Find research datasets worth reusing

Fig. 18 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids

Fig. 18. Synthesis of prenylated flavonoids (468–471). Reagents and conditions: (a) 1.3 N NaOH, acetone; 3,3-dimethylallyl bromide, benzene, reflux; (b) 3,3-dimethylallyl bromide, 10% KOH; (c) MOMCl, K CO, acetone, 0 ◦ C to RT; (d) p-methoxymethoxyl benzaldehyde, 10% KOH (H O/EtOH); (e) NaOAc, EtOH, reflux; (f) 3N 2 3 2 HCl, MeOH, reflux; (g) I, pyridine, 90 ◦ C.

Fig. 25 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids

Fig. 25. Synthetic route of C-6/C-8 prenylated flavonoids from natural precusor. Reagents and conditions: (a) CH3OCH2Cl, K2CO3, acetone, RT; (b) prenyl bromide, K CO, acetone, 45 ◦ C; (c) Florisil, toluene, reflux; (d) Montmorillonite K10, toluene, reflux; (e) dilute HCl (aq.), CH OH, RT.

Fig. 17 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids

Fig. 17. Chemical structures of prenylated flavonoids with anti-diabetes activity (445–465) and estrogenic activity (466–467).

Fig. 15 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids

Fig. 15. Synthesis of icaritin derivatives (403–412). Reagents and conditions: (f) α,ω-dibromoalkanes (15 equiv), K2CO3 (5 equiv), acetone, reflux, 12 h; (g) diethylamine or dimethylamine, DMSO, RT, 4 h; (h) 1-iodopentane, Cs2CO3, acetone, reflux, 12 h, then diethylamine, DMSO, RT, 4 h.

Fig. 14 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids

Fig. 14. Synthesis of icaritin derivatives (393–402). Reagents and conditions: (a) ethyl iodoacetate, K2CO3, acetone, reflux, 12 h; (b) LiOH, THF, H2O, RT, 1.5 h; (c) corresponding basic amino acid, DIC, HOBt, anhydrous DMF, RT, overnight, His = histidine, Arg = arginine, Lys = lysine; (d) corresponding basic amino acid, HATU, DIPEA, anhydrous DMF, RT, overnight; (e) piperidine, DMF, RT, 20 min.

Fig. 23 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids

Fig. 23. Synthetic route of C-8 prenylated flavonoids. Reagents and conditions: (a) CH3OCH2Cl, K2CO3, acetone, room temp., 83–90%; (b) 4-MOMO-benzaldehyde, KOH, EtOH, reflux, 85%; (c) I2, DMSO, reflux, 8 h, 70%; (d) oxone, acetone, CH2Cl2/NaHCO3/ Na2CO3, RT; then p-toluenesulfonic acid, RT, 76%; (e) dilute HCl (aq.), EtOH, RT, 89%; (f) prenyl bromide, K2CO3, acetone, reflux, 95%; (g) microwave, PhNEt2, reflux, 82%. (h) H2SO4 (20% aq.), CH3OH, reflux, 86%; (j) DDQ, 1,4-dioxane, reflux, 76%.

Fig. 10 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids

Fig. 10. Synthesis of isolaxifolin (369). Reagents and conditions: (a) 3-methyl-2-butenal, Ca(OH), MeOH, 18 ◦ C, 72 h; (b) Ac O, CH Cl, 18 ◦ C, 6 h; (c) 3-methyl-2- 2 2 2 2 buten-1-ol, DEAD, PPh, THF, 0–18 ◦ C, 6 h; (d) Eu(fod), CHCl, 60 ◦ C, 6 h; (e) K CO, MeOH, 0 ◦ C, 1 h.

Fig. 24 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids

Fig. 24. Regioselective synthesis of C-6/C-8 prenylated flavonoids. Reagents and conditions: (a) TEA, TBDMS-Cl, H2SO4, dichloromethane, room temp., 83%; (b) Prenyl alcohol, TPP, DIAD, dichloromethane, ice bath, 56%; (c) Eu(fod), toluene, 140 ◦ C, 81%; (d) NaH, pivaloyl vanilloyl chloride (aq.), tetrahydrofuran, reflux, 3 85%; (e) CuCl, TMS-Cl, dry acetonitrile, RT, 60%; (f) i TBAF (aq.) dry tetrahydrofuran ii Pyrrolidine, H SO, 60%; (g) Pivaloyl chloride, DMAP, dry pyridine, 40 ◦ C, 2 2 4 15 min, H SO dilution; (h) TFA, dichloromethane, water, 30 ◦ C, 72%.

Fig. 7 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids

Fig. 7. Synthesis of icaritin derivatives (237–272). Reagents and conditions: i. bromo-carboxylic acid ethyl esters (2.5–4.0 equiv.), acetone, K2CO3, reflux, 6 h; ii. bromo-carboxylic acid ethyl esters (1.0–1.5 equiv.), acetone, K2CO3, reflux, 6 h; iii. NaOH, MeOH/H2O (2:1), rt, 4 h; iv. glutaric anhydride, DMAP, TEA, DCM, rt, 8 h.

Fig. 4 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids

Fig. 4. Synthesis of antiproliferative prenyl flavonoid derivatives (197–207). Reagents and conditions: (a) CH CN, ZnCl, Et O, HCl g, 0–5 ◦ C; (b) H O, reflux, 2 h; 3 2 2 2 (c) Me SO, K CO, acetone, rt, 0.5 h; (d) benzaldehyde or p-anisaldehyde, KOH, EtOH, H O, rt, 3 h; (e) CH –CHCH Br, K CO, acetone, reflux, 12 h; (f) heat, 2 4 2 3 2 2– 2 2 3 210 ◦ C, 4 h; (g) CH COONa, C H OH, reflux, 24 h; (h) I, pyridine, 90 ◦ C, 16 h; (i) KMnO, HIO, i-PrOH, H O, rt; (j) R R CHP + Ph3Br, n-BuLi, THF, rt, 24 h; (k) 1 3 2 5 2 4 4 2 2 3 equiv BBr3, ClCH2CH2Cl, rt, 2 h; (l) 8 equiv BBr3, ClCH2CH2Cl, reflux, 4 h.

Fig. 6 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids

Fig. 6. Synthesis of potential MDR reversal icariin derivatives (231–236). Reagents and conditions: (a) H2SO4 (2–5 equiv), 90% EtOH, reflux; 1.5 h; (b) 20% H2SO4, MeOH, reflux, 2 h; (c) 20% H SO, MeOH, 25 ◦ C, 4 h; (d) ClSO CH, Et N, 4 h, then HCl; (e) ClSO CH, pyridine, 0 ◦ C, 3 h; then HCl; (f) ClSO NH, DMA, CH Cl, 2 4 2 3 3 2 3 2 2 2 2 0 ◦ C, 3 h; (g) ClSO H, Et N, 0 ◦ C, 3 h; then HCl.

Fig. 5 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids

Fig. 5. Synthesis of 4′-methoxy licoflavanone derivatives (208–230). Reagents and conditions: (a) RX, K CO, dry acetone, room temperature, 1–4 h, 75–86%; (b) 2 3 Propargyl bromide, K2CO3, dry acetone, room temperature, 2 h, 89% (c) TfN3, CuSO4 (aq.), Et3N, CH2Cl2/MeOH, 2–4 h, 90–96% (d) Sodium ascorbate, R–N3, CuSO4⋅5H2O, t-BuOH/water (1:1), 85–93%.

Fig. 27 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids

Fig. 27. Synthesis of C-3-prenylated flavonoids. Reagents and conditions: (a) CH OCH Cl, K CO, acetone 0 ◦ C, RT; (b) 3-methylbut-2-enyl bromide (2 equiv), fresh 3 2 2 3 LDA (2.5 equiv), THF, 75 ◦ C–4 ◦ C, 20 h, 50%; (c) ArCHO (2 equiv), NaHMDS (3 equiv), THF, 75 ◦ C to reflux, 30 h, 13–46%; (d) 4 N HCl, MeOH, reflux, 8–15 h, 22–63%.

opencc-by-4.0Aug 2023View details →

Metadata for Sensitivity of Simulations of Double Detonation Type Ia Supernova to Integration Methodology

inputs files, metadata, global diagnostics from runtime, and plot scripts for the suite of double detonation sub-Chandra SN Ia simulations from the paper "Sensitivity of Simulations of Double Detonation Type Ia Supernova to Integration Methodology"

opencc-by-4.0Sep 2023View details →

Sophie Gebeil and Federico Nanni: Comparing online transnational events: a methodological challenge

Sophie Gebeil and Federico Nanni: Comparing online transnational events: a methodological challenge WARCnet Luxembourg meeting Thursday 5 November 2020

FIGURES 27‒30. Oxycheila pseudostrandi Wiesner, 1999, male. 27 in Rediscovery and redescription of Oxycheila buestani Wiesner with the first female record and new methodology for observation of Oxycheila Dejean and Oxygonia Mannerheim (Coleoptera: Cicindelidae)

FIGURES 27‒30. Oxycheila pseudostrandi Wiesner, 1999, male. 27: habitus; 28: head; 29: elytral apex; 30: aedeagus. Bars in mm.

FIGURES 15‒26. Oxycheila buestani Wiesner, 1999 in Rediscovery and redescription of Oxycheila buestani Wiesner with the first female record and new methodology for observation of Oxycheila Dejean and Oxygonia Mannerheim (Coleoptera: Cicindelidae)

FIGURES 15‒26. Oxycheila buestani Wiesner, 1999. (15‒21 male, 22‒26 female). 15, 22: habitus; 16, 23: head; 17, 24: labrum; 18, 25: mandible; 19, 26: elytral apex; 20, 21: aedeagus male. Bars in mm.

FIGURES 9‒14. 9. Oxycheila affinis Horn, 1900. 10. Oxycheila brzoskai Wiesner, 1999. 11. Oxycheila buestani Wiesner, 1999. 12. Oxycheila pearsoni Wiesner, 1999. 13. Oxygonia oberthueri Horn, 1896. 14. Pseudoxycheila chaudoiri Dokhtouroff, 1882 in Rediscovery and redescription of Oxycheila buestani Wiesner with the first female record and new methodology for observation of Oxycheila Dejean and Oxygonia Mannerheim (Coleoptera: Cicindelidae)

FIGURES 9‒14. 9. Oxycheila affinis Horn, 1900. 10. Oxycheila brzoskai Wiesner, 1999. 11. Oxycheila buestani Wiesner, 1999. 12. Oxycheila pearsoni Wiesner, 1999. 13. Oxygonia oberthueri Horn, 1896. 14. Pseudoxycheila chaudoiri Dokhtouroff, 1882.

FIGURES 4‒8. Localities L1 in Rediscovery and redescription of Oxycheila buestani Wiesner with the first female record and new methodology for observation of Oxycheila Dejean and Oxygonia Mannerheim (Coleoptera: Cicindelidae)

FIGURES 4‒8. Localities L1 (Figs 4‒6) and L2 (Figs 7,8). 4, 8: habitat; 5: drinking water construction at L1; 6, 7: window trap instalations.

FIGURES 1‒3. 1. Satellite map Ecuador. 2 in Rediscovery and redescription of Oxycheila buestani Wiesner with the first female record and new methodology for observation of Oxycheila Dejean and Oxygonia Mannerheim (Coleoptera: Cicindelidae)

FIGURES 1‒3. 1. Satellite map Ecuador. 2. West sub Andean region north from the town of Cumandá-Bucay. 3. Study area with surveyed transects L1 (red line) and L2 (yellow line).