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29,897 results for “activism”
Neual activities of 126 mouse brain areas under itch-scratching cycles
<p>The data in a Cell Report paper: "An Atlas of Itch-associated Neural Dynamics in the Mouse Brain".</p> <p>The paper will be online about on Nov 1st, 2023.</p>
Smartphone and smartwatch inertial measurements from heterogeneous subjects for human activity recognition.
<p>This repository contains the dataset and contents described in the <i><strong>"Dataset of inertial measurements of smartphones and smartwatches for human activity recognition"</strong></i> data article.</p><blockquote><p>Matey-Sanz, M., Casteleyn, S., & Granell, C. (2023). Dataset of inertial measurements of smartphones and smartwatches for human activity recognition. <i>Data in Brief</i>, 109809.</p></blockquote>
Exogenous foods that activate the NRF2 protein: Systematic review
<p><strong>Background: </strong>The activation of the NRF2 signaling pathway, whether through natural compounds, diet, or supplements, plays a crucial role in protecting against oxidative stress and promoting health in various aspects. The objective of this research was to identify studies on exogenous foods that activate the NRF2 protein in the scientific literature.</p> <p><strong>Method: </strong>A comprehensive literature review was conducted with the aim of identifying manuscripts related to the activation of NRF2 with exogenous foods and their benefits within the human body. This search was carried out through a systematic review of articles in three languages: English and Spanish, using the MEDLINE, MUBMEB, SCIELO, and SCOPUS repositories. Inclusion criteria focused on foods that activate NRF2 and potential benefits, while exclusion criteria encompassed articles that did not discuss activation, unrelated topics, research in languages other than those specified, and those that did not specifically address the study's objective. The search and article filters were implemented during the period from January to February 2023. To minimize biases, filters were applied in multiple stages, beginning with title search and selection, followed by abstract review, and finally, reading the remaining articles to analyze the information relevant to the research.</p> <p><strong>Results: </strong>A total of 26 articles were analyzed, which discussed the adaptive mechanism of NRF2 and its role in hormone dose response, the effects of certain foods, health benefits associated with NRF2 activation, antioxidant, and anti-inflammatory effects, altered NRF2 association with aging, and neurodegenerative diseases.</p> <p><strong>Conclusion: </strong>The studies support the notion that NRF2 activation plays a fundamental role in promoting health in various spheres, underscoring the relevance of factors such as diet, natural components, and antioxidant supplementation in defending against oxidative stress and its implications for overall well-being. For future research on this topic, it is important to analyze how the population stands regarding the consumption of exogenous foods that activate NRF2, to understand both the consumption, quantity, and frequency of certain foods and whether they are doing so correctly.</p>
Data for: Potential of root acid phosphatase activity to reduce phosphorus fertilization in maize cultivated in Brazil
<p><strong>Potential of root acid phosphatase activity to reduce phosphorus fertilization in maize cultivated in Brazil</strong></p> <p class="Texto"><span>It is urgent to mitigate the environmental impacts resulting from agriculture, especially in highly biodiverse and threatened areas, as the Brazilian Cerrado. We aim to investigate whether root acid phosphatase activity is an alternative plant strategy for nutrient acquisition in maize genotypes cultivated under fertilized and unfertilized conditions in Brazil, potentially contributing to reducing the use of phosphate fertilizers needed for production. Three experiments were performed: the first was conducted in a glasshouse, with 17 experimental maize inbred lines and two phosphorus (P) treatments; the second in the field, with three maize inbred lines and two treatments, one without fertilization and another with NPK fertilization; and the third was also carried out in the field, with 13 commercial hybrids, grown either under NK or under NPK treatment. Plant variables were measured and tested for the response to fertilization, differences amongst genotypes and response to root acid phosphatase activity. The activity of root acid phosphatase was modulated by the availability of P and nitrogen (N) in the soil and promoted grain filling of commercial hybrids in soils with low P availability. These results demonstrate that it is possible to select genotypes that are more adapted to low soil P availability aiming at organic production or to use genotypes that have high phosphatase activity under P fertilization to reduce the amount of added P needed for maize production in Brazil. </span></p>
Data files for Axonal transport of autophagosomes is regulated by dynein activators JIP3/JIP4 and ARF/RAB GTPases
<p>Supporting data files for <strong>Axonal transport of autophagosomes is regulated by dynein activators JIP3/JIP4 and ARF/RAB GTPases</strong></p>
Understanding Activity-Stability Tradeoffs in Biocatalysts by Enzyme Proximity Sequencing
<p>Data and scripts of the manuscript "<strong>Understanding Activity-Stability Tradeoffs in Biocatalysts by Enzyme Proximity Sequencing</strong>" by Rosario Vanella, Christoph Küng, Alexandre A. Schoepfer, Vanni Doffini, Jin Ren and Michael A. Nash.</p>
Adolescence is characterized by more sedentary behavior and less physical activity even among highly active forager-farmers
<p>Over 80% of adolescents worldwide are insufficiently active, posing massive public health and economic challenges. Declining physical activity (PA) and sex differences in PA consistently accompany transitions from childhood to adulthood in post-industrialized populations and are often attributed to psychosocial and environmental factors. An overarching evolutionary theoretical framework and data from pre-industrialized populations are lacking. This cross-sectional study tests hypotheses from life history theory, that adolescent PA is inversely related to age, but this association is mediated by Tanner stage, reflecting higher and sex-specific energetic demands for growth and reproductive maturation. Detailed measures of PA and pubertal maturation are assessed among Tsimane forager-farmers (age: 7–22 yrs.; 50% female, n=110). Most Tsimane sampled (71%) meet World Health Organization PA guidelines (≥60 minutes/day of moderate-to-vigorous PA). Like post-industrialized populations, sex differences and inverse age-activity associations were observed. Tanner stage significantly mediated age-activity associations. Adolescence presents difficulties to PA engagement that warrant further consideration in PA intervention approaches to improve public health.</p>
Digital research data from: Magnesium activation affects the properties and phosphate sorption capacity of poultry litter biochar
<p>This is digital research data corresponding to a published manuscript, <em>Magnesium activation affects the properties and phosphate sorption capacity of poultry litter biochar</em>. Biochar 5:64. https://doi.org/10.1007/s42773-023-00263-5. </p> <p>Biochars with a high affinity for phosphorus (P) are promising soil amendments for reducing P in agricultural runoff. Poultry litter (PL) is an abundant biochar feedstock. However, PL-derived biochars are typically high in soluble P and therefore require chemical modification to become effective P sorbents. This study investigated the effect of magnesium (Mg) activation on extractable P (EP) and P sorption capacities of PL-derived biochars. Biochar was produced at 500–900 °C from PL activated with 0–1 M Mg. Three differentially aged PL feedstocks were evaluated (1-, 3–5-, and 7–9-year-old). </p>
Nesting activity of Olive ridley and effect of artificial shade at Cascajilloso Beach, a new inhabited nesting site in Pacific Panama
<p><span>Sea turtle nesting activity on newly monitored beaches yields important data to support future regional and global conservation assessments. Here we report on nesting activity of Olive Ridley (<em>Lepidochelys</em> <em>olivacea</em>) at Cascajilloso Beach in Pacific Panama based on data from a new hatchery during seasons 2019, 2020 and 2021. Besides, we conducted a field experiment analyzing the effects of artificial shading on </span><span>hatchlings' biometric characteristics, hatching success and the incubation period. Nesting activity based on number of egg clutches transferred to the hatchery reached a peak between September (33%) and October (25%). Curved carapace length (CCL) of nesting females (64.3–66.2 cm) was similar to other populations of the Eastern Tropical Pacific (ETP). The number of egg clutches was 80 in 2019, 74 in 2020 and 108 in 2021, however, the clutch size was slightly smaller (91.5 to 94.5 eggs) compared with other populations of the ETP. This could be a phenotypic variation of nesting females at this beach. The ability to move egg clutches to the hatchery was affected during 2020 season due to COVID-19 restrictions. Heavy rainfall during the incubation period influenced the nest temperatures registered under artificial shade and unshaded treatments (maximum average 29.9 °C), potentially resulting in males. The warmer temperatures in our experimental nests produced heavier hatchlings contrary to general assumptions, but this was also related to straight carapace length only after a threshold value of 40 mm. Hatchlings under the artificial shade were able to grow to a certain size but potentially at the cost of storing less mass (trade-off). The ongoing beach patrolling and hatchery management techniques with long-term baseline data collection are needed to secure the nesting population of <em>L. olivacea</em> at this recently surveyed beach.</span></p>
Exploring the anti-glioma mechanism of the active components of Cortex Periplocae based on network pharmacology and iTRAQ proteomics in vitro
<p>Hierarchical clustering analysis of candidate proteins was illustrated in heat map, which showed obvious differences between CP-induced cells and controls (Fig. 6). Each column is a sample and each rowindicates a differentially expressed protein. Log values (log<sub>2</sub>expression) of significantly differentially expressed proteins in different samples are displayed in heat maps in different colors. GreenandRedrepresent up-regulation and down-regulation, respectively. The gray part represents no quantitative information of the proteins. T1, T2 and T3 means the CP-treated U251 cells group and C2, C2 and C3 means control group (n=3).</p>
Data from: Dynamic shifts in predator diel activity patterns across landscapes and threat levels
<p>Understanding the constraints dominant predators impose on subordinate species is important for predicting ecosystem dynamics and anticipating outcomes of predator management. Subordinate predators may avoid dominant predators in time or space, making it difficult to quantify antipredator behaviours unless joint spatiotemporal analyses are used. Here, we tested whether an invasive dominant predator (red fox <em>Vulpes vulpes</em>) alters the spatiotemporal activity of an invasive subordinate predator (feral cat <em>Felis catus</em>). We collated records of both species from 3,667 camera-traps deployed experimentally across two regions of south-eastern Australia with simplified predator guilds. Foxes were poison-baited in some landscapes within each region. We used generalised additive models to quantify changes in predator spatiotemporal activity across geographic space, vegetation types, human footprint and (artificially manipulated) gradients of dominant predator activity. Foxes and cats had similar diel activity patterns when averaged across all sites, however there was important differentiation at a finer scale cats did not reduce their spatial activity but shifted diel patterns when localised fox activity was high. Cats were crepuscular on average. However, across dry vegetation types of both regions (where foxes were nocturnal), cats shifted to diurnal behaviour with increasing fox activity. In contrast, fox activity was relatively consistent throughout the daily cycle in the wet forest; here cats avoided dawn when fox activity was high. Changes in cat diel activity patterns may facilitate spatial coexistence between these two invasive predators, potentially shifting feral cat impacts onto different native prey. It is well-appreciated that predator activity varies spatially and fluctuates throughout the daily cycle. However, our study demonstrates that diel activity patterns also vary across space, likely mediated by both landscape-context and fear. Dominant predator avoidance in time appears to be spatially dynamic a key nuance which is overlooked when simply comparing the average activity overlap between two species.</p>
Molecular Dynamics Analysis of Fibroblast Activation Protein (FAP) and Dipeptidyl Peptidase IV (DPP-IV) Complexes with Known Inhibitors
<p>MD Input and Trajectories associated with the Manuscript entitled “Solving the Fibroblast Activation Protein (FAP) Conundrum: An in Depth In Silico Analysis Suggests Key Roles for Ala657 and Tyr541 in Endopeptidase Activity and Ligand Selectivity” </p>
Figure 1 in Comparison of feeding apparatus and feeding intensity of the European sardine (Sardina pilchardus) off Morocco in two Atlantic upwelling areas with different seasonal activity
Figure 1. – Map showing the study area and different fishery areas in the Atlantic off Morocco.
Support for Physical Activity in Everyday Life With Parkinson's Disease
ClinicalTrials.gov study NCT05510739. IPD Sharing: NO. Countries: 1. Publications: 1.
Evaluation of Safety, Tolerability, and Antiviral Activity of Chlorcyclizine HCl in Patients With Chronic Hepatitis C
ClinicalTrials.gov study NCT02118012. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ProACTIVE SCI Physical Activity Intervention
ClinicalTrials.gov study NCT03111030. IPD Sharing: NO. Countries: 1. Publications: 4.
TP05 for the Treatment of Mild to Moderate Active Ulcerative Colitis (UC)
ClinicalTrials.gov study NCT01903252. IPD Sharing: NO. Countries: 1. Publications: 3.
Primary Care Pediatrics Learning Activity and Nutrition With Families
ClinicalTrials.gov study NCT02873715. IPD Sharing: NO. Countries: 1. Publications: 8.
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of Multiple Doses of ABT-333 Alone and in Combination With Pegylated Interferon (pegIFN) and Ribavirin (RBV) in S
ClinicalTrials.gov study NCT00851890. IPD Sharing: Not stated. Countries: 2. Publications: 1.
The Efficacy of Cobitolimod in Patients With Moderate to Severe Active Ulcerative Colitis
ClinicalTrials.gov study NCT03178669. IPD Sharing: NO. Countries: 10. Publications: 1.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.