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413 results for “Candida albicans”
Data from: Host-induced genome instability rapidly generates phenotypic variation across Candida albicans strains and ploidy states
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Data from: Decrease in ribosomal RNA in Candida albicans induced by serum exposure
Candida albicans is an important polymorphic human pathogen. It can switch from a unicellular yeast form to germinating hypha, which may play a role in making it the successful pathogen it is. This hyphal transformation can be triggered by various extracellular stimuli, the most potent one being serum from any source. We have previously reported that Candida albicans transiently polyadenylates portions of both the large and small subunits of ribosomal RNA, shortly after serum exposure. Northern blots at the same time suggested that serum might induce a decrease in total ribosomal RNA. We have carried out a number of experiments to carefully assess this possibility and now report that serum significantly reduces ribosomal RNA in Candida albicans. Fluorometric measurements, Northern blotting and quantitative RT-PCR, have all confirmed this decrease. Timed experiments show that serum induces this decrease rapidly, as it was seen in as early as five minutes. Cell mass is not decreased as total cellular protein content remains the same and metabolic activity does not appear to slow, as assessed by XTT assay, and by the observation that cells form hyphal structures robustly. Another hyphal inducer, N-acetylglucosamine, also caused RNA decrease, but to a lesser extent. We also observed it in non-germinating yeast, such as Candida glabrata. The reason for this decrease is unknown and overall our data suggests that decrease in rRNA does not play a causal role in hyphal transformation. Rapid and significant decrease in a molecule so central to the yeast's biology is of some importance, and further studies, such as its effect on protein metabolism, will be required to better understand its purpose.
Data for / Comparison of Antifungal Activity of Thymus Vulgaris Essential Oil and Triple Antibiotic Paste Against Candida Albicans Isolated from Root Canal (In Vitro Study)
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Antibacterial effect of Hibiscus sabdariffa (Roselle) extract in synergism with voriconazole and fluconazole against fluconazole-resistant Candida albicans isolates: An in vitro study.
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Imaging-based screening identifies modulators of the eIF3 translation initiation factor complex in Candida albicans
<p>Fungal pathogens like Candida albicans can cause devastating human disease. Treatment of candidemia is complicated by the high rate of resistance to common antifungal therapies. Additionally, there is host toxicity associated with many antifungal compounds due to the conservation between essential mammalian and fungal proteins. An attractive new approach for antimicrobial development is to target virulence factors: non-essential processes that are required for the organism to cause disease in human hosts. This approach expands the potential target space while reducing the selective pressure towards resistance, as these targets are not essential for viability. In C. albicans, a key virulence factor is the ability to transition to hyphal morphology. We developed a high-throughput image analysis pipeline to distinguish between yeast and filamentous growth in C. albicans at the single cell level. Based on this phenotypic assay, we screened the FDA drug repurposing library of 2,017 compounds for their ability to inhibit filamentation and identified 33 compounds that block the hyphal transition in C. albicans with IC50 values ranging from 0.2 to 150 µM. Multiple compounds showed a phenyl vinyl sulfone chemotype, prompting further analysis. Of these phenyl vinyl sulfones, NSC 697923 displayed the most efficacy, and by selecting for resistant mutants, we identified eIF3 as the target of NSC 697923 in C. albicans. </p>
Fig. 3 in Terpenoids from the Chinese liverwort Heteroscyphus coalitus and their antivirulence activity against Candida albicans
Fig. 3. Selected NOESY correlations (H↔H) of 1, 2, 10 and 14.
Fig. 4. X in Terpenoids from the Chinese liverwort Heteroscyphus coalitus and their antivirulence activity against Candida albicans
Fig. 4. X-ray crystallographic structure of 1.
Fig. 2 in Terpenoids from the Chinese liverwort Heteroscyphus coalitus and their antivirulence activity against Candida albicans
Fig. 2. Selected HMBC (H 1 – 1 ▬ →C) and H H COSY (H H) correlations of 1, 2, 10, and 14.
Fig. 5 in Terpenoids from the Chinese liverwort Heteroscyphus coalitus and their antivirulence activity against Candida albicans
Fig. 5. Experimental ECD and calculated ECD curves of 4 (1:1).
Fig. 1 in Terpenoids from the Chinese liverwort Heteroscyphus coalitus and their antivirulence activity against Candida albicans
Fig. 1. Structures of compounds 1–15.
Evaluation of Candida Albicans Growth on BreFlex Versus PEEK Denture Base in Maxillary Bounded Partial Denture
ClinicalTrials.gov study NCT03462862. IPD Sharing: UNDECIDED. Countries: 0. Publications: 5.
Efflux Pump Mediated Azole Resistance in Candida Albicans
ClinicalTrials.gov study NCT03659162. IPD Sharing: UNDECIDED. Countries: 0. Publications: 10.
Data from: Reduced PICD in monocytes mounts altered neonate immune response to Candida albicans
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Data from: Decrease in ribosomal RNA in Candida albicans induced by serum exposure
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Extrathymic expression of Aire controls the induction of effective TH17 cell-mediated immune response to Candida albicans
GEO Series GSE203158. Mus musculus. 50 samples. Type: Expression profiling by high throughput sequencing.
Differential gene expression in the grf10Δ mutant of Candida albicans in high copper containing growth medium
GEO Series GSE223217. Candida albicans. 12 samples. Type: Expression profiling by high throughput sequencing.
Cell wall integrity is linked to mitochondria and phospholipid homeostasis in Candida albicans through the activity of the post-transcriptional regulator Ccr4-Pop2
GEO Series GSE25891. Candida albicans. 4 samples. Type: Expression profiling by array.
Dot6 is a major regulator of cell size and a transcriptional activator of ribosome biogenesis in the opportunistic yeast Candida albicans
GEO Series GSE119089. Candida albicans. 3 samples. Type: Expression profiling by array.
Transcriptional Response of Candida albicans Cells Following Phagocytosis by Mouse Macrophages
GEO Series GSE11399. Candida albicans. 24 samples. Type: Expression profiling by array.
The impact of the SCFA crotonate on Candida albicans and macrophage transcriptomes
GEO Series GSE234554. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.