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462
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462 results for “Lung injury”
SB-681323 IV for Subjects at Risk of Acute Lung Injury or ARDS
ClinicalTrials.gov study NCT00996840. IPD Sharing: YES. Countries: 1. Publications: 1.
Ganciclovir/Valganciclovir for Prevention of CMV Reactivation in Acute Injury of the Lung and Respiratory Failure
ClinicalTrials.gov study NCT01335932. IPD Sharing: NO. Countries: 1. Publications: 1.
Data from: High-throughput mRNA sequencing-based DEGs: HNF4A mitigates sepsis-associated lung injury by upregulating NCOR2/GR/STAB1 axis and promoting macrophage polarization towards M2 phenotype
Open the record for dataset details and reuse information.
Treatment with 3-aminobenzamide during ex vivo lung perfusion of damaged rat lungs reduces graft injury and dysfunction after transplantation
<p>Ex vivo lung perfusion (EVLP) with pharmacological reconditioning may increase donor lung utilization for transplantation (LTx). 3-Aminobenzamide (3-AB), an inhibitor of poly (ADP-ribose) polymerase (PARP), reduces ex vivo lung injury in rat lungs damaged by warm ischemia (WI). Here we determined the effects of 3-AB reconditioning on graft outcome after LTx. Three groups of donor lungs were studied: Control (Ctrl): 1 hour WI + 3 hours cold ischemia (CI) + LTx; EVLP: 1 hour WI + 3 hours EVLP + LTx; EVLP + 3-AB: 1 hour WI + 3 hours EVLP + 3-AB (1 mg<sup>.</sup>mL<sup>−1</sup>) + LTx. Two hours after LTx, we determined lung graft compliance, edema, histology, neutrophil counts in bronchoalveolar lavage (BAL), mRNA levels of adhesion molecules within the graft, as well as concentrations of interleukin-6 and 10 (IL-6, IL-10) in BAL and plasma. 3-AB reconditioning during EVLP improved compliance and reduced lung edema, neutrophil infiltration, and the expression of adhesion molecules within the transplanted lungs. 3-AB also attenuated the IL-6/IL-10 ratio in BAL and plasma, supporting an improved balance between pro- and anti-inflammatory mediators. Thus, 3-AB reconditioning during EVLP of rat lung grafts damaged by WI markedly reduces inflammation, edema, and physiological deterioration after LTx, supporting the use of PARP inhibitors for the rehabilitation of damaged lungs during EVLP.</p>
Dataset for Subnormothermic ex vivo lung perfusion attenuates ischemia reperfusion injury from donation after circulatory death donors
<p>Use of normothermic <i>ex vivo</i> lung perfusion (EVLP) was adopted in clinical practice to assess the quality of marginal donor lungs. Subnormothermic perfusion temperatures are in use among other solid organs to improve biochemical, clinical and immunological parameters. In a rat EVLP model of donation after circulatory death (DCD) lung donors, we tested the effect of four subnormothermic EVLP temperatures that could further improve organ preservation. Warm ischemic time was of 2 hours. EVLP time was of 4 hours. Lung physiological data were recorded and metabolic parameters were assessed. Lung oxygenation at 21°C and 24°C were significantly improved whereas pulmonary vascular resistance and edema formation at 21°C EVLP were significantly worsened when compared to 37°C EVLP. The perfusate concentrations of potassium ions and lactate exiting the lungs with 28°C EVLP were significantly lower whereas sodium and chlorine ions with 32°C EVLP were significantly higher when compared to 37°C EVLP. Also compared to 37°C EVLP, the pro-inflammatory chemokines MIP2, MIP-1α, GRO-α, the cytokine IL-6 were significantly lower with 21°C, 24°C and 28°C EVLP, the IL-18 was significantly lower but only with 21°C EVLP and IL-1β was significantly lower at 21°C and 24°C EVLP. Compared to the 37°C EVLP, the lung tissue ATP content after 21°C, 24°C and 28°C EVLP were significantly higher, the carbonylated protein content after 28°C EVLP was significantly lower and we measured significantly higher myeloperoxidase activities in lung tissues with 21°C, 24°C and 32°C. The 28°C EVLP demonstrated acceptable physiological variables, significantly higher lung tissue ATP content and decreased tissue carbonylated proteins with reduced release of pro-inflammatory cytokines. In conclusion, the 28°C EVLP is a non inferior setting in comparison to the clinically approved 37°C EVLP and significantly improve biochemical, clinical and immunological parameters and may reduce I/R injuries of DCD lung donors.</p>
Incidence of Acute Lung Injury: The Alien Study
ClinicalTrials.gov study NCT00736892. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Nebulized Heparin for the Treatment of COVID-19 Induced Lung Injury
ClinicalTrials.gov study NCT04397510. IPD Sharing: NO. Countries: 1. Publications: 14.
TRANSPIRE: Lung Injury in a Longitudinal Cohort of Pediatric HSCT Patients
ClinicalTrials.gov study NCT04098445. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Prone Positioning in Pediatric Acute Lung Injury
ClinicalTrials.gov study NCT00133614. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Anti-TF Antibody (ALT-836) to Treat Septic Patients With Acute Lung Injury or Acute Respiratory Distress Syndrome
ClinicalTrials.gov study NCT00879606. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study on the Correlation Between Alveolar Macrophage-derived Autophagosomes and the Severity of Lung Injury in ARDS
ClinicalTrials.gov study NCT05101694. IPD Sharing: YES. Countries: 1. Publications: 13.
Neurogenic Myocardial and Lung Injury in SAH Patients
ClinicalTrials.gov study NCT05408988. IPD Sharing: NO. Countries: 1. Publications: 7.
Exhaled Breath Particles as a Clinical Indicator for Lung Injury and Acute Respiratory Distress Syndrome (ARDS)
ClinicalTrials.gov study NCT04503057. IPD Sharing: NO. Countries: 1. Publications: 3.
Dead Mesenchymal Stem Cells for Radiation Lung Injury
ClinicalTrials.gov study NCT06021067. IPD Sharing: NO. Countries: 1. Publications: 25.
Evaluation of Variable Pressure Support Ventilation in the Therapy of Acute Lung Injury
ClinicalTrials.gov study NCT00786292. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Clinical Effect of the Association of Noninvasive Ventilation and High Flow Nasal Oxygen Therapy in Resuscitation of Patients With Acute Lung Injury (FLORALI Study)
ClinicalTrials.gov study NCT01320384. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Early Versus Delayed Enteral Feeding and Omega-3 Fatty Acid/Antioxidant Supplementation for Treating People With Acute Lung Injury or Acute Respiratory Distress Syndrome (The EDEN-Omega Study)
ClinicalTrials.gov study NCT00609180. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Ruxolitinib for Treatment of Covid-19 Induced Lung Injury ARDS
ClinicalTrials.gov study NCT04359290. IPD Sharing: YES. Countries: 1. Publications: 12.
Intraoperative Mechanical Power and Ventilation-Associated Lung Injury: Assessing Complications
ClinicalTrials.gov study NCT06375980. IPD Sharing: NO. Countries: 1. Publications: 5.
Incidence of Acute Lung Injury in Children
ClinicalTrials.gov study NCT01142544. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.