Figure 5.(a)Linear (y=0.45x + 57.74) dose-response relationship between plasma propranolol to % β- adrenergeric blockade derived from healthy study participants and translate into patients with angina pectoris. This image has been adapted from(Pine et al., 1975).-The Brain and Propranolol Pharmacokinetics in the Elderly

<p>Apharmacodynamic model,with parameters in the table below, may be used to visualize the<br> propranolol concentration-effect (&beta;-blockade) relationship in patients suffering from angina pectoris.<br> These results have been adapted from the Pine et al article published in Circulation in 1975 which<br> identified a linear relationship plasma Propranolol (ng/mL) to an effect of % &beta;-Adrenergic Blockade<br> in a single-oral dose of 40mg Propranolol in exercising individuals (Pine et al., 1975).</p>