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18,621 results for “development;”
Pregnancy-related diagnosis codelist developed for the ConcePTION pregnancy algorithm
<p><span>The IMI ConcePTION project aims to build an ecosystem to generate Real World Evidence to address the information gap in medication safety in pregnancy. </span></p> <p><span>The ConcePTION pregnancy algorithm was developed as part of the IMI ConcePTION project and aimed at identifying a comprehensive list of pregnancies experienced by the population in European healthcare data sources. To achieve this, the ConcePTION pregnancy algorithm was designed to retrieve any record implying a pregnancy at record date from multiple data provenance, for instance, records of birth registries, congenital anomalies register, hospital admission and discharge, primary care. </span></p> <p><span>The diagnosis code list named “PrA_Codelist” was developed and integrated into the ConcePTION pregnancy algorithm to identify records with a diagnostic code implying that the person is experiencing an ongoing or an end of pregnancy.</span></p>
Historical 'as-if' cash flow diagrams according to all strategies developed
<p><span>In the context of the project activities of WP6, entitled "Strategies to increase the financial resilience of coastal cities", this document briefly describes the contents of D6.6 "Historical ‘as-if’ cash flow diagrams according to all strategies developed". The data provided, in conjunction with the DSS tool (D6.7), serves decision makers in Massa, Vilanova i la Geltrú, and Oarsoaldea CCLLs by helping them evaluate and choose among different financial resilience strategies to manage flood related financial risk.</span></p>
Timeline of drug development in inflammatory bowel disease
<p>Timeline of drug development in inflammatory bowel disease from the first trial published in 1955 until 2024.</p> <p>Detailed explanation of these trials can be found at www.ibd-eii.com</p>
Figure 4 in Husbandry, captive breeding, larval development and stages of the Malayan horned frog Megophrys nasuta (Schlegel, 1858) (Amphibia: Anura: Megophryidae)
Figure 4. Megophrys nasuta larvae in stages 25 to 45. Drawings: M. Wildenhues.
Figure 3 in Husbandry, captive breeding, larval development and stages of the Malayan horned frog Megophrys nasuta (Schlegel, 1858) (Amphibia: Anura: Megophryidae)
Figure 3. Megophrys nasuta larvae in stages 18 to 22. Drawings: R. Bach.
Figure 7 in Husbandry, captive breeding, larval development and stages of the Malayan horned frog Megophrys nasuta (Schlegel, 1858) (Amphibia: Anura: Megophryidae)
Figure 7. Megophrys nasuta larvae in stages 30 to 34. Photos: M. Wildenhues.
Figure 6 in Husbandry, captive breeding, larval development and stages of the Malayan horned frog Megophrys nasuta (Schlegel, 1858) (Amphibia: Anura: Megophryidae)
Figure 6. Megophrys nasuta larvae in stages 25 to 29. Photos: M. Wildenhues.
Figure 9 in Husbandry, captive breeding, larval development and stages of the Malayan horned frog Megophrys nasuta (Schlegel, 1858) (Amphibia: Anura: Megophryidae)
Figure 9. Megophrys nasuta larvae in stages 41 to 46. Photos: M. Wildenhues.
Combining AlphaFold with Focused Virtual Library Design in the Development of Novel CCR2 and CCR5 Antagonists
<p>Collection of code and data accompanying the manuscript titled "Combining AlphaFold with Focused Virtual Library Design in the Development of Novel CCR2 and CCR5 Antagonists ". Read the included README.md file for more information.</p>
What Affects Developer Experience in Software Platforms?
<p>this study aims to investigate and characterize the factors that affect Developer Experience (DX) in software platforms. To do so, we reviewed the existing literature on scientific databases and digital libraries to map and analyze the state-of-the-art of DX in development on software platforms. As the main contribution, we provide a set of DX factors as a reference guide to support researchers and practitioners in improving the development processes of the products and services on software platforms.</p>
Table 1 in Delphinid brain development from neonate to adulthood with comparisons to other cetaceans and artiodactyls
<p><i>Table 1.</i> Comparison of adult and neonate index of encephalization (EQ) for 15 cetacean (1 mysticete, 14 odontocete) species. EQs were derived from brain and body masses in Table S1.</p><table><thead><tr><th>Family</th><th>Species</th><th>Adult EQ</th><th>Neonate EQ</th></tr></thead><tbody><tr><th>Balaenopteridae</th><td><i>B. physalus</i></td><td>0.495</td><td>2.297</td></tr><tr><th>Delphinidae</th><td><i>C. commersonii</i></td><td>5.149</td><td>7.234</td></tr><tr><th></th><td><i>D. delphis</i></td><td>3.962</td><td>7.801</td></tr><tr><th></th><td><i>G. griseus</i></td><td>4.055</td><td>5.807</td></tr><tr><th></th><td><i>L. acutus</i></td><td>3.805</td><td>6.632</td></tr><tr><th></th><td><i>L. obliquidens</i></td><td>4.635</td><td>8.315</td></tr><tr><th></th><td><i>O. orca</i></td><td>2.425</td><td>8.317</td></tr><tr><th></th><td><i>S. bredanensis</i></td><td>5.633</td><td>8.065</td></tr><tr><th></th><td><i>T. truncatus</i></td><td>3.972</td><td>8.328</td></tr><tr><th>Physeteridae</th><td><i>P. macrocephalus</i></td><td>0.681</td><td>4.402</td></tr><tr><th>Kogiidae</th><td><i>K. breviceps</i></td><td>1.703</td><td>4.767</td></tr><tr><th>Pontoporiidae</th><td><i>P. blainvillei</i></td><td>1.930</td><td>2.571</td></tr><tr><th>Monodontidae</th><td><i>D. leucas</i></td><td>2.643</td><td>5.764</td></tr><tr><th>Phocoenidae</th><td><i>P. phocoena</i></td><td>2.837</td><td>4.406</td></tr><tr><th></th><td><i>P. dalli</i></td><td>2.909</td><td>3.275</td></tr></tbody></table>
Database on chemotherapy-induced cognitive impairment and its long-term development in patients with breast cancer - results from the observational CICARO Study
<p>Raw data and edited data on the observational CICARO-study on chemotherapy-induced cognitive impairment and its long-term development in patients with breast cancer</p>
Selected quantitative measurements of Ceratitis capitata embryonic development
<p>Selected quantitative measurements of <em>Ceratitis capitata</em> embryonic development (processed image data, Mathematica notebooks, as well as intermediate measurement and visualization files)</p>
Deliverable D1.2 - Supplementary material : Datasets on substance prioritization for subsequent development of target analytical methods for relevant iPM(T) substances in waters in case studies CS#1, CS#2, CS#3 & CS#7.
<p>Additional information on deliverable D1.2. Data sets for substance prioritization and subsequent development of target analytical methods for relevant iPM(T) substances in waters in case studies CS#1, CS#2, CS#3 and CS#7.</p>
A transposase-derived gene responsible for human brain development
<p><span>Vertebrate brain development is associated with prominent neuronal cell death and DNA breaks, but their causes and functions are not well understood. DNA transposable elements and transposase-derived genes could contribute to DNA breaks and somatic genome rearrangements, however their contributions to brain development are largely unknown. PiggyBac Transposable Element Derived 5 (PGBD5) is an evolutionarily conserved vertebrate DNA transposase-derived gene with retained nuclease activity in human cells. Here, we show that PGBD5 contributes to normal brain development in mice and humans, and its deficiency causes disorder of intellectual disability, movement, and seizures. In mice, Pgbd5 is required for the developmental induction of post-mitotic DNA breaks and recurrent somatic brain<em> </em>genome rearrangements. In the cerebral cortex, loss of Pgbd5 leads to aberrant differentiation and gene expression of distinct neuronal populations, including specific types of glutamatergic neurons, which can explain the features of PGBD5 deficiency in humans. Thus, PGBD5 is a transposase-derived gene required for brain development in mammals. </span></p>
Targeting Plasmodium falciparum chondroitin sulfate a ligand: A highly conserved malaria antigen with potential for pregnancy-associated malaria vaccine development
<p>The dataset represents the details of sera samples collected from participants recruited for a longitudinal study. The sera was used for ELISA <em>in vitro</em> assays. The immunoreactivity of PfCSA-L antigen was assessed with the utilization of the gravidity status of the study participants. The antigen is used by the <em>plasmodium falciparum</em> parasite to adhere to the placenta during pregnancy and causes challenges both to the mother and her fetus.</p> <h5>Variables</h5> <ul> <li> <p>Sample_ID - This is the coded details of the study participant.</p> </li> <li> <p>Mean*od <em>_1st_visit, Mean</em>od <em>_2nd_visit, and Mean</em>od *_3rd_visit - These represent the mean reactivity values for antibody (IgG) to PfCSA-L antigen for antenatal visits 1,2 and 3 respectively.</p> </li> <li> <p>Gravida - Refers to the total number of confirmed pregnancies a female has had, regardless of the outcome of the pregnancy.</p> </li> <li> <p>PCR_Results - these are molecular diagnostic results for <em>Plasmodium falciparum</em> to assess whether the study participants were positive or negative for this species. positive = 1 and negative = 0</p> </li> <li> <p>Gestation..weeks - Refers to how far along the pregnancy is, from the first day of the woman's last menstrual cycle to the delivery</p> </li> <li> <p>Newborn outcome - Describes the health status of the childlren when they were born</p> </li> <li> <p>Gravida_class - Describes the different classes of gravida, such that primigravida means single pregnancy, secundigravida-second pregnancy, and tertigravida-third pregnancy</p> </li> <li> <p>Age - Describes the age of the participants recruited for the study</p> </li> <li> <p>HB_level - Describes the amount of hemoglobin in whole blood expressed in grams per deciliter (g/dl) during<br>enrolment</p> </li> <li> <p>Type of delivery - A spontaneous vaginal delivery (SVD) describes when a pregnant female goes into labor without the use of drugs or techniques to induce labor, and delivers her baby in the normal manner, without forceps, vacuum extraction, or a cesarean section (cs)</p> </li> <li> <p>N/A - Missing values for different variables</p> </li> </ul>
Membrane staining and segmentation of a developing mouse embryo from 4 to 26 cells
<h1>Intent</h1> <p>The role of this dataset is to provide an example of segmentable and trackable data using signal from cell membrane. This dataset contains one file with the pre-processed imaged embryo (imaging.zip -> imaging.tif) and one file with the outcome of a segmentation using Cellpose (segmentation.zip -> segmentation.tif).</p> <blockquote> <p>This embryo corresponds to the embryo "C1" in the <a href="https://doi.org/10.1126/science.adh1145" target="_blank" rel="noopener">original publication</a></p> </blockquote> <h1>Animal</h1> <p>This set of data represents a mouse embryo developing from the 4-cell stage. The embryo at the last processed timepoint has 26 cells. The mother and the father were both mTmG animals (tdTomato anchored at the membrane of the cells).</p> <blockquote> <p>Details can be found in the <a href="https://doi.org/10.1126/science.adh1145" target="_blank" rel="noopener">original publication</a></p> </blockquote> <h1>Culture conditions</h1> <p>The embryo was imaged in an inverted SPIM from Luxendo (now Bruker), laying at the bottom of a PFE imaging dish. The embryo developed in a small pocket made by deforming the PFE with a glass tip. We used approx. 150μL of KSOM-AA to cutlure the embryos at 37ºC ± 0.2ºC in 5% CO2 and 5% O2. The medium was covered with approx. 100μL of mineral oil.</p> <blockquote> <p>Details can be found in the <a href="https://doi.org/10.1126/science.adh1145" target="_blank" rel="noopener">original publication</a></p> </blockquote> <h1>Imaging conditions</h1> <p>The tdTomato was excited with a 561nm laser using as little intensity as possible (0% in the settings + a small fraction leaking through the shutter). We used a 561 LP filter to acquire the signal. Imaging was set with a lateral resolution of 0.208μm and a axial resolution of 1μm. Because of technical issues with the stage of the microscope at the time, the resulting axial resolution was ultimately 1.338μm. In total, 181 slices were acquired per time point. Two consecutive timepoints start with 15 minutes of interval.</p> <p>Although this embryo was imaged for a longer period of time, this dataset shows only the first 117 timepoints.</p> <blockquote> <p>Details can be found in the <a href="https://doi.org/10.1126/science.adh1145" target="_blank" rel="noopener">original publication</a></p> </blockquote> <h1>Processing conditions</h1> <table> <tbody> <tr> <td><strong>Operation</strong></td> <td><strong>Lateral resolution</strong></td> <td><strong>Axial resolution</strong></td> <td><strong>File</strong></td> </tr> <tr> <td><strong>Imaging</strong></td> <td>0.208 μm</td> <td>1.338 μm</td> <td>-</td> </tr> <tr> <td><strong>Cropping<br></strong></td> <td>0.208 μm</td> <td>1.338 μm</td> <td>-</td> </tr> <tr> <td><strong>Lateral binning (average)</strong></td> <td>0.416 μm</td> <td>1.338 μm</td> <td>-</td> </tr> <tr> <td><strong>Isotropic rescaling</strong></td> <td>0.416 μm</td> <td>0.416 μm</td> <td>-</td> </tr> <tr> <td><strong>Lateral binning (average)</strong></td> <td>0.832 μm</td> <td>0.832 μm</td> <td>imaging.tif</td> </tr> <tr> <td><strong>Segmentation (cellpose)</strong></td> <td>0.832 μm</td> <td>0.832 μm</td> <td>segmentation.tif</td> </tr> </tbody> </table>
Development of a High-Energy-Density Lithiated Silicon-Sulfur Full Cell with Enhanced Stability and Longevity
<p>The raw materials for the draft: "Development of a High-Energy-Density Lithiated Silicon-Sulfur Full Cell with Enhanced Stability and Longevity"</p>
Underlying data for "Development of a framework of potential adverse effects of interventions to improve critical thinking about health choices: A mixed methods study."
Open the record for dataset details and reuse information.
Properties of selected alkali-activated materials for sustainable development
<p>The presented research focuses on three selected variants of alkali-activated materials, where the goal is to compare key properties from the point of view of material engineering and structural design. Tests of the mechanical properties of the examined materials are carried out and their durability is compared, namely frost resistance, resistance to chemical and de-icing substances and resistance to elevated temperature.</p>
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.