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Video S1: Spider presence indication in the field, Yoram Zvik;
<p>Video S1: Spider presence indication in the field, Yoram Zvik;</p> <p> </p> <p>Video S1 Five-year monitoring of a desert burrow-dwelling spider fol-lowing an environmental disaster indicates long-term impacts.</p> <p> </p> <p>submitted to the jornal Insects</p>
Video S2 Five-year monitoring of a desert burrow-dwelling spider fol-lowing an environmental disaster indicates long-term impacts.
<p>A supplementary video S2</p> <p><em>Sahastata aravaensis</em> sp. nov. feeding in captivity with ants, Efrat Gavish-Regev. The spiders usually bite the ant’s leg before feeding.</p> <p>Five-year monitoring of a desert burrow-dwelling spider fol-lowing an environmental disaster indicates long-term impacts.</p> <p>Submitted to the Journal: Insects</p> <p> </p>
Artemisia pollen datasets for exploring the potential ecological indicator in deep time
<p><em>Artemisia</em>, along with Chenopodiaceae is the dominant component growing in the desert and grassland of the Northern Hemisphere. The Chenopodiaceae/<em>Artemisia</em> (C/A) pollen ratio is a traditional bio-indicator to evaluate environmental aridity prior to meteorological records. However, when applying the C/A ratio from the original point in the Middle East to other regions, the validity was questioned. Compared with Chenopodiaceae pollen, which is inversely proportional to precipitation, <em>Artemisia</em> pollen with its diverse habitats is probably responsible for this uncertainty.</p> <p>Here we provided the <em>Artemisia</em> pollen morphological datasets covering 36 species from 9 clades and 3 outgroups under a phylogenetic framework to ensure maximum variation range and their source plant habitat ranges. The new pollen classification with a key to the pollen types of <em>Artemisia</em> was established by hierarchical cluster analysis. The <em>Artemisia</em> pollen classification (1) improves the resolution of bio-indicators in deep-time environmental assessment; (2) reveals that the diverse habitats colonized by <em>Artemisia</em> could be responsible for the uncertainty of the C/A pollen ratio in different regions; (3) changes the traditional concept of <em>Artemisia</em> being restricted to arid and semi-arid environments.</p> <p>We hope to establish an open dataset that welcomes new <em>Artemisia</em> data from all over the world in the future for better serving the global paleoenvironment assessment and refined reconstruction of paleovegetation.</p>
Aortic Area as an Indicator of Subclinical Cardiovascular Disease
<p>Dataset for generation of the results for Aortic Area as an Indicator of Subclinical Cardiovascular Disease for publication in The Open Journal of Cardiovascular Medicine. The data were collected by the Tobago Health Study and accessed by investigators at the University of Pittsburgh and Vanderbilt University. This work was supported by grants K01-HL125658 and R03-HL 144668 (PI: Kuipers) from the National Heart, Lung and Blood Institute, and by grant R01-DK097084 (PI: Miljkovic) from the National Institute of Diabetes and Digestive and Kidney. There are no relationships with industry to disclose.</p>
Sonication data related to article " preclinical study of diffusion-weighted MRI contrast as an early indicator of thermal ablation"
<p>data analysis table and workflow</p> <p> </p>
Database - Some indicators of PISA (2000-2015), by countries
<p>Database - Some indicators of PISA (2000-2015), by countries</p>
Database - Some indicators of PISA (2000-2015), by countries
<p>Database - Some indicators of PISA (2000-2015), by countries</p>
Database - Some Indicators of PISA (2000-2015), by countries
<p>Database - Some Indicators of PISA (2000-2015), by countries</p>
Dataset related to article: "Could We Safely Avoid a Second Resection in Selected Patients With T1 Non-Muscle-Invasive Bladder Cancer? Preliminary Results of Cost-Effectiveness Study From HUmanitas New Indications for ReTUR (HuNIRe) Multicenter Prospective Trial"
<p>The paper reports the preliminary results of a study which aims to avoid re-turbt in patients who have pT1</p>
Clinical performance indicators for monitoring the management of cutaneous melanoma: a population-based perspective
<p>The prognosis of cutaneous malignant melanoma (CMM) is based on disease progression. The highly heterogeneous clinical-pathological characteristics of CMM necessitate standardized diagnostic and therapeutic interventions tailored to cancer's stage. This study utilizes clinical performance indicators to assess the quality of CMM care in Veneto (Northeast Italy). This population-based study focuses on all incidences of CMMs registered by the Veneto Cancer Registry in 2015 (1279 patients) and 2017 (1368 patients). An interdisciplinary panel of experts formulated a set of quality-monitoring indicators for diagnostic, therapeutic, and end-of-life clinical interventions for CMM. The quality of clinical care for patients was assessed by comparing the reference thresholds established by experts to the actual values obtained in clinical practice. The prevalence of stage I-CMM decreased significantly from 2015 to 2017 (from 71.8 to 62.4%; P < 0.001), and almost all the pathology reports mentioned the number of nodes dissected during a lymphadenectomy. More than 90% of advanced CMMs were promptly tested for molecular BRAF status, but the proportion of patients given targeted therapies fell short of the desired threshold (61.1%). The proportion of stage I-IIA CMM patients who inappropriately underwent computerized tomography/MRI/PET dropped from 17.4 to 3.3% ( P < 0.001). Less than 2% of patients received medical or surgical anticancer therapies in the month preceding their death. In the investigated regional context, CMM care exhibited both strengths and weaknesses. The evaluated clinical indicators shed essential insight on the clinical procedures requiring corrective action. It is crucial to monitor clinical care indicators to improve care for cancer patients and promote the sustainability of the healthcare system.</p>
This record contains raw data related to the article "Sex-Specific Cell Types and Molecular Pathways Indicate Fibro-Calcific Aortic Valve Stenosis"
<p>This record contains raw data related to the article "Sex-Specific Cell Types and Molecular Pathways Indicate Fibro-Calcific Aortic Valve Stenosis"</p> <p><strong>Background:</strong> Aortic stenosis (AS) is the most common valve disorder characterized by fibro-calcific remodeling of leaflets. Recent evidence indicated that there is a sex-related difference in AS development and progression. Fibrotic remodeling is peculiar in women’s aortic valves, while men’s leaflets are more calcified. Our study aimed to assess aortic valve fibrosis (AVF) in a severe AS cohort using non-invasive diagnostic tools and determine whether sex-specific pathological pathways and cell types are associated with severe AS.</p> <p><strong>Materials and Methods:</strong> We have included 28 men and 28 women matched for age with severe AS who underwent echocardiography and cardiac contrast-enhanced computed tomography (CT) before intervention. The calcium and fibrosis volumes were assessed and quantified using the ImageJ thresholding method, indexed calcium and fibrosis volume were calculated by dividing the volume by the aortic annular area. For a deeper understanding of molecular mechanisms characterizing AS disorder, differentially expressed genes and functional inferences between women and men’s aortic valves were carried out on a publicly available microarray-based gene expression dataset (GSE102249). Cell types enrichment analysis in stenotic aortic valve tissues was used to reconstruct the sex-specific cellular composition of stenotic aortic valves.</p> <p><strong>Results:</strong> In agreement with the literature, our CT quantifications showed that women had significantly lower aortic valve calcium content compared to men, while fibrotic tissue composition was significantly higher in women than men. The expression profiles of human stenotic aortic valves confirm sex-dependent processes. Pro-fibrotic processes were prevalent in women, while pro-inflammatory ones, linked to the immune response system, were enhanced in men. Cell-type enrichment analysis showed that mesenchymal cells were over-represented in AS valves of women, whereas signatures for monocytes, macrophages, T and B cells were enriched men ones.</p> <p><strong>Conclusions:</strong> Our data provide the basis that the fibro-calcific process of the aortic valve is sex-specific, both at gene expression and cell type level. The quantification of aortic valve fibrosis by CT could make it possible to perform population-based studies and non-invasive assessment of novel therapies to reduce or halt sex-related calcific aortic valve stenosis (CAVS) progression, acting in an optimal window of opportunity early in the course of the disease.</p>
Is early MIDAS reduction at 3 months the best indicator predictor for erenumab treatment continuation? A open-label trial
<p>This database includes the raw data linked with the paper “Is early MIDAS reduction at 3 months the best indicator predictor for erenumab treatment continuation? A open-label trial”, published on The Journal of Headache and Pain.</p> <p> </p> <p>In this paper, we described migraine disability, quantified as a MIgraine Disability ASsessment (MIDAS).</p> <p>• A moderate to severe disability, MIDAS score 11, is required for prescription.</p> <p>• Score reduction of at least 50% after the first three months (T3) is mandatory to continue treatment.</p> <p>• Primary aim of this study:</p> <p>• - to evaluate whether 50% MIDAS reduction at T3 (MIDASRes) is a reliable response predictor of one-year erenumab treatment (classified as a reduction of baseline MMDs 50%).</p> <p>• The 50% reduction of monthly migraine days (MMD) at T3 Co-primary outcome</p> <p>• Secondary outcomes:</p> <p>• - the search of other predictors represents</p> <p> </p> <p>• Methods:</p> <p>• In this prospective, open-label study, 77 CM patients (mean age 49.8±9.5 years, chronicity history 13.1±10.3years, 93.5% of medication overuse headache) were treated with erenumab 70-140mg subcutaneous injections every 28 days for one year (T13). We assessed demographic and headache features, monthly migraine and headache days (MMD and MHDs respectively), days and doses of symptomatic intake. Patients also completed questionnaires evaluating migraine related disability (MIDAS and HIT-6), psychological comorbidities (HADS-A and HADS-D), quality of life (MSQ and 0 to 100 visual analogue scale) and allodynia (ASC-12). ANOVA for repeated measures was performed for quantifying erenumab efficacy and logistic regression model was used for evaluating one-year predictors of response.</p> <p> </p> <p>• Results:</p> <p>• Erenumab induced a sustained reduction of MMDs, MHDs and symptomatic intake during treatment. At T13 64.9% of patients presented MMDs baseline reduction 50% (RespondersT13). At T3, 55.8% of patients were MIDASRes. Contextually, 55.4% of patients were MMD Responders, these were also more likely to qualify as RespondersT13 when compared to non-responders (83.3% vs 42.9%; p=0.001). MMD response at T3 also demonstrated to be a predictor of long-term outcome according to a multivariate analysis ((Exp(B)=7.128; p=0.001)). When MIDAS reduction at T3 is considered as decision-making predictor of long-term outcome, 36.0% of patients who may benefit from 1-year erenumab administration are early excluded. By contrast, a lower percentage of Responders T13 (16%) would be discontinued if MIDASRes or MMD responders at T3 were alternatively considered.</p>
Dynamics of recurrent indicators during night recording
<p>The archive contains time dependencies of recurrent indicators for night recordings of fifteen generally healthy subjects (N = 15; age: 51.5 ± 29.5 years; median age: 42 years; male/female ratio: 8/7). For each of them, nighttime EEG recordings were performed twice using six leads. In accordance with the hypnogram (they are also attached to the data), the recording was divided into 30-second segments corresponding to different stages of sleep. The stages of sleep were marked out earlier by a somnologist. For each segment, a recurrent indicator was calculated in a classical way, after which a final file was generated with recurrent indicators for all six channels for all time intervals. The proposed data can be used to verify the results of recurrent analysis using polysomnographic recordings in small groups of patients.</p>
mRNA degradome analysis indicating miRNA regulation in muscle mass development
GEO Series GSE129681. Sus scrofa. 12 samples. Type: Expression profiling by high throughput sequencing.
Genomic biomarkers from urine cells indicate a unique metabolomic difference between sepsis and sterile inflammation
GEO Series GSE168443. Homo sapiens. 264 samples. Type: Expression profiling by array.
Expression data from CD19-positive B-cells isolated from splenocytes from 8 week-old ingeneered mice from the indicated genotypes
GEO Series GSE69367. Mus musculus. 8 samples. Type: Expression profiling by array.
Data set from Ranucci M, Barile L, Ambrogi F, Pistuddi V; Surgical and Clinical Outcome Research (SCORE) Group. Discrimination and calibration properties of the hypotension probability indicator during cardiac and vascular surgery. Minerva Anestesiol. 2019 Jul;85(7):724-730. doi: 10.23736/S0375-9393.18.12620-4. Epub 2018 Nov 22. PMID: 30481996.
<p>Data set from Ranucci M, Barile L, Ambrogi F, Pistuddi V; Surgical and Clinical Outcome Research (SCORE) Group. Discrimination and calibration properties of the hypotension probability indicator during cardiac and vascular surgery. Minerva Anestesiol. 2019 Jul;85(7):724-730. doi: 10.23736/S0375-9393.18.12620-4. Epub 2018 Nov 22. PMID: 30481996.</p> <p> </p> <p>This is the abstract:</p> <p><strong>Background: </strong> Hypotension during surgery is linked to postoperative complications. Recently, a new hemodynamic algorithm intended to predict hypotensive events (hypotension probability indicator [HPI]) has been developed. The aim of the present study is to test the discrimination and calibration properties of the HPI.</p> <p><strong>Methods: </strong> The intraoperative files of 23 patients undergoing cardiac and major vascular surgery receiving the HPI-based hemodynamic monitoring were retrospectively investigated for prediction of hypotensive events (mean arterial pressure <65 mmHg). The HPI was available at 20 seconds intervals; the values of HPI five to seven minutes before a hypotensive event (HPI5-7) were tested for discrimination and calibration.</p> <p><strong>Results: </strong> The HPI5-7 has a fair level of discrimination (area under the curve 0.768) and a poor calibration, due to overestimation of the hypotensive risk. At the observed prevalence, a cut-off value of 85% carries a sensitivity of 62.4% and a specificity of 77.7%, a negative predictive value (NPV) of 97.8% and a positive predictive value (PPV) of 12.6%; a value of 98% has a PPV of 64% and an NPV of 95.3%.</p> <p><strong>Conclusions: </strong> The HPI5-7 may offer some useful insights. Values ≤85% carry a clinically acceptable NPV for hypotensive events at the observed prevalence and may represent a "safe zone" during surgery. Values >85% do not carry enough PPV to trigger hemodynamic interventions, but represent a warning signal. Values >98% are highly suggesting a hypotensive event after 5-7 minutes. Further studies exploring the predictive ability of the HPI at different times are needed.</p>
Data set from Ranucci M, Barile L, Ambrogi F, Pistuddi V; Surgical and Clinical Outcome Research (SCORE) Group. Discrimination and calibration properties of the hypotension probability indicator during cardiac and vascular surgery. Minerva Anestesiol. 2019 Jul;85(7):724-730. doi: 10.23736/S0375-9393.18.12620-4. Epub 2018 Nov 22. PMID: 30481996.
<p>Data set from Ranucci M, Barile L, Ambrogi F, Pistuddi V; Surgical and Clinical Outcome Research (SCORE) Group. Discrimination and calibration properties of the hypotension probability indicator during cardiac and vascular surgery. Minerva Anestesiol. 2019 Jul;85(7):724-730. doi: 10.23736/S0375-9393.18.12620-4. Epub 2018 Nov 22. PMID: 30481996.</p> <p> </p> <p>This is the abstract:</p> <p><strong>Background: </strong> Hypotension during surgery is linked to postoperative complications. Recently, a new hemodynamic algorithm intended to predict hypotensive events (hypotension probability indicator [HPI]) has been developed. The aim of the present study is to test the discrimination and calibration properties of the HPI.</p> <p><strong>Methods: </strong> The intraoperative files of 23 patients undergoing cardiac and major vascular surgery receiving the HPI-based hemodynamic monitoring were retrospectively investigated for prediction of hypotensive events (mean arterial pressure <65 mmHg). The HPI was available at 20 seconds intervals; the values of HPI five to seven minutes before a hypotensive event (HPI5-7) were tested for discrimination and calibration.</p> <p><strong>Results: </strong> The HPI5-7 has a fair level of discrimination (area under the curve 0.768) and a poor calibration, due to overestimation of the hypotensive risk. At the observed prevalence, a cut-off value of 85% carries a sensitivity of 62.4% and a specificity of 77.7%, a negative predictive value (NPV) of 97.8% and a positive predictive value (PPV) of 12.6%; a value of 98% has a PPV of 64% and an NPV of 95.3%.</p> <p><strong>Conclusions: </strong> The HPI5-7 may offer some useful insights. Values ≤85% carry a clinically acceptable NPV for hypotensive events at the observed prevalence and may represent a "safe zone" during surgery. Values >85% do not carry enough PPV to trigger hemodynamic interventions, but represent a warning signal. Values >98% are highly suggesting a hypotensive event after 5-7 minutes. Further studies exploring the predictive ability of the HPI at different times are needed.</p>
Prognostic indicators of persistent carotid intima-media thickness increase in postpartum period in a population of normotensive women with gestational diabetes mellitus
<p><strong>OBJECTIVE: </strong>The association between gestational diabetes mellitus (GDM) and common carotid artery (CCA)-intima media thickness (IMT) is still controversial. In the present study, we aimed to compare the CCA-IMT measured in GDM women to that obtained in healthy pregnant women in the third trimester of pregnancy. Secondly, we investigated the main independent predictors of persistent CCA-IMT increase (defined as CCA-IMT ≥0.6 mm) in postpartum period in GDM women.</p> <p><strong>STUDY DESIGN: </strong>30 consecutive GDM women and 30 healthy pregnant women matched for anagraphic age (34.1±4.5 vs 32.8 ± 4.2 yrs, p=0.25), ethnicity (caucasian 56.7 vs 63.3%, p=0.59), gestational age (36.2± 1.7 vs 36.5 ± 1.6 weeks, p=0.48) and cardiovascular risk factors were examined in this prospective case-control study. All women underwent obstetric visit, blood tests, conventional transthoracic echocardiography implemented with two-dimensional speckle tracking echocardiography analysis of left ventricular and left atrial myocardial strain parameters and carotid ultrasound examination at two time points: 36-38 weeks’ gestation and 6-10 weeks after delivery.</p> <p><strong>RESULTS: </strong>At 36.2±1.7 weeks of gestation, CCA-IMT was significantly increased in GDM women than controls (0.81±0.11 vs 0.55 ± 0.12, p <0.001). Twelve GDM women (40% of the total) were found with persistent CCA-IMT increase (0.76±0.14 mm) in postpartum period (8.2±2.2 weeks), whereas the remaining 18 (60% of the total) showed a normalization in CCA-IMT (0.56±0.1 mm). At multivariate logistic regression analysis, third trimester body mass index (BMI) (OR 1.78, 95%CI 1.24-2.54, p = 0.01), glycosylated hemoglobin (HbA1C) (OR 1.51, 95%CI 1.13-1.89, p = 0.03) and neutrophil-to-lymphocyte ratio (NLR) (OR 1.68, 95%CI 1.25-4.65, p = 0.02) resulted to be independently associated with persistent CCA-IMT increase in postpartum period in GDM women. A BMI ≥29.2 Kg/m<sup>2</sup>, an HbA1C ≥37.5 mmol/mol and a NLR ≥5.5 were the best cut-off values for identifying GDM women with persistent CCA-IMT increase in postpartum period.</p> <p><strong>CONCLUSIONS: </strong>GDM is associated with increased CCA-IMT during pregnancy. This increase may be persistent in postpartum period in GDM women with obesity, uncontrolled diabetes and increased inflammatory markers.</p>
Clinical indications for image-guided interventional procedures in the musculoskeletal system, lower limb
<p>Data set from Clinical indications for image-guided interventional procedures in the musculoskeletal system, lower limb: a Delphi-based consensus paper from the European Society of Musculoskeletal Radiology (ESSR)</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.