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7,370 results for “supplementation”
Supplemental data: The association of dilated perivascular spaces with cognitive decline and incident dementia
<p><span><b>Objective:</b></span></p> <p><span>To determine if severe perivascular space (PVS) dilation is associated with longitudinal cognitive decline and incident dementia over four and eight years respectively, we analyzed data from a prospective cohort study.</span></p> <p><span><b>Methods: </b></span></p> <p>414 community dwelling older adults aged 72-92 were assessed at baseline and biennially for up to eight years, with cognitive assessments, consensus dementia diagnoses and 3T MRI imaging. The numbers of PVS in two representative slices in the basal ganglia (BG) and centrum semiovale (CSO) were counted and severe PVS pathology defined as the top quartile. The effects of severe PVS pathology in i) either region; ii) both regions; and those with iii) severe BG PVS and iv) severe CSO PVS were examined. White matter hyperintensity volume, cerebral microbleed number and lacune number were calculated.</p> <p><span><b>Results:</b></span></p> <p>Participants with severe PVS pathology in both regions or in the CSO alone had greater decline in global cognition over four years, even after adjustment for the presence of other small vessel disease neuroimaging markers. The presence of severe PVS pathology in both regions was an independent predictor of dementia across eight years (OR 2.91, 95%CI 1.43–5.95, p= 0.003). Further, the presence of severe PVS pathology in all groups examined was associated with greater dementia risk at either year four or six.</p> <p><span><b>Conclusions: </b></span></p> <p>Severe PVS pathology is a marker for increased risk of cognitive decline and dementia, independent of other small vessel disease markers. The differential cognitive associations for BG and CSO PVS may represent differences in their underlying pathology.</p>
Molecular systematics of the tribe Physarieae (Brassicaceae) based on the nuclear ITS, LUMINIDEPENDENS, and chloroplast ndhF: Sequence alignments, trees, and supplemental figures
<p>Physarieae is a small tribe of herbaceous annual and woody perennial mustards that are mostly endemic to North America, with its members including a large amount of variation in floral, fruit and chromosomal variation. Building on a previous study of Physarieae based on morphology and <i>ndhF</i> plastid DNA, we reconstructed the evolutionary history of the tribe using new sequence data from two nuclear markers, and compared the new topologies against previously published cpDNA-based phylogenetic hypotheses. The novel analyses included ca. 420 new sequences of ITS and <i>LUMINIDEPENDENS</i> (<i>LD</i>) markers for 39 and 47 species, respectively, with sampling accounting for all seven genera of Physarieae, including nomenclatural type species, and 11 outgroup taxa. Maximum parsimony, maximum likelihood, and Bayesian analyses showed that these additional markers were largely consistent with the previous <i>ndh</i>F data that supported the monophyly of Physarieae and resolved two major clades within the tribe, i.e. DDNLS (<i>Dithyrea</i>, <i>Dimorphocarpa</i>, <i>Nerisyrenia</i>, <i>Lyrocarpa</i>, and <i>Synthlipsis</i>) and PP (<i>Paysonia</i> and <i>Physaria</i>). New analyses also increased internal resolution for some closely related species and lineages within both clades. The monophyly<i> </i>of <i>Dithyrea</i> and the sister relationship of <i>Paysonia</i> to <i>Physaria</i> was consistent in all trees, with the sister relationship of <i>Nerisyrenia </i>to <i>Lyrocarpa </i>supported by <i>ndhF</i> and <i>ITS</i>, and the positions of <i>Dimorphocarpa</i> and <i>Synthlipsis</i> shifted within the DDNLS Clade depending on the employed data set. Finally, using the strong, new phylogenetic framework of combined cpDNA + nDNA data, we discussed standing hypotheses of trichome evolution in the tribe suggested by <i>ndhF</i>.</p>
Pearls and oy-sters: Primary pineal melanoma with leptomeningeal carcinomatosis - Supplemental figures
<p><b>Pearls</b>:</p> <ul> <li>Pineal masses commonly present with Parinaud syndrome, a triad consisting of upgaze restriction, convergenceretraction nystagmus, and pupillary light-near dissociation from compression of the quadrigeminal plate.</li> <li>The differential diagnosis for pineal region tumors includes germ cell tumors, pineal parenchymal tumors, glioma, atypical teratoid rhabdoid tumor and metastatic disease. While exceedingly uncommon, primary pineal melanoma is also a known histopathologic entity that is suspected to arise from melanocytes in the pia mater of the pineal gland.</li> <li>Primary pineal melanoma is often treated with surgical resection, radiation, and either chemotherapy or immunotherapy. Some patients have received targeted therapy (such as vemurafenib in patients with <i>BRAF V600E</i> mutation) with varying degrees of success.</li> </ul> <p><b>Oy-sters:</b></p> <ul> <li>Cerebrospinal fluid (CSF) sampling can assist in the diagnosis of pineal tumor, specifically to test for germ cell tumor markers (alphafetoprotein, beta human chorionic gonadotropin, placental alkaline phosphatase), systemic tumor markers such as carcinoembryonic antigen, cell-free DNA or malignant cells on cytopathology.</li> <li> Pineal tumors can result in obstructive hydrocephalus, therefore lumbar puncture is not always a feasible option due to the risk of herniation. In patients with melanoma of the central nervous system (CNS), a careful survey consisting of systemic imaging and total body skin examination are warranted to exclude a separate primary melanoma lesion.</li> <li>The differential diagnosis for rapidly progressive bilateral sensorineural hearing loss includes meningitis, superficial siderosis, ototoxicity and leptomeningeal disease. Difficulty in speech comprehension in excess of pure tone audiometry may suggest involvement or compression of the inferior colliculus.</li> </ul>
Data supplement 4
<p>Data supplement 4</p>
MIg-RD supplemental
<p>MIg-RD supplemental</p>
GIANI Paper - Supplemental File 6
<p>GIANI and Imaris settings used to produce the data in Fig 6</p>
GIANI Paper - Supplemental File 4
<p>GIANI settings used to produce the data in Fig 4</p>
GIANI Paper - Supplemental File 5
<p>GIANI and Imaris settings used to produce the data in Fig 5</p>
GIANI Paper - Supplemental File 3
<p>GIANI settings used to produce the data in Fig 3</p>
GIANI Paper - Supplemental File 7
<p>GIANI and Imaris settings used to produce the data in Fig S1</p>
Influence of Mediterranean Foods on Gut Microbiota Functionality in Obese Children Compared to Lean Children (Supplemental information)
<p>Complete dataset including the antioxidant capacity for all foods tested with 3 antioxidant method.</p>
Supplemental material from: Can transcranial direct current stimulation enhance post-stroke motor recovery? Development of a theoretical patient-tailored model
<p>New treatments that can facilitate neural repair and reduce persistent impairments have significant value in promoting recovery following stroke. One technique that has gained interest is transcranial direct current stimulation (tDCS) as early research suggested it could enhance plasticity and enable greater behavioral recovery. However, several studies have now identified substantial inter-subject variability in response to tDCS and clinical trials revealed insufficient evidence of treatment effectiveness. A possible explanation for the varied and negative findings is that the physiological model of stroke recovery that researchers have used to guide the application of tDCS based treatments in stroke is overly simplistic and does not account for stroke heterogeneity or known determinants that affect the tDCS response. <a name="_Hlk62139152">Here, we propose that tDCS could have a more clearly beneficial role in enhancing stroke recovery</a> if greater consideration is given to individualizing treatment. By critically reviewing the proposed mechanisms of tDCS, stroke physiology across the recovery continuum, and known determinants of tDCS response, we propose a new, theoretical, patient-tailored approach to delivering tDCS after stroke. The proposed model includes a step-by-step principled selection strategy for identifying optimal neuromodulation targets and outlines key areas for further investigation. Tailoring tDCS treatment to individual neuroanatomy and physiology is likely our best chance at producing robust and meaningful clinical benefit for people with stroke and would, therefore, accelerate opportunities for clinical translation.</p>
Association of hemoglobin A1C with TDP-43 pathology: Supplemental materials
<p><b>Objective.</b> We tested the hypothesis that an inverse association exists between diabetes mellitus (DM) and hemoglobin A1C (A1C) with Transactive response DNA binding protein 43 (TDP-43) levels in older adults.</p> <p><b>Methods. </b>We leveraged antemortem and postmortem data of decedents from three community-based clinical-pathological studies. DM status, A1C levels, and medications for DM were documented annually. TDP-43 cytoplasmic inclusions, evaluated in 6 brain regions using immunohistochemistry, were used to obtain a semiquantitative TDP-43 score (0-5) in each region, and scores were averaged across regions to obtain a TDP-43 severity score. We used linear regressions to test the association of DM and A1C with the TDP-43 severity score.</p> <p><b>Results.</b> On average, participants (n=817) were 90 years old at the time of death, three fourth were women, and one fourth had DM. The mean A1C was 6.0% (SD=0.6). TDP-43 was observed in 54% of participants, and the mean TDP-43 score was 0.7 (range 0-4.5). A higher level of A1C was associated with a lower TDP-43 score (estimate=-0.156, S.E.=0.060, <i>p</i>=0.009) while DM had a borderline inverse association with the TDP-43 score (estimate=-0.163, S.E.=0.087, <i>p</i>=0.060). The association of higher levels of A1C with lower TDP-43 scores persisted after further adjustment by <i>Apolipoprotein ε</i>4, vascular risk factors, stroke, and hypoglycemic medications. Exclusion of the oldest old participants did not change the results.</p> <p><b>Conclusion.</b> Overall, the results suggest that a high level of A1C is associated with less TDP-43 proteinopathy in older persons while the relationship of DM with TDP-43 needs further study.</p>
Supplemental R code and csv files for statistical analysis on Doi et al. "Effects of species traits and ecosystem characteristics on species detection by eDNA metabarcoding in lake fish communities"
<p>Supplemental R code and csv files for statistical analysis on Doi et al. "Effects of species traits and ecosystem characteristics on species detection by eDNA metabarcoding in lake fish communities"</p>
Master-thesis supplement Del 2 parasite presence datasheet
<p>Datasett av telte hoppekreps og parasitter for bildene</p>
Master-thesis supplement Del 2 zooprocess-bilder
<p>Bildene analysert i del 2</p>
Supplemental information
<p>Supplemental information of a research letter</p>
SUPPLEMENTAL FIGURE S1 in Morphometric approach to supports distinction among three species of Paucibranchia Molina-Acevedo, 2018 (Annelida: Eunicidae)
SUPPLEMENTAL FIGURE S1. Pearson's correlation coefficient.
Dataset supplementing "B. Ojha, M. Schober, S. Turad, J. Jochum and H. Kohler; Gasification of biomass: Very sensitive monitoring of TAR in syngas by determination of the oxygen demand– A proof of concept,Processes 2022"
<p>Dataset supplementing "B. Ojha, M. Schober, S. Turad, J. Jochum and H. Kohler;Gasification of biomass: Very sensitive monitoring of TAR in syngas by determination of the oxygen demand– A proof of concept,Processes 2022 "</p>
sherror_supplement
<p>Spherical harmonics gravity field commission/omission error analysis datasets. Includes commission/omission data, recommended spherical harmonics degree truncation charts, and recommended spherical harmonics degree truncation curve fits.</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.