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3,476 results for “Parkinson disease”
Identification of transcriptional alterations that distinguish sensitive from insensitive neuronal populations in a genetic model of Parkinson’s disease.
GEO Series GSE80277. Drosophila melanogaster. 12 samples. Type: Expression profiling by array.
Single-cell transcriptomics revealed molecular vulnerability in a human midbrain-like organoid model of Parkinson's Disease [scRNA-Seq]
GEO Series GSE271116. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
GPR40 Agonist ameliorates neurodegeneration and motor impairment by regulating NLRP3 inflammasome in Parkinson’s disease animal models.
GEO Series GSE275257. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
The Parkinson's Disease Variant rs356182 Regulates Neuronal Differentiation Independently from Alpha-Synuclein
GEO Series GSE212535. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
17q21.31 locus regulates Parkinson’s disease relevant pathways through KANSL1 activity
GEO Series GSE283747. Homo sapiens. 40 samples. Type: Expression profiling by high throughput sequencing.
a-synuclein accumulation in an iPSC derived model of early onset sporadic Parkinson’s Disease reveals novel drug targets
GEO Series GSE120746. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Intermittent fasting reduces alpha-synuclein pathology and functional decline in a mouse model of Parkinson’s disease
GEO Series GSE252874. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
Direct reprogramming of human fibroblasts to expandable induced dopaminergic neuronal progenitors for Parkinson’s disease therapy [ChIP-seq]
GEO Series GSE157340. Homo sapiens. 9 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
GBA1 regulates the CLEAR network through Calcineurin and TFEB in cellular models of Parkinson´s disease
GEO Series GSE118511. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to article "Mechanical somatosensory stimulation decreases blood pressure in patients with Parkinson's disease."
<p>OBJECTIVE:</p> <p>The current study aimed to assess the effects of five cycles of automated mechanical somatosensory stimulation (AMSS) of the fore-feet on blood pressure (BP) and cardiovascular autonomic control in Parkinson's Disease patients.</p> <p>METHODS:</p> <p>Out of 23 patients, 16 underwent an AMSS session every 72 h, for a total of five sessions per patient. Electrocardiogram, noninvasive beat-to-beat blood pressure and respiratory activity were recorded for 20 min in supine position at baseline and after the AMSS sessions. Main outcomes were the changes in SBP and DBP, in the spectral indices of cardiac sympathetic (LFRRn.u.) and vagal (HFRR) modulatory activities, cardiac sympathovagal relationship (LF/HF), vascular sympathetic modulation (LFSAP) and arterial baroreflex sensitivity (sequence technique). Symbolic analysis of heart rate variability provided additional indices of cardiac sympathetic (0V%) and vagal (2UV%) modulation to the sinoatrial node.</p> <p>RESULTS:</p> <p>After five AMSS trials a reduction in SBP (baseline: 131.2 ± 15.5 mmHg; post-AMSS: 122.4 ± 16.2 mmHg; P = 0.0004) and DBP (baseline: 73.2 ± 6.1 mmHg; post-AMSS: 68.9 ± 6.2 mmHg; P = 0.008) was observed. Post-AMSS, spectral and symbolic indices of cardiovascular sympathetic control decreased and arterial baroreflex sensitivity increased (baseline: 5.7 ± 1.3 ms/mmHg; post-AMSS: 11.27 ± 2.7 ms/mmHg).</p> <p>CONCLUSION:</p> <p>AMSS sessions were effective in reducing BP, increasing baroreflex sensitivity and decreasing cardiovascular sympathetic modulation in Parkinson's disease patients. AMSS might be useful to control supine hypertension in Parkinson's disease.</p>
Technology-based therapy-response and prognostic biomarkers in a prospective study of a de novo Parkinson's disease cohort
<p>This database includes the raw data linked with the paper “ Technology-based therapy-response and prognostic biomarkers in a prospective study of a de novo Parkinson’s disease cohort” published on “NPJ Parkinson’s disease”.</p> <p>This work aims at identifying prognostic biomarkers in newly diagnosed PD patients and quantifying therapy-response. Forty de novo PD patients underwent clinical and technology-based kinematic assessments performing motor tasks (MDS-UPDRS part III) to assess tremor, bradykinesia, gait, and postural stability (T0). A visit after 6 months (T1) and a clinical and kinematic assessment after 12 months (T2) where scheduled. A clinical follow-up was provided between 30 and 36 months after the diagnosis (T3).</p> <p>We performed an ANOVA for repeated measures to compare patients’ kinematic features at baseline and at T2 to assess therapy response. Pearson correlation test was run between baseline kinematic features and UPDRS III score variation between T0 and T3, to select candidate kinematic prognostic biomarkers. A multiple linear regression model was created to predict the long-term motor outcome using T0 kinematic measures. All motor tasks significantly improved after the dopamine replacement therapy.</p> <p>A significant correlation was found between UPDRS scores variation and some baseline bradykinesia (toe tapping amplitude decrement, p = 0.009) and gait features (velocity of arms and legs, sit-to-stand time, p = 0.007; p = 0.009; p = 0.01, respectively).</p> <p>A linear regression model including four baseline kinematic features could significantly predict the motor outcome (p = 0.000214). Technology-based objective measures represent possible early and reproducible therapy-response and prognostic biomarkers.</p> <p> </p> <p> </p> <p> </p>
The effects of intensive neurorehabilitation on sequence effect in Parkinson's disease patients with and without freezing of gait
<p><strong>This dataset includes </strong>raw data from the article “The Effects of Intensive Neurorehabilitation on Sequence Effect in Parkinson's Disease Patients With and Without Freezing of Gait”.</p> <p><strong>The aim of the study</strong> was to investigate the effects of a 4-week rehabilitation program on dSE in patients with PD with and without FOG.</p> <p><strong>The dataset show</strong> forty-three patients (30 males, 70.6 ± 7.5 years old) with idiopathic PD were enrolled. The subjects were divided into two groups: patients with (PD + FOG, n = 23) and without FOG (PD - FOG, n = 20). All patients underwent a standardized 4-week intensive rehabilitation in-hospital program. At hospital admission (T0) and discharge (T1), all subjects were evaluated with an inertial gait analysis for dSE recording</p> <p><strong>Results. </strong>At T0, the dSE was more negative in the PD + FOG group (−0.80 ± 0.6) when compared to the PD – FOG group (−0.39 ± 0.3) (p = 0.007), even when controlling for several clinical and demographic features. At T1, the dSE was reduced in the overall study population (p = 0.001), with a more pronounced improvement in the PD + FOG group (T0: −0.80 ± 0.6; T1: −0.23 ± 0.4) when compared to the PD – FOG group (T0: −0.39 ± 0.3; T1: −0.22 ± 0.5) (p = 0.012). At T1, we described in the overall study population an improvement in speed, cadence, stride duration, and stride length (p = 0.001 for all variables).</p>
BINAURAL BEATS ON PARKINSON DISEASE: A LONGITUDINAL STUDY
<p>File structure description:</p> <ul> <li><strong>Patient data:</strong> Excel file with the most relevant patient data.</li> <li><strong>RAW:</strong> Contains the raw data in the appropriate format to be processed in BRAINSTORM. These are the records of all patients (ID 5,14, 16, 23, 30, 33, 33, 35, 38, 39, 40, 64, 65) in the pre-stimulation (PRE) and post-stimulation (POST) condition in each of the sessions (Session 1, 2, 3).</li> <li><strong>Theta power:</strong> This folder contains the Excel files with the results of the relative power of the theta band obtained in Brainstorm, conveniently ordered to later generate the .mat files with the patients to be analyzed. The files are sorted by session (S1, S2, S3) and in turn by condition (PRE, POST).</li> <li><strong>Matlab scripts:</strong> Folder containing the .txt scripts that generate the heads of the figures in the paper.</li> <li><strong>Matlab Functions:</strong> Contains the necessary functions to obtain the heads of the figures in the paper, including the .mat files with the relative powers of the theta band of the 8 patients analyzed. It includes the FieldTrip software, since the scripts call some functions of this program, some of them have been modified for this particular study. FieldTrip is the MATLAB software toolbox for MEG, EEG and iEEG analysis, which is released free of charge as open source software under the GNU general public license. Fieldtrip version 20160222 was used for this study, although the updated version can be downloaded at https://www.fieldtriptoolbox.org/download/.</li> </ul> <p> </p>
DATSET RELATED TO ARTICLE"short- and long-term motor outcome of STN-DBS in Parkinson's Disease focus on sex differences
<p>Sheet with clinical raw data related to patients involved in the study reported at title</p>
Datset related to article "Magnetic Resonance-Guided Focused Ultrasound Thalamotomy May Spare Dopaminergic Therapy in Early-Stage Tremor-Dominant Parkinson's Disease: A Pilot Study"
<p>clinical dataset with anonimyzed inormation on patients involved in the pilot study described at title</p>
Human iPSC-derived microglia carrying LRRK2-G2019 mutation show Parkinson's disease related transcriptional profile and functions
<p>This repository contains the data and the code used in Ohtone Sohvi's project.</p> <p>A folder can contain the starting raw data in "data", the R scripts in order of execution (op1, op2 ..) and the "output" folder that contains the final processed data of each operation.</p> <ul> <li>"PD_bulk_analysis" contains the processing and analysis of the bulk RNA sequencing data</li> <li>"PD_bulk_fastq" contains the raw fastq sequences of the bulk RNA sequencing</li> <li>"PD_bulk_nfcore" contains the results of processing the fasta sequences with nfcore rnaseq workflow </li> <li>"PD_scRNA_analysis" contains the analysis of the snRNA sequencing dataset</li> <li>"PD_spatial" contains the raw data of the spatial sequencing, the assempbly of the spatial expression profiles starting from the DAPI images and the transcripts coordinates, the analysis performed on the data</li> </ul>
Health behaviors, function and quality of life among people with Parkinson's disease
<p>This repository contains data from a study about Health behaviors, function and quality of life among people with Parkinson's disease</p>
Dataset: Does transcranial direct current stimulation of the primary motor cortex improve implicit motor sequence learning in Parkinson's disease?
<p>This is the fully anonymized dataset for the study titled "Does transcranial direct current stimulation of the primary motor cortex improve implicit motor sequence learning in Parkinson’s disease?", by Firouzi and colleagues (2023).</p> <p>The protocol of this study was published as a Stage 1 Registered Report in the Journal of Neuroscience Research (https://doi.org/10.1002/jnr.24908).</p>
Dataset related to article "Parkinson's disease midbrain organoids link GBA1 to Lewy pathology"
<p>This record contains data related to the article "Parkinson’s disease midbrain organoids link GBA1 to Lewy pathology".</p> <p><strong>Abstract</strong></p> <p>Aggregation of α-synuclein protein in “Lewy bodies” or “Lewy neurites” is a defining hallmark of Parkinson’s disease neuropathology. Mutations in <em>GBA1</em>, encoding the glucosylceramide-hydrolyzing enzyme glucocerebrosidase, cause Gaucher’s disease and are the most frequent genetic risk factor for Parkinson’s disease. However, a defined link between mutations in <em>GBA1</em> and α-synuclein pathology is yet to be determined, largely because of the absence of experimental models able to recapitulate the key neuropathological signatures of the disease. Here, we present an innovative midbrain organoid culture system derived from subjects with <em>GBA1</em>-related Parkinson’s disease as the first patient-based model able to reproduce fundamental neuropathological features of the disease. We show that retention of mutant glucocerebrosidase in the endoplasmic reticulum and increased glucosylceramide levels are determinants of α-synuclein aggregation into inclusions resembling Lewy bodies and Lewy neurites in both mono- and biallelic <em>GBA1</em> mutated midbrain organoids. In this process, the entity of glucocerebrosidase activity reduction acts as an accelerating factor in the progression of α-synuclein pathology by favoring the conversion of soluble α-synuclein to its insoluble forms. We provide evidence that α-synuclein extracted from Parkinson’s samples displays seeding activity <em>in vitro</em> and, following inoculation in unaffected organoids, propagates the pathology. Finally, we demonstrate pharmacological rescue of pathological phenotypes with molecules engaging in the glucocerebrosidase pathway, suggesting that midbrain organoids could represent valuable <em>in vitro</em> platforms for drug testing in Parkinson’s disease and potentially other Lewy body disorders still lacking a definitive therapy.</p> <p> </p>
A rewiring of the earliest immune events leading to T-cell mediated disease following intestinal microbial infection in a PINK1KO mouse model of Parkinson’s disease
GEO Series GSE271210. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.