OF CALIFORNIA-IRVINE, CA$1,413,000ZRG1
2022Structure and dynamics of RNA elements regulating viral aberrant RNA synthesis1DP2AI175474-01TE VELTHUIS, AREND JANPRINCETON UNIVERSITY, NJ$1,412,295ZRG1
2022Multifunctional phase sensors for probing and manipulation of intracellular biomolecular condensates1DP2GM149749-01GARCIA QUIROZ, FELIPEEMORY UNIVERSITY, GA$1,408,500ZRG1
2022Boosting efficacy of oral vaccine candidates by enabling spore display of nitrated antigens1DP2AI176137-01KUNJAPUR, ADITYA MOHANUNIVERSITY OF DELAWARE, DE$1,406,279ZRG1
2022Compliant Limb Reconstruction: Co-engineering Body and Machine to Revolutionize Limb Salvage1DP2HD111538-01CLITES, TYLER RUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$1,404,000ZRG1
2022Improving drug design to eliminate side effects: From computational to animal models1DP2GM149753-01OKAFOR, C. DENISEPENNSYLVANIA STATE UNIVERSITY, THE, PA$1,400,649ZRG1
2022Post-translational modification proteomics in 4D: Chemoenzymatic tools to map the dynamic spatial organization of eukaryotic signaling pathways1DP2GM149548-01WEEKS, AMY MUNIVERSITY OF WISCONSIN-MADISON, WI$1,399,500ZRG1
2022A phylodynamic time machine for solid tumors1DP2CA280623-01FEDER, ALISON FUNIVERSITY OF WASHINGTON, WA$1,399,500ZRG1
2022AI-assisted Imaging and Prediction of Cardiac Arrhythmia Origins using 4D Ultrasound1DP2HL168071-01CHRISTOPH, JANUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$1,392,000ZRG1
2022Deciphering the crosstalk between bacteria and their mammalian hosts1DP2AT012346-01WHITELEY, AARON THOMASUNIVERSITY OF COLORADO, CO$1,385,900ZRG1
2022Unraveling the Telomere Black Box: A New Single-Molecule Approach to Define the Telomere Chromatin Landscape and its Functional Mechanisms1DP2GM150023-01LIM, CI JIUNIVERSITY OF WISCONSIN-MADISON, WI$1,385,625ZRG1
2022Signaling via MHC: engineering immune cells with new capabilities1DP2AI176138-01JOGLEKAR, ALOKUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$1,383,783ZRG1
2022In-situ architecture of membrane contact sites mediating organelle fission1DP2GM150019-01MOSALAGANTI, SHYAMALUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$1,382,214ZRG1
2022Understanding and restoring speech production using an intracortical brain-computer interface1DP2DC021055-01STAVISKY, SERGEYUNIVERSITY OF CALIFORNIA AT DAVIS, CA$1,382,019ZRG1
2022Causal Representation Learning for the Spatial Analysis of Transcriptomic and Imaging Data in Tissue Contexts1DP2AT012345-01UHLER, CAROLINEBROAD INSTITUTE, INC., MA$1,378,800ZRG1
2022Gel-based Optical-isolation Single-Cell 3D Spatial Multiomics1DP2GM150017-01SHI, XIAOYUUNIVERSITY OF CALIFORNIA-IRVINE, CA$1,378,306ZRG1
2022Transdiagnostic Intervention to Reduce Internalized Health-Related Stigma1DP2MH132938-01PEARL, REBECCA LUNIVERSITY OF FLORIDA, FL$1,372,500ZRG1
2022Immunocompatible electronic polymers and devices for implantable sensors and stimulators that resist foreign-body responses1DP2EB034563-01WANG, SIHONGUNIVERSITY OF CHICAGO, IL$1,364,944ZRG1
2022Tumor suppressor vulnerability conferred by aneuploid loss of haploinsufficient metallothionein genes1DP2CA280626-01DELANEY, JOE RMEDICAL UNIVERSITY OF SOUTH CAROLINA, SC$1,359,000ZRG1
2022Synthetic metabolism to armor and enhance a new class of cell therapies1DP2CA280622-01BLAZECK, JOHN JAMESGEORGIA INSTITUTE OF TECHNOLOGY, GA$1,356,578ZRG1
2022Universally-applicable RNA mapping at subcellular and single-base resolution1DP2GM149554-01DING, FANGYUANUNIVERSITY OF CALIFORNIA-IRVINE, CA$1,354,500ZRG1
2022A Novel Semi-autonomous Surgeon-in-the-loop in situ Robotic Bioprinting System for Functional and Cosmetic Restoration of Volumetric Muscle Loss Injuries1DP2AR082471-01ALAMBEIGI, FARSHIDUNIVERSITY OF TEXAS AT AUSTIN, TX$1,354,107ZRG1
2022Microbial regulation of mammalian circadian rhythms and the sexual dimorphism: from metabolism to immunity1DP2DK136278-01KUANG, ZHENGCARNEGIE-MELLON UNIVERSITY, PA$1,352,700ZRG1
2022New classes of optogenetic and chemogenetic tools with a feedback control1DP2MH132939-01WANG, WENJINGUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$1,350,000ZRG1
2022Building a two-way communication system: Bio-orthogonal superhydrophobic nanoparticles for controlled stimulation and real-time sensing of neurotransmitters1DP2GM150018-01MOUSAVI, MARALUNIVERSITY OF SOUTHERN CALIFORNIA, CA$1,344,764ZRG1
2022Elucidation of P2X7 Receptor Signaling and Development of Novel Small Molecule and Aptamer Ligand Therapies1DP2GM149551-01MANSOOR, STEVEN ELIASOREGON HEALTH & SCIENCE UNIVERSITY, OR$1,340,100ZRG1
2022Integrated Nano-Opto-Fluidic System on Sapphire towards Single-Molecule Protein Sequencing1DP2GM149552-01WANG, CHAOARIZONA STATE UNIVERSITY-TEMPE CAMPUS, AZ$1,339,472ZRG1
2022How does neuromodulation shape the fluidity of spatial working memory?1DP2NS132373-01FISHER, YVETTE EUNIVERSITY OF CALIFORNIA BERKELEY, CA$1,305,654ZRG1
2022Towards a Smart Bionic Eye: AI-Powered Artificial Vision for the Treatment of Incurable Blindness1DP2LM014268-01BEYELER, MICHAELUNIVERSITY OF CALIFORNIA SANTA BARBARA, CA$1,250,136ZRG1
2022Unraveling the genetic basis of cellular behaviors with deep learning and imaging-based reverse genetics1DP2GM149556-01VAN VALEN, DAVID ACALIFORNIA INSTITUTE OF TECHNOLOGY, CA$1,173,600ZRG1
2022High-throughput methods for measuring cortical synaptic connectivity at single-cell resolution1DP2MH132942-01GRANGER, ADAMBROAD INSTITUTE, INC., MA$900,000ZRG1
2022Engineering Novel Precision Genome Editing Tools1DP2GM149550-01LAPINAITE, AUDRONEARIZONA STATE UNIVERSITY-TEMPE CAMPUS, AZ$727,790ZRG1
2022DESIGNING A HIGH-THROUGHPUT PLATFORM TO BIOPROSPECT THE HUMAN MICROBIOME AND MANIPULATE ITS INTERPLAY WITH HOST ENVIRONMENTS1DP2GM149553-01NIEPA, TAGBO HERMAN ROLANDUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$142,992ZRG1
2022Defining the Chemical Perturbome of Neural Development and Activity1DP2NS132107-01THYME, SUMMER BUNIVERSITY OF ALABAMA AT BIRMINGHAM, AL$113,932ZRG1
2022Methods to Rapidly Explore Combinatorial Diversity and Their Application to CRISPR-Cas9 Systems1DP2NS131566-01CHAVEZ, ALEJANDROCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$1ZRG1

Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-10-0.1.1. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

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RFA-RM-21-016: NIH Directors New Innovator Award Program (DP2 Clinical Trial Optional) | ScienceDex | ConductScience