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2,996
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2,996 results for “copd”
Transcriptional profiles of peripheral eosinophils in COPD and asthma - a preliminary study
GEO Series GSE237284. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Expression data from lung tissue in mild-moderate COPD
GEO Series GSE103174. Homo sapiens. 53 samples. Type: Expression profiling by array.
COPD lung tissue expression
GEO Series GSE69818. Homo sapiens. 70 samples. Type: Expression profiling by array.
Gene expression profile at single cell level of clinical mild to moderate COPD
GEO Series GSE279570. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome changes in lung after the intervention of Wendan Decoction on COPD rats
GEO Series GSE262476. Rattus norvegicus. 15 samples. Type: Expression profiling by high throughput sequencing.
MiRNAs expression in peripheral blood monouclear cells from stable COPD and healthy adults
GEO Series GSE102915. Homo sapiens. 12 samples. Type: Non-coding RNA profiling by array.
Identification of target genes in human lung tissue of COPD patients
GEO Series GSE106986. Homo sapiens. 19 samples. Type: Expression profiling by array.
Single-cell sequencing highlights increased atypical AT2 interacting with M1 macrophage in COPD
GEO Series GSE270667. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Comparison of Treg and Teff cells in healthy and COPD smokers.
GEO Series GSE56923. Homo sapiens. 24 samples. Type: Non-coding RNA profiling by array.
Results of differentially expressed lncRNAs in COPD and healthy smoker using the Arraystar Human LncRNA Microarray
GEO Series GSE107426. Homo sapiens. 2 samples. Type: Expression profiling by array.
Effect of Cigarette Smoking on Clinical and Molecular End-points in COPD Patients
<p><span>Cigarette smoking is a primary contributor to mortality risks and is associated with various diseases. Among these, COPD represents a significant contributor to global mortality and disability. The objective of this study is to investigate the effect of smoking on a selected battery of variables, with an emphasis on DNA damage. </span><span>Methods: A total of 87 elderly patients diagnosed with COPD, divided into three groups based on their smoking history (current, former, never-smokers), were evaluated using a cross-sectional approach. Clinical features including mortality, and inflammatory/oxidative parameters (Lymphocytes/Monocytes, Neutrophils/Lymphocytes, Platelets/Lymphocytes ratio), SII, MDA, 8-Oxo-dG, and IL6 (ELISA assay), as well as DNA damage (comet assay), were investigated. Virus infection, i.e., influenza A virus subtype H1N1, JC polyomavirus (JCPyV), BK polyomavirus (BKPyV), and Torquetenovirus (TTV), was also tested. </span><span>Results: Current smokers exhibit higher levels of comorbidity (CIRS; p<0.001), Platelets/Lymphocytes ratio (p<0.001), SII (p<0.05), and DNA damage (p<0.001). Former smokers showed also higher values for parameters associated to oxidative damage, and showed a much lower probability of surviving over 5 years compared to never and current-smokers (p<0.0017). </span><span>Conclusions: This study showed a clear interaction between events which are relevant to the oxidative pathway and cigarette smoking. A category of particular interest is represented by former smokers, especially for the lower survival, possibly due to the presence of more health problems. Our findings raise also the attention to other parameters which are significantly affected by smoking, useful to monitor COPD patients starting a program of pulmonary rehabilitation (DNA damage, inflammation parameters, selected viral infections)</span></p>
Meta-Analysis and Comparative Study of Proteomic Profiles in COPD Patients, Asymptomatic Smokers, and Healthy Individuals Using Mass Spectrometry-Based DIA Approaches on Serum Samples
<p>The provided files include raw data from Data Independent Acquisition (DIA) mass spectrometry proteomics and targeted proteomics of human clinical COPD samples, along with the study design.</p>
Dataset related to: "Relationship between perceived and neuromuscular fatigue in COPD patients with chronic respiratory failure with long‑term oxygen therapy: a cross‑sectional study"
<p>We provide the raw data used for the following article:</p> <p>Paneroni M, Vitacca M, Comini L, Salvi B, Saleri M, Schena F, Venturelli M. <strong>Relationship between perceived and neuromuscular fatigue in COPD patients with chronic respiratory failure with long-term oxygen therapy: a cross-sectional study</strong>. Eur J Appl Physiol. 2022 Nov;122(11):2403-2416. doi: 10.1007/s00421-022-05021-2.</p> <p>Abstract</p> <p><strong>Purpose: </strong>To evaluate perceived fatigue (PF) and neuromuscular fatigue (NMF) in patients with COPD and chronic respiratory failure (CRF) on long-term oxygen therapy (CRF-COPD group), and the relationships between PF, NMF, patient's characteristics, comparing severe patients with COPD to patients without CRF (COPD group).</p> <p><strong>Methods: </strong>This cross-sectional study compared 19 CRF-COPD patients with 10 COPD patients attending a rehabilitation program. PF was determined by Fatigue Severity Scale (FSS), while dyspnea by the Barthel Dyspnea Index (BDI). We assessed quadriceps NMF via electrical nerve stimulation during and following a Maximal Voluntary Contraction (MVC) detecting changes after a Constant Workload Cycling Test (CWCT) at 80% of the peak power output at exhaustion.</p> <p><strong>Results: </strong>CRF-COPD patients showed higher PF (+ 1.79 of FSS score, p = 0.0052) and dyspnea (+ 21.03 of BDI score, p = 0.0023) than COPD patients. After the fatiguing task and normalization for the total work, there was a similar decrease in the MVC (CRF-COPD -1.5 ± 2.4 vs COPD -1.1 ± 1.2% baseline kJ<sup>-1</sup>, p = 0.5819), in the potentiated resting twitch force (CRF-COPD -2.8 ± 4.7 vs COPD -2.0 ± 3.3% baseline kJ<sup>-1</sup>, p = 0.7481) and in the maximal voluntary activation (CRF-COPD -0.1 ± 3.9 vs COPD -0.9 ± 1.2 -2.0 ± 3.3% baseline kJ<sup>-1</sup>, p = 0.4354). FSS and BDI were closely related (R = 0.5735, p = 0.0011), while no correlation between PF and NMF was found.</p> <p><strong>Conclusion: </strong>Patients with CRF-COPD develop higher levels of perceived fatigue and dyspnea than patients with COPD; while neuromuscular fatigue is similar, suggesting a mismatch between symptoms and neuromuscular dysfunction.</p> <p> </p>
Telithromycin: in the Treatment of Acute Exacerbation of Chronic Bronchitis in Adult Outpatients With COPD
ClinicalTrials.gov study NCT00538148. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Prevalence of COPD: First Epidemiological Data From a Large Region of Turkey
ClinicalTrials.gov study NCT00388232. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Medication Adherence in COPD--A Self-Regulation Study
ClinicalTrials.gov study NCT00005717. IPD Sharing: Not stated. Countries: 0. Publications: 0.
The Role of Nebulized Budesonide in the Treatment of Acute Exacerbations of COPD
ClinicalTrials.gov study NCT00274222. IPD Sharing: Not stated. Countries: 0. Publications: 0.
DNA methylation in airway and parenchymal fibroblasts from individuals with and wthout COPD
GEO Series GSE111396. Homo sapiens. 61 samples. Type: Methylation profiling by genome tiling array.
A preliminary study on the screening and mechanism of miRNA as a biomarker for patients with different progressive chronic obstructive pulmonary disease (COPD)
GEO Series GSE220441. Homo sapiens. 19 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Pathophysiological features of disease in a large animal model of COPD
GEO Series GSE242416. Ovis aries. 54 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.