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46 results for “Aminoglycosides”
Stop Codon Context Influences Genome-Wide Stimulation of Termination Codon Readthrough by Aminoglycosides [Dataset 2]
GEO Series GSE138639. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Small molecule Y-320 stimulates ribosome biogenesis, protein synthesis and aminoglycoside-induced premature termination codon readthrough
GEO Series GSE152142. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Structural and functional analyses of STM14_5441-STM14_5442: A potential mechanism for persister formation against aminoglycosides [resT RNA-seq]
GEO Series GSE276713. Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S. 4 samples. Type: Expression profiling by high throughput sequencing.
Stop Codon Context Influences Genome-Wide Stimulation of Termination Codon Readthrough by Aminoglycosides [Dataset 4]
GEO Series GSE138641. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Data from: Fe-S cluster biosynthesis controls uptake of aminoglycosides in a ROS-less death pathway
All bactericidal antibiotics were recently proposed to kill by inducing reactive oxygen species (ROS) production, causing destabilization of iron-sulfur (Fe-S) clusters and generating Fenton chemistry. We find that the ROS response is dispensable upon treatment with bactericidal antibiotics. Furthermore, we demonstrate that Fe-S clusters are required for killing only by aminoglycosides. In contrast to cells, using the major Fe-S cluster biosynthesis machinery, ISC, cells using the alternative machinery, SUF, cannot efficiently mature respiratory complexes I and II, resulting in impendence of the proton motive force (PMF), which is required for bactericidal aminoglycoside uptake. Similarly, during iron limitation, cells become intrinsically resistant to aminoglycosides by switching from ISC to SUF and down-regulating both respiratory complexes. We conclude that Fe-S proteins promote aminoglycoside killing by enabling their uptake.
Impact of Aminoglycosides in Hypotensive Septic Oncology Patients
ClinicalTrials.gov study NCT05045963. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Evaluation of Pharmacokinetic / Pharmacodynamic Data and Interest Individualized Therapeutic Drug Monitoring Glycopeptides and β-lactam-aminoglycoside ICU
ClinicalTrials.gov study NCT02846298. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Aminoglycoside Administration in Septic Patients
ClinicalTrials.gov study NCT06226441. IPD Sharing: NO. Countries: 1. Publications: 0.
Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study
ClinicalTrials.gov study NCT05548283. IPD Sharing: Not stated. Countries: 2. Publications: 0.
Adjustment of Aminoglycoside Dosing Based on Peak Serum Concentration and Bacterial Minimal Inhibitory Concentration
ClinicalTrials.gov study NCT05618457. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Once Daily Aminoglycoside Pharmacokinetics and Optimal Dosing in the Burn Population: A Prospective Study
ClinicalTrials.gov study NCT02269969. IPD Sharing: Not stated. Countries: 1. Publications: 0.
N-acetylcysteine Protects From Aminoglycosides Induced Nephrotoxicity
ClinicalTrials.gov study NCT00267384. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Identification of Gene and Protein Markers of Kidney Injury in Aminoglycoside-treated Children
ClinicalTrials.gov study NCT00308906. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Patient Satisfaction and Long-term Safety of Intravesical Aminoglycoside Instillations in UTI Prevention
ClinicalTrials.gov study NCT05376670. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Prospective Observational Study to Evaluate Biomarkers of Aminoglycoside Nephrotoxicity in Patients With Cystic Fibrosis
ClinicalTrials.gov study NCT01543620. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: Fe-S cluster biosynthesis controls uptake of aminoglycosides in a ROS-less death pathway
Open the record for dataset details and reuse information.
Stop Codon Context Influences Genome-Wide Stimulation of Termination Codon Readthrough by Aminoglycosides [Dataset 5]
GEO Series GSE138642. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
A KDPG sensor RccR governs Pseudomonas aeruginosa carbon metabolism and aminoglycoside antibiotic tolerance
GEO Series GSE237535. Pseudomonas aeruginosa. 8 samples. Type: Expression profiling by high throughput sequencing.
Single cell RNA seq analysis of the chicken basilar papilla following in vivo aminoglycoside induced hair cell ablation
GEO Series GSE240187. Gallus gallus. 3831 samples. Type: Expression profiling by high throughput sequencing.
Aminoglycosides and Duct
ClinicalTrials.gov study NCT04415554. IPD Sharing: Not stated. Countries: 0. Publications: 0.
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