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267 results for “Patents”
Inactive-enriched machine-learning models exploiting patent data improve structure-based virtual screening for PDL1 dimerizers
<p>The 12 VS scenarios considered in this study employing six training-test data partitions<strong> </strong>(A-F). All training sets employ the same set of 371 actives (WO2015160641A2), but differ on the considered set of inactives and hence are uniquely identified by the latter (either TrueInactives, DeepCoys, RandomDecoys or ActivesOnly). Likewise, all test sets employ the same 297 actives (WO201503820A1), none of them also included in the training set, but different sets of inactives (TrueInactives or DeepCoys). </p> <p> </p> <table align="center"> <caption>Table 1. Six virtual screening scenarios corresponding to six pairs of training-test data for each type of SFs (classification or regression)</caption> <thead> <tr> <th scope="col">Partition ID</th> <th scope="col">Training set</th> <th scope="col">Test set</th> <th scope="col">Type</th> </tr> </thead> <tbody> <tr> <td>A</td> <td>DeepCoys</td> <td>TrueInactives</td> <td>Classification</td> </tr> <tr> <td>B</td> <td>RandomDecoys</td> <td>TrueInactives</td> <td>Classification</td> </tr> <tr> <td>C</td> <td>ActivesOnly</td> <td>TrueInactives</td> <td>Classification</td> </tr> <tr> <td>D</td> <td>TrueInactives</td> <td>DeepCoys</td> <td>Classification</td> </tr> <tr> <td>E</td> <td>RandomDecoys</td> <td>DeepCoys</td> <td>Classification</td> </tr> <tr> <td>F</td> <td>ActivesOnly</td> <td>DeepCoys</td> <td>Classification</td> </tr> <tr> <td>A</td> <td>DeepCoys</td> <td>TrueInactives</td> <td>Regression</td> </tr> <tr> <td>B</td> <td>RandomDecoys</td> <td>TrueInactives</td> <td>Regression</td> </tr> <tr> <td>C</td> <td>ActivesOnly</td> <td>TrueInactives</td> <td>Regression</td> </tr> <tr> <td>D</td> <td>TrueInactives</td> <td>DeepCoys</td> <td>Regression</td> </tr> <tr> <td>E</td> <td>RandomDecoys</td> <td>DeepCoys</td> <td>Regression</td> </tr> <tr> <td>F</td> <td>ActivesOnly</td> <td>DeepCoys</td> <td>Regression</td> </tr> </tbody> </table> <p> </p>
PaCL: A Multi-Domain and Bilingual Benchmark for Cross-Lingual Patent Ranking
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Main policosanol extraction patents.
<p>Main policosanol extraction patents (parameters and yields) by saponification, transesterification, solvent extraction, supercritical CO<sub>2</sub> extraction and ultrasonic extraction. </p> <p> </p>
Mechanisms of ineffective patent foramen ovale closure using the percutaneous suture-mediated NobleStitch system.
<p>Zannoni J, Popolo Rubbio A, Tusa MB, Corciu AI, Casenghi M, Cannone G, Barletta M, Stefanini E, Mantovani V, Gorla R, Brambilla N, Testa L, Bedogni F, De Marco F. Mechanisms of ineffective patent foramen ovale closure using the percutaneous suture-mediated NobleStitch system. EuroIntervention. 2022 May 15;18(1):68-70. doi: 10.4244/EIJ-D-21-01021. PMID: 35403602.</p> <p>Introduction Percutaneous suture-mediated patent foramen ovale (PFO) closure with the “device-less” NobleStitch system (HeartStitch) has been employed in clinical practice as an effective and safe alternative to traditional device closure123. In previous studies, recurrence of a residual atrial right-to-left shunt (RLS) during follow-up was estimated at almost 20%123. In any case, specific mechanisms of failure have not been systematically described and they still remain unknown. The aim of the study was to describe the mechanisms of failure after NobleStitch from a prospective single-centre cohort.</p>
Mechanisms of ineffective patent foramen ovale closure using the percutaneous suture-mediated NobleStitch system
<p>Zannoni J, Popolo Rubbio A, Tusa MB, Corciu AI, Casenghi M, Cannone G, Barletta M, Stefanini E, Mantovani V, Gorla R, Brambilla N, Testa L, Bedogni F, De Marco F. Mechanisms of ineffective patent foramen ovale closure using the percutaneous suture-mediated NobleStitch system. EuroIntervention. 2022 May 15;18(1):68-70. doi: 10.4244/EIJ-D-21-01021. PMID: 35403602; PMCID: PMC9903156.</p> <p> </p>
Biodiversity and registered patents in Brazil: What are the patterns?
<p><strong>Forest restoration is crucial to mitigate human impacts on climate, biodiversity, and ecosystem services. However, it is still monetarily non-competitive due to high costs and low economic returns, urging attractive alternatives. Non-timber forest products with a high economic value could provide a way forward, requiring knowledge of options and native species' potential. To summarize scientific knowledge about species potential, challenges, and opportunities, we conducted a forest inventory of regenerating forests in the southeast Atlantic Forest, Brazil. We surveyed the proportion of species patented by companies, identified registered patent patterns, and analyzed the reasons. </strong></p> <p><strong>We surveyed the Brazilian National Institute of Industrial Property — INPI, the top 30 companies with the most patent registrations for biodiversity products or processes in the pharmaceuticals, cosmetics and crop care segments to gain insight into the potential of the native species sampled compared with those that have been registered in our other database (10.5281/zenodo.7826787). We chose companies based on their representativity in the number of patents on the use of biodiversity in each market segment. Next, we build a list of natural ingredients to determine the proportion of Atlantic Forest native tree species used regarding its biotechnological potential. We do not consider natural products or ingredients derived from minerals, sand, clay, fungi, or bacteria. Similarly, we do not consider those isolated from fatty acids or essential oils unless accompanied by a clear species description. Instead, we consider plants like herbs, shrubs, trees, and palm species and their fruits, roots, bark, leaves, branches, wood, seeds, oils, and resin processing to identify proportions between them.</strong></p>
raw dataset related to the article "Patent foramen ovale closure with the Occlutech Figulla Flex II device: A long-term (up to 10-years) follow-up"
<p><strong>Abstract</strong></p> <p><strong>Background.</strong> Percutaneous closure represents the first line of treatment In patients with cryptogenic stroke and documented patent foramen ovale (PFO). Scarce data report the long-term outcomes of patients undergoing PFO closure with the Figulla Flex II device (Occlutech, Germany).</p> <p><strong>Methods</strong>. Consecutive patients undergoing PFO closure with a Figulla Flex II device at a single, high-volume Institution were included. Baseline clinical and procedural features were collected and patients were followed up for up to 10 years. The device's long-term safety was assessed, as well as mortality, recurrent cerebrovascular events, new-onset atrial fibrillation (AF) and residual shunt.</p> <p><strong>Results.</strong> Overall, 442 patients were included. The main indication for PFO closure was cryptogenic stroke/transitory ischemic attack (65.5%), followed by migraine (21.7%), silent lesions at MRI (10.8%), and decompression disease (2.0%). Atrial septal aneurysm was present in 20.8% of cases, Eustachian valve in 9.0%, Chiari network in 19.9%. The most frequently implanted device was the 23/25 mm (49.5% of cases). One procedural failure due to device embolization; in-hospital complications occurred in 15 cases (3.4%; 4 minor access site complications, 11 transient supraventricular tachycardias (SVT)/AF). After a follow-up of 9.2 years, 2 patients suffered recurrent TIA (with no residual R-L shunt detected). A moderate or severe residual shunt was observed in 3 patients after discharge. </p> <p><strong>Conclusions</strong>. Figulla Flex II devices for PFO closure are associated with high procedural success and low incidence of adverse events even at long-term follow-up.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.