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6,467 results for “process”
Continuous process technology for glucoside production from sucrose using a whole cell-derived solid catalyst of sucrose phosphorylase
<p>We provide here the underlying data of the publication "Continuous process technology for glucoside production from sucrose using a whole cell-derived solid catalyst of sucrose phosphorylase". Please find the abstract below.</p> <p>Advanced biotransformation processes typically involve the upstream processing part performed continuously and interlinked tightly with the product isolation. Key in their development is a catalyst that is highly active, operationally robust, conveniently produced and recyclable. A promising strategy to obtain such catalyst is to encapsulate enzymes as permeabilized whole cells in porous polymer materials. Here, we show immobilization of the sucrose phosphorylase from Bifidobacterium adolescentis (P134Q-variant) by encapsulating the corresponding E. coli cells into polyacrylamide. Applying the solid catalyst, we demonstrate continuous production of the commercial extremolyte 2-α-D-glucosyl-glycerol (2-GG) from sucrose and glycerol. The solid catalyst exhibited similar activity (≥70%) as the cell free extract (~800 U g-1 cell wet weight) and showed excellent in-operando stability (40 °C) over 6 weeks in a packed-bed reactor. Systematic study of immobilization parameters related to catalyst activity led to the identification of cell loading and catalyst particle size as important factors of process optimization. Using glycerol in excess (1.8 M), we analyzed sucrose conversion dependent on space velocity (0.075 – 0.750 h-1) and revealed conditions for full conversion of up to 900 mM sucrose. The maximum 2-GG space-time yield reached was 45 g L-1 h-1 for a product concentration of 120 g L-1. Collectively, our study establishes a step-economic route towards a practical whole cell-derived solid catalyst of sucrose phosphorylase, enabling continuous production of glucosides from sucrose. This strengthens the current biomanufacturing of 2-GG, but also has significant replication potential for other sucrose-derived glucosides, promoting their industrial scale production using sucrose phosphorylase. </p>
Demoulding process assessment of elastomers in micro-textured moulds
<p>Micro-texturing is an increasingly used technique that aims at improving the functional behaviour of components during their useful life and it is applied in different industrial manufacturing processes for different purposes, such as reducing friction on dynamic rubber seals for pneumatic equipment, among others. Micro-texturing is produced on polymer components by transfer from the mould and might critically increase the adhesion and friction between the moulded rubber part with the mould, provoking issues during demoulding, both in the mould itself and in the rubber part. The mould design, the coating release agent applied to the mould surface and the operational parameters of the moulding/demoulding process are fundamental aspects to avoid problems and guarantee a correct texture transfer during the demoulding process. In this work, the lack of knowledge about demoulding processes is addressed with an in-house test rig and a robust experimental procedure to measure demoulding forces (DF) as well as the final quality of the moulded part between thermoset polymers and moulds. After the characterization of several Sol-Gel coatings formulations (inorganic; hybrid) the influence of several parameters is analysed experimentally, i.e.: Sol-Gel efficiency, texture effects, pattern geometry, roughness and material compound. The results obtained from the experimental studies reveal that texture depth is the most critical geometrical parameter showing high scatter among the selected compounds. Finally, the experimental results are used to compute a model through Reduced Order Modelling (ROM) technique for the prediction of DF.</p>
Processed data for the manuscript, entitled "Substantial increase in heavy precipitation events preceded by moist heatwaves over China during 1961–2019"
<p>This is the dataset on annual frequency of heatwaves, heavy precipitation, and heatwave-heavy precipitation events during 1961-2019 at 1776 stations across China. This dataset is the processed results based on daily observations that are provided by the National Meteorological Science Data Center (<a href="http://data.cma.cn/en">http://data.cma.cn/en</a>). In this processed dataset, the "HW_HI" column is the annual frequency of heat-index-based heatwaves; "HW_TW" column is the annual frequency of wet-bulb temperature based heatwaves; "HP" is the annual frequency of heavy precipitation with taking the 95<sup>th</sup> percentile of non-zero precipitation at the threshold. "HWHP_HI"/"HWHP_TW" column indicate annual frequency of heavy precipitation preceded by HW_HI/HW_TW. All the results shown in the manuscript entitled "<strong>Substantial increase in heavy precipitation events preceded by moist heatwaves over China during 1961</strong>–<strong>2019</strong>", are obtained based on this processed dataset.</p>
Remote and Local Processes Controlling Decadal Sea Ice Variability in the Weddell Sea
<p>These datasets are based on the 270-yr simulation results of CTR and SAOWED experiments, which include annual average of atmospheric and ocean variables used to make figures in a paper by Morioka and Behera (2021).</p>
Database of non-communicable disease reports contributing to UN high-level meeting process (2000-2020)
<p>Database of the key non-communicable disease reports, policy papers, strategies and journal series published 2000-2020 that fed into the UN high-level meeting process</p>
Results of the Web-Delphi process to INAMI stakeholders (three rounds)
<p>IMPACT HTA, WP7 (Methodological tools using multi-criteria value methods for HTA decision-making), Task 3 (Testing the framework with empirical applications), Results of the Web-Delphi process to INAMI stakeholders (three rounds), about the views of stakeholders regarding “The relevance of the following value aspects for the evaluation of new medicines in this disease context is” (2020)</p> <p>For details on the Web-Delphi process, see: IMPACT HTA, Work Package 7 (Methodological tools using multi-criteria value methods for HTA decision-making), Task 3, Deliverable 7.3 (Testing the framework with empirical applications), Testing the IMPACT-HTA Value Framework in collaboration with HTA agencies: Case studies on Non-Small Cell Lung Cancer and Spinal Muscular Atrophy (2021), Aris Angelis (LSHTM, LSE), Mónica Oliveira (IST), Teresa Rodrigues (IST), Liliana Freitas (IST), Carlos Bana e Costa (IST), Panos Kanavos (LSE)</p>
IMPACT HTA, WP7 (Methodological tools using multi-criteria value methods for HTA decision-making), Task 2 (Multi-criteria evaluation framework), Results of the 2nd Web-Delphi process to HTA stakeholders, organized in a single panel
<p>IMPACT HTA, WP7 (Methodological tools using multi-criteria value methods for HTA decision-making), Task 2 (Multi-criteria evaluation framework), Results of the 2<sup>nd</sup> Web-Delphi process to HTA stakeholders, organized in a single panel (all stakeholder groups in a single panel, 2 rounds), about the views of stakeholders regarding “This aspect should be considered in the evaluation of new medicines on a common basis” (2019)</p> <p>For details on the Web-Delphi process, see: IMPACT HTA, Work Package 7 (Methodological tools using multi-criteria value methods for HTA decision-making), Task 2, Deliverable 7.2 (Multi-criteria evaluation framework), Advancing knowledge and MCDA tools to assist HTA agencies in evaluating medicines on a common basis (2021) Oliveira, M.D. (IST), Panos Kanavos (LSE), Bana e Costa, C. (IST)</p>
IMPACT HTA, WP7 (Methodological tools using multi-criteria value methods for HTA decision-making), Task 2 (Multi-criteria evaluation framework), Results of the 1st Web-Delphi process to HTA stakeholders, organized into 6 separate parallel panels
<p>IMPACT HTA, WP7 (Methodological tools using multi-criteria value methods for HTA decision-making), Task 2 (Multi-criteria evaluation framework), Results of the 1<sup>st</sup> Web-Delphi process to HTA stakeholders, organized into 6 separate parallel panels (one panel per stakeholder group, 2 rounds), about the views of stakeholders regarding “This aspect should be considered in the evaluation of new medicines on a common basis” (2019)</p> <p>For details on the Web-Delphi process, see: IMPACT HTA, Work Package 7 (Methodological tools using multi-criteria value methods for HTA decision-making), Task 2, Deliverable 7.2 (Multi-criteria evaluation framework), Advancing knowledge and MCDA tools to assist HTA agencies in evaluating medicines on a common basis (2021) Oliveira, M.D. (IST), Panos Kanavos (LSE), Bana e Costa, C. (IST)</p>
Processed EUVM and NGIMS data from the MAVEN spacecraft
<p>The .csv files contain EUVM and NGIMS data that have been interpolated onto a uniform altitude grid and time scale. For every orbit, the data are interpolated onto a uniform altitude scale. The time at for the average of these points is used to interpolate the EUVM data. the density is recorded in the 'density' variable and the EUVM data are recorded for four spectral bands: (0-7 nm = da, 17-22 nm = db, 0-45 nm = dc, 117-125 nm = dd). Auxiliary parameters of local solar time (LST), longitude (lon), latitude (lat), solar zenith angle (SZA), and the distance between maven and the sun (Rs), are also provided.</p> <p>The .p file contains the same data, but with additional fields for the relative changes in both the EUVM and NGIMS data as well as the slope and r value for a linear fit inside of a rolling 27 day bin. The relative change is defined as the 5 day running mean of the 27-day residuals. Additionally, days with high flares are removed as these data may be affected. The .p file is a pickle file, made with python. </p>
TCGA WES processed by Demichelis Lab
<p>Here we provide processed data of the TCGA WES collection related to the study by Ciani Y. et al, "Allele-specific informed genomic analysis identifies loss of heterozygosity as a common trait of impaired tumor-suppressive processes" that implements the SPICE pipeline. Processed data includes SNV/indels, genomic calls as allele specific copy number, and LOH/gene expression linear models results. For more information visit <a href="https://github.com/demichelislab/SPICE-pipeline">https://github.com/demichelislab/SPICE-pipeline</a></p>
Visual perturbation of balance suggests impaired motor control but intact visuomotor processing in Parkinson's disease, J Neurophysiol (2021): Data
<p>Data set accompanying the publication:</p> <p>Engel, D., Student, J., Schwenk, J., Morris, A. P., Waldthaler, J., Timmermann, L., & Bremmer, F. (2021). Visual perturbation of balance suggests impaired motor control but intact visuomotor processing in Parkinson's disease. <em>Journal of neurophysiology</em>, <em>126</em>(4), 1076–1089. https://doi.org/10.1152/jn.00183.2021</p>
Data sharing and processing infrastructures
<p>These illustrations depict a variety of options for sharing and processing large (research) datasets typically containing human (sometimes personal) data. They were inspired in part by the research article "Bringing Code to Data: Do Not Forget Governance"*, and make use of source material available openly at <a href="https://undraw.co/">https://undraw.co/</a>.</p> <p>When using any of these images, please credit it with:</p> <p>"This image was created by Stephan Heunis and is used under a CC-BY licence."</p> <p>The use and re-use of these images are encouraged, including remixing the images for example changing the colours or merging them together with additional (openly licensed) images.</p> <p><em>*Suver C, Thorogood A, Doerr M, Wilbanks J, Knoppers B. Bringing Code to Data: Do Not Forget Governance. J Med Internet Res 2020;22(7):e18087. DOI: <a href="https://www.jmir.org/2020/7/e18087">10.2196/18087</a></em></p>
Processing differences in Explicit and Transition Cues in Task Switching
<p>This dataset consists of 5 experiments that compare cue and task processing performance in task switching with explicit and transition cues. Experiments 1-3 have been published in Van Loy, Liefooghe and Vandierendonck (2010). The entire data set is used in a study on the utility of integrated measures of speed and accuracy (Vandierendonck, submitted).</p>
Pathobionts in the tumour microbiota predict survival following resection for colorectal cancer - pre-processed data
<p>A multicentre, prospective observational study was conducted of colorectal cancer (CRC) patients undergoing primary surgical resection in the United Kingdom and Czech Republic. Analysis was performed using metataxonomics (microbiome) and ultra-performance liquid chromatography mass spectrometry (UPLC-MS, metabolomics). Both datasets were pre-processed as described in the methods section of the main article. The data here were used as the input to the data analysis workflows available from <a href="https://github.com/jmp111/CRC">Github</a>.</p>
HadISDH v2.0.0 process diagram
Flow chart of dataset processing for HadISDH-land v2.0.0 from hourly quality-controlled values to monthly mean homogenised station values. [Figure 1 of Willett, K. M., Dunn, R. J. H., Thorne, P. W., Bell, S., de Podesta, M., Parker, D. E., Jones, P. D., and Williams Jr., C. N.: HadISDH land surface multi-variable humidity and temperature record for climate monitoring, Clim. Past, 10, 1983-2006, doi:10.5194/cp-10-1983-2014, 2014.]
Processed Synthetic Real-World Data for tristate modelling
<p>This model learning dataset is created out of the <a href="https://zenodo.org/record/7409763">Raw Synthetic RWD</a> raw dataset, including some of the original attributes. It is distributed in JOBLIB files, where .joblib files contain the vectors and _ids.joblib contain the ID of the person from which each vector is extracted.</p> <p>This is useful in case it is needed to map the vectors to metadata about the people that are found in the original raw dataset. Note that corresponds to , or , depending on the dataset.</p> <p>The split is roughly 60% of the people are in the training dataset, and 20% in each of the validation and the testing datasets. The input attributes are the age, the short-term averages and the trends of the current week’s BMI, steps walked, calories burned, sleep quality, mood and water consumption, as well as the previous week’s short-term average and trend of the answer to the health self-assessment question.</p> <p>The outcome to be predicted is a tristate quantized version of the health self-assessment answer to be given in the current week. The dataset is normalized based on the training set. The means and standard deviations used can be found in the train_statistics.joblib file. Finally, the output_descriptions.joblib file contains descriptions of the outcomes to be predicted (not actually needed, since included here).</p>
Processed Synthetic Real-World Data for binary modelling
<p>This model learning dataset is created out of the <a href="https://zenodo.org/record/7409763">Raw Synthetic RWD</a> raw dataset, including some of the original attributes. It is distributed in JOBLIB files, where .joblib files contain the vectors and _ids.joblib contain the ID of the person from which each vector is extracted.</p> <p>This is useful in case it is needed to map the vectors to metadata about the people that are found in the original raw dataset. Note that corresponds to , or , depending on the dataset. The split is roughly 60% of the people are in the training dataset, and 20% in each of the validation and the testing datasets. The input attributes are the age, the short-term averages and the trends of the current week’s BMI, steps walked, calories burned, sleep quality, mood and water consumption, as well as the previous week’s short-term average and trend of the answer to the health self-assessment question.</p> <p>The outcome to be predicted is the binary quantized health self-assessment answer to be given in the current week. The dataset is normalized based on the training set. The means and standard deviations used can be found in the train_statistics.joblib file. Finally, the output_descriptions.joblib file contains descriptions of the outcomes to be predicted (not actually needed, since included here).</p>
Dataset of image processing - High-throughput characterization of cortical microtubule arrays response to anisotropic tensile stress
<p>The data set contains the analysis data files from the image analysis workflow developed to quantify cortical microtubules rearrangements in the case of tensile stress (<a href="https://github.com/VergerLab/MT_Angle2Ablation_Workflow">https://github.com/VergerLab/MT_Angle2Ablation_Workflow</a>), generated form a specific dataset (https://doi.org/10.5878/17te-jg54). The files include the intermediary images processed at each step of the image analysis workflow in imageJ, the log files produced by the imageJ macro describing the input and the output images and the text files containing the quantified values. </p>
Ecotoxicity test results for the paper entitled "Evaluation of a bioelectrochemical reductive/oxidative sequential process for chlorinated aliphatic hydrocarbons (CAHs) removal from a real contaminated groundwater"
<p>Within the frame of the ELECTRA No. 826244 H2020 project, a sequential reductive/oxidative bioelectrochemical process at a laboratory scale was tested with real groundwater from a contaminated site in Northern Italy for chlorinated aliphatic hydrocarbons (CAHs) removal. The changes in groundwater ecotoxicity were followed by a complex ecotoxicity test battery including testorganisms from various trophic levels. The datasets (supplementary to Chapter 3.5) for this publication are presented here. Referred publication: Edoardo Dell'Armi, Marco Zeppilli, Maria Letizia Di Franca, Bruna Matturro, Viktória Feigl, Mónika Molnár, Zsófia Berkl, Imre Németh, Hafsa Yaqoubi, Simona Rossetti, Marco Petrangeli Papini, Mauro Majone, Evaluation of a bioelectrochemical reductive/oxidative sequential process for chlorinated aliphatic hydrocarbons (CAHs) removal from a real contaminated groundwater, Journal of Water Process Engineering, 49, 2022, 103101, https://doi.org/10.1016/j.jwpe.2022.103101.</p>
Raw and post-processed data for the microscopic investigation of the effect of random envelope fluctuations on phoneme-in-noise perception
<p>The current dataset consists of three main folders:</p> <ul> <li><strong>01-Stimuli/</strong>: Contains the three sets of noises (white noise, bump noise, MPS noise) for the 12 study participants (S01 to S12).</li> <li><strong>02-Raw-data/fastACI/</strong>: Contains the raw data as obtained for each participant, which are also available within the GitHub repository of the fastACI toolbox, using the same directory tree. The results for each (anonymised) participant (under: <strong>publ_osses2022b/data_SXX/1-experimental_results/</strong>) include their audiometric thresholds (folder: <strong>audiometry</strong>), the results for the Intellitest speech test (folder: <strong>intellitest</strong>), and for the phoneme-in-noise test /aba/-/ada/ for the three noises (savegame files in MAT format).</li> <li><strong>02-Raw-data/ACI_sim/</strong>: Contains the raw data as obtained for the artificial listener, i.e., the model osses2022a.m (available within the fastACI toolbox). Twelve sets of simulations (using the waveforms of participants S01 to S12) were run for the three types of test noises. The results of the simulations of the phoneme-in-noise test are stored in the savegame MAT files. The template derived from 100 repetitions of /aba/ and /aba/ at an SNR=-6 dB in white noise is also included (template-osses2022a-speechACI_Logatome-abda-S43M-trial-1-v1-white-2022-7-15-N-0100.mat). The same template was used in all simulations.</li> <li><strong>03-Post-proc-data/ACI_exp/</strong>: Auditory classification images (ACIs) derived from the participants' data (folder: <strong>ACI_exp</strong>) and from the simulations (folder: <strong>ACI_sim</strong>). For each participant (or artificial listener) there are three ACIs (MAT files) for each of the corresponding noises. Cross predictions are also included with performance predictions across 'participants' (Crosspred.mat, 12 cross predictions for each noise) or across 'noises' (Crosspred-noise.mat, 3 cross predictions for each participant). The cross predictions all have the same names but are stored in dedicated directories.</li> </ul> <p><strong>Use these data:</strong></p> <ol> <li>Download all these data, place them in a local directory of your computer. If you have MATLAB and you downloaded a local copy of the fastACI toolbox (open access at: <a href="http://github.com/aosses-tue/fastACI">GitHub</a>) you can recreate the figures of our paper.</li> <li>After initialising the toolbox (type 'startup_fastACI;', without quotation marks in MATLAB) and then type either of the following commands, to recreate the figure you want. To recreate the figures in the main text:</li> </ol> <pre><code class="language-javascript">publ_osses2022b_JASA_figs('fig1','zenodo'); publ_osses2022b_JASA_figs('fig2a','zenodo'); publ_osses2022b_JASA_figs('fig2b','zenodo'); publ_osses2022b_JASA_figs('fig3','zenodo'); publ_osses2022b_JASA_figs('fig4','zenodo'); publ_osses2022b_JASA_figs('fig5','zenodo'); publ_osses2022b_JASA_figs('fig6','zenodo'); publ_osses2022b_JASA_figs('fig7','zenodo'); publ_osses2022b_JASA_figs('fig8','zenodo'); publ_osses2022b_JASA_figs('fig8b','zenodo'); publ_osses2022b_JASA_figs('fig9','zenodo'); publ_osses2022b_JASA_figs('fig9b','zenodo'); publ_osses2022b_JASA_figs('fig10','zenodo');</code></pre> <p>To generate the figures of the supplementary materials (Appendix in the BioRxiv preprint):</p> <pre><code class="language-javascript">publ_osses2022b_JASA_figs('fig1_suppl','zenodo'); publ_osses2022b_JASA_figs('fig2_suppl','zenodo'); publ_osses2022b_JASA_figs('fig3_suppl','zenodo'); publ_osses2022b_JASA_figs('fig3b_suppl','zenodo'); publ_osses2022b_JASA_figs('fig4_suppl','zenodo'); publ_osses2022b_JASA_figs('fig4b_suppl','zenodo'); publ_osses2022b_JASA_figs('fig5_suppl','zenodo'); publ_osses2022b_JASA_figs('fig5b_suppl','zenodo');</code></pre> <p><strong>References:</strong></p> <ul> <li><strong>Preprint</strong>: Alejandro Osses, Léo Varnet. "A microscopic investigation of the effect of random envelope fluctuations on phoneme-in-noise perception." BioRxiv.</li> <li><strong>fastACI toolbox</strong>: Alejandro Osses, Léo Varnet. fastACI toolbox: the MATLAB toolbox for investigating auditory perception using reverse correlation (v1.2). Zenodo. doi:<a href="https://doi.org/10.5281/zenodo.7314014">10.5281/zenodo.7314014</a>. Supplement to: <a href="http://github.com/aosses-tue/fastACI/tree/v1.2">https://github.com/aosses-tue/fastACI/tree/v1.2</a></li> </ul>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.