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424 results for “Clinical characteristics”
Clinical characteristics, risk factors and complications of COVID-19 among critically ill older adults – A case control study
<p><strong>Background</strong>: The older population is often disproportionately and adversely affected during humanitarian emergencies, as has also been seen during the COVID-19 pandemic. Data regarding COVID-19 in older adults is usually over-generalised and does not delve into details of the clinical characteristics in them. This study was conducted to analyse clinical and laboratory characteristics, risk factors, and complications of COVID-19 between older adults who survived and those who did not.</p> <p><strong>Methods</strong>: We conducted a case-control study among older adults(age > 60 years) admitted to the Intensive Care Unit(ICU) during the COVID-19 pandemic. The non-survivors (cases) were matched with age and sex-matched survivors (control) in a ratio of 1: 3. The data regarding socio-demographics, clinical characteristics, complications, treatment, laboratory data, and outcomes were analysed.</p> <p><strong>Results</strong>: The most common signs and symptoms observed were fever (cases vs controls) (68.92 vs. 68.8%), followed by shortness of breath (62.2% Vs. 52.2%), and cough (47.3% Vs. 60.2%). Our analysis found no association between the presence of any of the comorbidities and mortality. At admission, laboratory markers such as LDH(Lactate Dehydrogenase), WBC(White Blood Count), creatinine, CRP(C-Reactive Protein), D-dimer, ferritin, and IL-6(Interleukin-6) were found to be significantly higher among the cases than among the controls. Complications such as development of seizure, bacteremia, acute renal injury, respiratory failure, and septic shock were seen to have a significant association with non-survivors.</p> <p><strong>Conclusions</strong>: Hypoxia, tachycardia, and tachypnoea at presentation were associated with higher mortality. The older adults in this study mostly presented with the typical clinical features of COVID-19 pneumonia. The presence of comorbid illnesses among them did not affect mortality. Higher death was seen among those with higher levels of CRP, LDH, D-dimer, and ferritin; and with lower lymphocyte counts.</p>
Clinical Features, Socio-Cultural Characteristics, Sleep Patterns, and Depression in Fibromyalgia Patients from India: A Cross-Sectional Study
<p><strong>Introduction</strong>: Fibromyalgia is a complex and chronic disease with significant regional variation and lack of studies from Indian population.</p> <p><strong>Objective</strong>: Aim to investigate the clinical features of fibromyalgia patients in India, including the prevalence and distribution of comorbidities, sleep patterns, and depression.</p> <p><strong>Method</strong>: Cross-sectional analysis of consecutive patients attending outpatient Rheumatology clinic from 2019-2020 satisfying ACR2016 criteria for fibromyalgia.</p> <p><strong>Results:</strong></p> <p>Of the 121 patients enrolled in the study, the majority (93.4%) were female, with a female-to-male ratio of 14:1. The mean age of the patients was 45 ±11 years. The socio-cultural profile of the patients revealed that the majority were married (88%) and homemakers (68.8%), lived in nuclear families (56%) and were middle to upper middle class (68.6%). Contrary to the existing literature, a higher prevalence of fibromyalgia has been observed in people with a higher educational status. Common clinical symptoms were extensive body aches (100%), fatigue (88%), difficulty concentrating (69.4%), irritability and gastrointestinal complaints (58.5%). We observed a high prevalence of primary headache (76%), mainly migraine (42%) and compulsive behaviour (OCB) (71%). Sleep disturbances and depression were found to be significant factors associated with fibromyalgia. The patients reported various sleep problems, such as snoring, waking up at night, daytime sleepiness, and taking daytime naps. Most of the patients had mild (50.8%) to moderate (29%) depression, while a smaller proportion experienced severe (6.6%) symptoms. Most of the patients had low vitamin D(91%).</p> <p><strong>Conclusion</strong>: The demographic profile of Indian patients was similar to that reported in the literature but had varied socio-cultural profiles needing further community-based studies. The high prevalence of psychological comorbidities and sleep disturbances highlights their importance in managing FM patients.</p>
The Obesity-hypoventilation Syndrome Study of Clinical Characteristics and Predictive Factors of Response to Treatment
ClinicalTrials.gov study NCT00938977. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Clinical, Virological, Serological and Immunological Characteristics During and Following COVID-19 Hospitalization
ClinicalTrials.gov study NCT05274373. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Incidence and Clinical Characteristics of Pulmonary Hypertension Secondary to ARDS in the Highland
ClinicalTrials.gov study NCT05166759. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Incidence, Clinical Characteristics and Outcomes of Unstable Angina in the contempoRary Area.
ClinicalTrials.gov study NCT06378333. IPD Sharing: NO. Countries: 1. Publications: 7.
Clinical Characteristics and Long Term Impact on Pediatric COVID-19 in Taiwan
ClinicalTrials.gov study NCT05582512. IPD Sharing: Not stated. Countries: 1. Publications: 30.
A Study to Determine the Clinical Characteristics, Comorbidities, Treatment Status and Exacerbations of Asthma Patients
ClinicalTrials.gov study NCT03239431. IPD Sharing: YES. Countries: 1. Publications: 26.
A Study to Describe the Characteristics of Patients Treated With Apremilast for Plaque Psoriasis in Italian Routine Clinical Practice
ClinicalTrials.gov study NCT04031027. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Demographic, Clinical, Biological, Treatment Characteristics and Cardiovascular Events of Patients With Heart Failure in Vietnam: a Multicenter Prospective Observational Study
ClinicalTrials.gov study NCT06516562. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Delayed Puberty in Boys; Clinical and Biochemical Characteristics and Effect of Testosterone Treatment
ClinicalTrials.gov study NCT02034487. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study to Understand Clinical Characteristics, Treatment Pathway in Chronic Lymphocytic Leukemia
ClinicalTrials.gov study NCT04964908. IPD Sharing: YES. Countries: 17. Publications: 1.
Clinical Characteristics of Importance to Outcome in Patients With Spondyloarthritis
ClinicalTrials.gov study NCT02948608. IPD Sharing: NO. Countries: 1. Publications: 1.
Clinical Characteristics and Discharge Assessment of Patients From Palliative Care
ClinicalTrials.gov study NCT04755374. IPD Sharing: NO. Countries: 1. Publications: 3.
Management of Headache Disorders: A Clinical Trial Screening for Prognostic Patient Characteristics
ClinicalTrials.gov study NCT00298142. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Malnutrition Clinical Characteristics Validation and Staffing Optimization Study (MCC Study)
ClinicalTrials.gov study NCT03928548. IPD Sharing: NO. Countries: 1. Publications: 4.
Clinical Characteristics and Prognosis of Acute Stroke in Pregnancy and Puerperium
ClinicalTrials.gov study NCT06527807. IPD Sharing: NO. Countries: 1. Publications: 1.
Prospective Cohort Study to Describe the Clinical Characteristics of COVID-19, the Acquired Immune Response and the Biological and Clinical Parameters of Patients Followed in Oncology by the Saint-Jos
ClinicalTrials.gov study NCT04437719. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Hospital-wide Incidence, Clinical Characteristics and Outcomes of ARDS
ClinicalTrials.gov study NCT03546699. IPD Sharing: UNDECIDED. Countries: 3. Publications: 1.
Phenotypic Clinical, and Genetic Characteristics of Patients With Nontuberculosis Mycobacteria
ClinicalTrials.gov study NCT01616745. IPD Sharing: Not stated. Countries: 1. Publications: 10.
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OpenNeuro
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