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12,799 results for “Immunization”
Blockade of LAG3 and PD1 leads to co-expression of cytotoxic and exhaustion gene modules in CD8+ T cells to promote antitumor immunity
<p>This is the data necessary to reproduce the figures from "<em>Blockade of LAG3 and PD1 leads to co-expression of cytotoxic and exhaustion gene modules in CD8+ T cells to promote antitumor immunity</em>" by Cillo et al.</p>
Intramuscular prime/intranasal boost vaccination to induce sterilizing immunity against influenza A virus infection
<p>Primary data of manuscript </p>
Dataset: Immunic, Inc. (IMUX) Stock Performance
This dataset provides historical stock market performance data for specific companies. It enables users to analyze and understand the past trends and fluctuations in stock prices over time. This information can be utilized for various purposes such as investment analysis, financial research, and market trend forecasting.
Fig. 4 in Trichoplusia ni (Lepidoptera: Noctuidae) survival, immune response, and gut bacteria changes afer exposure to Azadirachta indica (Sapindales: Meliaceae) volatiles
Fig. 4. Dose-response test using dried neem leaves and 5 doses. In brief, 60 neonates of the NL or Gto strain in a 1 L container with artificial diet were placed aside the dried neem leaves inside an airtight plastic box, and were examined afer 7 d incubation. Data represent the mean ± standard deviation of 2 replicate experiments per treatment.
Fig. 5 in Trichoplusia ni (Lepidoptera: Noctuidae) survival, immune response, and gut bacteria changes afer exposure to Azadirachta indica (Sapindales: Meliaceae) volatiles
Fig. 5. Transcription of selected immune and chemical resistance markers and the ribosomal protein S5 gene from rRNA samples of Trichoplusia ni NL strain larval midguts, dissected from unexposed (control) larvae or larvae exposed to 10 g of neem leaves, determined by reverse transcriptase polymerase chain reaction (RTPCR). A) DNA amplification bands as detected by RT-PCR in agarose gels; B) DNA density estimated values in units compared with the ribosomal protein S5 band using the image sofware Image J, where bars on each column represent the standard error value from 3 replicate samples.
Supplementary Material from: "Wnt/B-catenin activation and TP53 mutations associate with distinct immune profiles in advanced thyroid cancer"
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Supplementary material 1 from: Felden A, Paris C, Chapple DG, Suarez AV, Tsutsui ND, Lester PJ, Gruber MAM (2019) Native and introduced Argentine ant populations are characterised by distinct transcriptomic signatures associated with behaviour and immunity. NeoBiota 49: 105-126. https://doi.org/10.3897/neobiota.49.36086
: Data type: molecular data
Dynamic multi-dose vaccination with initial immunity on higher-order networks
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Dataset related to NAPCAUMAB Project, article title: "Real-practice analysis of potential antibiotic interactions in patients treated with Immune Checkpoint Inhibitors: an observational study from an Italian referral cancer center"
<p>The datasets uploaded are related to data collected for NAPCAUMAB observational project, which aims to analyze potential antibiotic interactions in cancer patients treated with Immune Checkpoint Inhibitors (ICIs) and the outcomes of immunotherapy tretament in these patients in terms of Progression Free Survival (PFS) and Overall Survival (OS). </p>
Supplementary Tables for the manuscript be Kuligina et al. "Germline variants in the immune response-related genes: possible modifying effect on age-dependent BRCA1 penetrance in breast cancer patients"
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Immune Imbalance Transcriptomics (IIT) Algorithm Supplementary Materials
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supplementary materials: Sex hormones and the immune system: a bibliometric analysis
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COVID-19: Longitudinal immune correlates studies icddr,b (GH-VAP-SI-55)
<p><span>The goal of this project is to characterize the humoral immune response to SARS-COV-2 in COVID-19+ individuals in a longitudinal cohort in Bangladesh. </span></p> <p><span>We used plasma samples to run the Olink inflammation panel.</span></p>
Dataset related to the poster entitled "Vitamin D3 deficiency disturbed immune response and respiratory function in the murine model of hypersensitivity pneumonitis"
<p><strong>The dataset contains the results presented on a poster presented at the European Academy of Allergy and Clinical Immunology Hybrid Congress, 31 May – 3 June 2024, Valencia, Spain<br><br></strong></p> <p><em>Project title</em><strong>:</strong> "Assessment of the possibility of using vitamin D3 in the prevention and treatment of pulmonary fibrosis in the course of hypersensitivity pneumonitis - <em>in vivo</em> studies"</p> <p><em>Founder</em><strong>: </strong>National Scientific Center, Poland</p> <p><em>Project number</em><strong>:</strong> UMO-2020/38/E/NZ7/00366</p> <p><em>Principal Investigator</em>: Marta Kinga Lemieszek</p> <p><em>Main investigators:</em><strong> </strong>Michał Chojnacki, Ilona Leśniowska, Jakub Anisiewicz</p> <p><em>Place of project implementation</em><strong>:</strong> Department of Medical Biology, Institute of Rural Health, Jaczewskiego 2, 20-090 Lublin, Poland</p>
Data from: Quantitative genetics of immunity and life history under different photoperiods
Insects with complex life-cycles should optimize age and size at maturity during larval development. When inhabiting seasonal environments, organisms have limited reproductive periods and face fundamental decisions: individuals that reach maturity late in season have to either reproduce at a small size or increase their growth rates. Increasing growth rates is costly in insects due to higher juvenile mortality, decreased adult survival, or increased susceptibility to parasitism by bacteria and viruses via compromised immune function. Environmental changes such as seasonality can also alter the quantitative genetic architecture. Here we explore the quantitative genetics of life history and immunity traits under two experimentally induced seasonal environments in the cricket Gryllus bimaculatus. Seasonality affected the life history but not the immune phenotypes. Individuals under decreasing day length developed slower and grew to a bigger size. We found ample additive genetic variance and heritability for components of immunity (haemocyte densities, proPhenoloxidase activity, resistance against Serratia marcescens), and for the life history traits, age and size at maturity. Despite genetic covariance among traits, the structure of G was inconsistent with genetically based trade-off between life history and immune traits (e.g., a strong positive genetic correlation between growth rate and haemocyte density was estimated). However, conditional evolvabilities support the idea that genetic covariance structure limits the capacity of individual traits to evolve independently. We found no evidence for GxE interactions arising from the experimentally induced seasonality.
Data from: A carbohydrate-rich diet increases social immunity in ants
Increased potential for disease transmission among nest-mates means living in groups has inherent costs. This increased potential is predicted to select for disease resistance mechanisms that are enhanced by cooperative exchanges among group members, a phenomenon known as social immunity. One potential mediator of social immunity is diet nutritional balance because traits underlying immunity can require different nutritional mixtures. Here, we show how dietary protein–carbohydrate balance affects social immunity in ants. When challenged with a parasitic fungus Metarhizium anisopliae, workers reared on a high-carbohydrate diet survived approximately 2.8× longer in worker groups than in solitary conditions, whereas workers reared on an isocaloric, high-protein diet survived only approximately 1.3× longer in worker groups versus solitary conditions. Nutrition had little effect on social grooming, a potential mechanism for social immunity. However, experimentally blocking metapleural glands, which secrete antibiotics, completely eliminated effects of social grouping and nutrition on immunity, suggesting a causal role for secretion exchange. A carbohydrate-rich diet also reduced worker mortality rates when whole colonies were challenged with Metarhizium. These results provide a novel mechanism by which carbohydrate exploitation could contribute to the ecological dominance of ants and other social groups.
Data from: Generalized selection to overcome innate immunity selects for host breadth in an RNA virus
Virus-host co-evolution has selected for generalized host defense against viruses, exemplified by interferon production/signaling and other innate immune function in eukaryotes such as humans. Although cell-surface binding primarily limits virus infection success, generalized adaptation to counteract innate immunity across disparate hosts may contribute to RNA virus emergence potential. We examined this idea using vesicular stomatitis virus (VSV) populations prevoously evolved on strictly immune deficient (HeLa) cells, strictly immune competent (MDCK) cells, or on alternating deficient/competent cells. By measuring viral fitness in unselected human cancer cells of differing innate immunity, we confirmed that HeLa-adapted populations were specialized for innate immune-deficient hosts, whereas MDCK-adapted populations were relatively more generalized for fitness on hosts of differing innate immune capacity and of different species origin. We also confirmed that HeLa-evolved populations maintained fitness in immune-deficient non-human primate cells. These results suggest that innate immunity is more prominent than host species in determining viral fitness at the host-cell level. Finally, our prediction was inexact that selection on alternating deficient/competent hosts should produce innate viral generalists. Rather, fitness differences among alternating host-evolved VSV populations indicated variable capacities to evade innate immunity. Our results suggest that the evolutionary history of innate immune selection can affect whether RNA viruses evolve greater host-breadth.
Data from: Identification and validation of a novel immune-related signature associated with macrophages and CD8 T cell infiltration predicting overall survival for hepatocellular carcinoma
<p><b>Background:</b> Although the effects of macrophages and CD8 T cell infiltration on clinical outcomes have been widely reported, the association between immunity-associated gene with them for hepatocellular carcinoma (HCC) remains unclear.</p> <p><b>Materials and methods: </b>The ssGSEA served for quantifying the macrophages as well as CD8 T cell infiltration in the HCC samples obtained from TCGA database. Kaplan-Meier(KM) survival assay was used to determine the associations between macrophages and CD8 T cell infiltration with OS. LASSO Cox regressive method assisted in developing an immune gene signature as well as building a risk score. The performance was evaluated by the time-dependent ROC together with the KM survival analysis. The ICGC database were adopted for external verification. CIBERSORT was applied to the correlation analysis on the immune-related signature and the immunocyte infiltration. GSEA were employed exploring the underlying molecular mechanisms.</p> <p><b>Results:</b> Increased CD8+ T cell infiltration was associated with longer OS, whereas a greater infiltration of macrophages was related to shorter OS. There were 398 differential expression genes (DEGs) between the high- and low infiltration groups with the "edgeR" package. A prognostic signature consisted of 10 immune genes was built in TCGA and examined in ICGC. The uniform cutoff (0.927) was adopted for separating sufferers into the high-risk(HR) and low-risk(LR) groups. The ROC curves revealed that the AUC data for this signature predicting 1,2,3,4 and 5 year were all above 0.7 in both TCGA and ICGC cohort and patients in the HR<sub> </sub>group exhibited evidently weaker prognostic results compared with the LR group. The HR<sub> </sub>group presented evidently greater Tregs and Macrophage M0 relative to the LR group, whereas the LR group saw the enrichment of CD8 T cells.</p> <p><b>Conclusion:</b> The immune signature associated with macrophages as well as CD8 T cell infiltration has reliable prognostic and predictive value for HCC patients.</p>
Stronger population differentiation at infection-sensing than infection-clearing innate immune loci in songbirds: different selective regimes for different defenses
<p><span><span><span><span><span><span><span><span><span><span><span>Parasite-mediated selection is widespread at loci involved in immune defence, but different defences may experience different selective regimes. For defences involved in clearing infections, purifying selection favouring a single most efficacious allele likely predominates. However, for defences involved in sensing and recognizing infections, evolutionary arms races may make positive selection particularly important. This could manifest primarily within populations (e.g., balancing selection maintaining variation) or among them (e.g., spatially varying selection enhancing population differences in allele frequencies). We genotyped three toll-like receptors (TLR; involved in sensing infections) and three avian beta-defensins (involved in clearing infections) in 96 song sparrows (<i>Melospiza melodia</i>) from three breeding populations that differ in disease resistance. Variation-based indicators of selection (proportion of variable sites, proportion of nonsynonymous SNPs, proportion of sites bearing signatures of positive or purifying selection, rare allele frequencies) did not differ appreciably between the two locus types. However, differentiation was generally higher at infection-sensing than infection-clearing loci. Allele frequencies differed markedly at TLR3, driven by a variant predicted to alter protein function. Geographically structured variants at infection-sensing loci may reflect local adaptation to spatially heterogeneous parasite communities. Selective regimes experienced by infection-sensing versus infection-clearing loci may differ primarily due to parasite-mediated population differentiation.</span></span></span></span></span></span></span></span></span></span></span></p>
Data from: Obligate intrinsic constraints underpin the trade-off between reproduction and immunity
<p>Data for follicle growth, qPCR and immune challenge analyses from manuscript 'Obligate intrinsic constraints underpin the trade-off between reproduction and immunity'. See readme.txt for description of variables in each data file. </p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.