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49 results for “Hypoxia tolerance”
Data from: Metabolic depression and the evolution of hypoxia tolerance in threespine stickleback, Gasterosteus aculeatus
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Data from: Individual variation in whole-animal hypoxia tolerance is associated with cardiac hypoxia tolerance in a marine teleost
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Hypoxia inducible factor-1α knockout does not impair acute thermal tolerance or heat hardening in zebrafish
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Data from: The costs of a big brain: extreme encephalization results in higher energetic demand and reduced hypoxia tolerance in weakly electric African fishes
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Data from: Cardiorespiratory adjustments to chronic environmental warming improves hypoxia tolerance in European perch
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Fig. 2 in Temperature affects the hypoxia tolerance of neotropical Cichlid Geophagus brasiliensis
Fig. 2. Lactate Dehydrogenase enzyme activity of Geophagus brasiliensis exposed to normoxic (90% oxygen saturation) and hypoxic (20% oxygen saturation) conditions for 8 hours at 20°C, 24°C and 28°C. a. in liver; b. in white muscle; and c. in heart. Asterisks indicates significant differences between treatments at the same temperature, p <0.05. Different lowercase letters indicate significant differences for the same treatment at the temperatures studied, p <0.05.
Oxygen-mediated plasticity confers hypoxia tolerance in a corallivorous polychaete
<p><span>There is mounting evidence that the deoxygenation of coastal marine ecosystems has been underestimated, particularly in the tropics. These physical conditions appear to have far-reaching consequences for marine communities, and have been associated with mass mortalities. Yet little is known about hypoxia in tropical habitats or about the effects it has on reef-associated benthic organisms. We explored patterns of dissolved oxygen (DO) throughout Almirante Bay, Panama and found a hypoxic gradient, with areas closest to the mainland having the largest diel variation in DO, as well as more frequent persistent hypoxia. We then designed a laboratory experiment replicating the most extreme <i>in situ</i> DO regime found on shallow patch reefs (3 m) to assess the response of the corallivorous fireworm, <i>Hermodice carnaculata</i> to hypoxia. Worms were exposed to hypoxic conditions (8 h ~ 1 mg l<sup>-1 </sup>or 3.2 kPa) 16 times over an 8-week period, and at 4 and 8 weeks their oxygen consumption (respiration rates) were measured upon reoxygenation, along with regrowth of severed gills. Exposure to low DO resulted in worms regenerating significantly larger gills compared to worms under normoxia. This response to low DO was coupled with an ability to maintain elevated oxygen consumption/respiration rates after low DO exposure. In contrast, worms from the normoxic treatment had significantly depressed respiration rates after being exposed to low DO (week 8). This indicates that oxygen-mediated plasticity in both gill morphology and physiology may confer tolerance to increasingly frequent and severe hypoxia in one important coral predator associated with reef decline. </span></p>
Data from: Hypoxia-inducible factor-1 mediates adaptive developmental plasticity of hypoxia tolerance in zebrafish, Danio rerio
In recent years, natural and anthropogenic factors have increased aquatic hypoxia the world over. In most organisms, the cellular response to hypoxia is mediated by the master regulator hypoxia-inducible factor-1 (HIF-1). HIF-1 also plays a critical role in the normal development of the cardiovascular system of vertebrates. We tested the hypothesis that hypoxia exposures which resulted in HIF-1 induction during embryogenesis would be associated with enhanced hypoxia tolerance in subsequent developmental stages. We exposed zebrafish (Danio rerio) embryos to just 4 h of severe hypoxia or total anoxia at 18, 24 and 36 h post-fertilization (hpf). Of these, exposure to hypoxia at 24 and 36 hpf as well as anoxia at 36 hpf activated the HIF-1 cellular pathway. Zebrafish embryos that acutely upregulated the HIF-1 pathway had an increased hypoxia tolerance as larvae. The critical window for hypoxia sensitivity and HIF-1 signalling was 24 hpf. Adult male fish had a lower critical oxygen tension (Pcrit) compared with females. Early induction of HIF-1 correlated directly with an increased proportion of males in the population. We conclude that mounting a HIF-1 response during embryogenesis is associated with long-term impacts on the phenotype of later stages which could influence both individual hypoxia tolerance and population dynamics.
Data from: A positive genetic correlation between hypoxia tolerance and heat tolerance supports a controversial theory of heat stress
We used quantitative genetics to test a controversial theory of heat stress, in which animals overheat when the demand for oxygen exceeds the supply. This theory, referred to as oxygen- and capacity-limited thermal tolerance, predicts a positive genetic correlation between hypoxia tolerance and heat tolerance. We demonstrate the first genetic correlation of this kind in a model organism, Drosophila melanogaster. Genotypes more likely to fly under hypoxic stress (12% O2) were also more likely to fly under heat stress (39°C). This finding prompts new questions about mechanisms and limits of adaptation to heat stress.
Fig. 3 in Effects of the interannual variations in the flood pulse mediated by hypoxia tolerance: the case of the fish assemblages in the upper Paraná River floodplain
Fig. 3. Interannual variation of the absolute and mean ± s.e. values of dissolved oxygen (a, c) and water transparency (b, d) in lakes (circle) and river channels (square) of the upper Paraná River floodplain, in years of short (2000 and 2001) and moderate (2002 and 2003) floods. Numbers 1-6 are codes of the sampling stations (see Fig. 1).
Effect of 2-Week Nightly Moderate Hypoxia on Glucose Tolerance in Individuals With Type 2 Diabetes
ClinicalTrials.gov study NCT02513641. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: Hypoxia-inducible factor-1 mediates adaptive developmental plasticity of hypoxia tolerance in zebrafish, Danio rerio
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Oxygen-mediated plasticity confers hypoxia tolerance in a corallivorous polychaete
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Data from: A positive genetic correlation between hypoxia tolerance and heat tolerance supports a controversial theory of heat stress
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Flow increases tolerance of heat and hypoxia of an aquatic insect
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MYLIP attenuates hypoxia tolerance by inducing K27-linked polyubiquitination and subsequent proteasomal degradation of HIF-α
GEO Series GSE283363. Megalobrama amblycephala. 10 samples. Type: Expression profiling by high throughput sequencing.
Hypoxia tolerance in the Norrin-deficient retina and the chronically hypoxic brain stuied at single-cell resolution
GEO Series GSE125708. Mus musculus. 23 samples. Type: Expression profiling by high throughput sequencing.
Pharmacologic Induction of Tolerance for Hypoxia & Hypothermia
ClinicalTrials.gov study NCT06129825. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
GlitazOne Treatment for Coronavirus HypoxiA, a Safety and Tolerability Open Label With Matching Cohort Pilot Study
ClinicalTrials.gov study NCT04473274. IPD Sharing: NO. Countries: 1. Publications: 0.
CPOD Patient's Tolerance of Intermittent Exercise With Inter-exercise Recovery Under Normoxic Hypoxia
ClinicalTrials.gov study NCT07072975. IPD Sharing: NO. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.