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Dataset results
311 results for “function dataset”
Murine GMP- and MDP-derived classical monocytes have distinct functions and fates [dataset 2]
GEO Series GSE261594. Mus musculus. 47 samples. Type: Expression profiling by high throughput sequencing.
Functional precision medicine identifies new therapeutic candidates for medulloblastoma (methylation dataset)
GEO Series GSE151344. Homo sapiens. 30 samples. Type: Methylation profiling by genome tiling array.
Partial dataset related to the article: "Fibrosis Rescue Improves Cardiac Function in Dystrophin-Deficient Mice and Duchenne Patient-Specific Cardiomyocytes by Immunoproteasome Modulation".
<p>This record contains raw data related to the article: "Fibrosis Rescue Improves Cardiac Function in Dystrophin-Deficient Mice and Duchenne Patient-Specific Cardiomyocytes by Immunoproteasome Modulation".</p> <p>Abstract</p> <p>Patients affected by Duchenne muscular dystrophy (DMD) develop a progressive dilated cardiomyopathy<br> characterized by inflammatory cell infiltration, necrosis, and cardiac fibrosis. Standard<br> treatments consider the use of b-blockers and angiotensin-converting enzyme inhibitors that are<br> symptomatic and unspecific toward DMD disease. Medications that target DMD cardiac fibrosis are<br> in the early stages of development. We found immunoproteasome dysregulation in affected hearts<br> of mdx mice (murine animal model of DMD) and cardiomyocytes derived from induced pluripotent<br> stem cells of patients with DMD. Interestingly, immunoproteasome inhibition ameliorated cardiomyopathy<br> in mdx mice and reduced the development of cardiac fibrosis. Establishing the<br> immunoproteasome inhibitionedependent cardioprotective role suggests the possibility of modulating<br> the immunoproteasome as new and clinically relevant treatment to rescue dilated cardiomyopathy<br> in patients with DMD.</p>
Dataset related to article "Chemotherapy accelerates immune-senescence and functional impairments of Vδ2pos T cells in elderly patients affected by liver metastatic colorectal cancer."
<p>Human (gamma delta) γδ T cells are unconventional innate-like lymphocytes displaying a broad array of anti-tumor activities with promising perspectives in cancer immunotherapy. In this context, Vδ2<sup>pos</sup> T cells represent the preferential target of several immunotherapy protocols against solid tumors. However, the impact of both aging and chemotherapy (CHT) on Vδ2<sup>pos</sup> T cells is still unknown. The present study evaluates with multi-parametric flow cytometry the frequencies, terminal differentiation, senescence and effector-functions of peripheral blood and tumor infiltrating Vδ2<sup>pos</sup> T cells purified from liver metastases (CLM) of patients affected by colorectal cancer (CRC) compared to those of sex- and age-matched healthy donors. The peripheral blood of CLM patients underwent CHT is characterized by decreased amounts of Vδ2<sup>pos</sup> T cells showing a relative increase of terminally-differentiated CD27<sup>neg</sup>/CD45RA<sup>pos</sup> (T<sub>EMRA</sub>) cells. The enrichment of this latter subset is associated with an increased expression of the senescent marker CD57. The acquisition of CD57 on T<sub>EMRA</sub> Vδ2<sup>pos</sup> T cells is also coupled with impairments in cytotoxicity and production of TNF-α and IFN-γ. These features resemble the acquisition of an immune-senescent profile by Vδ2<sup>pos</sup> T cells from CLM patients that received CHT, a phenomenon that is also associated with the loss of the co-stimulatory marker CD28 and with the induced expression of CD16. The group of CLM patients underwent CHT and older than 60 years old showed higher frequencies of CD57<sup>pos</sup> and T<sub>EMRA</sub> Vδ2<sup>pos</sup> T cells. Similar results were found for tumor infiltrating Vδ2<sup>pos</sup> T cell subset purified from CLM specimens of patients treated with CHT. The toxicity of CHT regimens also affects the homeostasis of Vδ2<sup>pos</sup> T cells by inducing higher frequencies of circulating CD57<sup>pos</sup> T<sub>EMRA</sub> subset in CLM underwent CHT and younger than 60 years old. Taken together, our data demonstrate that the enrichment of senescent Vδ2<sup>pos</sup> T cells in CLM patients is not only induced by patients' aging but also by the toxicity of CHT that further accelerates the accumulation of CD57<sup>pos</sup> T<sub>EMRA</sub> cells highly dysfunctional in their anti-tumor activities. These results are important to both predict the clinical outcome of CLM and to optimize those protocols of cell cancer immunotherapy employing unconventional Vδ2<sup>pos</sup> T cells.</p>
Dataset related to article "Donor-Specific Anti-HLA Antibodies in Haploidentical Stem Cell Transplantation with Post-Transplantation Cyclophosphamide: Risk of Graft Failure, Poor Graft Function, and Impact on Outcomes."
<p>The presence of donor-specific anti-HLA antibodies (DSA) is associated with a 10-fold increased risk of graft failure in haploidentical stem cell transplantation (haplo-SCT). Consensus guidelines from the European Society for Blood and Marrow Transplantation set a mean fluorescence intensity (MFI) >1000 as a cutoff for DSA positivity. In the absence of an alternative donor, it is recommended that patients undergo desensitization therapy, especially with high DSA levels (>5000 MFI). The aim of this study was to analyze the impact of DSA on risk of graft failure and poor graft function, as well as on major outcomes in a consecutive cohort of patients who were systematically screened for DSA before haplo-SCT. A total of 141 consecutive patients were candidates for unmanipulated haplo-SCT with post-transplantation cyclophosphamide (PT-Cy) at our center between January 2012 and January 2018, and 135 were analyzed for the presence of HLA antibodies. Of these 134 patients underwent haplo-SCT. HLA antibodies were detected in 40 patients, including 19 with DSA and 21 without DSA. Ten of the 19 patients with DSA underwent transplantation using that donor, whereas 2 underwent a desensitization program before transplantation. Only 2 patients experienced primary graft failure (1.4 %), both of whom were without DSA. Twenty patients developed a poor graft function (15%). The 3-year overall survival (OS), 3-year progression-free survival (PFS), and 1-year nonrelapse mortality (NRM) were analyzed according to the presence or absence of DSA. No statistically significant difference was found. No impact of the presence of DSA on the risk of developing graft failure and poor graft function was revealed. Major outcomes of transplantation were analyzed separately in patients with poor graft function and those with good graft function. The 3-year OS, 3-year PFS, and 1-year NRM in good graft function and poor graft function populations were 62% versus 20% (P < .0001), 53% versus 20% (P < .0001), and 12% versus 40% (P = .009), respectively. The presence of low-level DSA in the absence of desensitization did not correlate with the risk of developing graft failure and poor graft function. Patients who experienced poor graft function had worse outcomes than patients with good graft function.</p>
Dataset related to article "NKG2A expression identifies a subset of human Vδ2 T cells exerting the highest antitumor effector functions"
<p>This record contains data related to article "NKG2A expression identifies a subset of human Vδ2 T cells exerting the highest antitumor effector functions"</p> <p> </p> <p>Human Vδ2 cells are innate-like γδ T effectors performing potent immune surveillance against tumors. The constitutive expression of NKG2A identifies a subset of Vδ2 T cells licensed with an intrinsic hyper-responsiveness against cancer. Indeed, the transcriptomic profiles of NKG2A+ and NKG2A- cells characterize two distinct "intralineages" of Vδ2 T lymphocytes that appear early during development, keep their phenotypes, and show self-renewal capabilities in adult life. The hyper-responsiveness of NKG2A+ Vδ2 T cells is counterbalanced by the inhibitory signaling delivered by human leukocyte antigen E (HLA-E) expressed on malignant cells as a tumor-escape mechanism. However, either masking or knocking out NKG2A restores the capacity of Vδ2 T cells to exert the highest effector functions even against HLA-E+ tumors. This is highly relevant in the clinic, as the different degrees of engagement of the NKG2A-HLA-E checkpoint in hepatocellular carcinoma, glioblastoma, and non-small cell lung cancer directly impact patients' overall survival. These findings open avenues for developing combined cellular and immunologic anticancer therapies.</p>
Dataset related to article "Direct effects of octreotide on osteoblast cell proliferation and function"
<p>This record contains data related to article" Direct effects of octreotide on osteoblast cell proliferation and function<strong>".</strong></p> <p> </p> <p><em>Purpose.</em> Octreotide (OCT) is a first-generation somatostatin analog (SSA) used in the treatment of acromegaly and neuroendocrine tumors (NETs). In both diseases, OCT interacts with somatostatin receptors 2 and 5 (SSTR2 and SSTR5), inhibiting hormone hypersecretion and cell proliferation. Skeletal health is an important clinical concern with acromegaly and NETs since acromegalic osteopathy and NET bone metastasis occur in a remarkable number of patients. While OCT’s effect on NET cells has been extensively investigated, its direct action on bone cells remains unknown.</p> <p><em>Methods.</em> Here we investigated OCT direct effects on cell proliferation, differentiation, mineralization, and chemoattractant capacity of murine primary osteoblasts and osteoblast cell line MC3T3-E1.</p> <p><em>Results.</em> OCT inhibited osteoblasts and MC3T3-E1 cell proliferation (-30% ± 16%, and -22 ± 4%, both p<0.05) and increased MC3T3-E1 cell apoptosis (+76 ± 32%, p<0.05 vs control).</p> <p>The anti-proliferative action of OCT was mediated by SSTR2 and SSTR5 in MC3T3-E1, while its proapoptotic effect was abrogated in SSTR2-silenced cells. The analysis of genes related to the early and late phases of osteoblast differentiation showed that OCT did not affect <em>Alp, Runx2</em>, <em>Bglap, Spp1, and Sost </em>levels in MC3T3-E1 cells. Similarly, OCT had no effect on ALP activity and mineralization in osteoblasts. In addition, <em>Vegfa</em> expression decreased in OCT-treated MC3T3-E1 cells and OCT inhibited pancreatic NET cell migration towards osteoblast-conditioned medium.</p> <p><em>Conclusion.</em>This study provides the first evidence of the direct action of OCT on osteoblasts which may have clinically relevant implications for the management of skeletal health in subjects with acromegaly and metastatic NETs.</p>
Dataset related to the article "Comparison between Automatic and Semiautomatic System for the 3D Echocardiographic Multiparametric Evaluation of RV Function and Dimension"
<p>This record contains raw data related to the article “Comparison between Automatic and Semiautomatic System for the 3D Echocardiographic Multiparametric Evaluation of RV Function and Dimension”</p> <p>Background: The right ventricle (RV) plays a pivotal role in cardiovascular diseases and 3-dimensional echocardiography (3DE) has gained acceptance for the evaluation of RV volumes and function. Recently, a new artificial intelligence (AI)–based automated 3DE software for RV evaluation has been proposed and validated against cardiac magnetic resonance. The aims of this study were three-fold: (i) feasibility of the AI-based 3DE RV quantification, (ii) comparison with the semi-automatic 3DE method and (iii) assessment of 2-dimensional echocardiography (2DE) and strain measurements obtained automatically. Methods: A total of 203 subject (122 normal and 81 patients) underwent a 2DE and both the semi-automatic and automatic 3DE methods for Doppler standard, RV volumes and ejection fraction (RVEF) measurements. Results: The automatic 3DE method was highly feasible, faster than 2DE and semi-automatic 3DE and data obtained were comparable with traditional measurements. Both in normal subjects and patients, the RVEF was similar to the two 3DE methods and 2DE and strain measurements obtained by the automated system correlated very well with the standard 2DE and strain ones. Conclusions: results showed that rapid analysis and excellent reproducibility of AI-based 3DE RV analysis supported the routine adoption of this automated method in the daily clinical workflow.</p>
Spanish Dataset for non-functional requirements classification
<p>This dataset is conformed by requirements collected from final degree projects from one University. Manual labeling was performed by 7 annotators in such a way that each requirement had at least 3 labels. The labels were the categories and subcategories of the ISO/IEC 25010 quality model. The label ’No agreement’ was used for requirements with no majority in the labeling process. The final classification of each requirement is based on unanimity or majority. This dataset was created following the FAIR principles.</p>
Spanish Dataset for non-functional requirements classification
<p>NFR Spanish dataset is conformed by requirements collected from final degree projects from one University. Manual labeling was performed by 7 annotators in such a way that each requirement had at least 3 labels. The labels were the categories and subcategories of the ISO/IEC 25010 quality model. The label ’No agreement’ was used for requirements with no majority in the labeling process. The final classification of each requirement is based on unanimity or majority. This dataset was created following the FAIR principles. </p>
Dataset related to article: Resting-state fMRI functional connectome of C9orf72 mutation status
<p><span>The database includes clinical and connectome data from a sample of ALS patients carrying the C9orf72 mutation (ALSC9+), non-mutation-carriers ALS patients (ALSC9-), and ALS mimics (ALSmimics). The reported data consist of:<span> </span>demographic data (i.e., Age and Sex assigned at birth), clinical data (i.e., Bulbar/spinal onset, ALSFRS, Survival, disease duration, and King's Staging System scores), and connectome results.</span><span></span></p>
CSRM Level 2 dataset: inter-station empirical Green's functions (Z-Z component) in continental China from seismic ambient noise data
<p>This dataset contains the <strong>377,770</strong> inter-station empirical Green's functions and associated Rayleigh wave phase/group velocity dispersion curves that are calculated from continuous seismic ambient noise waveforms of <strong>2513</strong> seismic stations deployed in the continent China. This dataset results from a project of constructing the high-resolution China Seismological Reference Model (<strong>CSRM-1.0</strong>) in the top 100 km of the crust and uppermost mantle in continental China (<a href="https://doi.org/10.1029/2024JB029520">Xiao et al, JGR, 2024</a>) (<a href="https://doi.org/10.5281/zenodo.11098135">model link</a>). </p> <p>本数据库包含了利用中国大陆区域 <strong>2513</strong> 个地震台站记录的连续波形数据计算的 <strong>377,770 </strong>条台站间经验格林函数及其瑞利波相/群速度频散曲线。该数据库源于构建中国大陆区域高精度地壳和上地幔顶部 100 公里三维地震学模型(<strong>CSRM-1.0</strong>)的工作 (<a href="https://doi.org/10.1029/2024JB029520">Xiao et al, JGR, 2024</a>) (<a href="https://doi.org/10.5281/zenodo.11098135">模型链接</a>) 。</p> <p>If you face any problem or issue in the usage of this dataset, please feel free to communicate with the corresponding author Xiao Xiao (<strong>xiaox.seis@gmail.com</strong>). </p>
Dataset related to article "Very rapid improvement of extended nitric oxide parameters, associated with clinical and functional betterment, in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) treated with Dupilumab "
<p>This record contains raw data related to article “Very rapid improvement of extended nitric oxide parameters, associated with clinical and functional betterment, in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) treated with Dupilumab"</p> <p>Abstract</p> <p><strong>Background and objective: </strong> Background: Dupilumab, an anti-IL-4 receptor alpha monoclonal antibody, has been recently approved for the treatment of chronic rhinosinusitis with nasal polyps (CRSwNP) and moderate to severe asthma, demonstrating a rapid onset of clinical effects. CRSwNP is characterized by an extended type-2 inflammatory involvement that can be assessed by extended nitric oxide analysis. Objective: In this study we investigated whether Dupilumab is associated with a rapid improvement in extended nitric oxide parameters, lung function and clinical outcomes in patients with CRSwNP.</p> <p><strong>Methods: </strong> : Consecutive patients with CRSwNP and indication to be treated with Dupilumab were evaluated for extended nitric oxide analysis (exhaled, FENO; bronchial, JawNO and alveolar, CalvNO components; nasal, nNO) and lung function 15 and 30 days after treatment initiation, and for clinical outcomes (nasal polyps score, NPS; quality of life questionnaires; visual analogue scales, VAS, for main symptoms, asthma control test, ACT) after 30 days of treatment initiation.</p> <p><strong>Results: </strong> 33 patients were enrolled. All extended nitric oxide and lung function parameters significantly improved after 15 days of treatment remaining stable at 30 days. NPS, VAS for main CRSwNP symptoms, quality of life questionnaires and ACT significantly improved after 30 days of treatment initiation.</p> <p><strong>Conclusion: </strong> Dupilumab is associated with very rapid improvement in type 2 inflammation in all airway districts and this is associated with improved lung function and clinical parameters in patients with CRSwNP.</p>
Dataset related to: "Walking function determinants in parkinson patients undergoing rehabilitation"
<p>We provide the raw data used for the following article:</p> <p>Gialanella B, Gaiani M, Comini L, Olivares A, Di Pietro D, Vanoglio F, Cenicola A, Vezzadini G. <strong>Walking function determinants in parkinson patients undergoing rehabilitation</strong>. NeuroRehabilitation. 2022;51(3):481-488. doi: 10.3233/NRE-220103. </p> <p>Abstract</p> <p><strong>Background: </strong>To date little is known about factors affecting walking rehabilitation in Parkinson's disease (PD) patients.</p> <p><strong>Objective: </strong>This prospective observational cohort study evaluated the walking distance covered in 6 minutes (6 MWD) before and after conventional rehabilitation and verified which among PD motor disorders was the most important determinant of walking distance in PD patients undergoing rehabilitation.</p> <p><strong>Methods: </strong>Data were collected from 55 PD patients, performing a conventional outpatient motor rehabilitation program. The 6MWD at the end of rehabilitation and gain in 6MWD were the outcome measures. The Unified Parkinson's Disease Rating Scale, Hoehn and Yahr scale, Nine Hole Peg Test, Grip and Pinch test, ROM wrist motility, and Berg Balance Scale (BBS) were used to assess PD patients at admission and were considered as dependent variables. Backward multiple regression analyses identified the determinants of 6MWD outcomes.</p> <p><strong>Results: </strong>The 6MWD was 246.58±115 meters at admission and 286.90±116 at the end of rehabilitation. At end of rehabilitation, the 6MWD was 42.32±47 meters greater than admission (p < 0.001), corresponding to an increase of +17.16%. At the end of rehabilitation, the 6MWD was significantly longer in PD patients with stages 1-3 of the Hoehn and Yahr scale. Berg Balance Scale (β= 0.47, p < 0.001) and right Grip and Pinch at admission (β= 0.36, p = 0.001) were the only determinants of final 6MWD. The R2 value of the model was 0.47 (R2 adjusted 0.45). No variable was a determinant of gain in 6MWD.</p> <p><strong>Conclusions: </strong>The study indicates that balance and generalized muscle strength are important determinants of walking rehabilitation in PD patients, in whom it is essential to maintain high levels of balance and muscle strength for a time as long as possible. These findings suggest planning more intensive rehabilitation treatments in PD patients with low levels of balance and muscle strength.</p>
Dataset related to: "Predictive factors of functional abilities in older patients with peripheral neuropathy"
<p>We provide the raw data used for the following article:</p> <p>Gialanella B, Prometti P, Comini L, Monguzzi V, Santoro R. <strong>Predictive factors of functional abilities in older patients with peripheral neuropathy.</strong> Aging Clin Exp Res. 2022 Jan;34(1):193-199. doi: 10.1007/s40520-021-01910-2. </p> <p>Abstract</p> <p><strong>Background and aims: </strong>Little is known about the outcome predictors in peripheral neuropathy (PN). This prospective observational study aimed to identify possible factors predicting the functional abilities in older patients with PN undergoing motor rehabilitation.</p> <p><strong>Methods: </strong>Data were collected in 80 PN patients, aged over 65 years, performing a standard inpatient motor rehabilitation program. The total Functional Independence Measure (FIM) score after rehabilitation, as well as efficiency and effectiveness in total-FIM, were the outcome measures. Backward multiple regression analyses identified the predictors of functional status.</p> <p><strong>Results: </strong>At the end of rehabilitation, total-FIM score was 102.66 ± 10.75, efficiency in total-FIM 0.64 ± 0.29 and effectiveness in total-FIM 48.81 ± 15.35%. Katz index at admission was a predictor of the final total-FIM score (beta 0.46, p < 0.001) and efficiency in total-FIM (beta - 0.38, p = 0.001). Conversely, age was a predictor of the final total-FIM score (beta - 0.31, p = 0.002) and effectiveness in total-FIM (beta - 0.49, p < 0.001). The R<sup>2</sup> values of the models were, respectively, 0.39, 0.15, and 0.24.</p> <p><strong>Discussion: </strong>In PN patients, functional impairment at admission and age are important predictors of functional abilities at the end of rehabilitation.</p> <p><strong>Conclusions: </strong>These findings suggest the need for more intensive rehabilitation in older, more disabled PN patients because they risk achieving lower functional levels with standard rehabilitation programs.</p>
dataset related to article "Autophagy and Lysosomal Functionality in CMT2B Fibroblasts Carrying the RAB7K126R Mutation"
<p>Autophagy, lipophagy and lysosomal activity in CMT2B fibroblasts carrying the p.K126R RAB7 novel mutation, associated with predominantly motor phenotype</p>
Dataset related to article "Acute Blood Levels of Neurofilament Light Indicate One-Year White Matter Pathology and Functional Impairment in Repetitive Mild Traumatic Brain Injured Mice"
<p>Raw data related to the article "Acute Blood Levels of Neurofilament Light Indicate One-Year White Matter Pathology and Functional Impairment in Repetitive Mild Traumatic Brain Injured Mice"</p>
Dataset related to: "Determinants of improvement in functional abilities in peripheral neuropathy patients undergoing rehabilitation: the role of Berg Balance Scale items"
<p>We provide the raw data used for the following article:</p> <p>Gialanella B, Comini L, Prometti P. <strong>Determinants of improvement in functional abilities in peripheral neuropathy patients undergoing rehabilitation: the role of Berg Balance Scale items</strong>. Acta Neurol Belg. 2023 Feb;123(1):173-179. doi: 10.1007/s13760-021-01806-y. </p> <p>Abstract<br> Purpose This prospective observational cohort study aimed to verify whether single Berg Balance Scale (BBS) items were<br> important determinants of improvement in functional abilities in patients with peripheral neuropathy (PN).<br> Methods Data were collected in 75 older patients with PN performing a standard motor rehabilitation program. Backward<br> stepwise multiple regression analyses were performed to identify determinants of outcome measures. Gain in total and motor<br> Functional Independence Measure (FIM) and gain in motor-FIM areas were the outcome measures.<br> Results Among BBS items, at the end of rehabilitation, the score was higher in "sitting unsupported" (3.94 ± 0.22) and lower<br> in "standing on one foot" (1.18 ± 1.06). The gain was higher in "standing to sitting" (1.02 ± 0.67) and "standing unsupported"<br> (1.00 ± 1.00), and lower in "sitting unsupported" (0.22 ± 0.60) and "standing on one foot" (0.65 ± 0.77). "Standing unsupported"<br> was the only determinant of gain in motor-FIM (beta − 0.36, p = 0.002) and gain in self-care (beta − 0.37, p = 0.002).<br> The R2 value of the models was 0.13 and 0.14, respectively. No independent variable was a determinant of gain in total-FIM.<br> Conclusions The study shows that "unsupported standing" is an important determinant of results of ADL rehabilitation in<br> PN patients and indicates that ability to stand without support for a fairly long time is an essential requirement to achieve<br> with rehabilitation higher gain levels in functional abilities in PN patients.</p>
Dataset related to: "Perceptual and qualitative voice alterations detected by GIRBAS in patients with Parkinson's disease: is there a relation with lung function and oxygenation?"
<p>We provide the raw data used for the following article:</p> <p>Olivares A, Comini L, Di Pietro DA, Vezzadini G, Luisa A, Boccali E, Boccola S, Vitacca M. <strong>Perceptual and qualitative voice alterations detected by GIRBAS in patients with Parkinson's disease: is there a relation with lung function and oxygenation?</strong> Aging Clin Exp Res. 2023 Mar;35(3):633-638. doi: 10.1007/s40520-022-02324-4. </p> <p>Abstract</p> <p><strong>Background: </strong>Impairments in respiration, voice and speech are common in people with Parkinson's disease (PD).</p> <p><strong>Aims: </strong>To evaluate the prevalence of dysphonia, assessed by a specific acoustic evaluation and description of the voice by the speech therapist (GIRBAS), and its relation with lung function and oxygenation, in particular cough ability and during the night or exercise desaturation.</p> <p><strong>Methods: </strong>This is a posthoc analysis of a prospective cross-sectional observational study on PD patients collecting anthropometric and clinical data, comorbidities, PD severity, motor function and balance, respiratory function at rest, during exercise and at night, voice function with acoustic analysis and presence of speech disorders, in addition to the GIRBAS scale. Based on GIRBAS Global dysphonia ('G') score, we divided patients into dysphonic (moderate-to-severe deviance from the euphonic condition) vs. no/mild dysphonic and analyzed the relations with respiratory impairments.</p> <p><strong>Results: </strong>We analyzed 55 patients and found significant impairments in both respiratory and voice/speech functions. Most patients (85.5%) presented mild-to-severe deviance from the euphonic condition in at least one GIRBAS perceptual element (80% of cases for Global dysphonia) and only 14.5% did not show deviance in all elements simultaneously. At Odds Ratio analysis, the risk of presenting nocturnal desaturation and reduced peak cough expiratory flow was approximately 24 and 8 times higher, respectively, in dysphonic patients vs. those with no/mild dysphonia.</p> <p><strong>Conclusion: </strong>Perceptual and qualitative evaluation of the voice with GIRBAS showed that mild-to-severe dysphonia was highly prevalent in PD patients, and associated with nocturnal oxygen desaturation and poor cough ability.</p>
Dataset related to article "Important functional role of the protein Osteopontin in the progression of malignant pleural mesothelioma"
<p>This record contains raw data related to article “Important functional role of the protein Osteopontin in the progression of malignant pleural mesothelioma"</p> <p>Background: Malignant Pleural Mesothelioma (MPM) is an aggressive cancer of the mesothelial lining associated with exposure to airborne non-degradable asbestos fibers. Its poor response to currently available treatments prompted us to explore the biological mechanisms involved in its progression. MPM is characterized by chronic non-resolving inflammation. in this study we investigated which inflammatory mediators are mostly expressed in biological tumour samples from MPM patients.<br> Methods: Expression and quantification of Osteopontin (OPN) was detected in tumour and plasma samples of MPM patients by mRNA, immunohistochemistry and ELISA. The functional role of OPN was investigated in mouse MPM cell lines in vivo using an orthotopic syngeneic mouse model.<br> Results: In patients with MPM, the protein OPN was significantly more expressed in tumours than in normal pleural tissues and predominantly produced by mesothelioma cells; plasma levels were elevated in patients and associated with poor prognosis. However, modulation of OPN levels was not significantly different in a series of 18 MPM patients receiving immunotherapy with durvalumab alone or with pembrolizumab in combination with chemotherapy, some of whom achieved a partial clinical response. Two established murine mesothelioma cell lines: AB1 and AB22 of sarcomatoid and epithelioid histology, respectively, spontaneously produced high levels of OPN. Silencing of the OPN gene (Spp1) dramatically inhibited tumour growth in vivo in an orthotopic model, indicating that OPN has an important promoting role in the proliferation of MPM cells. Treatment of mice with anti-CD44 mAb, blocking a major OPN receptor, significantly reduced tumour growth in vivo.<br> Conclusions: These results demonstrate that OPN is an endogenous growth factor for mesothelial cells and inhibition of its signaling may be helpful to restrain tumour progression in vivo. These findings have translational potential to improve the therapeutic response of human MPM</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.