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46 results for “Immunoassay”
Novel immunoassay detecting p-Tau Thr217 distinguishes Alzheimer's Disease from other dementias
<p><b>Objective</b></p> <p>To investigate whether p-tau T217 assay in cerebrospinal fluid (CSF) can distinguishes Alzheimer's disease from other dementias and healthy controls.</p> <p><b>Methods</b></p> <p>We developed and validated a novel Simoa immunoassay to detect p-tau T217 in CSF. There was a total of 190 participants from three cohorts with AD (n = 77) and other neurodegenerative diseases (n = 69) as well as healthy subjects (n = 44).</p> <p><b>Results</b></p> <p>The p-tau T217 assay (cut-off 242 pg/ml) identified AD subjects with accuracy of 90%, with 78% positive predictive value (PPV), 97% negative predictive value (NPV), 93% sensitivity, 88% specificity compared favorably with p-tau T181 ELISA (52 pg/ml) showing 78% accuracy, 58% PPV, 98% NPV, 71% specificity; 97% sensitivity. The assay distinguished AD patients from age-matched healthy subjects (cut-off 163 pg/ml, sensitivity 98%, specificity 93%) similarly to p-tau T181 ELISA (cut-off 60 pg/ml, 96% sensitivity and 86% specificity). In AD patients, we found a strong correlation between p-tau T217-tau and p-tau T181, t-tau and Aβ40 but not with Aβ42.</p> <p><b>Conclusions</b></p> <p>This study demonstrates that p-tau T217 displayed better diagnostic accuracy than p-tau T181. The data suggests that new p-tau T217 assay has a potential as an AD diagnostic test in the clinical evaluation.</p> <p><b>Classification of Evidence</b>: </p> <p>This study provides Class III evidence that a CSF immunoassay for p-tau T217 distinguishes AD from other dementias and healthy controls.</p>
Estradiol reference intervals in children, postmenopausal women and men using a noncompetitive immunoassay detection system
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Mass Evaluation of Lateral Flow Immunoassays for the Detection of SARS-CoV-2 (Covid-19) Antibodies
ClinicalTrials.gov study NCT05148806. IPD Sharing: NO. Countries: 1. Publications: 0.
Accuracy of Point of Care (POC) or In-office Urine Drug Testing (Immunoassay) in Chronic Pain Patients
ClinicalTrials.gov study NCT01052155. IPD Sharing: Not stated. Countries: 0. Publications: 3.
Novel immunoassay detecting p-Tau Thr217 distinguishes Alzheimer’s Disease from other dementias
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Dataset for the article "Electron-Transfer-Mediated by Detonation Nanodiamonds for Enhanced Cortisol Immunoassay"
<p>Dataset for the article "Electron-Transfer-Mediated by Detonation Nanodiamonds for Enhanced Cortisol Immunoassay".</p> <p>Chakavak Esmaeili1*, Jaroslav Kuliček1, Markéta Šlapal Bařinková1, Bohuslav Rezek1*</p> <p>1 Faculty of Electrical Engineering, CTU in Prague, Technicka 2, 16627 Prague, Czech Republic</p> <p>Figure 1. The preparation and immobilization step of the cortisol fabrication based on electrochemical immunosensor <br>Figure 2. 3D AFM images of (1) carbon bare electrode, (2) carbon electrode /DND, (3) carbon electrode/DND/EDC NHS (4) carbon electrode/ DND /EDC NHS/Ab, (5) carbon electrode/ DND /EDC NHS/Ab /BSA, (6) carbon electrode/ DND /EDC NHS/Ab/BSA/Ag<br>Figure 3. Raman spectra of immunosensor composition<br>Figure 4. FTIR spectra of DND (gray line), DND/ EDC NHS (blue line), DND/EDC NHS/Ab (green line). All spectra were recorded in the region between 4000–800 cm−1 with a resolution of 4 cm− 1 and 128 scans<br>Figure 5. Functionalization step. (1) carbon bare electrode, (2) carbon electrode /DND, (3) carbon electrode /DND/EDC NHS, (4) carbon electrode/DND/ EDC NHS/Ab and sensing step (5) carbon electrode/DND/ EDC NHS/Ab/BSA and (6) carbon electrode/DND/ EDC NHS/Ab/BSA/Ag in the presence of 100 nM cortisol in pH 7.0, containing 250 mM KCl and 5 mM K3[Fe(CN)6] and 5 mM K4[Fe(CN)6], Scan rate 0.1Vs−1<br>Figure 6. (a) Calibration curve of DPV with varying Ag concentrations. (b) Sensitivity comparison between configurations without Ab receptor (carbon electrode/DND/EDC NHS/Ag) and with Ab receptor (carbon electrode/DND/EDC NHS/Ab/BSA/Ag) in PBS solution, pH 7.0, containing 250 mM KCl and 5 mM K3[Fe (CN)6] and 5 mM K4[Fe (CN)6]<br>Figure 7. Interference study involving progesterone (2430 pg/ml), β-oestradiol (32 pg/ml), cortisone (28.6 nM), and corticosterone (3.94 nM) with respect to cortisol (100nM)<br>Figure 8. Stability of the immunosensor with repeated measurements of cortisol</p> <p> </p> <p>Figure S1. Optical images obtained for (1) bare carbon electrode, (2) DND, (3) DND/EDC NHS, (4) DND/EDC NHS/Ab, (5) DND/EDC NHS/Ab/BSA, (6) DND/EDC NHS/Ab/BSA/Ag.<br>Figure S2. SEM images of (1) bare carbon SPE, (2) carbon electrode/ DND, (3) carbon electrode/ DND /EDC NHS, (4) carbon electrode/ DND /EDC NHS/Ab, (5) carbon electrode/DND/EDC NHS/Ab/BSA, (6) carbon electrode/ DND /EDC NHS/Ab/BSA/Ag<br>Figure S3. (a) CV and (b) DPV of carbon bare electrode, carbon electrode /EDC NHS, carbon electrode/EDC NHS/Ab, carbon electrode/EDC NHS/Ab/BSA, carbon electrode/EDC NHS/Ab/BSA/Ag, in the presence of 100 nM cortisol, pH 7.0, containing 250 mM KCl and 5 mM K3[Fe(CN)6] and 5 mM K4[Fe(CN)6], Scan rate 0.1Vs−1.</p> <p><br>Table 1. Determination of cortisol in artificial saliva sample (n = 3)<br>Table S1. Surface roughness of immunosensors</p>
Lateral flow immunoassay-based laboratory algorithm for rapid diagnosis of diphtheria
<p><strong>Results of the ‘DIFTERIA’ Lateral Flow Immunoassay (LFIA) validation.</strong></p>
Evaluation of the Clinical Specificity of the Active Anthrax Detect™ Plus (AAD Plus) Lateral Flow Immunoassay (LFI)
ClinicalTrials.gov study NCT04320485. IPD Sharing: NO. Countries: 1. Publications: 0.
Harmonization of Thyroid-stimulating Hormone Immunoassays Reagents
ClinicalTrials.gov study NCT05151120. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Microbiota and Immunoassay in Women With and Without Endometriosis: a Pilot Study
ClinicalTrials.gov study NCT05433909. IPD Sharing: NO. Countries: 1. Publications: 0.
Strep A Fluorescent Immunoassay and Analyzer Field Study
ClinicalTrials.gov study NCT01441479. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Performance Value of Research of Occult Gastrointestinal Bleeding by Immunoassay in the Diagnostic Process of Iron Deficiency Anemia in Patients Over 75 Years
ClinicalTrials.gov study NCT02727075. IPD Sharing: NO. Countries: 1. Publications: 0.
Efficacy Study of Rapid Immunoassay Diagnostic Test Utilizing PP12 and AFP, ROM Plus
ClinicalTrials.gov study NCT02524691. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Point-of-Care Immunoassay for Detection of Bacterial Sinusitis
ClinicalTrials.gov study NCT03584737. IPD Sharing: NO. Countries: 1. Publications: 0.
Evaluation of Commercial SARS-CoV-2 Antibody Immunoassays for COVID-19
ClinicalTrials.gov study NCT04496141. IPD Sharing: NO. Countries: 1. Publications: 0.
A Comparison of Rapid Immunoassay Tests for the Detection of Ruptured Membranes
ClinicalTrials.gov study NCT01668472. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Clinical Trial of Anti-PLA2R-IgG Detection Kit (Time-resolved Fluorescence Immunoassay)
ClinicalTrials.gov study NCT06456801. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Immunoassay and Regulation of Traditional Chinese Medicine on Cancer Patients
ClinicalTrials.gov study NCT04438564. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Serum Hepcidin Immunoassay - Laboratory to Marketplace
ClinicalTrials.gov study NCT03310736. IPD Sharing: NO. Countries: 1. Publications: 0.
Rapid Immunoassay Tests for the Detection of Ruptured Membranes
ClinicalTrials.gov study NCT02495441. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.