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Fig. 1 in Acute toxicity and antiproliferative and procoagulant activities of fractions derived from Thymus satureioides of the Moroccan High Atlas

Fig. 1. Effect of T. satureioides CE and indomethacin administration on the rat paw oedema development during the first 24 h after carrageenan injection. The animals (n = 6) were treated with CE of T. satureioides at 60 mg/kg body weight. Indomethacin was used as a positive control (12 mg/kg body weight). The differences between treatment and control were tested using ANOVA followed by Dunnett's test. Values are mean ± SD, (n = 6). where *P <.01 and **P <.001 compared to control.

Fig. 3 in Acute toxicity and antiproliferative and procoagulant activities of fractions derived from Thymus satureioides of the Moroccan High Atlas

Fig. 3. Effect of T. satureioides CE administration on body weight in wistar female mice. Results are expressed as the mean ± SD (n = 6 mouse/group). *P <.05; **P <.001; control vs. TSCE 2 g/kg and TSCE 5 g/kg. TSCE: T. satureioides crude extract.

Fig. 2 in Acute toxicity and antiproliferative and procoagulant activities of fractions derived from Thymus satureioides of the Moroccan High Atlas

Fig. 2. Antiproliferative effect of T. satureioides CE in human breast cancer MCF-7 cells. Results are presented as the mean ± SD and analysed with One-way ANOVA followed by Dunnett's test, n = 3. *P <.001 vs. control.

opencc-zeroOct 2021View details →

dryad32/100

Berberocarum, a new genus from the High Atlas Mountains (Morocco), with notes on some NW African Umbelliferae-Apioideae

<p>In the Northwest Africa (Morocco), Carum is represented by 6 species, which belong to little known taxa of Umbelliferae (Apiaceae). In order to clarify the relationships of these species within Carum, we have conducted detailed morphological studies and molecular sequence analysis based on the nuclear DNA internal transcribed spacer (ITS) and plastid rps16 intron (rps16) region for four species, namely C. atlanticum, C. jahandiezii, C. lacuum and C. proliferum. According to molecular data, Moroccan Carum species form three isolated evolutionary lines distant from that of the generitype C. carvi. The morphological study shows that fruits of C. atlanticum belong to a carpological type markedly different from that of other Carum species. Based on the correlation of obtained carpological and molecular data, we have proposed to separate C. atlanticum to a new monotypic genus Berberocarum, endemic to the High Atlas Mountains.</p>

FIGURE 4 in Centaurea peltieri (Asteraceae), a new endemic species from the Oriental High Atlas of Morocco

FIGURE 4. Shape of appendages of middle involucral bracts of C. peltieri (A), C. takredensis (B), C. atlantis (C) and C. gattefossei (D) and C. oriolii-bolosii (from holotype!) (E).

FIGURE 3 in Centaurea peltieri (Asteraceae), a new endemic species from the Oriental High Atlas of Morocco

FIGURE 3. Shape of middle involucral bracts and their appendage of C. peltieri (A), C. takredensis (B), C. atlantis (C), C. gattefossei (D) and C. oriolii-bolosii (from holotype!) (E).

FIGURE 2 in Centaurea peltieri (Asteraceae), a new endemic species from the Oriental High Atlas of Morocco

FIGURE 2. Centaurea peltieri. Plant (A), involucral bracts outer (B), middle (C) and inner (D), leave (E), achene (F), capitula (G), outer sterile flower (H), inner fertile flower (I).

closedIPD-NOFeb 2026View details →

ClinicalTrials.gov32/100

An Efficacy and Safety Study of JNJ-56021927 (Apalutamide) in High-risk Prostate Cancer Subjects Receiving Primary Radiation Therapy: ATLAS

ClinicalTrials.gov study NCT02531516. IPD Sharing: NO. Countries: 23. Publications: 1.

dryad32/100

Berberocarum, a new genus from the High Atlas Mountains (Morocco), with notes on some NW African Umbelliferae-Apioideae

Open the record for dataset details and reuse information.

publicOct 2021View details →

opencc-by-4.0Dec 2023View details →

Plate XXII, Figs J.1–J.9 – Type J (High Atlas, Morocco and Algeria, M'Corn and M'Goun massifs). J.1, adult ♂b, sclerotized apex of aedeagus, left side damaged (M'Corn); J.2, adult ♂b, mesal field with sensilla (M'Corn); J.3, adult ♂b, hemitergal lobes, lateral view (M'Corn); J.4, rounded paraprocts of nymph, ventral view (M'Goun); J.5, cerci of nymph, lateral view (M'Goun); J.6, tergites of nymph, dorsal view (M'Goun); J.7, head, pronotum and mesonotum of ♂b nymph (M'Goun); J.8, adult ♂b, head and pronotum (M'Corn); J.9, mediodorsal setation on tergites of nymph (M'Goun). in Steps towards a revision of the Perla bipunctata Pictet, 1833 species complex (Plecoptera: Perlidae)

Plate XXII, Figs J.1–J.9 – Type J (High Atlas, Morocco and Algeria, M'Corn and M'Goun massifs). J.1, adult ♂b, sclerotized apex of aedeagus, left side damaged (M'Corn); J.2, adult ♂b, mesal field with sensilla (M'Corn); J.3, adult ♂b, hemitergal lobes, lateral view (M'Corn); J.4, rounded paraprocts of nymph, ventral view (M'Goun); J.5, cerci of nymph, lateral view (M'Goun); J.6, tergites of nymph, dorsal view (M'Goun); J.7, head, pronotum and mesonotum of ♂b nymph (M'Goun); J.8, adult ♂b, head and pronotum (M'Corn); J.9, mediodorsal setation on tergites of nymph (M'Goun).

Table 7 in Acute toxicity and antiproliferative and procoagulant activities of fractions derived from Thymus satureioides of the Moroccan High Atlas

<p><b>Table 7</b> Effect of CE and polar fractions from <i>T. satureioides</i> on APTT and PT.</p><table><tbody><tr><th>Concentration in the clotting mixture [mg/mL]</th><th>Crude extract</th><th>Methanol fraction</th><th>Aqueous fraction</th></tr></tbody><tbody><tr><th></th><td>APTT</td><td>PT</td><td>APTT</td><td>PT</td><td>APTT</td><td>PT</td></tr><tr><th>Control</th><td>15.35 ± 0.03</td><td>14.17 ± 0.01</td><td>15.35 ± 0.03</td><td>14.25 ± 0.02</td><td>15.35 ± 0.03</td><td>14.32 ± 0.06</td></tr><tr><th>0.18</th><td>14.93 ± 0.02*</td><td>14.07 ± 0.02*</td><td>14.51 ± 0.01**</td><td>14.16 ± 0.01</td><td>14.55 ± 0.01**</td><td>14.23 ± 0.01*</td></tr><tr><th>0.36</th><td>14.04 ± 0.00*</td><td>13.36 ± 0.01**</td><td>13.98 ± 0.01**</td><td>13.46 ± 0.02**</td><td>14.02 ± 0.01**</td><td>13.52 ± 0.02**</td></tr><tr><th>0.71</th><td>13.22 ± 0**</td><td>12.75 ± 0.02**</td><td>13.15 ± 0.01**</td><td>12.83 ± 0.01**</td><td>13.19 ± 0.01**</td><td>12.9 ± 0.01**</td></tr><tr><th>1.43</th><td>ND</td><td>ND</td><td>12.96 ± 0.03**</td><td>ND</td><td>13.00 ± 0.03**</td><td>ND</td></tr><tr><th>2.86</th><td>ND</td><td>ND</td><td>ND</td><td>ND</td><td>ND</td><td>ND</td></tr><tr><th>5.71</th><td>ND</td><td>ND</td><td>ND</td><td>ND</td><td>ND</td><td>ND</td></tr><tr><th>11.43</th><td>ND</td><td>–</td><td>ND</td><td>–</td><td>ND</td><td>–</td></tr></tbody></table><p>Results are presented as the mean of 6 measurements ± SD and analysed with one-way ANOVA followed by Dunnett's test. * <i>P</i> <.05, ** <i>P</i> <.001. Crude extract, methanol fraction, aqueous fraction <i>vs.</i> control.</p>

Table 5 in Acute toxicity and antiproliferative and procoagulant activities of fractions derived from Thymus satureioides of the Moroccan High Atlas

<p><b>Table 5</b> Effect of the CE and organic fractions from <i>T. satureioides</i> in ear oedema model induced by croton oil.</p><table><tbody><tr><th>Group</th><th>Ear oedema rate (%)</th></tr></tbody><tbody><tr><th></th><td>2 h</td><td>4 h</td><td>6 h</td><td>8 h</td><td>10 h</td></tr><tr><th>Control</th><td>28.89 ± 0.75</td><td>41.31 ± 0.79</td><td>41.30 ± 0.60</td><td>47.39 ± 0.50</td><td>37.32 ± 0.67</td></tr><tr><th>Crude extract</th><td>11.04 ± 0.27</td><td>23.05 ± 0,48</td><td>40.13 ± 1.28</td><td>33.33 ± 1.36**</td><td>41.86 ± 0.22**</td></tr><tr><th>Dichloromethane fraction</th><td>20.22 ± 4.97*</td><td>28.26 ± 4.01**</td><td>23.07 ± 8.72*</td><td>23.75 ± 3.94</td><td>12.80 ± 5.78**</td></tr><tr><th>E. acetate fraction</th><td>21.99 ± 0.95*</td><td>30.09 ± 0.46 **</td><td>15.97 ± 7.01**</td><td>12.27 ± 5.93</td><td>5.79 ± 6.63***</td></tr><tr><th>Methanol fraction</th><td>30.28 ± 1.08</td><td>39.70 ± 0.79</td><td>40.51 ± 0.43</td><td>35.74 ± 2.27*</td><td>31.24 ± 9.27</td></tr><tr><th>Aqueous fraction</th><td>30.38 ± 4.66</td><td>40.81 ± 1.01</td><td>46.56 ± 1.59</td><td>45.32 ± 0.18</td><td>38.46 ± 5.70</td></tr><tr><th>Indomethacin</th><td>34.23 ± 0.95*</td><td>33.33 ± 1.36**</td><td>17.59 ± 0.72</td><td>15.51 ± 0.64***</td><td>11.57 ± 0.07***</td></tr></tbody></table><p>The animals (n = 6) were treated with CE and fractions from <i>T.satureioides</i> at 1 mg/ear.Indomethacin was used as a positive control (600 μg/ear). The differences between treatment and control were tested using ANOVA followed by Turkey's test. Values are mean ± SEM, (n = 6), where * <i>P</i> <.05, ** <i>P</i> <.01 and *** <i>P</i> <.001 compared to control.</p>

Table 1 Table 3 in Acute toxicity and antiproliferative and procoagulant activities of fractions derived from Thymus satureioides of the Moroccan High Atlas

<p><b>Table 1</b> Polyphenol and flavonoid contents of CE and organic fractions from <i>T. satureioides</i>.</p><table><tbody><tr><th>Plant samples</th><th>Polyphenols (mg equivalent caffeic acid/g DR)</th><th>Flavonoids (mg equivalent rutin/g DR)</th></tr></tbody><tbody><tr><th>Crude extract</th><td>475.00 ± 8.30</td><td>182.79 ± 3.23</td></tr><tr><th>Dichloromethane fraction</th><td>100.57 ± 2.51</td><td>62.09 ± 1.26</td></tr><tr><th>Ethyl acetate fraction</th><td>441.00 ± 5.33</td><td>90.80 ± 2.67</td></tr><tr><th>Methanol fraction</th><td>238.00 ± 2.82</td><td>61.14 ± 1.41</td></tr><tr><th>Aqueous fraction</th><td>169.64 ± 3.89</td><td>46.95 ± 1.95</td></tr></tbody></table><p>Results are presented as the mean ± SD of three experiments and analysed with One-way</p><p>ANOVA followed by Dunnett's test. * <i>P</i> <.01; ** <i>P</i> <.001 <i>vs.</i> Trolox; DR: dry residue.</p><p>Values are presented as the mean ± SD of three experiments. DR: dry residue.</p>

Table 4 in Acute toxicity and antiproliferative and procoagulant activities of fractions derived from Thymus satureioides of the Moroccan High Atlas

<p><b>Table 4</b> Antihaemolytic activity of CE and organic fractions from T. satureioides.</p><table><tbody><tr><th>Plant samples</th><th>Haemolysis half-time</th><th>% Deviation a</th><th>% Deviation b</th></tr></tbody><tbody><tr><th>Control</th><td>151.00 ± 3.27</td><td>–</td><td>–</td></tr><tr><th>AAPH sample</th><td>70.22 ± 4.21 a***</td><td><i>−</i> 53.49</td><td>–</td></tr><tr><th>AAPH + Crude extract 2%</th><td>260.00 ± 17.32 a * b***</td><td>72.19</td><td>270.26</td></tr><tr><th>AAPH + Dichloromethane extract 2%</th><td>170.00 ± 15.50 a ns b***</td><td>12.58</td><td>142.10</td></tr><tr><th>AAPH + Ethyl acetate extract 2%</th><td>213.33 ± 20.66 a * b***</td><td>41.28</td><td>203.80</td></tr><tr><th>AAPH + Methanol extract 2%</th><td>166.67 ± 10.33 a ns b***</td><td>10.38</td><td>136.86</td></tr><tr><th>AAPH + Aqueous fraction 2%</th><td>166.67 ± 18.62 a ns b**</td><td>10.38</td><td>136.86</td></tr><tr><th>AAPH + Ascorbic acid 1%</th><td>320.94 ± 14.23 a*** b***</td><td>112.54</td><td>357.05</td></tr></tbody></table><p>Results are presented as the mean ± SD of three experiments and analysed with One-way ANOVA followed by Turkey's test. * <i>P</i> <.05; ** <i>P</i> <.01; *** <i>P</i> <.001; ns: not significant; Control <i>vs.</i> AAPH; a: crude extract, fractions and ascorbic acid <i>vs.</i> Control; b: crude extract, fractions and ascorbic acid <i>vs.</i> AAPH sample.</p>

Table 8 in Acute toxicity and antiproliferative and procoagulant activities of fractions derived from Thymus satureioides of the Moroccan High Atlas

<p><b>Table 8</b> Acute effects of <i>T. satureioides</i> CE (TSCE) after oral administration in <i>wistar</i> mice.</p><table><tbody><tr><th>Toxic signs</th><th>Control</th><th>TSCE (2000 mg/kg) %</th><th>TSCE (5000 mg/kg) %</th></tr></tbody><tbody><tr><th>Reduction of locomotor activity</th><td>0</td><td>0</td><td>33,3</td></tr><tr><th>Occurrence interval (h)</th><td>–</td><td>0–1</td><td>0–6</td></tr><tr><th>Ptosis</th><td>0</td><td>0</td><td>66,6</td></tr><tr><th>Occurrence interval (h)</th><td>–</td><td>–</td><td>0–4</td></tr><tr><th>Tremors</th><td>0</td><td>33,3</td><td>100</td></tr><tr><th>Occurrence interval (h)</th><td>–</td><td>0–1</td><td>0–4</td></tr><tr><th>Increased respiration rate</th><td>0</td><td>33,3</td><td>66,6</td></tr><tr><th>Occurrence interval (h)</th><td>–</td><td>0–1</td><td>0–2</td></tr><tr><th>Salivation</th><td>0</td><td>66,6</td><td>66,6</td></tr><tr><th>Occurrence interval (h)</th><td>–</td><td>0–1</td><td>0–4</td></tr></tbody></table><p>The animals (n = 6) were orally treated with CE of crude extract from <i>T. satureioides</i> at 2000 and 5000 mg/kg. %: The percentage refers to the proportion of animals in the group that expressed the respective signals at some points during the observational period (up to 6 h). TSCE: <i>T. satureioides</i> crude extract.</p>

FIGURE 1 in Centaurea peltieri (Asteraceae), a new endemic species from the Oriental High Atlas of Morocco

FIGURE 1. Holotype of Centaurea peltieri.

openGEO-OpenDec 2019View details →

Transcriptomic and open chromatin atlas of high-resolution anatomical regions in the rhesus macaque brain

GEO Series GSE128537. Macaca mulatta. 449 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.

openGEO-OpenApr 2023View details →

Atlas of nascent RNA transcripts reveals high confidence enhancer associated bidirectionals linked with genes across different tissue types

GEO Series GSE227931. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.

openGEO-OpenNov 2022View details →

Temporal single cell transcriptome atlas of zebrafish anterior segment development reveals high degree of conservation between the trabecular meshwork and the annular ligament

GEO Series GSE218068. Danio rerio. 5 samples. Type: Expression profiling by high throughput sequencing.