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230 results for “propranolol”
The Brain and Propranolol Pharmacokinetics in the Elderly-Figure 1.(a)Results of the Monte-Carlo simulations to describe pharmacokinetics of young patients with validation from the Taegtmeyer 2014 publication(Taegtmeyer et al., 2014)
<p>Propranolol has been found to be therapeutically effective, to obtain a clinical response by<br> beta-adrenoceptor blockade, at plasma levels of greater than 20 ng/mL(Coltart et al., 1971;<br> Frishman, 1988; Johnsson and Regàrdh, 1976). Thus, to display the data, we used highlighted<br> plasma concentration where the pharmacokinetic curve falls below 20ng/mL threshold for<br> therapeutic efficacy in the patient’s plasma.</p>
Figure 2.(a)Results of the Monte-Carlo simulations describing a population of elderly patients after a single oral dose of propranolol.-The Brain and Propranolol Pharmacokinetics in the Elderly
<p>In effort to identify the recommended Propranolol dosage for elderly patients, we identified<br> the patient package inserts from the Food and Drug Administration (FDA) Inderal label, who<br> manufacture propranolol. Based from FDA Wyeth Propranolol label, for dosing in the geriatric<br> population,the label states that there were not sufficient numbers of clinical study participants who<br> were 65-years and older to properly determine the difference in response young and elderly<br> patients.</p>
Figure 6.Amygdala hypofunction after a single oral 40-mg dose, 1.5-hours post-dose, in young study participants.The image has been adapted from (Hurlemann et al., 2010).-The Brain and Propranolol Pharmacokinetics in the Elderly
<p>In the past decade, there has been much interest in identifying treatment in adding to the<br> current treatment options for war veterans suffering from Post-Traumatic Stress Disorder (PTSD).<br> The studies investigating secondary-preventative measures for PTSD using Propranolol due to the<br> drug’s ability to inhibit the actions of the neurotransmitter norepinephrine,which has been<br> implicated to enhance the consolidation(McGhee et al., 2009; Pitman et al., 2002; Stein et al.,<br> 2007).Further, in a double-blind, placebo-controlled,functional Magnetic Resonance Imaging<br> (fMRI) study, in healthy volunteers, Hurlemann et al. found that a single oral 40mg dose of<br> propranolol attenuatedthe leftbasolateral amygdala responses to the face perception<br> paradigm(Hurlemann et al., 2010). The study participants were eighteen healthy (9 females, 9<br> males; mean age 23 years; age range 19–31 years) who had their fMRI acquisition 1.5-hours after<br> the oral administration of propranolol. An adapted image of the study findings are shown in Figure<br> 6.</p>
Figure 5.(a)Linear (y=0.45x + 57.74) dose-response relationship between plasma propranolol to % β- adrenergeric blockade derived from healthy study participants and translate into patients with angina pectoris. This image has been adapted from(Pine et al., 1975).-The Brain and Propranolol Pharmacokinetics in the Elderly
<p>Apharmacodynamic model,with parameters in the table below, may be used to visualize the<br> propranolol concentration-effect (β-blockade) relationship in patients suffering from angina pectoris.<br> These results have been adapted from the Pine et al article published in Circulation in 1975 which<br> identified a linear relationship plasma Propranolol (ng/mL) to an effect of % β-Adrenergic Blockade<br> in a single-oral dose of 40mg Propranolol in exercising individuals (Pine et al., 1975).</p>
Figure 4. Simulation (Monte-Carlo, n=200) results elderly patients taking a 10mg oral dose resulting in similar Cmax, maximum plasma concentration, to the young patients taking a 40mg oral dose. The dotted lines illustrate the 10th and 90th percentiles of plasma levels of the elderly population with a 10mg oral administration of propranolol.-The Brain and Propranolol Pharmacokinetics in the Elderly
<p>Thus, the package insert (see 1) recommends clinicians start at the lower end of the dosing<br> range, without further details.<br> Similarly, Pfizer manufactures Inderal® LA (Propranolol HCI), which is the long-acting<br> form of propranolol and their package insert (see 2) states, “There is no information available for<br> elderly patients.” Though the kinetics for the long-acting formdiffers from the standard form,<br> manufactured by Wyeth, we would suspect a 10mg dose for the elderly would achieve a similar<br> maximum plasma concentration (Cmax) to that of the younger patient cohort.This 10mg, which is<br> 25% of the original 40mg, dosing schedule is based on our simulations at 10mg in the geriatric<br> population.</p>
Propranolol Versus Prednisolone for Treatment of Symptomatic Hemangiomas
ClinicalTrials.gov study NCT00967226. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Study of Orofacial Pain and PropRANOlol
ClinicalTrials.gov study NCT02437383. IPD Sharing: Not stated. Countries: 1. Publications: 8.
Propranolol in Treating Hypoglycemia Unawareness
ClinicalTrials.gov study NCT03161964. IPD Sharing: NO. Countries: 1. Publications: 20.
A Psychophysiologic Study of Weakening Traumatic Combat Memories With Post-Reactivation Propranolol
ClinicalTrials.gov study NCT00709735. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Propranolol Versus Placebo for Induction of Labor in Nulliparous Patients
ClinicalTrials.gov study NCT03348683. IPD Sharing: NO. Countries: 1. Publications: 11.
The Safety and Efficiency of Propranolol as an Initial Treatment for Pediatric Hemangioma
ClinicalTrials.gov study NCT01908972. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Study of Propranolol as Anti-Adhesive Therapy in Sickle Cell Disease (SCD)
ClinicalTrials.gov study NCT01077921. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Propranolol Rescue of Prolonged Labor
ClinicalTrials.gov study NCT04299438. IPD Sharing: NO. Countries: 1. Publications: 1.
Corticosteroids With Placebo Versus Corticosteroids With Propranolol Treatment of Infantile Hemangiomas (IH)
ClinicalTrials.gov study NCT01074437. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Study of Propranolol to Decrease Gene Expression of Stress-Mediated Beta-Adrenergic Pathways in HCT Recipients
ClinicalTrials.gov study NCT02420223. IPD Sharing: NO. Countries: 1. Publications: 2.
Propranolol for Sleep Apnea Therapy
ClinicalTrials.gov study NCT03049306. IPD Sharing: NO. Countries: 1. Publications: 0.
Propranolol and Botulinum Toxin for Essential Vocal Tremor
ClinicalTrials.gov study NCT02111369. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Effect of Propranolol on Preventing Posttraumatic Stress Disorder
ClinicalTrials.gov study NCT00158262. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Does Propranolol Attenuate Inflammatory Responses to a Psychological Stressor?
ClinicalTrials.gov study NCT02972554. IPD Sharing: NO. Countries: 1. Publications: 28.
Study to Demonstrate the Efficacy and Safety of Propranolol Oral Solution in Infants With Proliferating Infantile Hemangiomas Requiring Systemic Therapy
ClinicalTrials.gov study NCT01056341. IPD Sharing: Not stated. Countries: 16. Publications: 3.
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