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3,508 results for “Observation study”
Dataset Internalised stigma of epilepsy in Indonesian social media communities : an observational study
<p>The prevalence of epilepsy cases in developing countries is currently more than 10 per 1000 population. Stigma plays a role in the successful treatment of epilepsy. Demographic and clinical information, along with an internal stigma surrounding PWE (people with epilepsy), is necessary to perform optimal treatment for epilepsy. This study applied a descriptive observational design with a cross-sectional approach. The data were collected from an online questionnaire from PWE who are members of the social media community for PWE. A total of 64.65% of the total 99 respondents were PWE themselves, 57.57% were 20–40 years old; 56,57% were females; 42.42% were university graduates; 51.52% were single; 47.47% were employed; and 43.43% reported an above-average income. Furthermore, 86.87% had seizure onset before 20 years old; 72.73% had generalised seizure type; and 41.41% used polytherapy anti-epileptic drugs (AED). A total of 88.89% of the respondents felt helped by the PWE social media community they were part of; 66 people reported moderate stigmas; and 33 people reported low stigmas. The demographic data, clinical characteristics and perceptions of internal stigmas of PWE were also obtained. Therefore, internal stigmas are still present amongst Indonesian PWE.</p>
Dataset related to article: "Nocturnal Hypoxemia Impacts Right Ventricle Diastolic Function in Obstructive Sleep Apnea: A Retrospective Observational Study"
<p>We provide the raw data used for the following article:</p> <ul> <li>Scotti C, Porta R, Olivares A, Comini L, Cinelli A, Scalvini S, Vitacca M.<br> <em>Nocturnal Hypoxemia Impacts Right Ventricle Diastolic Function in Obstructive Sleep Apnea: A Retrospective Observational Study.</em><br> "J Clin Med." 2020 Jan 7;9(1):162. doi: 10.3390/jcm9010162. PMID: 31936097; PMCID: PMC7019852.</li> </ul> <p> </p> <p><strong>Abstract</strong><br> Obstructive sleep apnea (OSA), although a growing healthcare problem and documented risk factor for cardiovascular diseases, is still under-diagnosed in cardiac patients. To investigate the correlation between OSA and echocardiographic parameters of right ventricle diastolic (RVD) dysfunction, in particular trans-tricuspid E-wave deceleration time (EDT), we retrospectively analyzed data of 103 pure (comorbidity-free) OSA patients with comprehensive echocardiographic examination (ETT). Apnea/hypopnea index (AHI), oxygen desaturation index (ODI), mean nighttime oxyhemoglobin saturation (SpO2), time elapsed with SpO2 < 90% (T90) and mean peak desaturation of nocturnal events (Mdes, graded as mild, medium or severe) were compared with echocardiographic parameters. We found RVD dysfunction present in 58.3% of patients. Altered EDT correlated significantly with mean SpO2, T90, and Mdes (p < 0.01, all). Nocturnal desaturators had a significantly worse EDT than non-desaturators (p = 0.027) and a higher risk of prolonged EDT (odds ratio, OR = 2.86). EDT differed significantly according to Mdes severity (p = 0.005) with a higher risk of prolonged EDT in medium/severe vs. mild Mdes (OR = 3.44). EDT detected the presence of RVD dysfunction in 58.3% of our pure OSA patients. It correlated poorly with AHI severity but strongly with nocturnal desaturation severity, independently of age. This ETT marker may be useful for deciding appropriate diagnostic and therapeutic strategies.</p>
Mild to moderate post-COVID- 19 alters markers of lymphocyte activation, exhaustion, and immunometabolic responses that can be partially associated by physical activity level— an observational sub-analysis fit- COVID study
<p>Physical activity status seems to be protective against the severe form of SARS-CoV-2, reducing risk of hospitalization and worsened clinical outcome. However, the impact of physical activity after mild-to-moderate COVID-19 episode on immune and metabolic profiles is unknown. Therefore, this study aimed to evaluate if physical activity is associated with systemic and<br> cellular immunometabolic responses, in young adults after mild-to-moderate COVID-19 infection. Patients previously infected with COVID-19 and healthy controls were recruited for this cross-sectional observational study.</p>
Dataset related to article "Clinical and radiological outcomes of an uncemented metaphyseal short stem at minimum 10 years of follow‑up: a prospective observational study".
<p>This record contains raw data related to article "Clinical and radiological outcomes of an uncemented metaphyseal short stem at minimum 10 years of follow‑up: a prospective observational study"</p> <p>Abstract</p> <p><strong>Purpose: </strong>There is growing interest around short stems as they provide a less invasive approach for total hip arthroplasty preserving bone stock for a possible revision surgery if required. The main purpose of this work was to assess the long-term performance of an uncemented metaphyseal short stem in terms of survival rate and in addition its clinical and radiological outcomes.</p> <p><strong>Materials and methods: </strong>From January to December 2010, we prospectively enrolled all consecutive patients undergoing primary total hip arthroplasty with an uncemented metaphyseal short stem in our institution with a minimum follow-up of 10 years. The radiographic features investigated were the varus-valgus stem orientation, areas of osteolysis and radiolucencies, stress shielding, and heterotopic calcifications. The clinical outcomes were measured using the HHS.</p> <p><strong>Results: </strong>A total of 163 patients (172 hips) were finally included and the measured survival rate at 10 years was 99.6%. The average HHS increased from 55.0 preoperatively to 97.8 at the last follow-up (p < 0.0001). Among them, 137 patients (164 hips) were also available for radiographic assessment. Mild varus malalignment was observed in 40% of cases and remained stable in the serial X-rays and was not associated with step loosening. Mild stress shielding was observed around 13 stems (9%) and moderate only around 3 implants.</p> <p><strong>Conclusion: </strong>In conclusion, the uncemented metaphyseal short stems showed excellent survival and clinical results at 10 years and at a radiographical level very low stress shielding was observed; moreover, besides the high frequency of varus alignment the implanted stems was not associated with revision surgery or with worse clinical outcomes.</p> <p><strong>Keywords: </strong>Long-term; Outcomes; Short stem; THA.</p>
Dataset related to the article "High sensitivity C-reactive protein and acute kidney injury in patients wit acute myocardial infarction: a prospective observational study"
<p>This record contains raw data related to the article "High sensitivity C-reactive protein and acute kidney injury in patients wit acute myocardial infarction: a prospective observational study"</p> <p><strong>Abstract:</strong> Background. Accumulating evidence suggests that inflammation plays a key role in acute<br> kidney injury (AKI) pathogenesis. We explored the relationship between high-sensitivity C-reactive<br> protein (hs-CRP) and AKI in acute myocardial infarction (AMI). Methods. We prospectively included<br> 2,063 AMI patients in whom hs-CRP was measured at admission. AKI incidence and a clinical<br> composite of in-hospital death, cardiogenic shock, and acute pulmonary edema were the study<br> endpoints. Results. Two-hundred-thirty-four (11%) patients developed AKI. hs-CRP levels were<br> higher in AKI patients (45 87 vs. 16 41 mg/L; p < 0.0001). The incidence and severity of AKI, as well<br> as the rate of the composite endpoint, increased in parallel with hs-CRP quartiles (p for trend <0.0001<br> for all comparisons). A significant correlation was found between hs-CRP and the maximal increase<br> of serum creatinine (R = 0.23; p < 0.0001). The AUC of hs-CRP for AKI prediction was 0.69 (p < 0.001).<br> At reclassification analysis, addition of hs-CRP allowed to properly reclassify 14% of patients when<br> added to creatinine and 8% of patients when added to a clinical model. Conclusions. In AMI,<br> admission hs-CRP is closely associated with AKI development and severity, and with in-hospital<br> outcomes. Future research should focus on whether prophylactic renal strategies in patients with<br> high hs-CRP might prevent AKI and improve outcome.</p>
SYSTACT CyTOF dataset associated with Multiomics approaches disclose very-early molecular and cellular switches during insect-venom allergen-specific immunotherapy: an observational study
<p>This dataset contains all the raw mass cytometry (CyTOF) fcs files associated with Pogorelov et al. 'Multiomics approaches disclose very-early molecular and cellular switches during insect-venom allergen-specific immunotherapy: an observational study', <em>Nature Communications</em>, 2024, in Press. The dataset contains all the raw fcs files generated by CyTOF analysis of 199 time-series samples including ~200 million of deeply characterized immune cells, either from patients with insect-venom allergy or patients with pollen allergy following allergen-specific immunotherapy (AIT) or from healthy controls (HC), who did not receive any AIT or other immunotherapy. As specified in the manuscript, we sampled different individuals up to seven times (0h, 8h, 24h, Day 7, Week 2, Week 6 and Week 12) over a three-month period. All the samples from insect-venom allergy patients are stored in the zipper folder called "Venom" and all the samples from pollen allergy patients are in the zipper folder called "Pollen" while all the samples from HC are placed in the zipper folder called "Control". We also provide the following annotation files (metadata) to help the readers to better understand, validate and re-analyze our immunological dataset.</p> <p>1, In addition to the Supplementary Tables in our manuscript, we also attached one Word table file mapping the 36 specific metal isotypes and the specific Ab target markers.</p> <p>2, The Excel file with the list of 199 samples, showing the correct group and time point information (of note, the manually input sample information in the file name might be wrong for some samples). The correct time point information is in the column "Timepoint Detail" and "Timepoint Final".</p> <p>Associated with these raw fcs files, our processed results of all the CyTOF data are deposited in another webpage. Our large-scale interactive interlinked immunological Data resource (i3Dare) allows investigators to more effectively explore or reuse our immunological datasets of each immune subset from each participant at each time point (please refer to <a href="https://public.tableau.com/app/profile/lihpublicdata/viz/i3Dare_SYSTACT_Database/SYSTACTHome">https://public.tableau.com/app/profile/lihpublicdata/viz/i3Dare_SYSTACT_Database/SYSTACTHome</a>). OF note, to further protect privacy, the pseudoIDs within groups in i3Dare were re-labelled again. </p> <p><strong>Please read the accompanying information/metadata files, our main manuscript and Supplementary Information, our processed data on the i3Dare webpage and the published Source Data together with the raw fcs files in order to reproduce our published results.</strong></p>
Results of a prospective observational study of autologous peripheral blood mononuclear cell therapy for no-option critical limb-threatening ischemia and severe diabetic foot ulcers
<p>Abstract<br> Background: Cell therapy with autologous peripheral blood mononuclear cells (PB-MNCs) may help restore limb<br> perfusion in patients with diabetes mellitus and critical limb-threatening ischemia (CLTI) deemed not eligible for<br> revascularization procedures and consequently at risk for major amputation (no-option). Fundamental is to establish<br> its clinical value and to identify candidates with a greater benefit over time. Assessing the frequency of PB circulating<br> angiogenic cells and extracellular vesicles (EVs) may help in guiding candidate selection.<br> Methods: We conducted a prospective, non-controlled, observational study on no-option CLTI diabetic patients that<br> underwent intramuscular PB-MNCs therapy, which consisted of more cell treatments repeated a maximum of three<br> times. The primary endpoint was amputation rate at 1 year following the first treatment with PB-MNCs. We evaluated<br> ulcer healing, walking capability, and mortality during the follow-up period. We assessed angiogenic cells and EVs<br> at baseline and after each cell treatment, according to primary outcome and tissue perfusion at the last treatment<br> [measured as transcutaneous oxygen pressure (<br> TcPO2)].<br> Results: 50 patients were consecutively enrolled and the primary endpoint was 16%. TcPO2<br> increased after PB-MNCs<br> therapy (17.2 ± 11.6 vs 39.1 ± 21.8 mmHg, p < .0001), and ulcers healed with back-to-walk were observed in 60%<br> of the study population (88% of survivors) during follow-up (median 1.5 years). Patients with a high level of TcPO2<br> (≥ 40 mmHg) after the last treatment showed a high frequency of small EVs at enrollment.</p>
Progressive Additive Benefits of Prehabilitation and Subsequent Bariatric Surgery on Cardiac Autonomic Regulation as Assessed by Means of a Simple Unitary Composite Index: Preliminary Data from an Observational Study
<p>Obesity is associated with an increased risk of several chronic comorbidities, which may<br> also be determined by dysfunctional autonomic nervous system (ANS). The influence of bariatric<br> surgery (BS) on ANS balance was explored in previous studies, but with high heterogeneity in both<br> the assessment timing and methods employed. In the present observational study, we applied a<br> clinical protocol which considers two subsequent phases. Twenty-nine non-diabetic obese subjects<br> were studied at baseline (T0), after one month of lifestyle modification (prehabilitation) (phase 1-T1),<br> and after eight months following BS (phase 2-T2). ANS regulation was assessed across the three study<br> epochs by means of ANSI, a single composite percent-ranked proxy of autonomic balance, being free<br> of gender and age bias, economical and simple to apply in a clinical setting. The aim of the present<br> study was to investigate the effects of the clinical protocol based on prehabilitation and subsequent<br> BS on the ANS regulation by means of ANSI. Potential intertwined correlations with metabolic<br> parameters were also investigated. Notably, we observed a progressive improvement in ANS control,<br> even by employing ANSI. Moreover, the reduction in the markers of sympathetic overactivity was<br> found to significantly correlate with the amelioration in some metabolic parameters (fasting glucose,<br> insulin levels, and waist circumference), as well as in stress and tiredness perception. In conclusion,<br> this study provides convincing evidence that a unitary proxy of cardiac autonomic regulation (CAR)<br> may reflect the progressive improvement in autonomic regulation following behavioral and surgical<br> interventions in obese patients. Intriguingly, this might contribute to reducing cardiovascular and<br> metabolic risk.</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.