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311 results for “function dataset”
Dataset: 'Functional brain dynamics are shaped by connectome n-simplicial organization'
<p>Dataset related to the manuscript 'Functional brain dynamics are shaped by connectome n-simplicial organization'. - E. Mullier, J. Vohryzek, A. Griffa, Y. Alemán-Gómez, C. Hacker, K. Hess, P. Hagmann. ____________________________________</p> <p>We provide the resting-state functional MRI time series of 120 healthy subjects. <br> The detailed steps about acquisition and preprocessing are available in the methods section of the corresponding manuscript.<br> => File: concat_ts_120subs.txt</p> <p>We also provide a binary structural connectome based on 88 healthy subjects. A connection was kept in the binary structural<br> connectome if the connection was represented in at least 50% of the subjects. <br> => File: recSC_88CTRL_th0.5_scale4_cortical.txt</p> <p>The brain was parcellated using the cortical regions of Lausanne 2008 parcellation scale 4 (Cammoun2012).<br> The labels of the regions is available in this dataset.<br> => File: LABELS_cortical_scale250.txt</p> <p>Finally, we completed the dataset with a python script to open the data.<br> => File: Script_ReadData.py</p>
Dataset related to the article "Reduced Cardiorenal Function Accounts for Most of the In-Hospital Morbidity and Mortality Risk Among Patients With Type 2 Diabetes Undergoing Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction"
<p>This record contains raw data related to the article "Reduced Cardiorenal Function Accounts for Most of the In-Hospital Morbidity and Mortality Risk Among Patients With Type 2 Diabetes Undergoing Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction"</p> <p><strong>ABSTRACT</strong> ST-segment elevation myocardial infarction (STEMI) patients with diabetes mellitus<br> (DM) have higher in-hospital mortality than those without. Since cardiac and renal<br> functions are the main variables associated with outcome in STEMI, we hypothesized<br> that this prognostic disparity may depend on a higher rate of cardiac and<br> renal dysfunction in DM patients.<br> RESEARCH DESIGN AND METHODS<br> We retrospectively analyzed 5,152 STEMI patients treated with primary angioplasty.<br> Left ventricular ejection fraction (LVEF) and estimated glomerular filtration rate<br> (eGFR) were evaluated at hospital admission. The primary end point was in-hospital<br> mortality. A composite of in-hospital mortality, cardiogenic shock, and acute kidney<br> injury was the secondary end point.<br> RESULTS<br> There were 879 patients (17%) with DM. The incidence of LVEF £40% (30% vs. 22%),<br> eGFR £60 mL/min/1.73m2 (27% vs. 18%), or both (12% vs. 6%) was higher (P < 0.001<br> for all comparisons) inDMpatients. In-hospital mortality was higher inDMpatients<br> than in non-DM patients (6.1% vs. 3.5%; P = 0.002), with an unadjusted odds ratio<br> (OR) of 1.81 (95% CI 1.31–2.49; P < 0.001). However, DM was no longer associated<br> with an increased mortality risk after adjustment for cardiac and renal function (OR<br> 1.03, 95% CI 0.68–1.56; P = 0.89). A similar behavior was observed for the secondary<br> end point, with an unadjusted OR for DM of 1.52 (95% CI 1.25–1.85; P < 0.001) and<br> an OR after adjustment for cardiac and renal function of 1.07 (95% CI 0.85–1.36;<br> P = 0.53).<br> CONCLUSIONS<br> The study indicates that the increased in-hospital mortality and morbidity of DM<br> patients with STEMI is mainly driven by their underlying cardiorenal dysfunction.</p>
Dataset related to article "CRISPR Genome-Wide screening reveals chemosensor receptors as lipid-detecting regulators of macrophage functions in cancer"
<p>This record contains raw data related to article "CRISPR Genome-Wide screening reveals chemosensor receptors as lipid-detecting regulators of macrophage functions in cancer"</p> <p><strong><span>Abstract</span></strong><span>: </span></p> <p><span>The infiltration of macrophages is considered a hallmark of cancer progression and re-education of tumor-associated macrophages towards an anti-tumour status is considered a promising strategy of cancer immunotherapy. However, the mechanisms governing macrophage education by cancer cells remain largely elusive, posing challenges for therapeutic exploitation. To gain deeper insights into TAMs' plasticity, we conducted an unbiased genome-wide CRISPR screening on primary macrophages. Our investigation confirmed the role of known regulators, including Stat6, in orchestrating TAMs' responses and unveiled novel insights into TAMs' behaviour. We identified olfactory and vomeronasal receptors, commonly referred to as chemosensors, as major drivers of macrophages tumor-supportive status in multiple cancers. Collectively, our findings implicate chemosensors in macrophage sensing of the lipid-enriched milieu and highlight these receptors as therapeutic targets for enhancing antitumor immunity.</span></p>
Dataset related to article "Single-cell transcriptomic reveals functional heterogeneity of myeloid cells in glioma microenvironment"
<p>This record contains raw data related to article “single-cell transcriptomic reveals functional heterogeneity of myeloid cells in glioma microenvironment."</p> <p>High grade gliomas (HGG) are highly aggressive tumors with a particularly severe prognosis and an unmet medical need. HGG are characterized by a high degree of heterogeneity due to genetic and metabolic driving forces, either within and between individual patients. Temporal and spatial HGG heterogeneity contributes to response variability to conventional and adjuvant therapies among patients. HGG are also highly infiltrated by immune cells, tumor-associated macrophages (TAM) in particular, which are key drivers of the local immunosuppression supporting HGG progression and its resistance to immunomodulating therapeutic strategies. As the impact of HGG heterogeneity on macrophage biology remain poorly understood, we perform single-cell RNA sequencing, that reveals a large and dynamic myeloid landscape in patients with primary or secondary gliomas. To define the role in local immunosuppression and tumor progression, resident microglia and monocyte-derived macrophages are characterized, exhibiting additional heterogeneity across glioma subtypes. Understanding the immunosuppressive mechanisms operating in HGG is key to guide patients’ selection and optimize success rate of immunomodulating therapies.</p>
Dataset Tenascin-C knockout mice show an altered lung function at newborn and adult age
<p>This dataset is related to "Tenascin-C knockout mice show an altered lung function at newborn and adult age" (Gremlich S., Roth-Kleiner M., Equey L., Fytianos K., Schittny J.C., Cremona T.P.)</p>
Dataset_A Psychometric Tool for Evaluating Executive Functions in Parkinson's Disease
<p>Dataset of raw data used in the paper "A Psychometric Tool for Evaluating Executive Functions in Parkinson’s Disease"</p>
Dataset related to article: " ENTROPY METRICS CORRELATING WITH HIGHER RESIDUAL FUNCTIONING IN PATIENTS WITH CHRONIC DISORDERS OF CONSCIOUSNESS "
<p>the dataset contains data ENTROPY MEASURES</p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p>
Dataset for "Influence of kidney function and CSF/serum albumin ratio on plasma Aβ42 and Aβ40 levels measured on a fully automated platform in patients with Alzheimer's disease"
<p>This is dataset of the study whose results are reported in the article entitled "Influence of kidney function and CSF/serum albumin ratio on plasma Aβ42 and Aβ40 levels measured on a fully automated platform in patients with Alzheimer’s disease", which has been recently accepted for publication in "Neurological Sciences".</p>
CSRM Level 2 dataset: stacked receiver function in continental China
<p>This dataset contains the stacked receiver function (<strong>time before the arrival time of the Moho-converted PmS phase</strong>) estimated from <strong>2,125,021</strong> original receiver functions, calculated based on the waveforms of 9361 tele-seismic events recorded by <strong>3848</strong> seismic stations deployed in continental China. This dataset results from a project of constructing a 3-D seismic model of the shallow crust in continental China (<a href="https://doi.org/10.1093/gji/ggab022">Xiao et al, 2021, GJI</a>) (<a href="https://doi.org/10.5281/zenodo.8099245">model link</a>). </p> <p>本数据集包含了从 <strong>2,125,021</strong> 条原始接收函数计算的单台叠加接收函数(时间早于 Moho 面 PmS 转换波到时)。原始接收函数的计算基于中国大陆区域 <strong>3848</strong> 个地震台站接收的 9361 个远震事件的波形。该数据库源于构建中国大陆区域高精度浅层地壳三维地震学模型的工作 (<a href="https://doi.org/10.1093/gji/ggab022">Xiao et al, 2021, GJI</a>) (<a href="https://doi.org/10.5281/zenodo.8099245">模型链接</a>) 。</p> <p>If you face any problem or issue in the usage of this dataset, please feel free to communicate with the corresponding author Xiao Xiao (<strong>xiaox.seis@gmail.com</strong>). </p>
Dataset_Psychometric Calibration of a Tool Based on 360 Degree Videos for the Assessment of Executive Functions
<p>Dataset of papaer "Psychometric Calibration of a Tool Based on 360 Degree Videos for the Assessment of Executive Functions"</p>
Dataset related to article Perceived social isolation is associated with neurobehavioral functioning and fronto-parietal involvement in amyotrophic lateral sclerosis
<p>Clinical data related to article at title</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.