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86 results for “Dopamine Receptors”
Functional Relevance of Dopamine Receptors in Healthy Controls and Patients With Schizophrenia: Characterization Through [11C]NNC-112 and [18F]Fallypride Positron Emission Tomography
ClinicalTrials.gov study NCT00942981. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Data from: Genetic polymorphism in dopamine receptor D4 is associated with early body condition in a large population of greater flamingos, Phoenicopterus roseus
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Data from: Stimulation of dopamine D1 receptor improves learning capacity in cooperating cleaner fish
Accurate contextual decision-making strategies are important in social environments. Specific areas in the brain are tasked to process these complex interactions and generate correct follow-up responses. The dorsolateral and dorsomedial parts of the telencephalon in the teleost fish brain are neural substrates modulated by the neurotransmitter dopamine (DA), and are part of an important neural circuitry that drives animal behaviour from the most basic actions such as learning to search for food, to properly choosing partners and managing decisions based on context. The Indo-Pacific cleaner wrasse Labroides dimidiatus is a highly social teleost fish species with a complex network of interactions with its 'client' reef fish. We asked if changes in DA signalling would affect individual learning ability by presenting cleaner fish two ecologically different tasks that simulated a natural situation requiring accurate decision-making. We demonstrate that there is an involvement of the DA system and D1 receptor pathways on cleaners' natural abilities to learn both tasks. Our results add significantly to the growing literature on the physiological mechanisms that underlie and facilitate the expression of cooperative abilities.
Data from: Association between the dopamine D4 receptor gene exon III variable number of tandem repeats and political attitudes in female Han Chinese
Twin and family studies suggest that political attitudes are partially determined by an individual's genotype. The dopamine D4 receptor gene (DRD4) exon III repeat region that has been extensively studied in connection with human behaviour, is a plausible candidate to contribute to individual differences in political attitudes. A first United States study provisionally identified this gene with political attitude along a liberal–conservative axis albeit contingent upon number of friends. In a large sample of 1771 Han Chinese university students in Singapore, we observed a significant main effect of association between the DRD4 exon III variable number of tandem repeats and political attitude. Subjects with two copies of the 4-repeat allele (4R/4R) were significantly more conservative. Our results provided evidence for a role of the DRD4 gene variants in contributing to individual differences in political attitude particularly in females and more generally suggested that associations between individual genes, and neurochemical pathways, contributing to traits relevant to the social sciences can be provisionally identified.
The world of GPCR dimers - mapping dopamine receptor D2 homodimers in different activation states and configuration arrangements
<p>G protein-coupled receptors (GPCRs) are known to dimerize, but the molecular and structural basis of GPCR dimers is not well understood. We developed a computational framework to generate models of the dopamine receptor D2 (D<sub>2</sub>R) homodimer in different activation states of the monomers and identified their most likely interfaces with molecular detail and contacts formed between interfacial residues. Such contacts were followed along a 3 replicates of 500 ns molecular dynamics simulation. </p> <p>The dataset presented here is a summary of all interfacial contacts, such as hydrogen bonds, pi-cation, pi-stacking, salt-bridges and t-stacking interactions, which occur within the interfaces of the different dimer configurations. The information can be viewed as dynamical flareplots, by uploading the .json files to https://gpcrviz.github.io/flareplot/. </p> <p>Contacts were measured using GetContacts (https://getcontacts.github.io/).</p> <p> </p> <p>6CM4-6CM4 = inactive-inactive</p> <p>6CM4-6U1N = inactive-arrestin</p> <p>6U1N-6U1N = arrestin-arrestin</p> <p>6VMS-6CM4 = active-inactive</p> <p>6VMS-6U1N = active-arrestin</p> <p>6VMS-6VMS = active-active</p>
Fig. 2. Key 1H–1H in Corybungines A K: Isoquinoline alkaloids from Corydalis bungeana with dopamine D2 receptor activity
Fig. 2. Key 1H–1H COSY and HMBC correlations of compounds 1–11.
Fig. 1 in Corybungines A K: Isoquinoline alkaloids from Corydalis bungeana with dopamine D2 receptor activity
Fig. 1. Structures of compounds 1–18.
Fig. 4 in Isoquinoline alkaloid dimers with dopamine D1 receptor activities from Menispermum dauricum DC
Fig. 4. Experimental and calculated ECD spectra of 1 (A) and 6 (B).
Fig. 3 in Isoquinoline alkaloid dimers with dopamine D1 receptor activities from Menispermum dauricum DC
Fig. 3. The selected NOESY or ROESY correlations of compounds 1 8.
Fig. 2. The 1 H– 1 H in Isoquinoline alkaloid dimers with dopamine D1 receptor activities from Menispermum dauricum DC
Fig. 2. The 1 H– 1 H COSY and key HMBC correlations of compounds 1 8.
Fig. 1 in Isoquinoline alkaloid dimers with dopamine D1 receptor activities from Menispermum dauricum DC
Fig. 1. Structures of compounds 1‒8.
Positron Emission Tomography (PET) Study Investigating Dopamine and Serotonin Receptor Occupancy After Multiple Oral Dosing of Lu AF35700
ClinicalTrials.gov study NCT02333487. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Positron-Emission-Tomography (PET) Study to Measure the Blockade of Dopamine Receptors (D2) in Specific Areas of the Brain in Relation to the Plasma Concentrations of Paliperidone Extended Release (
ClinicalTrials.gov study NCT00934635. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Dopamine Receptor Contributions to Prediction Error and Reversal Learning in Anorexia Nervosa
ClinicalTrials.gov study NCT04128683. IPD Sharing: NO. Countries: 1. Publications: 0.
A Translational and Neurocomputational Evaluation of a Dopamine Receptor 1 Partial Agonist for Schizophrenia
ClinicalTrials.gov study NCT04457310. IPD Sharing: YES. Countries: 1. Publications: 0.
Dopamine Receptor Imaging to Predict Response to Stimulant Therapy in Chronic TBI
ClinicalTrials.gov study NCT02225106. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Dopamine D2 Receptors(D2R) Imaging in Prolactinomas
ClinicalTrials.gov study NCT03717454. IPD Sharing: NO. Countries: 0. Publications: 3.
Dopamine D2 Receptors(D2R) Imaging in Nonfunctioning Pituitary Adenoma(NFPA)
ClinicalTrials.gov study NCT03714763. IPD Sharing: NO. Countries: 0. Publications: 4.
Study to Evaluate the Efficacy and Safety of Sandostatin LAR at High Dose or in Combination Either With GH-receptor Antagonist or Dopamine-agonist in Acromegalic Patients
ClinicalTrials.gov study NCT01278342. IPD Sharing: Not stated. Countries: 5. Publications: 0.
Data from: Stimulation of dopamine D1 receptor improves learning capacity in cooperating cleaner fish
Open the record for dataset details and reuse information.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.