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Antifungal activity of propolis extract against Candida albicans in patients with vulvovaginal candidiasis

Abstract Objective: To evaluate the antifungal activity of propolis extract against Candida Albicans (or C. Albicans) in patients with vulvovaginal candidiasis. Method: The research presents a quantitative approach with an experimental design, with a population of C. Albicans strains isolated from patients diagnosed with vulvovaginal candidiasis who were admitted to the Gynecology Service of the Maria del Socorro Clinic, district of Ate - Lima, from which a sample of 34 strains was chosen in total, considering three repetitions per strain, obtaining 102 experimental units. The antifungal susceptibility test was carried out by the disc diffusion plate method using a single concentration of propolis extract, with fluconazole as a positive control. Resultados: Propolis extract was shown to inhibit all strains of C. albicans, as was fluconazole, with the effect of the latter being significantly greater than that of the product under investigation. Conclusion: The conclusion is that propolis extract does show antifungal activity against C. albicans in patients with vulvovaginal candidiasis. Keywords: Propolis extract, Candida Albicans, Antifungal activity, Vulvovaginal candidiasis.

opencc-zeroOct 2022View details →

dryad40/100

Evaluation of DNA extracted from timber rattlesnake (Cotalus horridus) cloacal and blood swabs for microsatellite genotyping

Genetic research is a key component to modern wildlife conservation, but it is contingent on the collection of reliable and high-quality genetic samples. Invasive genetic sampling techniques have potential to negatively impact individuals, which may be prohibitive when working with threatened and endangered species. Prior to sample collection, project managers must try to balance the negative impact on individuals included in the study with the demand for DNA and the difficulty of obtaining samples. Although established methods for blood and tissue collection in reptiles meet the need for high-quantity and quality DNA, they inherently require longer handling times and more skill to obtain. Thus, non-invasive DNA collection methods, such as cloacal swabs, may be preferred when animal welfare is a priority. Cloacal swabs are quicker, easier, require less training and reduce handling time. To evaluate cloacal swabbing as an alternative to collecting blood, we obtained both cloacal and blood swabs. We extracted DNA from cloacal and blood cells that were collected from 23 Timber Rattlesnakes (Crotalus horridus). We assessed DNA by purity (A260/A280), concentration, and microsatellite genotyping. Our results show high-quality DNA can be obtained from both cloacal swabs and blood samples, but quality and concentration of DNA was significantly lower from cloacal swabs. Further, degradation and contamination affects the performance of cloacal DNA when compared to blood DNA in microsatellite-based genotyping. Although we recommend collecting blood samples whenever possible to obtain the highest-quality DNA, cloacal swabs represent a viable alternative for genetic sampling when using microsatellite loci as genetic markers.

opencc-by-4.0Jan 2022View details →

Figure 1 in Toxicity and ovicidal activity of different entomopathogenic fungi, Hirsutella extracts on Tetranychus urticae (Acari: Tetranychidae)

Figure 1. Accumulated mortality of T. urticae females at 24, 48 and 72 h after being fed with mulberry leaf discs treated with different concentrations of crude extract, six species of Hirsutella under residual effect bioassay. For each extract and mite, means followed by the same letter are not significantly different (p = 0.05; Tukey HDS test).

Text-fig. 4. Mastixia cf. oregonensis (R.A.SCOTT) TIFFNEY et HAGGARD from the London Clay, originally included within the concept of M. cantiensis. a–c: V. 22960(1). a: Transverse fracture, showing c-shaped locule, dorsal infold, and sculptured endocarp, reflected light. b: Transverse digital section from micro-CT scan data. c: Surface view of ribbed endocarp extracted from micro-CT data. d: Transverse fracture, reflected light, V. 22955 (originally illustrated in pl. 25, fig. 4 of Reid and Chandler 1933). e, f: Transverse physical section, V. 22963(2) showing U-shaped locule and longitudinal dorsal infold. g–i reflected light. g: Detail from left of (d). h, i: Detail from right of (f). Scale bars 5 mm in (a–f), 1 mm in (g–i). in Mastixioid Fruits (Cornales) From The Early Eocene London Clay Flora: Morphology, Anatomy And Nomenclatural Revision

Text-fig. 4. Mastixia cf. oregonensis (R.A.SCOTT) TIFFNEY et HAGGARD from the London Clay, originally included within the concept of M. cantiensis. a–c: V. 22960(1). a: Transverse fracture, showing c-shaped locule, dorsal infold, and sculptured endocarp, reflected light. b: Transverse digital section from micro-CT scan data. c: Surface view of ribbed endocarp extracted from micro-CT data. d: Transverse fracture, reflected light, V. 22955 (originally illustrated in pl. 25, fig. 4 of Reid and Chandler 1933). e, f: Transverse physical section, V. 22963(2) showing U-shaped locule and longitudinal dorsal infold. g–i reflected light. g: Detail from left of (d). h, i: Detail from right of (f). Scale bars 5 mm in (a–f), 1 mm in (g–i).

Text-fig. 3. Examples of plant macrofossil assemblages from post-evaporitic sections. a: bedding plane from Ciabòt Cagna covered by impressions of plant parts, with dominance of leaves of cf. Oleinites liguricus M.SACHSE, MCEA-P05038. b: waterloggedcompressed seeds of Toddalia latisiliquata (R.LUDW.) H.-J.GREGOR sieved out of a bulk sediment sample from Pollenzo, MGPTPU141033. c: millimeter-sized, waterlogged-compressed seeds of Sambucus pulchella C.REID et E.REID with abundant cracks, probably formed during both diagenesis and extraction of the fossils (bulk sediment sample from Ciabòt Cagna), MGPT- in Late Messinian Flora From The Post-Evaporitic Deposits Of The Piedmont Basin (Northwest Italy)

Text-fig. 3. Examples of plant macrofossil assemblages from post-evaporitic sections. a: bedding plane from Ciabòt Cagna covered by impressions of plant parts, with dominance of leaves of cf. Oleinites liguricus M.SACHSE, MCEA-P05038. b: waterloggedcompressed seeds of Toddalia latisiliquata (R.LUDW.) H.-J.GREGOR sieved out of a bulk sediment sample from Pollenzo, MGPTPU141033. c: millimeter-sized, waterlogged-compressed seeds of Sambucus pulchella C.REID et E.REID with abundant cracks, probably formed during both diagenesis and extraction of the fossils (bulk sediment sample from Ciabòt Cagna), MGPT-

Text-fig. 2. Salicaceae (a–g), Cannabaceae (h–n), cf. Betulaceae (o–r). a–g: Saxifragispermum, USNM PAL 772341. Scale bar = 5 mm except as indicated. a–b: Lateral, c: apical, and d: basal views of fruit, reflected light, palladium coated; apex at top of (a, b). e: Equatorial transverse section reflected light; arrows indicate presumed seeds, scale bar = 2 mm. f: Detail of locule contents extracted from (e), transmitted light, scale bar = 200 Μm. g: Interwoven trichomes or fibers from locule, transmitted light, scale bar = 5 Μm. h–j: Celtis. h, i: USNM PAL 772342, reflected light, palladium coated, scale bar = 5 mm. h: Lateral view parallel with plane of dehiscence. i: Lateral view perpendicular to plane of dehiscence. j: DMNH EPI.47809, Celtis in lateral view; showing reticulate sculpture and the vertically-oriented, plane of dehiscence (arrow), scale bar = 5 mm. k–m: Aphananthe. USNM PAL 772344, reflected light, palladium coated, scale bar = 5 mm. k: Apical view, note triangular cross section and apical plug (arrow). l: Lateral view, apex up. m: Lateral view at 90° to (l). n: Detail of cellular pattern at surface of endocarp, scale bar = 0.5 mm. o–r: in The Early Middle Eocene Wagon Bed Carpoflora Of Central Wyoming, U.S.A.

Text-fig. 2. Salicaceae (a–g), Cannabaceae (h–n), cf. Betulaceae (o–r). a–g: Saxifragispermum, USNM PAL 772341. Scale bar = 5 mm except as indicated. a–b: Lateral, c: apical, and d: basal views of fruit, reflected light, palladium coated; apex at top of (a, b). e: Equatorial transverse section reflected light; arrows indicate presumed seeds, scale bar = 2 mm. f: Detail of locule contents extracted from (e), transmitted light, scale bar = 200 Μm. g: Interwoven trichomes or fibers from locule, transmitted light, scale bar = 5 Μm. h–j: Celtis. h, i: USNM PAL 772342, reflected light, palladium coated, scale bar = 5 mm. h: Lateral view parallel with plane of dehiscence. i: Lateral view perpendicular to plane of dehiscence. j: DMNH EPI.47809, Celtis in lateral view; showing reticulate sculpture and the vertically-oriented, plane of dehiscence (arrow), scale bar = 5 mm. k–m: Aphananthe. USNM PAL 772344, reflected light, palladium coated, scale bar = 5 mm. k: Apical view, note triangular cross section and apical plug (arrow). l: Lateral view, apex up. m: Lateral view at 90° to (l). n: Detail of cellular pattern at surface of endocarp, scale bar = 0.5 mm. o–r:

supplementary data about Extraction, Isolation and Structure elucidation of Two Phenolic acids from Aerial parts of Celery and Coriander.

supplementary  data about Extraction, Isolation and Structure elucidation of Two Phenolic acids from Aerial parts of Celery and Coriander. caffiec acid nmr 2.pdf                supplementary data.docx <a href="https://zenodo.org/api/files/52908924-99c6-4a2c-8047-ef7131714205/p%20coumaric%20acid%20nmr%202.pdf">p coumaric acid nmr 2.pdf</a>

opencc-by-4.0Oct 2022View details →

Ultrafast data of "Near-Infrared Plasmon-Induced Hot Electron Extraction Evidence in an Indium Tin Oxide Nanoparticle/Monolayer Molybdenum Disulfide Heterostructure"

Ultrafast differential transmission data: - Ito.txt : differential transmission map of indium tin oxide nanoparticles pumped at 1750 nm - Ito_Mos2.txt : differential transmission map of indium tin oxide nanoparticle / monolayer MoS2 heterojunction pumped at 1750 nm - MoS2_ir.txt : differential transmission map of monolayer MoS2 heterojunction pumped at 1750 nm - MoS2_vis.txt : differential transmission map of monolayer MoS2 heterojunction pumped at 500 nm   In the matrix the first line is the vector of the delays in femtosecond, while the first raw is the vector of the wavelengths in nanometers.

opencc-by-4.0Oct 2017View details →

CATCH-EyoU: Processes in Youth's Construction of Active EU Citizenship: Cross-national Wave 1 Questionnaires: Italy, Sweden, Germany, Greece, Portugal, Czech Republic, UK, and Estonia: EXTRACT: Identification with Europe and Home Country

It is a well-established fact that forming a mature and coherent political identity is one developmental task in adolescence and young adulthood. However, given different degrees of commitment on the regional, national, and European level, the question remains whether young people’s identification varies among those spheres? Drawing on data from the European Catch-EyoU-project, it was the goal of this study to examine whether young people can be classified according to their identification toward their home country and Europe and how these types are associated with age, gender, country as well as political interest, tolerance, and political participation. The study is based on adolescents and young adults from the Czech Republic, Germany, Great Britain, Greece, Estonia, Italy, Portugal, and Sweden (N = 9,339; Mage=19.62; 59.1% female). Cluster analysis revealed five types of young people’s identification with country and Europe which showed significant associations between group membership and tolerance, political interest, and participation. The implications of distinguishing types of identification and their associations with political outcomes are discussed.

opencc-by-4.0Nov 2017View details →

Table: Critical assessment of charge mobility extraction in field-effect transistors.

This TABLE lists the measurement reliability factor, r, the maximum power density, Pmax, dissipated in the transistor channel, as well as the maximum current density, jSDmax, in the channel of (organic) field-effect transistors (FETs) calculated from the data shown in recent literature reports. For the exact definitions of these parameters see Nature Mater. DOI: 10.1038/nmat5035.

Figure 6: Erythema values before and after 10 minutes from application 57 -STUDIES TOWARDS OBTAINING A PHOTOPROTECTIVE DERMO-COSMETIC COMPLEX PRODUCT WITH NATURAL EXTRACTS OF INORGANIC AND ORGANIC SUBSTANCES

The values of the erythema are relatively low, which indicates that the product is compatible with the skin and has no sensitizing potential (¯gure6). Having a complex composition of ingredients with varying degrees of un- saturation, with the major organic structure, the product is subjected to de- structive processes at the impact of UV radiation and atmospheric oxygen. As a result this organic substances undergo structural changes, embodied in the initial color change, division of chain, forming oxidizing action groups and oxygen free radicals that continue the destructive process. Because of these features, the product was subjected to accelerated tests of thermal and photo destruction. As a result of these tests, the product's characteristics have not changed signi¯cantly.

Figure 2: Variation of the shear stress depending on the speed rate 54-STUDIES TOWARDS OBTAINING A PHOTOPROTECTIVE DERMO-COSMETIC COMPLEX PRODUCT WITH NATURAL EXTRACTS OF INORGANIC AND ORGANIC SUBSTANCES

The evaluation of photodegradation was carried out through the variation of photoprotective factor of the studied product kept 60 minutes under UV radiation at 65±C. The tests revealed the preservation or even a slight increase in the SPF. The use of screen substances in the formulation of photoprotective products results in undesirable sensory characteristics: visible white ¯lm on the skin surface, unpleasant sensation, dry or oily skin after application.

Figure 1: Spreadability (plasticity) Figure-STUDIES TOWARDS OBTAINING A PHOTOPROTECTIVE DERMO-COSMETIC COMPLEX PRODUCT WITH NATURAL EXTRACTS OF INORGANIC AND ORGANIC SUBSTANCES

The physical and chemical methods used to characterize the row materials and the ¯nal products are as following: ² to ¯nd out the amount of inorganic substances (with screening role) the samples were incinerated for two hours at 800±C; ² the quantity of organic substance (with the UV ¯ltering role) was deter- mined by an UV-VIS spectrophotometric method; ² vitamins identi¯cation was done according to the European Pharma- copoeia VI-th edition; ² the photoprotective ability was tested by applying a standard amount of emulsion on a synthetic skin device (0,2g=cm2); ² to test the microbial stability were applied the European Pharmacopoeia VI-th edition stipulations; ² to estimate the compatibility with the human skin a standard quantity of sample (0,2g=cm2) was laid under an occlusive patch.

Figure 4: Determination of hydration of the skin before applying the product-STUDIES TOWARDS OBTAINING A PHOTOPROTECTIVE DERMO-COSMETIC COMPLEX PRODUCT WITH NATURAL EXTRACTS OF INORGANIC AND ORGANIC SUBSTANCES

The volunteers who applied the product on the skin appreciated the sensory characteristics such as: easiness of use, pleasant texture, easy absorption without oily traces, appearance, odor and pleasant color (¯gures 4, 5).

Figure 3: Viscosity variation depending on speed rate Table-STUDIES TOWARDS OBTAINING A PHOTOPROTECTIVE DERMO-COSMETIC COMPLEX PRODUCT WITH NATURAL EXTRACTS OF INORGANIC AND ORGANIC SUBSTANCES-

Microbiological characteristics The total number of aerobic germs and fungi was determined by the decimal dilution method or the multiple tube test. For identifying pathogenic species we have used speci¯c tests (table6). The evaluation of photodegradation was carried out through the variation of photoprotective factor of the studied product kept 60 minutes under UV radiation at 65±C. The tests revealed the preservation or even a slight increase in the SPF. The use of screen substances in the formulation of photoprotective products results in undesirable sensory characteristics: visible white ¯lm on the skin surface, unpleasant sensation, dry or oily skin after application.

opencc-by-4.0Mar 2024View details →

Synthetic dataset for end-to-end Relation Extraction of relationships between Organisms and Natural-Products with Mixtral-8x7B-Instruct-v0.1

A new synthetic dataset (training/validation) for end-to-end Relation Extraction of relationships between Organisms and Natural-Products. The new dataset was generated using <a href="https://huggingface.co/mistralai/Mixtral-8x7B-Instruct-v0.1">Mixtral-8x7B-Instruct-v0.1</a>. Like the model, the produced synthetic data are also submitted to the License of the model used for generation (apache-2.0). The new dataset was created based on the top-1000 (per biological kingdom) LOTUS literature references extracted with the <a href="https://github.com/idiap/gme-sampler">GME-sampler</a>. The dataset contains 8,913 items in the training set and 344 items in the validation set. The dataset was generated using the same protocol as described in the article.

opencc-by-4.0Apr 2024View details →

Extracted external domains from Wikipedia dump - 20/03/2024

This dataset contains 6,459,779 distinct domains derived from the external links section of Wikipedia pages. The external links section of a page such as <a href="https://en.wikipedia.org/wiki/OpenWeb" target="_blank" rel="noopener">OpenWeb</a>  contains only one <a href="https://www.openweb.com/" target="_blank" rel="noopener">link</a>. The primary objective of assembling this dataset is to improve content prioritization and filtering in web crawling techniques. The dataset is structured as a text file, with each line representing a distinct domain.

opencc-by-4.0Dec 2023View details →

SLR Extract

Output of a Scopus data search on 06.11.2023 without dublicatesTitle and Abstract Filter = Sustainable OR Sustainability AND Digital AND InnovationN = 59

opencc-by-4.0Apr 2024View details →

EnzChemRED, a rich enzyme chemistry relation extraction dataset

<h1>Abstract</h1> Expert curation is essential to capture knowledge of enzyme functions from the scientific literature in FAIR open knowledgebases but cannot keep pace with the rate of new discoveries and new publications. In this work we present EnzChemRED, for Enzyme Chemistry Relation Extraction Dataset, a new training and benchmarking dataset to support the development of Natural Language Processing (NLP) methods such as (large) language models that can assist enzyme curation. EnzChemRED consists of 1,210 expert curated PubMed abstracts in which enzymes and the chemical reactions they catalyze are annotated using UniProtKB and ChEBI identifiers. We show that fine-tuning language models with EnzChemRED significantly boosts their ability to identify proteins and chemicals in text (86.30% F1 score) and to extract the chemical conversions in which they participate (86.66% F1 score), and the enzymes that catalyze those conversions (83.79% F1 score). We apply our methods to abstracts at PubMed scale to create a draft map of enzyme functions in literature to guide curation efforts in UniProtKB and the reaction knowledgebase Rhea. Corresponding authors: Alan Bridge (alan.bridge@sib.swiss) and Zhiyong Lu (zhiyong.lu@nih.gov) <h1>Content</h1> This repository contains data to support the development of natural language processing (NLP) methods to mine biochemical reactions from text for Rhea and UniProt.