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223 results for “retinoblastoma”
The linker histone H1.2 directs the genome-wide chromatin-association and facilitates the biological effects of the retinoblastoma tumour suppressor protein
GEO Series GSE98728. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
RB1 Loss Triggers Dependence on ESRRG in Retinoblastoma
Retinoblastoma (Rb) is a deadly childhood eye cancer that is classically initiated by inactivation of the RB1 tumor suppressor. Clinical management continues to rely on nonspecific chemotherapeutic agents that are associated with treatment resistance and toxicity. Here, we analyzed whole exomes from primary Rb tumors to identify novel Rb dependencies. Several recurrent genomic aberrations implicate estrogen-related receptor gamma (ESRRG) in Rb pathogenesis. ESRRG is an essential mediator of hypoxic adaptation and cell survival in retinoblastoma, representing a promising new therapeutic target.
Retinoblastoma Survivors Follow-up Study
DCEG researchers are studying survivors of retinoblastoma (Rb), a cancer that forms in the tissues of the retina (the light-sensitive layers of nerve tissue at the back of the eye). Rb usually occurs in children younger than five years and may be hereditary or nonhereditary (sporadic). Sporadic Rb affects just one eye whereas hereditary typically Rb affects both eyes. For the past 30 years, investigators in DCEG have been studying Rb survivors to determine the long-term health effects for these individuals who were treated in childhood. Fortunately, treatment has a very high success rate and many survivors enjoy long productive lives, although some survivors may experience increased risks for developing new cancers.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.