Effect of antibiotic-loaded chitosan nanodroplets on Enterococci isolated from chronic ulcers of the lower limbs

<p>Dataset from the article&nbsp;Mazzaccaro D, Ticozzi R, D&#39;Alessandro S, Delbue S, Nano G, Costa E, Argenziano M, Cavalli R, Prato M, Basilico N. Effect of antibiotic-loaded chitosan nanodroplets on Enterococci isolated from chronic ulcers of the lower limbs. Future Microbiol. 2020 Sep;15:1227-1236. doi: 10.2217/fmb-2019-0255. PMID: 33026879.</p> <p><strong>Abstract&nbsp;</strong></p> <p><strong>Aim:</strong>&nbsp;To investigate the effect of a new platform of nanocarriers, called nanodroplets (NDs), to enhance the&nbsp;<em>in vitro</em>&nbsp;activity of vancomycin (Vm), against bacterial colonies isolated from chronic ulcers of the lower limbs.&nbsp;<strong>Materials &amp; methods:</strong>&nbsp;Oxygen-loaded nanodroplets (OLNDs) or oxygen-free nanodroplets (OFNDs) were loaded with Vm (Vm-OLNDs and Vm-OFNDs). MIC and minimal bactericidal concentrations were evaluated for Vm, OLNDs and OFNDs loaded with Vm, OLNDs and OFNDs.&nbsp;<strong>Results &amp; conclusion:</strong>&nbsp;Nanodroplets, either with or without oxygen, appeared as a suitable platform of antibiotic nanocarriers to enhance the antibacterial effects of Vm against&nbsp;<em>Enterococci</em>, with a decrease in both MIC and minimal bactericidal concentration against Vm-resistant&nbsp;<em>Enterococci</em>&nbsp;strains.</p>